NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|66932893|ref|NP_114146|]
View 

TM2 domain-containing protein 2 isoform b precursor [Homo sapiens]

Protein Classification

TM2 domain-containing protein( domain architecture ID 10524121)

TM2 domain-containing protein similar to Homo sapiens TM2 domain-containing protein 1 (TM2D1) that may participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42

Gene Ontology:  GO:0097190|GO:0004930|GO:0001540

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 103-152 4.04e-11

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


:

Pssm-ID: 428337  Cd Length: 50  Bit Score: 55.19  E-value: 4.04e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 66932893   103 TGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLI 152
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 103-152 4.04e-11

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 55.19  E-value: 4.04e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 66932893   103 TGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLI 152
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 108-157 2.56e-06

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 43.37  E-value: 2.56e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932893 108 ITTLLYSFFLGCFGVDRFCLGHTGTAVG--KLLTLGGLGIWWFVDLILLITG 157
Cdd:COG2314  11 LVAGLLAIFLGGFGIHRFYLGKTGTGIIylLFFWTGIPGIIGLIDGILYLTM 62
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 103-152 4.04e-11

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 55.19  E-value: 4.04e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 66932893   103 TGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLI 152
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 108-157 2.56e-06

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 43.37  E-value: 2.56e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932893 108 ITTLLYSFFLGCFGVDRFCLGHTGTAVG--KLLTLGGLGIWWFVDLILLITG 157
Cdd:COG2314  11 LVAGLLAIFLGGFGIHRFYLGKTGTGIIylLFFWTGIPGIIGLIDGILYLTM 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH