|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
125-1012 |
6.34e-170 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 516.41 E-value: 6.34e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 125 PRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEF 204
Cdd:COG4581 13 EALADFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVERF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 205 --QDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSA 282
Cdd:COG4581 93 gaENVGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 283 TIPNARQFAEWICHLHkQPCHVIYTDYRPTPL-QHYIFPAGGDGLHLVVDEngdfrednfntamqvlrdagdlakgdqkg 361
Cdd:COG4581 173 TVGNAEEFAEWLTRVR-GETAVVVSEERPVPLeFHYLVTPRLFPLFRVNPE----------------------------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 362 rkggTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAidclsDEDKKLPQVEH 441
Cdd:COG4581 223 ----LLRPPSRHEVIEELDRGGLLPAIVFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLFGKT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 442 VLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGR 521
Cdd:COG4581 294 LSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGR 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 522 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLR---VEEInpEYMLEKSFYQFQHYRAIPG 598
Cdd:COG4581 374 AGRRGIDTEGHVVVLAPEHDDPKKFARLASARPEPLRSSFRPSYNMVLNLLArpgLERA--RELLEDSFAQFQADRSVVG 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 599 VVEKVKNSEEQYNKIVI---PNEENVVIYYKIRQQLAKLgkeieeyihkpkyclpflqpgrlvkvknegddfgwgvvvnf 675
Cdd:COG4581 452 LARRARELERALAGVVErlaCDLGDLQEYFALRQPLSPL----------------------------------------- 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 676 skksnvkpnsgeldplyvvevllrcskeslknsatEAAKPAKPDEkgEMQVVPVLVHLLSAISTVRLYIPKDLRpvDNRQ 755
Cdd:COG4581 491 -----------------------------------EALERESPAY--ALDVVSVPEATLEDPRPVLLAQDRRAR--GEAA 531
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 756 SVLKSIQEVQRRfpdgvplldpiddmgiqdqglkkviqkVEAFEHRMYSHPLHNDPnLETVYTL----CERKAQIALDIK 831
Cdd:COG4581 532 AAMKAAIEYDER---------------------------MERLEEVLRPHPLHECP-LERAFELyretHPWVRDIELRPK 583
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 832 SAKRElkkartvlqMDELkcrKRVLRRLGFAtSSDVIEMKGRVACEISSAdelllTEMMFNGLFNDLSSEQATALLSCFV 911
Cdd:COG4581 584 SVARD---------FDRF---CELLREYGYL-DDLTLTSEGLLLRYLYDA-----AEALRQGVPDDLDPEELAALISWLV 645
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 912 F---QENSSEMPKL-TEQLAGPLRQMQECAKRIAKVSAEAKLEideetylssfKPHLmDVVYTWATGATFAHICKMTDVF 987
Cdd:COG4581 646 EevrRVDSSEWERLpSPANRRAFVLVNALFRRLELLERRHGLP----------ELDP-GLAGAWASGADLAEVLDATDLD 714
|
890 900
....*....|....*....|....*....
gi 21312352 988 EGSIIRCMRRL----EELLRQMCQAAKAI 1012
Cdd:COG4581 715 AGDFVRWVRQVidpdPELRRTARAAVDLI 743
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
108-310 |
4.41e-158 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 464.99 E-value: 4.41e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 108 CTHEVALPADEDYIPL--KPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIF 185
Cdd:cd18024 1 CTHEVALPPDYDYTPIsaHKPPGNPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 186 TSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWE 265
Cdd:cd18024 81 TSPIKALSNQKYRELQEEFGDVGLMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 21312352 266 ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYR 310
Cdd:cd18024 161 ETIILLPDKVRYVFLSATIPNARQFAEWICKIHKQPCHVVYTDYR 205
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
580-839 |
2.09e-108 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 337.72 E-value: 2.09e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 580 EYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVK 659
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKLKELEKELASIKIPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 660 VK-NEGDDFGWGVVVNFSKKSNvKPNSGELDPLYVVEVLLRCSKES-------LKNSATEAAKPAKPDEKGEMQVVPVLV 731
Cdd:pfam13234 81 VKdNGDQDFGWGVVVNFKKRKK-NGKAEPPQESYIVDVLLVLALVSspedldkFNDVNPEGFRPAPPGEKGEMEVVPVPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 732 HLLSAISTVRLYIPKDLRPVDNRQSVLKSIQEVQRRFPDGVPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDP 811
Cdd:pfam13234 160 SDIEAISSVRLKLPKDLRPAEAREAVLKALQELKRRFPDGIPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHKSP 239
|
250 260
....*....|....*....|....*...
gi 21312352 812 NLETVYTLCERKAQIALDIKSAKRELKK 839
Cdd:pfam13234 240 RLEELYALYHEKVELQEEIKELKKEISD 267
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
131-307 |
4.17e-85 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 272.22 E-value: 4.17e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 131 AKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLM 210
Cdd:cd18027 2 AFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 211 TGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQF 290
Cdd:cd18027 82 TGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVEF 161
|
170
....*....|....*..
gi 21312352 291 AEWICHLHKQPCHVIYT 307
Cdd:cd18027 162 ADWIGRIKKKNIYVIST 178
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
141-642 |
8.53e-80 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 270.23 E-value: 8.53e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 141 FQREAI-QCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREM---YEEFQ-DVGLMTGDVT 215
Cdd:COG1204 26 PQAEALeAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPLRALASEKYREFkrdFEELGiKVGVSTGDYD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 216 INP----TASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILL---PDNVHYVFLSATIPNAR 288
Cdd:COG1204 106 SDDewlgRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEVLLARLrrlNPEAQIVALSATIGNAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 289 QFAEWIchlhkqPCHVIYTDYRPTPLQHYIFPaggDGLHLVVDENGDFREDNFNTAMQVLRDAGdlakgdqkgrkggtkg 368
Cdd:COG1204 186 EIAEWL------DAELVKSDWRPVPLNEGVLY---DGVLRFDDGSRRSKDPTLALALDLLEEGG---------------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 369 psnvfkivkmimernfqPVIIFSFSKKDCEAYALQMTKL--DFNTDEEKKMVEEVFNNAIDC--LSDEDKKLPQvehvlp 444
Cdd:COG1204 241 -----------------QVLVFVSSRRDAESLAKKLADElkRRLTPEEREELEELAEELLEVseETHTNEKLAD------ 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 445 LLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDfrwISSGEYIQMSGRAGR 524
Cdd:COG1204 298 CLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMVP---IPVLEFKQMAGRAGR 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 525 RGMDDRGIVILMVDEKMSPT-IGKQLLKGSADPLNSAFHLTYNMVLNLLRV---------EEINpEYmLEKSFYQFQHYR 594
Cdd:COG1204 375 PGYDPYGEAILVAKSSDEADeLFERYILGEPEPIRSKLANESALRTHLLALiasgfansrEELL-DF-LENTFYAYQYDK 452
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 21312352 595 A-IPGVVEKVKNSEEQYNKIvipNEENVviyykiRQQLAKLGKEI-EEYI 642
Cdd:COG1204 453 GdLEEVVDDALEFLLENGFI---EEDGD------RLRATKLGKLVsRLYI 493
|
|
| KOW_Mtr4 |
cd13154 |
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a ... |
651-776 |
6.96e-70 |
|
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a core DExH region that cooperates with the eukaryotic nuclear exosome in RNA processing and degradation. KOW_Mtr4 motif might be involved in presenting RNA substrates to the helicase core. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW motif is located at the extended insertion of Mtr4 protein.
Pssm-ID: 240518 Cd Length: 129 Bit Score: 228.61 E-value: 6.96e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 651 FLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDP--LYVVEVLLRCSKESLKNSA-TEAAKPAKPDEKGEMQVV 727
Cdd:cd13154 1 FLQPGRLVKVKVGDDDFGWGVVVNFQKRPNKKNGSENSPPqeSYVVDVLLNCSSGSSINNGsPSGIRPPGPGEKGEMEVV 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 21312352 728 PVLVHLLSAISTVRLYIPKDLRPVDNRQSVLKSIQEVQRRFPDGVPLLD 776
Cdd:cd13154 81 PVLLSLIQAISSIRLYLPKDLRSADARQSVGKSLQEVKRRFPDGLPLLD 129
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
866-1033 |
7.14e-70 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 229.64 E-value: 7.14e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 866 DVIEMKGRVACEISSADELLLTEMMFNGLFNDLSSEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAkVSA 945
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYLPSPELAEALRLLEEIAHRIA-VSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 946 EakleideetylssFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGI 1025
Cdd:pfam08148 80 F-------------LDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEAI 146
|
....*...
gi 21312352 1026 TKIKRDIV 1033
Cdd:pfam08148 147 ELIKRDIV 154
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
310-538 |
2.16e-64 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 214.34 E-value: 2.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 310 RPTPLQHYIFPAGGDGLHLVVDENGDFrednfntamqvlrdagdlakgdqkgrkggtkgPSNVFKIVKMIMERNFQPVII 389
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKF--------------------------------DSDIIVLLKIETVSEGKPVLV 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 390 FSFSKKDCEAYALQMtkldfntdeekkmveevfnnaidclsdedkklpqvehvlpllkRGIGIHHGGLLPILKETIEILF 469
Cdd:cd18795 49 FCSSRKECEKTAKDL-------------------------------------------AGIAFHHAGLTREDRELVEELF 85
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312352 470 SEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD 538
Cdd:cd18795 86 REGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
138-294 |
1.28e-58 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 199.02 E-value: 1.28e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 138 LDAFQREAIQCVDN-NQSVLVSAHTSAGKTVCAEYAIALALRE-KQRVIFTSPIKALSNQKYREMYEEFQ----DVGLMT 211
Cdd:cd17921 2 LNPIQREALRALYLsGDSVLVSAPTSSGKTLIAELAILRALATsGGKAVYIAPTRALVNQKEADLRERFGplgkNVGLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 212 GDVTINPT----ASCLVMTTEILRSMLYRGSE-VMREVAWVIFDEIHYMRDSERGVVWEETIILLP---DNVHYVFLSAT 283
Cdd:cd17921 82 GDPSVNKLllaeADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinKNARFVGLSAT 161
|
170
....*....|.
gi 21312352 284 IPNARQFAEWI 294
Cdd:cd17921 162 LPNAEDLAEWL 172
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
136-572 |
4.01e-40 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 158.89 E-value: 4.01e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 136 FILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMyEEFQDVGLMT---- 211
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEEL-SRLRSLGMRVkisi 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 212 GDVTINPT----ASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETI----ILLPDnVHYVFLSAT 283
Cdd:PRK01172 100 GDYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLETVLssarYVNPD-ARILALSAT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 284 IPNARQFAEWIchlhkqPCHVIYTDYRPTPLQHYIFPAggDGLHLVVDENGDFREDnfntamqvlrdagdlakgdqkgrk 363
Cdd:PRK01172 179 VSNANELAQWL------NASLIKSNFRPVPLKLGILYR--KRLILDGYERSQVDIN------------------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 364 ggtkgpsnvfKIVKMIMERNFQpVIIFSFSKKDCEAYAlqmtkldfntdeekKMVEEVFN--NAIDCLSDEDKKLPqvEH 441
Cdd:PRK01172 227 ----------SLIKETVNDGGQ-VLVFVSSRKNAEDYA--------------EMLIQHFPefNDFKVSSENNNVYD--DS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 442 VLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGR 521
Cdd:PRK01172 280 LNEMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGR 359
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 21312352 522 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLL 572
Cdd:PRK01172 360 AGRPGYDQYGIGYIYAASPASYDAAKKYLSGEPEPVISYMGSQRKVRFNTL 410
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
142-536 |
3.46e-33 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 137.78 E-value: 3.46e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 142 QREAIQC-VDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREmYEEFQDVGLMTGDVTINP-- 218
Cdd:PRK02362 28 QAEAVEAgLLDGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEE-FERFEELGVRVGISTGDYds 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 219 ------TASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILL----PdNVHYVFLSATIPNAR 288
Cdd:PRK02362 107 rdewlgDNDIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAKLrrlnP-DLQVVALSATIGNAD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 289 QFAEWIchlhkqPCHVIYTDYRPTPLQ---HYifpagGDGLHLvvdengdfrednfntamqvlrdagdlakgDQKGRKGG 365
Cdd:PRK02362 186 ELADWL------DAELVDSEWRPIDLRegvFY-----GGAIHF-----------------------------DDSQREVE 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 366 TKGPSNVFKIVKMIMERNFQpVIIFSFSKKDCEAYALQMTkldfntDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPL 445
Cdd:PRK02362 226 VPSKDDTLNLVLDTLEEGGQ-CLVFVSSRRNAEGFAKRAA------SALKKTLTAAERAELAELAEEIREVSDTETSKDL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 446 ---LKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKD-FRWISSGEYIQMSGR 521
Cdd:PRK02362 299 adcVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGAgMQPIPVLEYHQMAGR 378
|
410
....*....|....*
gi 21312352 522 AGRRGMDDRGIVILM 536
Cdd:PRK02362 379 AGRPGLDPYGEAVLL 393
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
119-591 |
1.62e-32 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 135.72 E-value: 1.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 119 DYIPLKPRVGKAAKE------YPFILDAFQREAIQcvdnNQSVLVSAHTSAGKTVCAEYAIA-LALREKQRVIFTSPIKA 191
Cdd:PRK00254 4 DELRVDERIKRVLKErgieelYPPQAEALKSGVLE----GKNLVLAIPTASGKTLVAEIVMVnKLLREGGKAVYLVPLKA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 192 LSNQKYREmYEEFQDVGL----MTGDVtiNPTASCL------VMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERG 261
Cdd:PRK00254 80 LAEEKYRE-FKDWEKLGLrvamTTGDY--DSTDEWLgkydiiIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 262 VVWEETIILLPDNVHYVFLSATIPNARQFAEWIchlhkqPCHVIYTDYRPTPLQHYIFPAGgdglhLVVDENGdfREDNF 341
Cdd:PRK00254 157 ATLEMILTHMLGRAQILGLSATVGNAEELAEWL------NAELVVSDWRPVKLRKGVFYQG-----FLFWEDG--KIERF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 342 NTAMQVL-RDAGDLAKGdqkgrkggtkgpsnvfkivkmimernfqpVIIFSFSKKDCEAYALQMTKL--DFNTDEEKKMV 418
Cdd:PRK00254 224 PNSWESLvYDAVKKGKG-----------------------------ALVFVNTRRSAEKEALELAKKikRFLTKPELRAL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 419 EEvfnnaidcLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTN 498
Cdd:PRK00254 275 KE--------LADSLEENPTNEKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRD 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 499 ARKYdgKDFRW--ISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNM---VLNLL- 572
Cdd:PRK00254 347 TKRY--SNFGWedIPVLEIQQMMGRAGRPKYDEVGEAIIVATTEEPSKLMERYIFGKPEKLFSMLSNESAFrsqVLALIt 424
|
490 500
....*....|....*....|....
gi 21312352 573 -----RVEEINPeyMLEKSFYQFQ 591
Cdd:PRK00254 425 nfgvsNFKELVN--FLERTFYAHQ 446
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
139-294 |
7.49e-31 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 120.17 E-value: 7.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 139 DAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQD---------V 207
Cdd:cd18025 3 DAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLREsdDGVVVYVAPTKALVNQVVAEVYARFSKkyppsgkslW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 208 GLMTGDVTINPTASCLVMTT--EILRSML---YRGSEVMReVAWVIFDEIHYMRDSERGVVWEETIILLPdnVHYVFLSA 282
Cdd:cd18025 83 GVFTRDYRHNNPMNCQVLITvpECLEILLlspHNASWVPR-IKYVIFDEIHSIGQSEDGAVWEQLLLLIP--CPFLALSA 159
|
170
....*....|..
gi 21312352 283 TIPNARQFAEWI 294
Cdd:cd18025 160 TIGNPQKFHEWL 171
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
135-313 |
5.10e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 117.98 E-value: 5.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 135 PFILDAFQREAIQCV-DNNQSVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQD----- 206
Cdd:smart00487 6 FEPLRPYQKEAIEALlSGLRDVILAAPTGSGKTLAALLPALEALKRgkGGRVLVLVPTRELAEQWAEELKKLGPSlglkv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 207 VGLMTGDVT-------INPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVF 279
Cdd:smart00487 86 VGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLL 165
|
170 180 190
....*....|....*....|....*....|....
gi 21312352 280 LSATIPNarqFAEWICHLHKQPCHVIYTDYRPTP 313
Cdd:smart00487 166 LSATPPE---EIENLLELFLNDPVFIDVGFTPLE 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
142-285 |
1.16e-28 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 113.11 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 142 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ---RVIFTSPIKALSNQKYREMYEEFQDVGLM----TGDV 214
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDngpQALVLAPTRELAEQIYEELKKLGKGLGLKvaslLGGD 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312352 215 TINP------TASCLVMTTEILRSMLYRgSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIP 285
Cdd:pfam00270 84 SRKEqleklkGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
142-294 |
7.64e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 110.89 E-value: 7.64e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 142 QREAIQC-VDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKyremYEEFQD-------VGLMTGD 213
Cdd:cd18028 6 QAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEK----YEEFKKleeiglkVGISTGD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 214 VTINPT----ASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETII---LLPDNVHYVFLSATIPN 286
Cdd:cd18028 82 YDEDDEwlgdYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVArlrRLNPNTQIIGLSATIGN 161
|
....*...
gi 21312352 287 ARQFAEWI 294
Cdd:cd18028 162 PDELAEWL 169
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
151-558 |
7.96e-23 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 104.97 E-value: 7.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 151 NNQSVlVSAhTSAGKTVCAEYA-IALALREKQRVIFTSPIKALSNQKYREM---YEEFQDVGLMTGDVTIN-------PT 219
Cdd:COG1202 226 KDQLV-VSA-TATGKTLIGELAgIKNALEGKGKMLFLVPLVALANQKYEDFkdrYGDGLDVSIRVGASRIRddgtrfdPN 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 220 ASCLVMTTEILRSMLyRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILL----PDnVHYVFLSATIPNARQFAEwic 295
Cdd:COG1202 304 ADIIVGTYEGIDHAL-RTGRDLGDIGTVVIDEVHMLEDPERGHRLDGLIARLkyycPG-AQWIYLSATVGNPEELAK--- 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 296 HLHKQPchVIYtDYRPTPLQ-HYIFPAGGDGL----HLVVDEngdfrednFNTAmqvlrdagdlakgDQKGRKGGTkgps 370
Cdd:COG1202 379 KLGAKL--VEY-EERPVPLErHLTFADGREKIriinKLVKRE--------FDTK-------------SSKGYRGQT---- 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 371 nvfkivkmimernfqpvIIFSFSKKDCEAYAlqmtkldfntdeekkmveevfnnaidclsdedkklpqvehvlpllkRGI 450
Cdd:COG1202 431 -----------------IIFTNSRRRCHEIA----------------------------------------------RAL 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 451 GI----HHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLF-TNARkydGKDfrWISSGEYIQMSGRAGRR 525
Cdd:COG1202 448 GYkaapYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFdSLAM---GIE--WLSVQEFHQMLGRAGRP 522
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 21312352 526 GMDDRGIVILMV------DEKMSPT---IGKQLLKGSADPLN 558
Cdd:COG1202 523 DYHDRGKVYLLVepgksyHRSMEMTedeVAFKLLKGEMEDVA 564
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
142-311 |
9.78e-23 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 97.43 E-value: 9.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 142 QREAIQ-CVDNNQSVLVSAHTSAGKTVCAEYAIALALRE-------KQRVIFTSPIKALSNQKYREMYEEFQDVGL---- 209
Cdd:cd18023 6 QSEVFPdLLYSDKNFVVSAPTGSGKTVLFELAILRLLKErnplpwgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLscae 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 210 MTGDVTINPT---ASC-LVMTT-EILRSMLYRGSE---VMREVAWVIFDEIHYMRDsERGVVWE-------------ETI 268
Cdd:cd18023 86 LTGDTEMDDTfeiQDAdIILTTpEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEvvvsrmktlssssELR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 21312352 269 ILLPDNVHYVFLSATIPNARQFAEWichLHKQP--CHVIYTDYRP 311
Cdd:cd18023 165 GSTVRPMRFVAVSATIPNIEDLAEW---LGDNPagCFSFGESFRP 206
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
109-535 |
1.64e-16 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 84.50 E-value: 1.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 109 THEVALPA-DEDYIP----LKPRVGKA-AKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ- 181
Cdd:COG1205 22 VHVRTIPArEARYAPwpdwLPPELRAAlKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 182 -RVIFTSPIKALSNQKYREMYEEFQDVGL------MTGDVT------INPTASCLVMTTEIL-RSMLYRG---SEVMREV 244
Cdd:COG1205 102 aTALYLYPTKALARDQLRRLRELAEALGLgvrvatYDGDTPpeerrwIREHPDIVLTNPDMLhYGLLPHHtrwARFFRNL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 245 AWVIFDEIH-YmrdseRGVvweetiilLPDNVHYVF------------------LSATIPNARQFAEwicHLHKQPCHVI 305
Cdd:COG1205 182 RYVVIDEAHtY-----RGV--------FGSHVANVLrrlrricrhygsdpqfilASATIGNPAEHAE---RLTGRPVTVV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 306 YTDYRPTPLQHYIF---PAGGDGLhlvvdengdfREDNFNTAMQVLRDAgdlakgdqkgrkggtkgpsnvfkivkmiMER 382
Cdd:COG1205 246 DEDGSPRGERTFVLwnpPLVDDGI----------RRSALAEAARLLADL----------------------------VRE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 383 NFQpVIIFSFSkkdceayalqmtkldfntdeeKKMVEEVFNNAIDCLSDedkklpqvehvlPLLKRGIGIHHGGLLPILK 462
Cdd:COG1205 288 GLR-TLVFTRS---------------------RRGAELLARYARRALRE------------PDLADRVAAYRAGYLPEER 333
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312352 463 ETIEILFSEGLIKALFATETFAMGINMP---ArTVLftnarkyDGkdfrW---ISSgeYIQMSGRAGRRGmdDRGIVIL 535
Cdd:COG1205 334 REIERGLRSGELLGVVSTNALELGIDIGgldA-VVL-------AG----YpgtRAS--FWQQAGRAGRRG--QDSLVVL 396
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
152-294 |
3.92e-16 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 76.85 E-value: 3.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 152 NQSVLVSAHTSAGKTVCAEYAIALALREKQ----RVIFTSPIKALSNQKYR---EMYEEFQ---DVGLMTGDVT------ 215
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPekgvQVLYISPLKALINDQERrleEPLDEIDleiPVAVRHGDTSqsekak 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 216 -INPTASCLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVH----YVFLSATIPNAR 288
Cdd:cd17922 81 qLKNPPGILITTPESLELLLVnkKLRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLRKLTGrplrRIGLSATLGNLE 160
|
....*.
gi 21312352 289 QFAEWI 294
Cdd:cd17922 161 EAAAFL 166
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
438-526 |
4.60e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 74.17 E-value: 4.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 438 QVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMP-ARTVLFtnarkYDgkdfRWISSGEYI 516
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVII-----YD----LPWSPASYI 72
|
90
....*....|
gi 21312352 517 QMSGRAGRRG 526
Cdd:smart00490 73 QRIGRAGRAG 82
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
152-294 |
7.79e-15 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 73.95 E-value: 7.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 152 NQSVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQDV-GL----MTGDVTINPT----A 220
Cdd:cd18022 17 DNNVLLGAPTGSGKTIAAELAMFRAFNKypGSKVVYIAPLKALVRERVDDWKKRFEEKlGKkvveLTGDVTPDMKaladA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 221 SCLVMTTE----ILRSMLYRgsEVMREVAWVIFDEIHyMRDSERGVVWEetIILLPDN---------VHYVFLSATIPNA 287
Cdd:cd18022 97 DIIITTPEkwdgISRSWQTR--EYVQQVSLIIIDEIH-LLGSDRGPVLE--VIVSRMNyissqtekpVRLVGLSTALANA 171
|
....*..
gi 21312352 288 RQFAEWI 294
Cdd:cd18022 172 GDLANWL 178
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
140-294 |
1.32e-13 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 70.36 E-value: 1.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 140 AFQREAIQCV-DNNQSVLVSAHTSAGKTVCAEYAIALALR--EKQRVIFTSPIKALSNQKYREMYEEFQDVG-----LMT 211
Cdd:cd18021 6 PIQTQVFNSLyNTDDNVFVGAPTGSGKTVCAELALLRHWRqnPKGRAVYIAPMQELVDARYKDWRAKFGPLLgkkvvKLT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 212 GDVTINP---TASCLVMTT----EILrSMLYRGSEVMREVAWVIFDEIHyMRDSERGVVWEetIIL---------LPDNV 275
Cdd:cd18021 86 GETSTDLkllAKSDVILATpeqwDVL-SRRWKQRKNVQSVELFIADELH-LIGGENGPVYE--VVVsrmryissqLEKPI 161
|
170
....*....|....*....
gi 21312352 276 HYVFLSATIPNARQFAEWI 294
Cdd:cd18021 162 RIVGLSSSLANARDVGEWL 180
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
155-283 |
1.97e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 68.58 E-value: 1.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 155 VLVSAHTSAGKTVCAEYAIALALREKQ-RVIFTSPIKALSNQKYREMYEEFQ---DVGLMTGDVT-------INPTASCL 223
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGkKVLVLVPTKALALQTAERLRELFGpgiRVAVLVGGSSaeereknKLGDADII 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21312352 224 VMTTE-ILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETII--LLPDNVHYVFLSAT 283
Cdd:cd00046 84 IATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVrkAGLKNAQVILLSAT 146
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
140-311 |
2.56e-13 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 69.94 E-value: 2.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 140 AFQREAIQ--CVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQR-VIFTSPIKALSNQKYREMYEEFQDVGL----MTG 212
Cdd:cd18026 19 DWQKECLSlpGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKkALFVLPYVSIVQEKVDALSPLFEELGFrvegYAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 213 DVTINPTA-----SCLVMTTEILRSMLYRGSEVMR--EVAWVIFDEIHYMRDSERGVVWEETIILL----PDNVHYVFLS 281
Cdd:cd18026 99 NKGRSPPKrrkslSVAVCTIEKANSLVNSLIEEGRldELGLVVVDELHMLGDGHRGALLELLLTKLlyaaQKNIQIVGMS 178
|
170 180 190
....*....|....*....|....*....|
gi 21312352 282 ATIPNARQFAEWichLHKQpchVIYTDYRP 311
Cdd:cd18026 179 ATLPNLEELASW---LRAE---LYTTNFRP 202
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
140-328 |
7.04e-11 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 66.66 E-value: 7.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 140 AFQREAIQCVDNNQSVLVSAHTSAGKTV---------CAEYAIALALREKQRVIFTSPIKALSNQKYR-------EMYEE 203
Cdd:COG1201 27 PPQREAWPAIAAGESTLLIAPTGSGKTLaaflpaldeLARRPRPGELPDGLRVLYISPLKALANDIERnlrapleEIGEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 204 FQD------VGLMTGDvTinpTAS-----------CLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDSERGVVW 264
Cdd:COG1201 107 AGLplpeirVGVRTGD-T---PASerqrqrrrpphILITTPESLALLLTspDARELLRGVRTVIVDEIHALAGSKRGVHL 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312352 265 EETI----ILLPDNVHYVFLSATIPNARQFAEWIC-HLHKQPCHVIYTDYR----------PTPLQHYIFPAGGDGLHL 328
Cdd:COG1201 183 ALSLerlrALAPRPLQRIGLSATVGPLEEVARFLVgYEDPRPVTIVDAGAGkkpdlevlvpVEDLIERFPWAGHLWPHL 261
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
140-292 |
3.68e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 60.29 E-value: 3.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 140 AFQREAIQCVDNNQSVLVSAHTSAGKTVCaeY---AIALALREKQ-RVIFTSPIKALSN---QKYREMYEEFQ---DVGL 209
Cdd:cd17923 3 SHQAEAIEAARAGRSVVVTTGTASGKSLC--YqlpILEALLRDPGsRALYLYPTKALAQdqlRSLRELLEQLGlgiRVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 210 MTGD--------VTINPtASCLVMTTEILRSMLYRGSE----VMREVAWVIFDEIHYMrdseRGVVWEETIILL------ 271
Cdd:cd17923 81 YDGDtpreerraIIRNP-PRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTY----RGVFGSHVALLLrrlrrl 155
|
170 180
....*....|....*....|....*
gi 21312352 272 --PDNVHYVFL--SATIPNARQFAE 292
Cdd:cd17923 156 crRYGADPQFIltSATIGNPAEHAR 180
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
142-262 |
4.35e-10 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 63.75 E-value: 4.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 142 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAI-----ALA----LREKQRVIFTSPIKALSN--------------QKYR 198
Cdd:PRK13767 37 QRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIidelfRLGregeLEDKVYCLYVSPLRALNNdihrnleeplteirEIAK 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21312352 199 EMYEEFQD--VGLMTGDVT-------INPTASCLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDSERGV 262
Cdd:PRK13767 117 ERGEELPEirVAIRTGDTSsyekqkmLKKPPHILITTPESLAILLNspKFREKLRTVKWVIVDEIHSLAENKRGV 191
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
128-640 |
1.07e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 62.35 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 128 GKAAKEYPFILDAFQREAIQ-----CVDNNQSVLVSAHTSAGKTVCAEYAIAlALREKQRVIFTSPIKALSNQkYREMYE 202
Cdd:COG1061 71 GDEASGTSFELRPYQQEALEallaaLERGGGRGLVVAPTGTGKTVLALALAA-ELLRGKRVLVLVPRRELLEQ-WAEELR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 203 EFQDVGLMTGDvTINPTASCLVMTTEILRSMLYRgSEVMREVAWVIFDEIHYMRDSergvVWEETIILLPDNvhYVF-LS 281
Cdd:COG1061 149 RFLGDPLAGGG-KKDSDAPITVATYQSLARRAHL-DELGDRFGLVIIDEAHHAGAP----SYRRILEAFPAA--YRLgLT 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 282 ATiPNaRQFAEWIchLHKQPCHVIYtDYRPTPL--QHYIFPAggdgLHLVVDENGDFREDNFNTAMQVLRDAgdLAKGDQ 359
Cdd:COG1061 221 AT-PF-RSDGREI--LLFLFDGIVY-EYSLKEAieDGYLAPP----EYYGIRVDLTDERAEYDALSERLREA--LAADAE 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 360 kgrkggtkgpsNVFKIVKMIMER--NFQPVIIFSFSKKDCEAYAlqmtkldfntdeekKMVEEVFNNAIDCLSDEDKKlp 437
Cdd:COG1061 290 -----------RKDKILRELLREhpDDRKTLVFCSSVDHAEALA--------------ELLNEAGIRAAVVTGDTPKK-- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 438 qvehvlpllKRgigihhggllpilKETIEiLFSEGLIKALFATETFAMGINMP-ARTVLFTNARKydgkdfrwiSSGEYI 516
Cdd:COG1061 343 ---------ER-------------EEILE-AFRDGELRILVTVDVLNEGVDVPrLDVAILLRPTG---------SPREFI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 517 QMSGRAGRRGMD-DRGIVILMVDEKMSptigkqLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRA 595
Cdd:COG1061 391 QRLGRGLRPAPGkEDALVYDFVGNDVP------VLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEE 464
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 21312352 596 IPGVVEKVKNSEEQYNKIVIPNEENVVIYYKIRQQLAKLGKEIEE 640
Cdd:COG1061 465 LLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKAEEEE 509
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
131-285 |
2.65e-09 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 57.81 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 131 AKEYPFILDAFQREAIQCV--DNNQSV----LVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEF 204
Cdd:cd17918 9 CKSLPFSLTKDQAQAIKDIekDLHSPEpmdrLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKFL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 205 QD--VGLMTGDVT--INPTASCLVMTTEILRSmlyrgSEVMREVAWVIFDEIHYMrdserGVVWEETIILLpDNVHYVFL 280
Cdd:cd17918 89 PFinVELVTGGTKaqILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNL-GATHFLEA 157
|
....*.
