NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254587998|ref|NP_082924|]
View 

proline-rich protein 27 isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
175-312 1.60e-07

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 52.79  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 175 GTPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAP--HQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPEN 252
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPaaAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254587998 253 KPTSGEPAATQSLPAL--PAAGLAVEAKLPAAESAAGRPPPAEL-MASQSVVGKLITAEPTEA 312
Cdd:PRK14951 450 APPAQAAPETVAIPVRvaPEPAVASAAPAPAAAPAAARLTPTEEgDVWHATVQQLAAAEAITA 512
 
Name Accession Description Interval E-value
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 175-312 1.60e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 52.79  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 175 GTPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAP--HQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPEN 252
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPaaAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254587998 253 KPTSGEPAATQSLPAL--PAAGLAVEAKLPAAESAAGRPPPAEL-MASQSVVGKLITAEPTEA 312
Cdd:PRK14951 450 APPAQAAPETVAIPVRvaPEPAVASAAPAPAAAPAAARLTPTEEgDVWHATVQQLAAAEAITA 512
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 125-341 4.63e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  125 PFVIPPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQavKLGTPVPPSGPKPLAPEPAPSPfGAPEPAPVQ 204
Cdd:pfam03154 195 ATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQ--RLPSPHPPLQPMTQPPPPSQVS-PQPLPQPSL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  205 FGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPaglspenkPTSGEPAATQSLPALPAaglaveaklPAAES 284
Cdd:pfam03154 272 HGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPG--------PSPAAPGQSQQRIHTPP---------SQSQL 334

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 254587998  285 AAGRPPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQPFFYQVPMNKP 341
Cdd:pfam03154 335 QSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP 391
 
Name Accession Description Interval E-value
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 175-312 1.60e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 52.79  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 175 GTPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAP--HQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPEN 252
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPaaAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254587998 253 KPTSGEPAATQSLPAL--PAAGLAVEAKLPAAESAAGRPPPAEL-MASQSVVGKLITAEPTEA 312
Cdd:PRK14951 450 APPAQAAPETVAIPVRvaPEPAVASAAPAPAAAPAAARLTPTEEgDVWHATVQQLAAAEAITA 512
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 137-296 7.73e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 7.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 137 PVRPEPVAVPAMPAEGEGL------VPEFPVDKPILGLPQAVKLGTPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPEP 210
Cdd:PRK07764 624 PAAPAPAGAAAAPAEASAApapgvaAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP 703

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 211 APHQLEAAVPDASRLMAPEPAvplSVGAQSLAESPAGLSPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAESAAGRPP 290
Cdd:PRK07764 704 APAATPPAGQADDPAAQPPQA---AQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780


                 ....*.
gi 254587998 291 PAELMA 296
Cdd:PRK07764 781 EEEEMA 786
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 173-322 1.50e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 49.86  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 173 KLGTPVPPSGPKPLAPEPAPSPFGAPePAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLaESPAGLSPEN 252
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAP-TAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQL-QRAQGATKAK 439

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254587998 253 KPtsgEPAATQSLPALPAAGLAVEAKLPAAESAAGRPPPAELM---ASQSVVGKLITAEPTEAKPQVLEPVEA 322
Cdd:PRK07994 440 KS---EPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYrwkATNPVEVKKEPVATPKALKKALEHEKT 509
PHA03247 PHA03247
large tegument protein UL36; Provisional
 125-319 2.75e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  125 PFVIPPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKL-----------GTPVPPSGPKPLAPEPAPS 193
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprrarrlgraaQASSPPQRPRRRAARPTVG 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  194 PFGAPEPAPVQFGAPEPAPHQLEAAVP---DASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPtsGEPAATQ-----SL 265
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPlppGPAAARQASPALPAAPAPPAVPAGPATPGGPARP--ARPPTTAgppapAP 2771

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254587998  266 PALPAAG----LAVEAKLPAAESAAGRPPPAELMASQSVVGKLITAEPTEAKPQVLEP 319
Cdd:PHA03247 2772 PAAPAAGpprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
100-290 9.86e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 9.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 100 PADAPLNGPPVAPLPPPKHFPPRPYPFVIPPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPIlglPQAVKLGTPVP 179
Cdd:PRK12323 388 AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPA---PAAAPAAAARP 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 180 PSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEP 259
Cdd:PRK12323 465 AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPA 544

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254587998 260 AATQSLPALPAAGLAVEAKLPAAESAAGRPP 290
Cdd:PRK12323 545 PAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
127-302 1.40e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.79  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 127 VIPPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKL---GTPVPPSGPKPlAPEPAPSPFGAPEPAPV 203
Cdd:PRK12323 395 AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARgpgGAPAPAPAPAA-APAAAARPAAAGPRPVA 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 204 QFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAE 283
Cdd:PRK12323 474 AAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRA 553

                        170
                 ....*....|....*....
gi 254587998 284 SAAGRPPPAELMASQSVVG 302
Cdd:PRK12323 554 AAATEPVVAPRPPRASASG 572
PHA03247 PHA03247
large tegument protein UL36; Provisional
 137-326 1.55e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  137 PVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKLGTPVPP--------SGPKPLAPEPAPSPFGAPEPAPVQFGAP 208
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPgpaaarqaSPALPAAPAPPAVPAGPATPGGPARPAR 2759

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  209 EPAPHQLEAAVPDASRLMAPEPAVPLSVGAqSLAESPAGLSPENKPTSGEPAATQSLPALPAAGL--AVEAKLPAAESAA 286
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPPRRLTRPAVA-SLSESRESLPSPWDPADPPAAVLAPAAALPPAASpaGPLPPPTSAQPTA 2838

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 254587998  287 GRPPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAKSAS 326
Cdd:PHA03247 2839 PPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP 2878
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 163-329 3.19e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.63  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 163 KPILGLPQAVKLGTPVPPSGPKPLAPEPAPSPFGAPEPAPVQfgAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLA 242
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPP--ASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAK 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 243 ESPAGLSPENKPTsgePAATQSLPALPAAGLAVEAKLPAAESAAGRPPPAELMASQSVV--GKLITAEPTEAKPQVLEPV 320
Cdd:PRK07994 440 KSEPAAASRARPV---NSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVAtpKALKKALEHEKTPELAAKL 516


                 ....*....
gi 254587998 321 EAKSASQEA 329
Cdd:PRK07994 517 AAEAIERDP 525
PHA03247 PHA03247
large tegument protein UL36; Provisional
 137-341 4.27e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  137 PVRPEPVAVPAMPAEGEGLVPEFPVDK----PILGLPQAVKLGtPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAP 212
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQAspalPAAPAPPAVPAG-PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  213 HQLEAAVPDASRLMAPEP--------AVPLSVGAQSLAESPAGLSPenKPTSGEPAATQSLPALPAAGLAVE-------- 276
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPwdpadppaAVLAPAAALPPAASPAGPLP--PPTSAQPTAPPPPPGPPPPSLPLGgsvapggd 2861

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254587998  277 ------AKLPAAESAAGRPPPAELMA----SQSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQPFFYQVPMNKP 341
Cdd:PHA03247 2862 vrrrppSRSPAAKPAAPARPPVRRLArpavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
178-314 4.31e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 4.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 178 VPPSGPKPLAPEPAPSPFGAPEPAPVQFGAP--EPAPHQLE------AAVPDASRLMAPEPAVPLSVGAQSLAESPAGLS 249
Cdd:PRK07003 396 VPAVTAVTGAAGAALAPKAAAAAAATRAEAPpaAPAPPATAdrgddaADGDAPVPAKANARASADSRCDERDAQPPADSG 475

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254587998 250 PENKPTSGEPAATQSLPALPAAGLAVEAKLPAAESA--AGRPPPAELMASQSVVGKLITAEPTEAKP 314
Cdd:PRK07003 476 SASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARapAAASREDAPAAAAPPAPEARPPTPAAAAP 542
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 149-331 5.35e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 149 PAEGEGLVPEFPVDKPILGLPQAVKLGTPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPePAPHQLEAAVPDAS----- 223
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAA-PEHHPKHVAVPDASdggdg 668

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 224 -----RLMAPEPAVPLSVGAQSLAESP-AGLSPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAESAAGRPPPAELMAS 297
Cdd:PRK07764 669 wpakaGGAAPAAPPPAPAPAAPAAPAGaAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254587998 298 QSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQP 331
Cdd:PRK07764 749 PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
125-312 9.09e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 9.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 125 PFVIPPKISVISPVRPEPVAVPAmPAEGEGLVPEFPVDKPILGLPQAVKLGTPVPPSGPKPLAPEPAPSPFGAPEPAPVQ 204
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPA-PAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 205 FGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAES 284
Cdd:PRK12323 455 AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADP 534

                        170       180
                 ....*....|....*....|....*...
gi 254587998 285 AAGRPPPAELMASQSVVGKLITAEPTEA 312
Cdd:PRK12323 535 DDAFETLAPAPAAAPAPRAAAATEPVVA 562
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
176-337 9.58e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 9.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 176 TPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGA-PEPAPHQLEAAVPDASRLMAPEPA-VPLSVGAQSLAESPAGLS---- 249
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAaPAAAPAAAAAARAVAAAPARRSPApEALAAARQASARGPGGAPapap 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 250 -PENKPTSGEPAATQSLPALPAAGL---AVEAKLPAAESAAGRPPPAELMASQSVVGKLITAEPTEAkPQVLEPVEAKSA 325
Cdd:PRK12323 453 aPAAAPAAAARPAAAGPRPVAAAAAaapARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA-GWVAESIPDPAT 531

                        170
                 ....*....|..
gi 254587998 326 SQEAQPFFYQVP 337
Cdd:PRK12323 532 ADPDDAFETLAP 543
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 194-332 1.59e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 194 PFGAPEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPEnkptsgepaatqslPALPAAGL 273
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPA--------------PVAAPAAA 432

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 254587998 274 AVEAKLPAAESAAGRPPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQPF 332
Cdd:PRK14951 433 APAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 129-276 2.67e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 129 PPKISVISPVRPEPVAVPAMPAEGEGlVPEFPvdkpilglPQAVKLGTPVPPSG--PKPLAPEPAPSPFGAPEPAPVQFG 206
Cdd:PRK14951 376 AEKKTPARPEAAAPAAAPVAQAAAAP-APAAA--------PAAAASAPAAPPAAapPAPVAAPAAAAPAAAPAAAPAAVA 446

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254587998 207 APEPAPHQLEAAVPDASRLMAPEPAVPlsvgaqSLAESPAGLSPENKPTSGEP------AATQSLPALPAAGLAVE 276
Cdd:PRK14951 447 LAPAPPAQAAPETVAIPVRVAPEPAVA------SAAPAPAAAPAAARLTPTEEgdvwhaTVQQLAAAEAITALARE 516
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 175-292 4.37e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 175 GTPVPPSGPKPLAPEPAPSPfGAPEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAG-LSPENK 253
Cdd:PRK07764 391 AGAPAAAAPSAAAAAPAAAP-APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPsAQPAPA 469

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 254587998 254 PTSGEPAATQSLPALPAAGLAVEAklPAAESAAGRPPPA 292
Cdd:PRK07764 470 PAAAPEPTAAPAPAPPAAPAPAAA--PAAPAAPAAPAGA 506
PHA03378 PHA03378
EBNA-3B; Provisional
 129-268 5.98e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 5.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 129 PPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKLGTPVPPSGPKPLAPEPAPSPfGAPEPAPVQFGAP 208
Cdd:PHA03378 706 PPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP-GAPTPQPPPQAPP 784

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254587998 209 E--------PAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEPAATQSLPAL 268
Cdd:PHA03378 785 ApqqrprgaPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAA 852
rne PRK10811
ribonuclease E; Reviewed
 197-331 8.05e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.18  E-value: 8.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  197 APEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEPAATQSLPALPAAGLAVE 276
Cdd:PRK10811  861 AEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQ 940

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254587998  277 AKLPAAESAAGRPPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQP 331
Cdd:PRK10811  941 EVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVT 995
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
129-322 8.44e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 41.19  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 129 PPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVD--KPILGLPQAVKLGtPVPPSGPKPlAPEPAPSPfgAPEPAPVQFG 206
Cdd:PRK14960 363 PNEILVSEPVQQNGQAEVGLNSQAQTAQEITPVSavQPVEVISQPAMVE-PEPEPEPEP-EPEPEPEP--EPEPEPEPEP 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 207 APEPAPHQ-LEAAVPDASRLMAPEPAVPLSVgaQSLAESPAGLSPENKPTSGEpAATQSLPALPAAGLAVEA----KLPA 281
Cdd:PRK14960 439 EPEPQPNQdLMVFDPNHHELIGLESAVVQET--VSVLEEDFIPVPEQKLVQVQ-AETQVKQIEPEPASTAEPiglfEASS 515

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 254587998 282 AESAAGRPPPAELMASQSVVGK--LITAEPTEAKPQVLEPVEA 322
Cdd:PRK14960 516 AEFSLAQDTSAYDLVSEPVIEQqsLVQAEIVETVAVVKEPNAT 558
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
186-331 9.45e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 9.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 186 LAPEPAPSPFGAP---EPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSlAESPAGLSPENKPTSGEPAAT 262
Cdd:PRK07003 356 LAFEPAVTGGGAPgggVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPK-AAAAAAATRAEAPPAAPAPPA 434

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254587998 263 QSLPALPAAGLAVEAKLPAAESAAGRPPPAELMASQSVVGKLITAEPTEAKPQV---LEPVEAKSASQEAQP 331
Cdd:PRK07003 435 TADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAafePAPRAAAPSAATPAA 506
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 130-282 9.92e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 9.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 130 PKISVISPVRPePVAVPAMPAEGEGLVPEFPVDKPILGLPQAVklGTPVPPSGPKPLAPEPAPSPFGA------------ 197
Cdd:PRK07994 361 PAAPLPEPEVP-PQSAAPAASAQATAAPTAAVAPPQAPAVPPP--PASAPQQAPAVPLPETTSQLLAArqqlqraqgatk 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 198 -PEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAvPLSVGAQSLAESPAGLSPEN---KPTSGEPAATQSLPALPAAGL 273
Cdd:PRK07994 438 aKKSEPAAASRARPVNSALERLASVRPAPSALEKA-PAKKEAYRWKATNPVEVKKEpvaTPKALKKALEHEKTPELAAKL 516


                 ....*....
gi 254587998 274 AVEAKLPAA 282
Cdd:PRK07994 517 AAEAIERDP 525
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
100-331 1.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 100 PADAPLNGPPVAPLPPPKHFPPRPYPFVIPPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKLGTPVP 179
Cdd:PRK07003 397 PAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGS 476

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 180 PSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAglspenkptSGEP 259
Cdd:PRK07003 477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPA---------ARAG 547

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254587998 260 AATQSLPALPAAGLAVEAKLPAAESAAGRPPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQP 331
Cdd:PRK07003 548 GAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQA 619
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
177-331 1.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 177 PVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPE----PAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPEN 252
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGasavPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 253 KPTSGEPAATQSLPALPAAGLAVEAKLPAAESAAGR---------PPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAK 323
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGsasapasdaPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASRE 519


                 ....*...
gi 254587998 324 SASQEAQP 331
Cdd:PRK07003 520 DAPAAAAP 527
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 142-314 1.28e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  142 PVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKLGTPVPPSGPKPLAPEPApspfGAPEPAPVQFGAPEPAPHQLEAAVPD 221
Cdd:PHA03307   54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPARE----GSPTPPGPSSPDPPPPTPPPASPPPS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  222 ASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAESAAGRPPPAELMASQSVV 301
Cdd:PHA03307  130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209

                         170
                  ....*....|...
gi 254587998  302 GKLITAEPTEAKP 314
Cdd:PHA03307  210 SSPISASASSPAP 222
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 139-287 1.82e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 139 RPEPVAVPAMPAEGEGLVPefPVDKPILGLPQAVKLGTPVPPSGPKPLAPEPAPSPFGAPePAPVQ---FGAPEPAPHQL 215
Cdd:PRK14951 365 KPAAAAEAAAPAEKKTPAR--PEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAP-PAPVAapaAAAPAAAPAAA 441

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254587998 216 EAAVPDASRLMAPEPAVPLSVGAQSLAEsPAGLSPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAESAAG 287
Cdd:PRK14951 442 PAAVALAPAPPAQAAPETVAIPVRVAPE-PAVASAAPAPAAAPAAARLTPTEEGDVWHATVQQLAAAEAITA 512
rne PRK10811
ribonuclease E; Reviewed
 142-329 1.84e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 40.41  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  142 PVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKLGTPVPPsgpkplAPEPAPSPFGAPEPAPVQfgapepaphqlEAAVPD 221
Cdd:PRK10811  846 PVVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVS------APVVEAVAEVVEEPVVVA-----------EPQPEE 908

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  222 ASRLMAPEPAVPlsvgAQSLAESPAGLSPENKPTsGEPAATQSLPALPAAglAVEAKLPAAESAAGRPPPAELMASQSVV 301
Cdd:PRK10811  909 VVVVETTHPEVI----AAPVTEQPQVITESDVAV-AQEVAEHAEPVVEPQ--DETADIEEAAETAEVVVAEPEVVAQPAA 981

                         170       180
                  ....*....|....*....|....*...
gi 254587998  302 GKLITAEPTEAKPQVLEPVEAKSASQEA 329
Cdd:PRK10811  982 PVVAEVAAEVETVTAVEPEVAPAQVPEA 1009
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
99-274 2.36e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  99 YPADAPLNGPPVAPLPPPKHFPPRPYPFVIPPKISVISPVR---PEPVAVPAMPAegeglVPEFPVDKPILGLPQAVKLG 175
Cdd:PRK12323 402 PPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARgpgGAPAPAPAPAA-----APAAAARPAAAGPRPVAAAA 476

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 176 TPVPPSGPKPLAPEPAPSPFGAPEPAPVQFgaPEPAPHQLEAAVPDASRLMAPEPAV-PLSVGAQSLAESPAGLSPENKP 254
Cdd:PRK12323 477 AAAPARAAPAAAPAPADDDPPPWEELPPEF--ASPAPAQPDAAPAGWVAESIPDPATaDPDDAFETLAPAPAAAPAPRAA 554

                        170       180
                 ....*....|....*....|
gi 254587998 255 TSGEPAATQSLPALPAAGLA 274
Cdd:PRK12323 555 AATEPVVAPRPPRASASGLP 574
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 125-341 4.63e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  125 PFVIPPKISVISPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQavKLGTPVPPSGPKPLAPEPAPSPfGAPEPAPVQ 204
Cdd:pfam03154 195 ATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQ--RLPSPHPPLQPMTQPPPPSQVS-PQPLPQPSL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  205 FGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPaglspenkPTSGEPAATQSLPALPAaglaveaklPAAES 284
Cdd:pfam03154 272 HGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPG--------PSPAAPGQSQQRIHTPP---------SQSQL 334

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 254587998  285 AAGRPPPAELMASQSVVGKLITAEPTEAKPQVLEPVEAKSASQEAQPFFYQVPMNKP 341
Cdd:pfam03154 335 QSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP 391
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
137-331 4.70e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.70  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 137 PVRPEPVAVPAMPAEGEGLVPEFPVDKPilglpqavklGTPVPPSGPKPLAPEPAPSPfGAPEPAPVQFGAPEPAPHQLE 216
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPP----------AAPAAAPAAAAAARAVAAAP-ARRSPAPEALAAARQASARGP 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 217 AAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPenKPTSGEPAATQSL------------PALPAAGLAVEAKLPAAES 284
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAA--APARAAPAAAPAPadddpppweelpPEFASPAPAQPDAAPAGWV 522

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 254587998 285 AAGRPPPAELMASQsvvgklitAEPTEAKPQVLEPVEAKSASQEAQP 331
Cdd:PRK12323 523 AESIPDPATADPDD--------AFETLAPAPAAAPAPRAAAATEPVV 561
motB PRK12799
flagellar motor protein MotB; Reviewed
 163-275 6.38e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 38.16  E-value: 6.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 163 KPILGLPQ--AVKLGTPVPPSGPKPLAPEPAPSPFGAPEPAPVQFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQS 240
Cdd:PRK12799 299 VPVAAVTPssAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVNMQPQP 378

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 254587998 241 LAESPAGLSPENKPTSGEPAATQSLPALPAAGLAV 275
Cdd:PRK12799 379 MSTTETQQSSTGNITSTANGPTTSLPAAPASNIPV 413
PHA03247 PHA03247
large tegument protein UL36; Provisional
 102-292 6.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 6.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  102 DAPLNGPPVAPLPPPKHFPPRPYPFVIPPKISVISpvRPEPVAVPAMPAEgeglvPEFPVDKPilGLPQAVKLGTPVPPS 181
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTS--RARRPDAPPQSAR-----PRAPVDDR--GDPRGPAPPSPLPPD 2620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998  182 GPKPLAPEPAPSPFGAPEPAPVQFGAPEPAPHQLEAAVPDASR------------LMAP-----EPAVPLSVGA-QSLAE 243
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprrarrlgraaqASSPpqrprRRAARPTVGSlTSLAD 2700

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 254587998  244 SPAglsPENKPTSGEPAATQSLPALPAAGLAVEAKLPAAESAAGRPPPA 292
Cdd:PHA03247 2701 PPP---PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 136-223 8.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.04  E-value: 8.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 136 SPVRPEPVAVPAMPAEGEGLVPEFPVDKPILGLPQAVKLGTPVPPSGPKP---LAPEPAPSPFGAPEPAPVQFGAPEPAP 212
Cdd:PRK07764 425 PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPeptAAPAPAPPAAPAPAAAPAAPAAPAAPA 504

                         90
                 ....*....|.
gi 254587998 213 HQLEAAVPDAS 223
Cdd:PRK07764 505 GADDAATLRER 515
PRK04654 PRK04654
sec-independent translocase; Provisional
 183-263 9.81e-03

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 37.10  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254587998 183 PKPLAPEPAPSPFGAPEPAPV--QFGAPEPAPHQLEAAVPDASRLMAPEPAVPLSVGAQSLAESPAGLSPENKPTSGEPA 260
Cdd:PRK04654 128 AAGAEPGAGQAHTPVPAPAPViaQAQPIAPAPHQTLVPAPHDTIVPAPHAAHLPSAPATPVSVAPVDAGTSASPTPSEPT 207


                 ...
gi 254587998 261 ATQ 263
Cdd:PRK04654 208 KIQ 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH