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Conserved domains on  [gi|83523742|ref|NP_082875|]
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WD repeat-containing protein 75 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-315 2.38e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742   2 VEEGVRVVRCGGSRLNFRRAVFSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGT 80
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  81 IKLWDYVDGILIKTFTigpklhaffiplHAEDSVF-LTISkeePDIFQLVS------VKLPkstsqDVEARQLTFVLDYI 153
Cdd:COG2319 186 VRLWDLATGKLLRTLT------------GHTGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATGKLLRTLTGH 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 154 NRSPKCIAFGNEGEYVAAV-RDFYLSVYFFKKKKtCNFTLPStknkknAKNKFTCVACHPKEDCIASGHMDGKIRLWrnf 232
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGsADGTVRLWDLATGE-LLRTLTG------HSGGVNSVAFSPDGKLLASGSDDGTVRLW--- 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 233 hsDQKyTYTCLHW---HHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHS 309
Cdd:COG2319 316 --DLA-TGKLLRTltgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 83523742 310 DNKITV 315
Cdd:COG2319 393 DGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
208-569 8.00e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 8.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 208 VACHPKEDCIASGHMDGKIRLWRnfhSDQKYTYTCLHWHHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPR 287
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 288 LGSSIEHISVSPAGDLFCTSHSDNkiTVIHRNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQGDKQ 367
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDG--TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 368 LYNLDIiQQEYINDegltqteltkAAFgcS--GTWLATVEQRQenenelelQMKLWNYSKKTQGFVLNTkiampHDDHIT 445
Cdd:COG2319 239 LRTLTG-HSGSVRS----------VAF--SpdGRLLASGSADG--------TVRLWDLATGELLRTLTG-----HSGGVN 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 446 ALCFnnaeSYEKPILVTASRDGHFKVWiltddsDIYKKAIAWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319 293 SVAF----SPDGKLLASGSDDGTVRLW------DLATGKLLRT--LTG--HTGAVRSVAFSPDGKTLASgSDDGTVRLWD 358

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 83523742 525 SQTWELKCTFCQRAGKIRHLCF---GRltcskYLLGTTDNGILCCWNL 569
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFspdGR-----TLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-315 2.38e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742   2 VEEGVRVVRCGGSRLNFRRAVFSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGT 80
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  81 IKLWDYVDGILIKTFTigpklhaffiplHAEDSVF-LTISkeePDIFQLVS------VKLPkstsqDVEARQLTFVLDYI 153
Cdd:COG2319 186 VRLWDLATGKLLRTLT------------GHTGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATGKLLRTLTGH 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 154 NRSPKCIAFGNEGEYVAAV-RDFYLSVYFFKKKKtCNFTLPStknkknAKNKFTCVACHPKEDCIASGHMDGKIRLWrnf 232
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGsADGTVRLWDLATGE-LLRTLTG------HSGGVNSVAFSPDGKLLASGSDDGTVRLW--- 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 233 hsDQKyTYTCLHW---HHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHS 309
Cdd:COG2319 316 --DLA-TGKLLRTltgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 83523742 310 DNKITV 315
Cdd:COG2319 393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-313 1.32e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  23 FSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHlQLYSCSFDGTIKLWDYVDGILIKTFTigpkl 101
Cdd:cd00200  17 FSPDGKLLATGSGDgTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRTLT----- 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 102 haffiplHAEDSVF-LTISkeePDIfQLVSvklpkSTSQD-------VEARQLTFVLDYINRSPKCIAFGNEGEYVA-AV 172
Cdd:cd00200  91 -------GHTSYVSsVAFS---PDG-RILS-----SSSRDktikvwdVETGKCLTTLRGHTDWVNSVAFSPDGTFVAsSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 173 RDFYLSVYFFKKKKTC-NFTLPStknkknakNKFTCVACHPKEDCIASGHMDGKIRLWRNFHSDQKYTYTClhwHHDMVM 251
Cdd:cd00200 155 QDGTIKLWDLRTGKCVaTLTGHT--------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVN 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83523742 252 DLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHSDNKI 313
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
208-569 8.00e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 8.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 208 VACHPKEDCIASGHMDGKIRLWRnfhSDQKYTYTCLHWHHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPR 287
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 288 LGSSIEHISVSPAGDLFCTSHSDNkiTVIHRNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQGDKQ 367
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDG--TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 368 LYNLDIiQQEYINDegltqteltkAAFgcS--GTWLATVEQRQenenelelQMKLWNYSKKTQGFVLNTkiampHDDHIT 445
Cdd:COG2319 239 LRTLTG-HSGSVRS----------VAF--SpdGRLLASGSADG--------TVRLWDLATGELLRTLTG-----HSGGVN 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 446 ALCFnnaeSYEKPILVTASRDGHFKVWiltddsDIYKKAIAWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319 293 SVAF----SPDGKLLASGSDDGTVRLW------DLATGKLLRT--LTG--HTGAVRSVAFSPDGKTLASgSDDGTVRLWD 358

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 83523742 525 SQTWELKCTFCQRAGKIRHLCF---GRltcskYLLGTTDNGILCCWNL 569
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFspdGR-----TLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-85 4.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 4.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 83523742     45 TEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWD 85
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-534 6.49e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 6.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 206 TCVACHPKEDCIASGHMDGKIRLWRNFHSDQKYTYTClhwHHDMVMDLAFTVTGTSLLSGG--RECVLVEWRDGSEKNke 283
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSsdKTIRLWDLETGECVR-- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 284 flpRLG---SSIEHISVSPAGDLFCTSHSDNKITVIHrnldasaviqglvkdrsistglmVDPRTKALVLNGKPGHLQFY 360
Cdd:cd00200  88 ---TLTghtSYVSSVAFSPDGRILSSSSRDKTIKVWD-----------------------VETGKCLTTLRGHTDWVNSV 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 361 SLQGDKQlynldiiqqeyindegltqteltkaaFGCSGTWLATVeqrqenenelelqmKLWNYskKTQGFVlntKIAMPH 440
Cdd:cd00200 142 AFSPDGT--------------------------FVASSSQDGTI--------------KLWDL--RTGKCV---ATLTGH 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 441 DDHITALCFnnaeSYEKPILVTASRDGHFKVWiltddsDIYKKaiAWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIV 520
Cdd:cd00200 177 TGEVNSVAF----SPDGEKLLSSSSDGTIKLW------DLSTG--KCLGTLRG--HENGVNSVAFSPDGYLLASGSEDGT 242

                       330
                ....*....|....*
gi 83523742 521 T-IWDSQTWELKCTF 534
Cdd:cd00200 243 IrVWDLRTGECVQTL 257
WD40 pfam00400
WD domain, G-beta repeat;
47-85 7.30e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 83523742    47 ECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWD 85
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-315 2.38e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742   2 VEEGVRVVRCGGSRLNFRRAVFSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGT 80
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  81 IKLWDYVDGILIKTFTigpklhaffiplHAEDSVF-LTISkeePDIFQLVS------VKLPkstsqDVEARQLTFVLDYI 153
Cdd:COG2319 186 VRLWDLATGKLLRTLT------------GHTGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATGKLLRTLTGH 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 154 NRSPKCIAFGNEGEYVAAV-RDFYLSVYFFKKKKtCNFTLPStknkknAKNKFTCVACHPKEDCIASGHMDGKIRLWrnf 232
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGsADGTVRLWDLATGE-LLRTLTG------HSGGVNSVAFSPDGKLLASGSDDGTVRLW--- 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 233 hsDQKyTYTCLHW---HHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHS 309
Cdd:COG2319 316 --DLA-TGKLLRTltgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 83523742 310 DNKITV 315
Cdd:COG2319 393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-313 1.32e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  23 FSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHlQLYSCSFDGTIKLWDYVDGILIKTFTigpkl 101
Cdd:cd00200  17 FSPDGKLLATGSGDgTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRTLT----- 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 102 haffiplHAEDSVF-LTISkeePDIfQLVSvklpkSTSQD-------VEARQLTFVLDYINRSPKCIAFGNEGEYVA-AV 172
Cdd:cd00200  91 -------GHTSYVSsVAFS---PDG-RILS-----SSSRDktikvwdVETGKCLTTLRGHTDWVNSVAFSPDGTFVAsSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 173 RDFYLSVYFFKKKKTC-NFTLPStknkknakNKFTCVACHPKEDCIASGHMDGKIRLWRNFHSDQKYTYTClhwHHDMVM 251
Cdd:cd00200 155 QDGTIKLWDLRTGKCVaTLTGHT--------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVN 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83523742 252 DLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHSDNKI 313
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-230 2.90e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 2.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  23 FSVDSKYIFCVSGDF-VKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWDYVDGILIKTFTIgpkl 101
Cdd:cd00200 101 FSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-VASSSQDGTIKLWDLRTGKCVATLTG---- 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 102 HaffiplhaEDSVF-LTISkeePDIFQLVS------VKLPKSTSQDVEArQLTFVLDYINrspkCIAFGNEGEYVAAVrD 174
Cdd:cd00200 176 H--------TGEVNsVAFS---PDGEKLLSsssdgtIKLWDLSTGKCLG-TLRGHENGVN----SVAFSPDGYLLASG-S 238

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 83523742 175 FYLSVYFFK-KKKTCNFTLPSTknkknaKNKFTCVACHPKEDCIASGHMDGKIRLWR 230
Cdd:cd00200 239 EDGTIRVWDlRTGECVQTLSGH------TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-403 4.08e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742   2 VEEGVRVVRCGGSRLNFRRAVFSVDSKYIFCVSGDF-VKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGT 80
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGtVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  81 IKLWDYVDGILIKTFTigpklhaffiplHAEDSVFltiskeepdifqlvsvklpkstsqdvearqltfvldyinrspkCI 160
Cdd:COG2319 144 VRLWDLATGKLLRTLT------------GHSGAVT-------------------------------------------SV 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 161 AFGNEGEYVAAV-RDFYLSVYFFKKKKtCNFTLPSTKNKknaknkFTCVACHPKEDCIASGHMDGKIRLWRnfHSDQKYT 239
Cdd:COG2319 169 AFSPDGKLLASGsDDGTVRLWDLATGK-LLRTLTGHTGA------VRSVAFSPDGKLLASGSADGTVRLWD--LATGKLL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 240 YTcLHWHHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHSDNKITVIhrN 319
Cdd:COG2319 240 RT-LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--D 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 320 LDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQGDKQLYNLdiiqqeyindEGLTQTeLTKAAFGCSGT 399
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL----------TGHTGA-VTSVAFSPDGR 385


                ....
gi 83523742 400 WLAT 403
Cdd:COG2319 386 TLAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
208-569 8.00e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 8.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 208 VACHPKEDCIASGHMDGKIRLWRnfhSDQKYTYTCLHWHHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPR 287
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 288 LGSSIEHISVSPAGDLFCTSHSDNkiTVIHRNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQGDKQ 367
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDG--TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 368 LYNLDIiQQEYINDegltqteltkAAFgcS--GTWLATVEQRQenenelelQMKLWNYSKKTQGFVLNTkiampHDDHIT 445
Cdd:COG2319 239 LRTLTG-HSGSVRS----------VAF--SpdGRLLASGSADG--------TVRLWDLATGELLRTLTG-----HSGGVN 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 446 ALCFnnaeSYEKPILVTASRDGHFKVWiltddsDIYKKAIAWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319 293 SVAF----SPDGKLLASGSDDGTVRLW------DLATGKLLRT--LTG--HTGAVRSVAFSPDGKTLASgSDDGTVRLWD 358

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 83523742 525 SQTWELKCTFCQRAGKIRHLCF---GRltcskYLLGTTDNGILCCWNL 569
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFspdGR-----TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-371 1.29e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 1.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742  48 CVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWDYVDGILIKTFtigpKLHAFFIplhaedsvfltiskeepdifq 127
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTL----KGHTGPV--------------------- 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 128 lvsvklpkstsqdvearqltfvldyinrspKCIAFGNEGEYVAAV-RDFYLSVYFFKKKKtCNFTLpstknkKNAKNKFT 206
Cdd:cd00200  55 ------------------------------RDVAASADGTYLASGsSDKTIRLWDLETGE-CVRTL------TGHTSYVS 97

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 207 CVACHPKEDCIASGHMDGKIRLWRNFHSDQKYTYTClhwHHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLP 286
Cdd:cd00200  98 SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 287 RLGSSIEHISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQGDK 366
Cdd:cd00200 175 GHTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252


                ....*
gi 83523742 367 QLYNL 371
Cdd:cd00200 253 CVQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
243-608 1.42e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 1.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 243 LHWHHDMVMDLAFTVTGTSLLSGGRECVLVEWRDGSEKNKEFLPRLGSSIEHISVSPAGDLFCTSHSDNKITVihRNLDA 322
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL--WDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 323 SAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQGDKQLYNLDIiQQEYINDegltqteltkAAFGCSGTWLA 402
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTS----------VAFSPDGKLLA 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 403 TVEQRQenenelelQMKLWNYSKKTQGFVLNtkiamPHDDHITALCFNnaesyekP---ILVTASRDGHFKVWiltddsD 479
Cdd:COG2319 179 SGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVRSVAFS-------PdgkLLASGSADGTVRLW------D 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 480 IYKKAIAWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWDSQTWELKCTFCQRAGKIRHLCF---GRltcskYL 555
Cdd:COG2319 233 LATGKLLRT--LTG--HSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspdGK-----LL 303

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 83523742 556 LGTTDNGILCCWNLlscsiqwsaKLNVRVMEPDPYSDHVAAVAQSSAGSDLFV 608
Cdd:COG2319 304 ASGSDDGTVRLWDL---------ATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-96 2.99e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 2.99e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83523742  19 RRAVFSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWDYVDGILIKTFT 96
Cdd:cd00200 181 NSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
2-85 1.89e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742   2 VEEGVRVVRCGGSRLNFRRAVFSVDSKYIFCVSGD-FVKVYSTTTEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGT 80
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDgTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGT 395


                ....*
gi 83523742  81 IKLWD 85
Cdd:COG2319 396 VRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-85 4.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 4.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 83523742     45 TEECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWD 85
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-534 6.49e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 6.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 206 TCVACHPKEDCIASGHMDGKIRLWRNFHSDQKYTYTClhwHHDMVMDLAFTVTGTSLLSGG--RECVLVEWRDGSEKNke 283
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSsdKTIRLWDLETGECVR-- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 284 flpRLG---SSIEHISVSPAGDLFCTSHSDNKITVIHrnldasaviqglvkdrsistglmVDPRTKALVLNGKPGHLQFY 360
Cdd:cd00200  88 ---TLTghtSYVSSVAFSPDGRILSSSSRDKTIKVWD-----------------------VETGKCLTTLRGHTDWVNSV 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 361 SLQGDKQlynldiiqqeyindegltqteltkaaFGCSGTWLATVeqrqenenelelqmKLWNYskKTQGFVlntKIAMPH 440
Cdd:cd00200 142 AFSPDGT--------------------------FVASSSQDGTI--------------KLWDL--RTGKCV---ATLTGH 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 441 DDHITALCFnnaeSYEKPILVTASRDGHFKVWiltddsDIYKKaiAWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIV 520
Cdd:cd00200 177 TGEVNSVAF----SPDGEKLLSSSSDGTIKLW------DLSTG--KCLGTLRG--HENGVNSVAFSPDGYLLASGSEDGT 242

                       330
                ....*....|....*
gi 83523742 521 T-IWDSQTWELKCTF 534
Cdd:cd00200 243 IrVWDLRTGECVQTL 257
WD40 pfam00400
WD domain, G-beta repeat;
47-85 7.30e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 83523742    47 ECVHILHGHTDLVSGILVNPSNHLqLYSCSFDGTIKLWD 85
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-574 1.01e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 418 MKLWNYSKKTQGFVLNTkiampHDDHITALCFnnaeSYEKPILVTASRDGHFKVWiltDDSDIYKKAIawtcdFVGsyHK 497
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-----HTDWVNSVAF----SPDGTFVASSSQDGTIKLW---DLRTGKCVAT-----LTG--HT 177

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 83523742 498 YQATNCCFSEDGSLLAVSFEE-IVTIWDSQTWELKCTFCQRAGKIRHLCFgrLTCSKYLLGTTDNGILCCWNLLSCSI 574
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAF--SPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 419-571 5.34e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 5.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 419 KLWNYSKKTQGFVLNTkiampHDDHITALCFNNaesyEKPILVTASRDGHFKVWiltdDSDIYKkaiawtCDFVGSYHKY 498
Cdd:cd00200  76 RLWDLETGECVRTLTG-----HTSYVSSVAFSP----DGRILSSSSRDKTIKVW----DVETGK------CLTTLRGHTD 136

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 83523742 499 QATNCCFSEDGSLLAV-SFEEIVTIWDSQTWELKCTFCQRAGKIRHLCFgRLTCSKYLLGTTDNGILcCWNLLS 571
Cdd:cd00200 137 WVNSVAFSPDGTFVASsSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIK-LWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 440-571 2.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523742 440 HDDHITALCFnnaeSYEKPILVTASRDGHFKVWILTDDSDIYKkaiawtcdFVGSYHKYQATNCCfSEDGSLLAVSFEEI 519
Cdd:cd00200   8 HTGGVTCVAF----SPDGKLLATGSGDGTIKVWDLETGELLRT--------LKGHTGPVRDVAAS-ADGTYLASGSSDKT 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 83523742 520 VTIWDSQTWELKCTFCQRAGKIRHLCFgrLTCSKYLLGTTDNGILCCWNLLS 571
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-229 5.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.09e-03
                           10        20
                   ....*....|....*....|....
gi 83523742    206 TCVACHPKEDCIASGHMDGKIRLW 229
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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