gi 21312352 281 SAT-IP 285
Cdd:cd17918 158 TATpIP 163
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
475-536 |
2.99e-08 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 53.33 E-value: 2.99e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21312352 475 KALFATETFAMGINMPARTVLFTNARKYDGKDFRWISSGEYIQMSGRAGRRGMD-DRGIVILM 536
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSHfPEGEVTTL 134
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
374-526 |
4.76e-08 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 52.21 E-value: 4.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 374 KIVKMIMERNFQPVIIFSFSKKDCEAyalqmtkldfntdeekkmveevfnnaidclsdedkklpqvEHVLPLLKRGIGIH 453
Cdd:pfam00271 5 ALLELLKKERGGKVLIFSQTKKTLEA----------------------------------------ELLLEKEGIKVARL 44
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21312352 454 HGGLLPILKETIEILFSEGLIKALFATETFAMGINMP-ARTVLFtnarkYDGKDfrwiSSGEYIQMSGRAGRRG 526
Cdd:pfam00271 45 HGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN-----YDLPW----NPASYIQRIGRAGRAG 109
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
157-294 |
4.92e-08 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 57.63 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 157 VSAHTSAGKTVCA-EYAIALALREK------------QRVIFTSPIKALSNQKYREMYEEFQ----------------DV 207
Cdd:PRK09751 1 VIAPTGSGKTLAAfLYALDRLFREGgedtreahkrktSRILYISPIKALGTDVQRNLQIPLKgiaderrrrgetevnlRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 208 GLMTGDVTINPTA-------SCLVMTTEILRSMLY-RGSEVMREVAWVIFDEIHYMRDSERG----VVWEETIILLPDNV 275
Cdd:PRK09751 81 GIRTGDTPAQERSkltrnppDILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHTSA 160
|
170
....*....|....*....
gi 21312352 276 HYVFLSATIPNARQFAEWI 294
Cdd:PRK09751 161 QRIGLSATVRSASDVAAFL 179
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
138-283 |
4.73e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 50.38 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 138 LDAFQREAIQCVD---NNQSVLVSAHTSAGKTVCAEYAIALALreKQRVIFTSPIKALSNQkyreMYEEFQD------VG 208
Cdd:cd17926 1 LRPYQEEALEAWLahkNNRRGILVLPTGSGKTLTALALIAYLK--ELRTLIVVPTDALLDQ----WKERFEDflgdssIG 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312352 209 LMTGDVTINPTASCLVMTT-EILRSMLYRGSEVMREVAWVIFDEIHymRDSERGvvWEEtiILLPDNVHYVF-LSAT 283
Cdd:cd17926 75 LIGGGKKKDFDDANVVVATyQSLSNLAEEEKDLFDQFGLLIVDEAH--HLPAKT--FSE--ILKELNAKYRLgLTAT 145
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
152-291 |
4.32e-06 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 48.91 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 152 NQSVLVSAHTSAGKTVCAEYAIalaLREKQR--------------VIFTSPIKALsnqkYREMYEEFQD--------VGL 209
Cdd:cd18019 33 DENLLLCAPTGAGKTNVALLTI---LREIGKhrnpdgtinldafkIVYIAPMKAL----VQEMVGNFSKrlapygitVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 210 MTGDVT-----INPTaSCLVMTTEILRSMLYRGSE--VMREVAWVIFDEIHYMRDsERGVVWE-------ETIILLPDNV 275
Cdd:cd18019 106 LTGDQQltkeqISET-QIIVTTPEKWDIITRKSGDrtYTQLVRLIIIDEIHLLHD-DRGPVLEsivartiRQIEQTQEYV 183
|
170
....*....|....*.
gi 21312352 276 HYVFLSATIPNARQFA 291
Cdd:cd18019 184 RLVGLSATLPNYEDVA 199
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
140-284 |
4.82e-06 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 49.06 E-value: 4.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 140 AFQREAIQCVDNNQSVLVSAHTSAGKTV-CAEYAIALALREKQ----RVIFTSP--IKALSNQKyREMYEEFQDVGLMTG 212
Cdd:cd17972 63 KFREEILEAISNNPVVIIRGATGCGKTTqVPQYILDDFIQNDRaaecNIVVTQPrrISAVSVAE-RVAFERGEEVGKSCG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 213 ------DVTINPTASCLVMTTEILRSMLYRGsevMREVAWVIFDEIHyMRDSERG---VVWEETIILLPDnVHYVFLSAT 283
Cdd:cd17972 142 ysvrfeSVLPRPHASILFCTVGVLLRKLEAG---IRGISHVIVDEIH-ERDINTDfllVVLRDVVQAYPD-LRVILMSAT 216
|
.
gi 21312352 284 I 284
Cdd:cd17972 217 I 217
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
161-264 |
7.16e-06 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 46.78 E-value: 7.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 161 TSAGKTvcaeYAiAL-ALREKQRVIFTSPIKALSnqkyREMYEEFQDVG----LMTGD-VTINPTASCLVMTTEilrsML 234
Cdd:cd17913 10 TNSGKT----YH-ALqRLKSAKSGVYCGPLRLLA----WEVYERLNAEGvpcdLVTGQeRREVEGATHVSCTVE----MA 76
|
90 100 110
....*....|....*....|....*....|
gi 21312352 235 YRGSEVmrEVAwVIfDEIHYMRDSERGVVW 264
Cdd:cd17913 77 SISEPY--DVA-VI-DEIQMIGDPQRGWAW 102
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
462-535 |
9.54e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 44.62 E-value: 9.54e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21312352 462 KETIEILFSEglIKALFATETFAMGINMP-ARTVLFTNarkydgkdfRWISSGEYIQMSGRAGrRGMDDRGIVIL 535
Cdd:cd18785 13 IEHAEEIASS--LEILVATNVLGEGIDVPsLDTVIFFD---------PPSSAASYIQRVGRAG-RGGKDEGEVIL 75
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
152-294 |
7.89e-05 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 44.73 E-value: 7.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 152 NQSVLVSAHTSAGKTVCAEYAIALALREKQR-----------VIFTSPIKALSNqkyrEMYEEFQD--------VGLMTG 212
Cdd:cd18020 17 NENMLICAPTGAGKTNIAMLTILHEIRQHVNqggvikkddfkIVYIAPMKALAA----EMVEKFSKrlaplgikVKELTG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 213 DVTINPT---ASCLVMTTEILRSMLYRGS----EVMREVAWVIFDEIHYMRDsERGVVWEETIILLPDNVH-------YV 278
Cdd:cd18020 93 DMQLTKKeiaETQIIVTTPEKWDVVTRKSsgdvALSQLVRLLIIDEVHLLHD-DRGPVIESLVARTLRQVEstqsmirIV 171
|
170
....*....|....*.
gi 21312352 279 FLSATIPNARQFAEWI 294
Cdd:cd18020 172 GLSATLPNYLDVADFL 187
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
405-527 |
1.46e-04 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 42.58 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 405 TKLDFNTDEEKKMVEEVFNNA--IDCLSDEDkklpqVEHVLPLLKRgIGIH----HGGLLPILKETIEILFSEGLIKALF 478
Cdd:cd18794 12 DKKDEKLDLLKRIKVEHLGGSgiIYCLSRKE-----CEQVAARLQS-KGISaaayHAGLEPSDRRDVQRKWLRDKIQVIV 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 21312352 479 ATETFAMGINMP-ARTVLFTNARKydgkdfrwiSSGEYIQMSGRAGRRGM 527
Cdd:cd18794 86 ATVAFGMGIDKPdVRFVIHYSLPK---------SMESYYQESGRAGRDGL 126
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
135-288 |
9.98e-04 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 41.16 E-value: 9.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 135 PFILDAFQReaiqcvdNNQSVLVsAHTSAGKTVCAEYAIALAL-REKQRVIFTSPIKALSNQKYREMYEEF-----QDVG 208
Cdd:cd17990 8 PALRAALDA-------GGQVVLE-APPGAGKTTRVPLALLAELwIAGGKIIVLEPRRVAARAAARRLATLLgeapgETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 209 L-MTGDVTINPTASCLVMTTEILRSMLYRGSEvMREVAWVIFDEIHymrdsERGV--------VWEETIILLPDnVHYVF 279
Cdd:cd17990 80 YrVRGESRVGRRTRVEVVTEGVLLRRLQRDPE-LSGVGAVILDEFH-----ERSLdadlalalLLEVQQLLRDD-LRLLA 152
|
....*....
gi 21312352 280 LSATIPNAR 288
Cdd:cd17990 153 MSATLDGDG 161
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
141-293 |
1.44e-03 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 40.98 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 141 FQREAIQCVDNNQSVLVSAHTSAGKT-----VCAEYAIALALREKQRVIFTSP--IKALSNQKyREMYEEFQDVGLmtGD 213
Cdd:cd17981 6 MKQEIINMIDNNQVTVISGETGCGKTtqvtqFILDDAIERGKGSSCRIVCTQPrrISAISVAE-RVAAERAESCGL--GN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 214 VT----------INPTASCLVMTTEILRSMLyRGSEVMREVAWVIFDEIHyMRDSERGVVWEETIILLP--DNVHYVFLS 281
Cdd:cd17981 83 STgyqirlesrkPRKQGSILYCTTGIVLQWL-QSDPHLSNVSHLVLDEIH-ERNLQSDVLMGIVKDLLPfrSDLKVILMS 160
|
170
....*....|..
gi 21312352 282 ATIpNARQFAEW 293
Cdd:cd17981 161 ATL-NAEKFSDY 171
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
155-288 |
1.56e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 40.74 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 155 VLVSAHTSAGKTvcaEYAIALALR-----EKQRVIFTSPIKALSNQ---KYREMYEEFQD---VGLMTGDVTINPT---- 219
Cdd:cd17930 4 VILEAPTGSGKT---EAALLWALKlaargGKRRIIYALPTRATINQmyeRIREILGRLDDedkVLLLHSKAALELLesde 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312352 220 --------------------ASCLVMTT--EILRSML-YRGSEVM-----REVawVIFDEIHyMRDSErgvVWEETIILL 271
Cdd:cd17930 81 epdddpveavdwalllkrswLAPIVVTTidQLLESLLkYKHFERRlhglaNSV--VVLDEVQ-AYDPE---YMALLLKAL 154
|
170 180
....*....|....*....|..
gi 21312352 272 PD-----NVHYVFLSATIPNAR 288
Cdd:cd17930 155 LEllgelGGPVVLMTATLPALL 176
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