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Conserved domains on  [gi|45580709|ref|NP_112192|]
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protein unc-93 homolog B1 [Homo sapiens]

Protein Classification

protein unc-93 homolog B1( domain architecture ID 13024470)

protein unc-93 homolog B1 (Unc-93B1) plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_unc93B1 cd17408
Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 ...
64-520 0e+00

Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 homolog B1 (UNC93B1) controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. It regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity. UNC93B1 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340966 [Multi-domain]  Cd Length: 456  Bit Score: 849.85  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709  64 VLAASAGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAV 143
Cdd:cd17408   1 VVAASLGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLQDIDSKMLMGINVTPIVALLYTPVLIRFFGTKWMMFLAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 144 GIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMAQKYHEYSHYKEQDGQGMkQRPPRGSHAPYLLVFQAI 223
Cdd:cd17408  81 GIYALFVSTNYWERYYTLVPSAVAIGVAIVPLWASMGNYITRMAQKYYEYVNYKEEDVQEQ-KRPPRGAYHKYIIIFQSV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 224 FYSFFHLSFACAQLPMIYFLNHYLYDLNHTLYNVQSCGTNSHGILSGFNKTVLRTLPRSGNLIVVESVLMAVAFLAMLLV 303
Cdd:cd17408 160 FYAIFHLSFVCAQLPMIFFLNNYLYDYNHTLYNVKHCGAQSKGILEGFNKTVLITLPRSLNLIIVESALMGAAFLSMLLV 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 304 LGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYGVCSVGLERLAYLLVAYS 383
Cdd:cd17408 240 LLLCGAAYRPTEEIDLRSIGWGNIFQLPFKHLRDYRLRLLIPFFIYSGFEVLFACTGFALSYGVCSLGLERLAYLLMAYG 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 384 LGASAASLLGLLGLWLPRPVPLVAGAGVHLLLTFILFFWAPVPRVLQHSWILYVAAALWGVGSALNKTGLSTLLGILYED 463
Cdd:cd17408 320 LSASLCSLLALSLLRLPRPVPLVAGAFLHLTLLITLFFWAPTPRLTSQMPLLYVVAALWGLGSALNKTGLSTLLGILYED 399
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45580709 464 KERQDFIFTIYHWWQAVAIFTVYLGSSLHMKAKLAVLLVTLVAAAVSYLRMEQKLRR 520
Cdd:cd17408 400 KERQDFIFTIYHWWQALAIFIVYLWSNLPMKAKLGILLATLVIALLSYLWMERKLAR 456
 
Name Accession Description Interval E-value
MFS_unc93B1 cd17408
Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 ...
64-520 0e+00

Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 homolog B1 (UNC93B1) controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. It regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity. UNC93B1 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340966 [Multi-domain]  Cd Length: 456  Bit Score: 849.85  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709  64 VLAASAGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAV 143
Cdd:cd17408   1 VVAASLGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLQDIDSKMLMGINVTPIVALLYTPVLIRFFGTKWMMFLAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 144 GIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMAQKYHEYSHYKEQDGQGMkQRPPRGSHAPYLLVFQAI 223
Cdd:cd17408  81 GIYALFVSTNYWERYYTLVPSAVAIGVAIVPLWASMGNYITRMAQKYYEYVNYKEEDVQEQ-KRPPRGAYHKYIIIFQSV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 224 FYSFFHLSFACAQLPMIYFLNHYLYDLNHTLYNVQSCGTNSHGILSGFNKTVLRTLPRSGNLIVVESVLMAVAFLAMLLV 303
Cdd:cd17408 160 FYAIFHLSFVCAQLPMIFFLNNYLYDYNHTLYNVKHCGAQSKGILEGFNKTVLITLPRSLNLIIVESALMGAAFLSMLLV 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 304 LGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYGVCSVGLERLAYLLVAYS 383
Cdd:cd17408 240 LLLCGAAYRPTEEIDLRSIGWGNIFQLPFKHLRDYRLRLLIPFFIYSGFEVLFACTGFALSYGVCSLGLERLAYLLMAYG 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 384 LGASAASLLGLLGLWLPRPVPLVAGAGVHLLLTFILFFWAPVPRVLQHSWILYVAAALWGVGSALNKTGLSTLLGILYED 463
Cdd:cd17408 320 LSASLCSLLALSLLRLPRPVPLVAGAFLHLTLLITLFFWAPTPRLTSQMPLLYVVAALWGLGSALNKTGLSTLLGILYED 399
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45580709 464 KERQDFIFTIYHWWQAVAIFTVYLGSSLHMKAKLAVLLVTLVAAAVSYLRMEQKLRR 520
Cdd:cd17408 400 KERQDFIFTIYHWWQALAIFIVYLWSNLPMKAKLGILLATLVIALLSYLWMERKLAR 456
 
Name Accession Description Interval E-value
MFS_unc93B1 cd17408
Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 ...
64-520 0e+00

Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 homolog B1 (UNC93B1) controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. It regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity. UNC93B1 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340966 [Multi-domain]  Cd Length: 456  Bit Score: 849.85  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709  64 VLAASAGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAV 143
Cdd:cd17408   1 VVAASLGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLQDIDSKMLMGINVTPIVALLYTPVLIRFFGTKWMMFLAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 144 GIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMAQKYHEYSHYKEQDGQGMkQRPPRGSHAPYLLVFQAI 223
Cdd:cd17408  81 GIYALFVSTNYWERYYTLVPSAVAIGVAIVPLWASMGNYITRMAQKYYEYVNYKEEDVQEQ-KRPPRGAYHKYIIIFQSV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 224 FYSFFHLSFACAQLPMIYFLNHYLYDLNHTLYNVQSCGTNSHGILSGFNKTVLRTLPRSGNLIVVESVLMAVAFLAMLLV 303
Cdd:cd17408 160 FYAIFHLSFVCAQLPMIFFLNNYLYDYNHTLYNVKHCGAQSKGILEGFNKTVLITLPRSLNLIIVESALMGAAFLSMLLV 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 304 LGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYGVCSVGLERLAYLLVAYS 383
Cdd:cd17408 240 LLLCGAAYRPTEEIDLRSIGWGNIFQLPFKHLRDYRLRLLIPFFIYSGFEVLFACTGFALSYGVCSLGLERLAYLLMAYG 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 384 LGASAASLLGLLGLWLPRPVPLVAGAGVHLLLTFILFFWAPVPRVLQHSWILYVAAALWGVGSALNKTGLSTLLGILYED 463
Cdd:cd17408 320 LSASLCSLLALSLLRLPRPVPLVAGAFLHLTLLITLFFWAPTPRLTSQMPLLYVVAALWGLGSALNKTGLSTLLGILYED 399
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45580709 464 KERQDFIFTIYHWWQAVAIFTVYLGSSLHMKAKLAVLLVTLVAAAVSYLRMEQKLRR 520
Cdd:cd17408 400 KERQDFIFTIYHWWQALAIFIVYLWSNLPMKAKLGILLATLVIALLSYLWMERKLAR 456
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
64-517 1.28e-114

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 346.64  E-value: 1.28e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709  64 VLAASAGGMLTYGVYLGLLQMQLILHYDetyrevkygnmglpDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAV 143
Cdd:cd17338   1 VIILSFGFLLIFLAYSALQNLQTSLHEN--------------GLGSISLGILYSSFAVSSFIAPLLVKLLGEKITLVLGG 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 144 GIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMAQKyheyshykeqdgqgmkqrpprgshaPYLLVFQAI 223
Cdd:cd17338  67 LGYAIFIASNIFPIWGTLVPASIILGFAAAILWTAQGTYITRISDE-------------------------SNIGRNFGI 121
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 224 FYSFFHLSFACAQLPMIYFLNHYLYDLNHTLynvqscgtnshgilsgfnktvlrtlprsgnlivVESVLMAVAFLAMLLV 303
Cdd:cd17338 122 FWSIFQLSQVFGNLISLALLNHSKGSSGTTI---------------------------------LFIVFMAIMLVGIILL 168
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 304 LGLCGAAYRPTEEIDLRSVGWG----NIFQLPFKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYGVCSVGLERLAYLL 379
Cdd:cd17338 169 FFLRGPDNEVITEIESSSVGESmekkNLFKLPFTLLKDKRFLLLIPLLIYSGLEQTFFSGVFTLIIGTPTTGIARVGYVM 248
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 380 VAYSLGASAASLLGLLGLW--LPRPVPLVAGAGVHLLLTFILFFWAPV-PRVLQHSWILYVAAALWGVGSALNKTGLSTL 456
Cdd:cd17338 249 AVYGFGDALGSLVAGLLSDwrFGRIVLAVIGAFVHIASLILLFLSGNVtPYGLGGSWLAYVSAILWGLGDAIFNTQIYAL 328
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45580709 457 LGILYEdkERQDFIFTIYHWWQAVAIFTVYLGS-SLHMKAKLAVLLVTLVAAAVSYLRMEQK 517
Cdd:cd17338 329 LGSLYE--NDSESAFAVYKLWQSIATAIAYFLSpYLPLFVKLFVLLALLILLAIFFLFVELK 388
MFS_unc93A_like cd17406
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ...
127-515 5.72e-32

Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340964 [Multi-domain]  Cd Length: 390  Bit Score: 127.76  E-value: 5.72e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 127 PVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMAQKYHEYSHykeQDGQGMKQ 206
Cdd:cd17406  52 PLLIKKLGCKWTIVLSMFCYVLYIAANFYPSWYTLIPASIILGFGAAPLWSAKCTYLTESGNRYAKLTG---KSGDDVIN 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 207 RpprgshapyllvFQAIFYSFFHLSFACAQLPMIYFLNHYLYDlnhTLYnvqscgtnshGILSGFNktvlrtlprsgnli 286
Cdd:cd17406 129 R------------FFGIFFMIFQSSQIWGNLISSLVFSQSLIY---TLL----------GIYLGCG-------------- 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 287 vVESVLMAVAFLAMLlvlglcgAAYRPTEEIDLRSVGWgNIFQLPFKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYG 366
Cdd:cd17406 170 -ILAVIIVAVFLDPL-------KRDKEKRKQETKFSVL-SLLLATFKHLKDPRQLLLIPLTIYSGLEQAFLSGDFTKSYV 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580709 367 VCSVGLERLAYLLVAYSLGASAASLLG-LLGLWLPRPVPLVAGAGVHLLLTFILFFWAPVPrvlQHSWILYVAAALWGVG 445
Cdd:cd17406 241 TCALGIWNVGYVMICFGVVNALCSFLFgRLVKYTGRIPLFALGALVNLGLIIALLLWEPDP---DQLAIFFVFAGLWGMA 317
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45580709 446 SALNKTGLSTLLGILYEDKerQDFIFTIYHWWQAVAIFTVY-LGSSLHMKAKLAVLLVTLVAAAVSYLRME 515
Cdd:cd17406 318 DAVWQTQINALYGVLFPKN--KEAAFSNYRLWESLGFVIAFaYSNFLCVYVKLYILLAVLLLGMVGYGVVE 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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