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Conserved domains on  [gi|198278498|ref|NP_082575|]
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histone PARylation factor 1 isoform 1 [Mus musculus]

Protein Classification

HPF1 family protein( domain architecture ID 10562970)

HPF1 family protein is a DUF2228 domain-containing protein similar to Homo sapiens histone PARylation factor 1 that acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2228 pfam10228
Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of ...
 77-328 8.86e-157

Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of approximately 700 residues found from worms to humans.


:

Pssm-ID: 463010  Cd Length: 251  Bit Score: 439.35  E-value: 8.86e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498   77 GLRLVGPYDILAGKHKMKKKPtGLNCNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDELPVYVGTNEAKKNCIIIQ 156
Cdd:pfam10228   1 GLKLVGPFDVLAGKHKRKKVD-GEDYLLHWRFYYDPPEFQTVLVGDDKTGYHYGYWRDSPDEKPVFVVSNDAKKGCEITV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498  157 NGDNVFAAIKLFLMKKLKEVTDRKKISILKNIDEKLTEAARKLGYSLeQRTVKMRQRDKKVVTKTFHGAGLVVPVD-KND 235
Cdd:pfam10228  80 VGDNVFAAVKHFLEKKLKKTDDKAKKKILKKLKKKLEDMAKELGISL-QKTEKMKKRKKKVVTKTFHGAGIVVPVDkKTD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498  236 VGYRELPETDADLKRICKAVVDAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPL 315
Cdd:pfam10228 159 VGYRPLPETDANLKKILKKIVEAKNDSERDKVFDPLQELVTFVQIANDECDYGMGLELGIDLFCYGSKYFHKVILQLLPT 238

                         250
                  ....*....|...
gi 198278498  316 AYNLLKRDLFAKI 328
Cdd:pfam10228 239 AYKLLKRPLFAEI 251
 
Name Accession Description Interval E-value
DUF2228 pfam10228
Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of ...
 77-328 8.86e-157

Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of approximately 700 residues found from worms to humans.


Pssm-ID: 463010  Cd Length: 251  Bit Score: 439.35  E-value: 8.86e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498   77 GLRLVGPYDILAGKHKMKKKPtGLNCNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDELPVYVGTNEAKKNCIIIQ 156
Cdd:pfam10228   1 GLKLVGPFDVLAGKHKRKKVD-GEDYLLHWRFYYDPPEFQTVLVGDDKTGYHYGYWRDSPDEKPVFVVSNDAKKGCEITV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498  157 NGDNVFAAIKLFLMKKLKEVTDRKKISILKNIDEKLTEAARKLGYSLeQRTVKMRQRDKKVVTKTFHGAGLVVPVD-KND 235
Cdd:pfam10228  80 VGDNVFAAVKHFLEKKLKKTDDKAKKKILKKLKKKLEDMAKELGISL-QKTEKMKKRKKKVVTKTFHGAGIVVPVDkKTD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498  236 VGYRELPETDADLKRICKAVVDAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPL 315
Cdd:pfam10228 159 VGYRPLPETDANLKKILKKIVEAKNDSERDKVFDPLQELVTFVQIANDECDYGMGLELGIDLFCYGSKYFHKVILQLLPT 238

                         250
                  ....*....|...
gi 198278498  316 AYNLLKRDLFAKI 328
Cdd:pfam10228 239 AYKLLKRPLFAEI 251
 
Name Accession Description Interval E-value
DUF2228 pfam10228
Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of ...
 77-328 8.86e-157

Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of approximately 700 residues found from worms to humans.


Pssm-ID: 463010  Cd Length: 251  Bit Score: 439.35  E-value: 8.86e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498   77 GLRLVGPYDILAGKHKMKKKPtGLNCNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDELPVYVGTNEAKKNCIIIQ 156
Cdd:pfam10228   1 GLKLVGPFDVLAGKHKRKKVD-GEDYLLHWRFYYDPPEFQTVLVGDDKTGYHYGYWRDSPDEKPVFVVSNDAKKGCEITV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498  157 NGDNVFAAIKLFLMKKLKEVTDRKKISILKNIDEKLTEAARKLGYSLeQRTVKMRQRDKKVVTKTFHGAGLVVPVD-KND 235
Cdd:pfam10228  80 VGDNVFAAVKHFLEKKLKKTDDKAKKKILKKLKKKLEDMAKELGISL-QKTEKMKKRKKKVVTKTFHGAGIVVPVDkKTD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278498  236 VGYRELPETDADLKRICKAVVDAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPL 315
Cdd:pfam10228 159 VGYRPLPETDANLKKILKKIVEAKNDSERDKVFDPLQELVTFVQIANDECDYGMGLELGIDLFCYGSKYFHKVILQLLPT 238

                         250
                  ....*....|...
gi 198278498  316 AYNLLKRDLFAKI 328
Cdd:pfam10228 239 AYKLLKRPLFAEI 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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