NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|13540602|ref|NP_110436|]
View 

cysteine/serine-rich nuclear protein 2 [Homo sapiens]

Protein Classification

cysteine/serine-rich nuclear protein( domain architecture ID 11240357)

cysteine/serine-rich nuclear protein (CSRNP) may bind to the consensus sequence 5'-AGAGTG-3' and have transcriptional activator activity, such as CSRNP1, also called AXUD1, that may have tumor-suppressor function and play a role in apoptosis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CSRNP_N pfam16019
Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the ...
 61-279 1.81e-146

Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the N-terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators.


:

Pssm-ID: 464977  Cd Length: 218  Bit Score: 419.78  E-value: 1.81e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13540602    61 LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTK 140
Cdd:pfam16019   1 KKKKSVRFDQVTVFYFPRCQGFTCVPSQGGSTLGMARKHSAFRRFTLAEHAIEQRRRRREKLRERRREEKLEALKQKLSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13540602   141 NGTVESVEADGLTLDDVSDEDIDveNVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLY 220
Cdd:pfam16019  81 SGTISDSEEEPLTIDDISDSDLD--GAELDDYGFLQPVPTKQRRALLRAAGVRKIDSEEKDECRAIRLSREDCGCDCRGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13540602   221 CDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELE 279
Cdd:pfam16019 159 CDPETCACSLAGIKCQVDRPSFPCGCTKDGCGNPQGRIEFNPTRVRTHFIHTLMRLELE 217
 
Name Accession Description Interval E-value
CSRNP_N pfam16019
Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the ...
 61-279 1.81e-146

Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the N-terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators.


Pssm-ID: 464977  Cd Length: 218  Bit Score: 419.78  E-value: 1.81e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13540602    61 LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTK 140
Cdd:pfam16019   1 KKKKSVRFDQVTVFYFPRCQGFTCVPSQGGSTLGMARKHSAFRRFTLAEHAIEQRRRRREKLRERRREEKLEALKQKLSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13540602   141 NGTVESVEADGLTLDDVSDEDIDveNVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLY 220
Cdd:pfam16019  81 SGTISDSEEEPLTIDDISDSDLD--GAELDDYGFLQPVPTKQRRALLRAAGVRKIDSEEKDECRAIRLSREDCGCDCRGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13540602   221 CDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELE 279
Cdd:pfam16019 159 CDPETCACSLAGIKCQVDRPSFPCGCTKDGCGNPQGRIEFNPTRVRTHFIHTLMRLELE 217
 
Name Accession Description Interval E-value
CSRNP_N pfam16019
Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the ...
 61-279 1.81e-146

Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the N-terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators.


Pssm-ID: 464977  Cd Length: 218  Bit Score: 419.78  E-value: 1.81e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13540602    61 LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTK 140
Cdd:pfam16019   1 KKKKSVRFDQVTVFYFPRCQGFTCVPSQGGSTLGMARKHSAFRRFTLAEHAIEQRRRRREKLRERRREEKLEALKQKLSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13540602   141 NGTVESVEADGLTLDDVSDEDIDveNVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLY 220
Cdd:pfam16019  81 SGTISDSEEEPLTIDDISDSDLD--GAELDDYGFLQPVPTKQRRALLRAAGVRKIDSEEKDECRAIRLSREDCGCDCRGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13540602   221 CDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELE 279
Cdd:pfam16019 159 CDPETCACSLAGIKCQVDRPSFPCGCTKDGCGNPQGRIEFNPTRVRTHFIHTLMRLELE 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH