NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|13591979|ref|NP_112310|]
View 

leukemia inhibitory factor receptor precursor [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 127-240 2.63e-63

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


:

Pssm-ID: 375455  Cd Length: 114  Bit Score: 210.00  E-value: 2.63e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    127 DVSLVPDTPEILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELP 206
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 13591979    207 LQCATHSVSIRWHIDYPRFSGYKEWSEWSPLKNI 240
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 51-125 1.32e-34

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


:

Pssm-ID: 436347  Cd Length: 78  Bit Score: 126.67  E-value: 1.32e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13591979     51 DLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKDRPHSCHRLETTNVKIPALSPGDHEVTINYQNGFQS---KFTLNE 125
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSstsKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 432-526 2.99e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979  432 PISLKVKDVNSTVVTLSWYLPGNFTKINLVCQIEICKANSKkEVRNVTMRGAEDSTYHVavDKLNPYTIYTFRVRCssET 511
Cdd:cd00063    4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGSETSYTL--TGLKPGTEYEFRVRA--VN 78

                         90
                 ....*....|....*
gi 13591979  512 FWKWSKWSNEKRYLT 526
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 725-817 1.78e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979  725 NFTVEDTSADSILVKWDdiPVEELRGFLRGYLFYFQKGERDTPKTrsletshsdiklKNITDISQKTLRIADLQGKTSYH 804
Cdd:cd00063    6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKE------------VEVTPGSETSYTLTGLKPGTEYE 71

                         90
                 ....*....|...
gi 13591979  805 LVLRAYTHGGLGP 817
Cdd:cd00063   72 FRVRAVNGGGESP 84
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 548-615 7.16e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 7.16e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13591979    548 LIIYWKPLPinEANGKILSYNVSCSSSEETQSLSEILDPQHKAEIKVNK----NDYIISVVARNSAGSSPPS 615
Cdd:pfam00041   16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 127-240 2.63e-63

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 210.00  E-value: 2.63e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    127 DVSLVPDTPEILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELP 206
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 13591979    207 LQCATHSVSIRWHIDYPRFSGYKEWSEWSPLKNI 240
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 51-125 1.32e-34

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 126.67  E-value: 1.32e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13591979     51 DLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKDRPHSCHRLETTNVKIPALSPGDHEVTINYQNGFQS---KFTLNE 125
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSstsKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 432-526 2.99e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979  432 PISLKVKDVNSTVVTLSWYLPGNFTKINLVCQIEICKANSKkEVRNVTMRGAEDSTYHVavDKLNPYTIYTFRVRCssET 511
Cdd:cd00063    4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGSETSYTL--TGLKPGTEYEFRVRA--VN 78

                         90
                 ....*....|....*
gi 13591979  512 FWKWSKWSNEKRYLT 526
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 432-507 6.26e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.26e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13591979     432 PISLKVKDVNSTVVTLSWYLP--GNFTKINLVCQIEICKANSKKEVRNVTmrgaeDSTYHVAVDKLNPYTIYTFRVRC 507
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVT-----PSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
435-516 3.65e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 3.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    435 LKVKDVNSTVVTLSWYLP----GNFTKINLVCQieicKANSKKEVRNVTMRGaedSTYHVAVDKLNPYTIYTFRVR-CSS 509
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPpdgnGPITGYEVEYR----PKNSGEPWNEITVPG---TTTSVTLTGLKPGTEYEVRVQaVNG 78


                   ....*..
gi 13591979    510 ETFWKWS 516
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 725-817 1.78e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979  725 NFTVEDTSADSILVKWDdiPVEELRGFLRGYLFYFQKGERDTPKTrsletshsdiklKNITDISQKTLRIADLQGKTSYH 804
Cdd:cd00063    6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKE------------VEVTPGSETSYTLTGLKPGTEYE 71

                         90
                 ....*....|...
gi 13591979  805 LVLRAYTHGGLGP 817
Cdd:cd00063   72 FRVRAVNGGGESP 84
fn3 pfam00041
Fibronectin type III domain;
725-818 6.37e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    725 NFTVEDTSADSILVKWDdiPVEELRGFLRGY-LFYFQKGERDTPKTRSLetshsdiklknitDISQKTLRIADLQGKTSY 803
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWT--PPPDGNGPITGYeVEYRPKNSGEPWNEITV-------------PGTTTSVTLTGLKPGTEY 69

                           90
                   ....*....|....*
gi 13591979    804 HLVLRAYTHGGLGPE 818
Cdd:pfam00041   70 EVRVQAVNGGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
548-615 7.16e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 7.16e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13591979    548 LIIYWKPLPinEANGKILSYNVSCSSSEETQSLSEILDPQHKAEIKVNK----NDYIISVVARNSAGSSPPS 615
Cdd:pfam00041   16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 720-816 7.97e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 7.97e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979     720 PIVAPNFTVEDTSADSILVKWDDIPVEELRGFLRGYlfyfqkgerdtpktRSLETSHSDIKLKNITDISQKTLRIADLQG 799
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGY--------------RVEYREEGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 13591979     800 KTSYHLVLRAYTHGGLG 816
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 127-240 2.63e-63

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 210.00  E-value: 2.63e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    127 DVSLVPDTPEILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELP 206
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 13591979    207 LQCATHSVSIRWHIDYPRFSGYKEWSEWSPLKNI 240
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 51-125 1.32e-34

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 126.67  E-value: 1.32e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13591979     51 DLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKDRPHSCHRLETTNVKIPALSPGDHEVTINYQNGFQS---KFTLNE 125
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSstsKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 432-526 2.99e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979  432 PISLKVKDVNSTVVTLSWYLPGNFTKINLVCQIEICKANSKkEVRNVTMRGAEDSTYHVavDKLNPYTIYTFRVRCssET 511
Cdd:cd00063    4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGSETSYTL--TGLKPGTEYEFRVRA--VN 78

                         90
                 ....*....|....*
gi 13591979  512 FWKWSKWSNEKRYLT 526
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 432-507 6.26e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.26e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13591979     432 PISLKVKDVNSTVVTLSWYLP--GNFTKINLVCQIEICKANSKKEVRNVTmrgaeDSTYHVAVDKLNPYTIYTFRVRC 507
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVT-----PSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
435-516 3.65e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 3.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    435 LKVKDVNSTVVTLSWYLP----GNFTKINLVCQieicKANSKKEVRNVTMRGaedSTYHVAVDKLNPYTIYTFRVR-CSS 509
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPpdgnGPITGYEVEYR----PKNSGEPWNEITVPG---TTTSVTLTGLKPGTEYEVRVQaVNG 78


                   ....*..
gi 13591979    510 ETFWKWS 516
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 725-817 1.78e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979  725 NFTVEDTSADSILVKWDdiPVEELRGFLRGYLFYFQKGERDTPKTrsletshsdiklKNITDISQKTLRIADLQGKTSYH 804
Cdd:cd00063    6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKE------------VEVTPGSETSYTLTGLKPGTEYE 71

                         90
                 ....*....|...
gi 13591979  805 LVLRAYTHGGLGP 817
Cdd:cd00063   72 FRVRAVNGGGESP 84
fn3 pfam00041
Fibronectin type III domain;
725-818 6.37e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979    725 NFTVEDTSADSILVKWDdiPVEELRGFLRGY-LFYFQKGERDTPKTRSLetshsdiklknitDISQKTLRIADLQGKTSY 803
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWT--PPPDGNGPITGYeVEYRPKNSGEPWNEITV-------------PGTTTSVTLTGLKPGTEY 69

                           90
                   ....*....|....*
gi 13591979    804 HLVLRAYTHGGLGPE 818
Cdd:pfam00041   70 EVRVQAVNGGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
548-615 7.16e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 7.16e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13591979    548 LIIYWKPLPinEANGKILSYNVSCSSSEETQSLSEILDPQHKAEIKVNK----NDYIISVVARNSAGSSPPS 615
Cdd:pfam00041   16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 720-816 7.97e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 7.97e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13591979     720 PIVAPNFTVEDTSADSILVKWDDIPVEELRGFLRGYlfyfqkgerdtpktRSLETSHSDIKLKNITDISQKTLRIADLQG 799
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGY--------------RVEYREEGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 13591979     800 KTSYHLVLRAYTHGGLG 816
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH