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Conserved domains on  [gi|255982604|ref|NP_083398|]
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dynein regulatory complex protein 11 isoform 1 [Mus musculus]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 543-702 3.54e-87

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19506:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 160  Bit Score: 273.25  E-value: 3.54e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 543 DVRQLITLYGILPLGSAEVHERAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQMMIHLVF 622
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 623 KVARQLQPSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPFDAELQPFCRVYQKIILV 702
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 543-702 3.54e-87

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 273.25  E-value: 3.54e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 543 DVRQLITLYGILPLGSAEVHERAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQMMIHLVF 622
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 623 KVARQLQPSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPFDAELQPFCRVYQKIILV 702
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 543-779 1.03e-14

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 76.87  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 543 DVRQLITLYGILPLGSAEVHERA--PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQmmIHL 620
Cdd:COG0464  164 EVKEELRELVALPLKRPELREEYglPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKN--LRE 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 621 VFKVARQLQPSVVWIQDTEKTFYKKVPQAE-----------KRFEPKRlkrylpkllkllkpdDRILIVGTTHRPF--DA 687
Cdd:COG0464  242 VFDKARGLAPCVLFIDEADALAGKRGEVGDgvgrrvvntllTEMEELR---------------SDVVVIAATNRPDllDP 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 688 ELQpfcRVYQKIILVPRPDYASRYVLWKeIILRnGGKLTNSLNISCLSKVTDGFTQGQIVQVIKDVLteRRLRQQAHKPL 767
Cdd:COG0464  307 ALL---RRFDEIIFFPLPDAEERLEIFR-IHLR-KRPLDEDVDLEELAEATEGLSGADIRNVVRRAA--LQALRLGREPV 379

                        250
                 ....*....|..
gi 255982604 768 TAIEFITMMTNM 779
Cdd:COG0464  380 TTEDLLEALERE 391
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 571-704 1.79e-13

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 68.00  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  571 LLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWI---------QDTEKT 641
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGES--EKRLRELFEAAKKLAPCVIFIdeidalagsRGSGGD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255982604  642 FYKKVPQAE--KRFEPKRlkrylpkllkllKPDDRILIVGTTHRP--FDAELQpfcRVYQKIILVPR 704
Cdd:pfam00004  79 SESRRVVNQllTELDGFT------------SSNSKVIVIAATNRPdkLDPALL---GRFDRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 508-752 6.65e-12

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 69.17  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  508 LIQALKVNLSDYIGEYSYL-GTTLRQVAIE-------PMPSLLDVRQLITLYGILPLGSAEVHE----RAPlvKSLLLAG 575
Cdd:TIGR01243 417 VLKELKVTMKDFMEALKMVePSAIREVLVEvpnvrwsDIGGLEEVKQELREAVEWPLKHPEIFEkmgiRPP--KGVLLFG 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  576 PSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWIQDTEKTfykkVPQAEKRFEP 655
Cdd:TIGR01243 495 PPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGES--EKAIREIFRKARQAAPAIIFFDEIDAI----APARGARFDT 568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  656 K---RLKRYLPKLLKLLKPDDRILIVGTTHRP--FDAELQPFCRvYQKIILVPRPDYASRYVLWKeiILRNGGKLTNSLN 730
Cdd:TIGR01243 569 SvtdRIVNQLLTEMDGIQELSNVVVIAATNRPdiLDPALLRPGR-FDRLILVPPPDEEARKEIFK--IHTRSMPLAEDVD 645

                         250       260
                  ....*....|....*....|..
gi 255982604  731 ISCLSKVTDGFTQGQIVQVIKD 752
Cdd:TIGR01243 646 LEELAEMTEGYTGADIEAVCRE 667
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 554-742 5.94e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 42.90  E-value: 5.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 554 LPLGSAEVHER----APlvKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKtGLQmMIHLVFKVARQLQ 629
Cdd:PRK03992 149 LPLKKPELFEEvgiePP--KGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKA 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 630 PSVVWIQDTEKTfykkvpqAEKR------------------------FEPKrlkrylpkllkllkpdDRILIVGTTHRP- 684
Cdd:PRK03992 225 PSIIFIDEIDAI-------AAKRtdsgtsgdrevqrtlmqllaemdgFDPR----------------GNVKIIAATNRId 281

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 255982604 685 -FD-AELQP--FCRvyqkIILVPRPDYASRyvlwkEIILR---NGGKLTNSLNISCLSKVTDGFT 742
Cdd:PRK03992 282 iLDpAILRPgrFDR----IIEVPLPDEEGR-----LEILKihtRKMNLADDVDLEELAELTEGAS 337
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 569-686 9.31e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 9.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604   569 KSLLLAGPSGVGKKMLVHAI---------------CTETGANLFNLSALNIAGKYPGKTGLQMMIHLVFKVARQLQPSVV 633
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALarelgppgggviyidGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 255982604   634 WIQDTEKtfykkvpQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPFD 686
Cdd:smart00382  83 ILDEITS-------LLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKD 128
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 543-702 3.54e-87

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 273.25  E-value: 3.54e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 543 DVRQLITLYGILPLGSAEVHERAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQMMIHLVF 622
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 623 KVARQLQPSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPFDAELQPFCRVYQKIILV 702
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 566-701 3.15e-26

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 105.44  E-value: 3.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 566 PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGlqMMIHLVFKVARQLQPSVVWIQDTEKTFYKK 645
Cdd:cd19481   24 GLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESE--KNLRKIFERARRLAPCILFIDEIDAIGRKR 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 255982604 646 VPQAEKRfEPKRLKRYLPKLLKLLKPDDRILIVGTTHRP--FDAELQPFCRVYQKIIL 701
Cdd:cd19481  102 DSSGESG-ELRRVLNQLLTELDGVNSRSKVLVIAATNRPdlLDPALLRPGRFDEVIEF 158
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 543-702 5.92e-17

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 78.93  E-value: 5.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 543 DVRQLITLYGILPLGSAEV--HERAPlVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHL 620
Cdd:cd19509    6 DAKEALKEAVILPSLRPDLfpGLRGP-PRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGES--EKIVRA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 621 VFKVARQLQPSVVWIQDTEKTFYKKVP---QAEKRFepkRLKRYLPKLLKLLKPDDRILIVGTTHRPFDAElQPFCRVYQ 697
Cdd:cd19509   83 LFALARELQPSIIFIDEIDSLLSERGSgehEASRRV---KTEFLVQMDGVLNKPEDRVLVLGATNRPWELD-EAFLRRFE 158


                 ....*
gi 255982604 698 KIILV 702
Cdd:cd19509  159 KRIYI 163
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 553-696 5.17e-15

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 73.35  E-value: 5.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 553 ILPLGSAEVHE--RAPlVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQP 630
Cdd:cd19524   17 ILPSLRPELFTglRAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEG--EKLVRALFAVARELQP 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 631 SVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPF---DAELQPFC-RVY 696
Cdd:cd19524   94 SIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQeldDAVLRRFTkRVY 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 543-779 1.03e-14

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 76.87  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 543 DVRQLITLYGILPLGSAEVHERA--PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQmmIHL 620
Cdd:COG0464  164 EVKEELRELVALPLKRPELREEYglPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKN--LRE 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 621 VFKVARQLQPSVVWIQDTEKTFYKKVPQAE-----------KRFEPKRlkrylpkllkllkpdDRILIVGTTHRPF--DA 687
Cdd:COG0464  242 VFDKARGLAPCVLFIDEADALAGKRGEVGDgvgrrvvntllTEMEELR---------------SDVVVIAATNRPDllDP 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 688 ELQpfcRVYQKIILVPRPDYASRYVLWKeIILRnGGKLTNSLNISCLSKVTDGFTQGQIVQVIKDVLteRRLRQQAHKPL 767
Cdd:COG0464  307 ALL---RRFDEIIFFPLPDAEERLEIFR-IHLR-KRPLDEDVDLEELAEATEGLSGADIRNVVRRAA--LQALRLGREPV 379

                        250
                 ....*....|..
gi 255982604 768 TAIEFITMMTNM 779
Cdd:COG0464  380 TTEDLLEALERE 391
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 553-686 2.74e-14

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 71.30  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 553 ILPLGSAEVHERAPLV---KSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQ 629
Cdd:cd19520   17 ILPLQRPELFDNSRLLqppKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGES--QKLVAAVFSLASKLQ 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 255982604 630 PSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPFD 686
Cdd:cd19520   95 PSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQD 151
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 501-684 3.91e-14

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 71.56  E-value: 3.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 501 ELVEKGLLIQALKVNLSDYIGeYSYLGTTLRQVAIEPM--PSLLDvrqlitlyGIlplgsaevheRAPlVKSLLLAGPSG 578
Cdd:cd19525    6 ELIMSEIMDHGPPINWADIAG-LEFAKKTIKEIVVWPMlrPDIFT--------GL----------RGP-PKGILLFGPPG 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 579 VGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWIQDTEKTFYKKvpqAEKRFEPKRL 658
Cdd:cd19525   66 TGKTLIGKCIASQSGATFFSISASSLTSKWVGEG--EKMVRALFSVARCKQPAVIFIDEIDSLLSQR---GEGEHESSRR 140

                        170       180
                 ....*....|....*....|....*....
gi 255982604 659 KRYLPKLL---KLLKPDDRILIVGTTHRP 684
Cdd:cd19525  141 IKTEFLVQldgATTSSEDRILVVGATNRP 169
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 571-704 1.79e-13

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 68.00  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  571 LLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWI---------QDTEKT 641
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGES--EKRLRELFEAAKKLAPCVIFIdeidalagsRGSGGD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255982604  642 FYKKVPQAE--KRFEPKRlkrylpkllkllKPDDRILIVGTTHRP--FDAELQpfcRVYQKIILVPR 704
Cdd:pfam00004  79 SESRRVVNQllTELDGFT------------SSNSKVIVIAATNRPdkLDPALL---GRFDRIIEFPL 130
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 545-684 2.03e-12

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 65.78  E-value: 2.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 545 RQLItlygILPLGSAEVHER--APLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVF 622
Cdd:cd19503   13 KELI----ELPLKYPELFRAlgLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGES--EKNLREIF 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255982604 623 KVARQLQPSVVWIQDTEKTFYKKvpqAEKRFEP-KRLKRYLPKLLKLLKPDDRILIVGTTHRP 684
Cdd:cd19503   87 EEARSHAPSIIFIDEIDALAPKR---EEDQREVeRRVVAQLLTLMDGMSSRGKVVVIAATNRP 146
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 508-752 6.65e-12

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 69.17  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  508 LIQALKVNLSDYIGEYSYL-GTTLRQVAIE-------PMPSLLDVRQLITLYGILPLGSAEVHE----RAPlvKSLLLAG 575
Cdd:TIGR01243 417 VLKELKVTMKDFMEALKMVePSAIREVLVEvpnvrwsDIGGLEEVKQELREAVEWPLKHPEIFEkmgiRPP--KGVLLFG 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  576 PSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWIQDTEKTfykkVPQAEKRFEP 655
Cdd:TIGR01243 495 PPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGES--EKAIREIFRKARQAAPAIIFFDEIDAI----APARGARFDT 568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  656 K---RLKRYLPKLLKLLKPDDRILIVGTTHRP--FDAELQPFCRvYQKIILVPRPDYASRYVLWKeiILRNGGKLTNSLN 730
Cdd:TIGR01243 569 SvtdRIVNQLLTEMDGIQELSNVVVIAATNRPdiLDPALLRPGR-FDRLILVPPPDEEARKEIFK--IHTRSMPLAEDVD 645

                         250       260
                  ....*....|....*....|..
gi 255982604  731 ISCLSKVTDGFTQGQIVQVIKD 752
Cdd:TIGR01243 646 LEELAEMTEGYTGADIEAVCRE 667
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 541-639 1.14e-11

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 63.85  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 541 LLDVRQLITLYGILPLGSAEVHE--RAPLvKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMI 618
Cdd:cd19522    5 LEEAKKLLEEAVVLPMWMPEFFKgiRRPW-KGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGES--EKLV 81

                         90       100
                 ....*....|....*....|.
gi 255982604 619 HLVFKVARQLQPSVVWIQDTE 639
Cdd:cd19522   82 RLLFEMARFYAPTTIFIDEID 102
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 565-696 3.83e-10

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 59.51  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 565 APLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWIQDTEKTFYK 644
Cdd:cd19523   30 LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEG--EKILQASFLAARCRQPSVLFISDLDALLSS 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 255982604 645 KVPQAEKrFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPfdAELQPFCRVY 696
Cdd:cd19523  108 QDDEASP-VGRLQVELLAQLDGVLGSGEDGVLVVCTTSKP--EEIDESLRRY 156
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 544-752 4.83e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 56.84  E-value: 4.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  544 VRQLITLygilPLGSAEVHERAPL--VKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLV 621
Cdd:TIGR01243 190 IREMVEL----PMKHPELFEHLGIepPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGES--EERLREI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604  622 FKVARQLQPSVVWIQDTEKTfykkvpqAEKRFE-----PKRLKRYLPKLLKLLKPDDRILIVGTTHRPfDAeLQPFCR-- 694
Cdd:TIGR01243 264 FKEAEENAPSIIFIDEIDAI-------APKREEvtgevEKRVVAQLLTLMDGLKGRGRVIVIGATNRP-DA-LDPALRrp 334

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 255982604  695 -VYQKIILVPRPDYASRyvlwKEII---LRNgGKLTNSLNISCLSKVTDGFTQGQIVQVIKD 752
Cdd:TIGR01243 335 gRFDREIVIRVPDKRAR----KEILkvhTRN-MPLAEDVDLDKLAEVTHGFVGADLAALAKE 391
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 554-637 7.80e-08

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 52.50  E-value: 7.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 554 LPLGSAEVHERAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPS 631
Cdd:cd19529   11 WPLLKPEVFKRLGIRppKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGES--EKAIREIFRKARQVAPC 88


                 ....*.
gi 255982604 632 VVWIQD 637
Cdd:cd19529   89 VIFFDE 94
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 553-639 4.32e-07

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 50.63  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 553 ILPLGSAE--VHERAPLvKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQP 630
Cdd:cd19521   24 ILPVKFPHlfTGNRKPW-SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGES--EKLVKQLFAMARENKP 100


                 ....*....
gi 255982604 631 SVVWIQDTE 639
Cdd:cd19521  101 SIIFIDEVD 109
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 565-642 1.98e-06

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 48.52  E-value: 1.98e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255982604 565 APLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGLQMmiHLVFKVARQLQPSVVWIQDTEKTF 642
Cdd:cd19507   28 LPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRL--RQMIQTAEAIAPCVLWIDEIEKGF 103
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 554-635 3.89e-06

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 47.72  E-value: 3.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 554 LPLGSAEVHERAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTGlqMMIHLVFKVARQLQPS 631
Cdd:cd19502   21 LPLKHPELFEELGIEppKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGA--RLVRELFEMAREKAPS 98


                 ....
gi 255982604 632 VVWI 635
Cdd:cd19502   99 IIFI 102
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 571-684 6.11e-06

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 47.40  E-value: 6.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 571 LLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMIHLVFKVARQLQPSVVWIQDTEKTFYKKvPQAE 650
Cdd:cd19518   37 VLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGES--EEKIRELFDQAISNAPCIVFIDEIDAITPKR-ESAQ 113

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 255982604 651 KRFEPKRLKRYLPKLLKLLKPDD---RILIVGTTHRP 684
Cdd:cd19518  114 REMERRIVSQLLTCMDELNNEKTaggPVLVIGATNRP 150
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 541-634 6.34e-06

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 47.10  E-value: 6.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 541 LLDVRQLITLYGILPLGSAEVHERAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKTglQMMI 618
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKALGIDlpTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGES--ERAV 78

                         90
                 ....*....|....*.
gi 255982604 619 HLVFKVARQLQPSVVW 634
Cdd:cd19530   79 RQVFQRARASAPCVIF 94
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 569-691 5.88e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 44.06  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 569 KSLLLAGPSGVGKKMLVHAICTET---GANLFNLSALNIAGKYPGKTGLQM-MIHLVFKVARQLQPSVVWIQDTEKTFYK 644
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHfLVRLLFELAEKAKPGVLFIDEIDSLSRG 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 255982604 645 KVPQAEKRFEPKRLKRYLPkllkllkpdDRILIVGTTHRPFDAELQP 691
Cdd:cd00009  100 AQNALLRVLETLNDLRIDR---------ENVRVIGATNRPLLGDLDR 137
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 554-742 5.94e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 42.90  E-value: 5.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 554 LPLGSAEVHER----APlvKSLLLAGPSGVGKKMLVHAICTETGANLFNLSALNIAGKYPGKtGLQmMIHLVFKVARQLQ 629
Cdd:PRK03992 149 LPLKKPELFEEvgiePP--KGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKA 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604 630 PSVVWIQDTEKTfykkvpqAEKR------------------------FEPKrlkrylpkllkllkpdDRILIVGTTHRP- 684
Cdd:PRK03992 225 PSIIFIDEIDAI-------AAKRtdsgtsgdrevqrtlmqllaemdgFDPR----------------GNVKIIAATNRId 281

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 255982604 685 -FD-AELQP--FCRvyqkIILVPRPDYASRyvlwkEIILR---NGGKLTNSLNISCLSKVTDGFT 742
Cdd:PRK03992 282 iLDpAILRPgrFDR----IIEVPLPDEEGR-----LEILKihtRKMNLADDVDLEELAELTEGAS 337
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 569-686 9.31e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 9.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255982604   569 KSLLLAGPSGVGKKMLVHAI---------------CTETGANLFNLSALNIAGKYPGKTGLQMMIHLVFKVARQLQPSVV 633
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALarelgppgggviyidGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 255982604   634 WIQDTEKtfykkvpQAEKRFEPKRLKRYLPKLLKLLKPDDRILIVGTTHRPFD 686
Cdd:smart00382  83 ILDEITS-------LLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKD 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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