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Conserved domains on  [gi|19718780|ref|NP_115484|]
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semaphorin-6B precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
57-524 0e+00

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


:

Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 987.79  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  57 TPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLR 136
Cdd:cd11267   1 TAERGRDRLNIQRVLRVNRTLYIGDRDNLYRVELDPTAGTEMRYHKKLTWRSNKNDINVCRMKGKHEGECRNFIKVLLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 137 DESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTL 216
Cdd:cd11267  81 DYGTLFVCGTNAFNPVCANYSIDTLEPVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 217 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPG 296
Cdd:cd11267 161 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSQRVLEKQWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 297 DSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPG 376
Cdd:cd11267 241 DSHFYFNVLQAVSDILNLGGRPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEELVPRPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLK 456
Cdd:cd11267 321 CCAAPGMRYNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYQLTHMVVDTEAGPHGNHTVVFLGSTRGTVLK 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19718780 457 FLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPggGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11267 401 FLIIPNASSSEISNQSVFLEELETYNPERCGWD--SPQAQKLLSLELDKGSGGLLLAFPSCVVRVPVA 466
PHA03247 super family cl33720
large tegument protein UL36; Provisional
706-888 2.21e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   706 LLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTP--DGRLYAARPGRAS 783
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdTHAPDPPPPSPSP 2633
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   784 HGDFPLTPHASPD----------------RRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTH 847
Cdd:PHA03247 2634 AANEPDPHPPPTVppperprddpapgrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPH 2713
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 19718780   848 TFNSGEARPGDRHRGCHARPGTDLAHLLPyggADRTAPPVP 888
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPAAPAPP---AVPAGPATP 2751
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
525-554 6.71e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.15  E-value: 6.71e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19718780   525 RCQQYSGCMKnCIGSQDPYCGW-APDGSCIF 554
Cdd:pfam01437   1 RCSQYTSCSS-CLAARDPYCGWcSSEGRCVR 30
 
Name Accession Description Interval E-value
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
57-524 0e+00

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 987.79  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  57 TPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLR 136
Cdd:cd11267   1 TAERGRDRLNIQRVLRVNRTLYIGDRDNLYRVELDPTAGTEMRYHKKLTWRSNKNDINVCRMKGKHEGECRNFIKVLLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 137 DESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTL 216
Cdd:cd11267  81 DYGTLFVCGTNAFNPVCANYSIDTLEPVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 217 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPG 296
Cdd:cd11267 161 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSQRVLEKQWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 297 DSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPG 376
Cdd:cd11267 241 DSHFYFNVLQAVSDILNLGGRPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEELVPRPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLK 456
Cdd:cd11267 321 CCAAPGMRYNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYQLTHMVVDTEAGPHGNHTVVFLGSTRGTVLK 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19718780 457 FLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPggGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11267 401 FLIIPNASSSEISNQSVFLEELETYNPERCGWD--SPQAQKLLSLELDKGSGGLLLAFPSCVVRVPVA 466
Sema smart00630
semaphorin domain;
65-483 1.31e-143

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 430.64  E-value: 1.31e-143
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780     65 LNIQRVLRVNRTLFIGDRDNLYRVELepptSTELRYQRKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLLLRDESTLFV 143
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSL----NLILEAELKTGPVLSSPDCEECVSKGKdPPTDCVNYIRLLLDYNEDRLLV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    144 CGSNAFNPVCANYSIdtlqpvgdnisgmarcpydpkhanvalfsdGMLFTATVTDFLAIDAVIYRSLGDRP-------TL 216
Cdd:smart00630  77 CGTNAFQPVCRLRNL------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSL 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    217 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGsPRVLEKQWTSFLKARLNCSVPG 296
Cdd:smart00630 127 RTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGG-PRSLDKKWTSFLKARLECSVPG 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    297 DSHFYFNVLQAVT-GVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRP 375
Cdd:smart00630 206 EDPFYFNELQAAFlLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRP 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    376 GCCAAPGMQynaSSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPwGNQTVVFLGSEAGTVL 455
Cdd:smart00630 286 GTCPNKPPS---SKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYLLTSIAVDRVATD-GNYTVLFLGTSDGRIL 361
                          410       420
                   ....*....|....*....|....*...
gi 19718780    456 KFLVRPnastSGTSGLSVFLEEFETYRP 483
Cdd:smart00630 362 KVVLSE----SSSSSESVVLEEISVFPD 385
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
305-483 2.72e-48

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 169.37  E-value: 2.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   305 LQAVTgVVSLGGR----PVVLAVFSTP-SNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPeDQVPRPRPGCCA 379
Cdd:pfam01403   1 LQDVF-VLKPGAGdaldTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYT-GKVPYPRPGTCI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   380 apgmQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRhqLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLV 459
Cdd:pfam01403  79 ----NDPLRLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVR--LTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVL 152
                         170       180
                  ....*....|....*....|....
gi 19718780   460 RPnastsgtSGLSVFLEEFETYRP 483
Cdd:pfam01403 153 VG-------SEESHIIEEIQVFPE 169
PHA03247 PHA03247
large tegument protein UL36; Provisional
706-888 2.21e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   706 LLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTP--DGRLYAARPGRAS 783
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdTHAPDPPPPSPSP 2633
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   784 HGDFPLTPHASPD----------------RRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTH 847
Cdd:PHA03247 2634 AANEPDPHPPPTVppperprddpapgrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPH 2713
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 19718780   848 TFNSGEARPGDRHRGCHARPGTDLAHLLPyggADRTAPPVP 888
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPAAPAPP---AVPAGPATP 2751
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
525-554 6.71e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.15  E-value: 6.71e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19718780   525 RCQQYSGCMKnCIGSQDPYCGW-APDGSCIF 554
Cdd:pfam01437   1 RCSQYTSCSS-CLAARDPYCGWcSSEGRCVR 30
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
525-553 1.35e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 37.52  E-value: 1.35e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 19718780    525 RCQQYSGCmKNCIGSQDPYCGW-APDGSCI 553
Cdd:smart00423   1 RCSKYTSC-SECLLARDPYCAWcSSQGRCT 29
 
Name Accession Description Interval E-value
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
57-524 0e+00

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 987.79  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  57 TPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLR 136
Cdd:cd11267   1 TAERGRDRLNIQRVLRVNRTLYIGDRDNLYRVELDPTAGTEMRYHKKLTWRSNKNDINVCRMKGKHEGECRNFIKVLLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 137 DESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTL 216
Cdd:cd11267  81 DYGTLFVCGTNAFNPVCANYSIDTLEPVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 217 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPG 296
Cdd:cd11267 161 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSQRVLEKQWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 297 DSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPG 376
Cdd:cd11267 241 DSHFYFNVLQAVSDILNLGGRPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEELVPRPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLK 456
Cdd:cd11267 321 CCAAPGMRYNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYQLTHMVVDTEAGPHGNHTVVFLGSTRGTVLK 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19718780 457 FLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPggGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11267 401 FLIIPNASSSEISNQSVFLEELETYNPERCGWD--SPQAQKLLSLELDKGSGGLLLAFPSCVVRVPVA 466
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
57-524 0e+00

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 913.82  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  57 TPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLR 136
Cdd:cd11242   1 DNTTARHRLDFQRMLRINRTLYIAARDHVYTVDLDASHTEEIVPSKKLTWRSRQADVENCRMKGKHKDECHNFIKVLVPR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 137 DESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTL 216
Cdd:cd11242  81 NDETLFVCGTNAFNPVCRNYRIDTLEQDGEEISGMARCPFDAKQANVALFADGKLYSATVTDFLASDAVIYRSLGDSPTL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 217 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPG 296
Cdd:cd11242 161 RTVKYDSKWLKEPHFVHAVEYGDYVYFFFREIAVEYNTLGKVVFSRVARVCKNDMGGSPRVLEKQWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 297 DSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPG 376
Cdd:cd11242 241 DSHFYFDVLQAVTDVIRINGRPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFEGRFKEQKSPDSAWTPVPEDRVPKPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAPGM--QYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTV 454
Cdd:cd11242 321 CCAGSGSaeKYKTSNDFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMVRYRLTQIAVDNAAGPYQNYTVVFLGSEAGTV 400
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 455 LKFLVRPNAStsgTSGLSVFLEEFETYRPDRCGRPggGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11242 401 LKFLARIGPS---GSNGSVFLEEIDVYNPAKCSYD--GEEDRRIIGLELDRASHALFVAFSGCVIRVPLS 465
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
65-524 0e+00

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 697.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  65 LNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVC 144
Cdd:cd11266   9 LDIQMIMIMNRTLYIAARDHIYTVDIDTSHTEEIYFSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKRNDDTLFVC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 145 GSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSK 224
Cdd:cd11266  89 GTNAFNPSCRNYKMDTLEFFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSK 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 225 WFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNV 304
Cdd:cd11266 169 WLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNI 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 305 LQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGM- 383
Cdd:cd11266 249 LQAVTDVIHINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSl 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 384 -QYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRpn 462
Cdd:cd11266 329 eKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIILKFLAR-- 406
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19718780 463 astSGTSGL---SVFLEEFETYRPDRCGRPGGGEtgQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11266 407 ---TGNSGFlndSLFLEEMNVYNSEKCSYDGVED--KRIMGMQLDKASSALYVAFSTCVIKVPLG 466
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
60-524 0e+00

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 602.40  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  60 EGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDES 139
Cdd:cd11269   4 ESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEVPKTEVTPSRKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 140 TLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTV 219
Cdd:cd11269  84 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 220 KHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSH 299
Cdd:cd11269 164 KYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 300 FYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCA 379
Cdd:cd11269 244 FYFDVLQSITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCA 323
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 380 APGM--QYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKF 457
Cdd:cd11269 324 KHGLaeAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYRLTAIAVDHAAGPHQNYTVIFVGSEAGVVLKI 403
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19718780 458 LVRPNASTSGTsglSVFLEEFETYRPDRCGrpGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11269 404 LAKTSPFSLND---SVLLEEIEAYNHAKCS--AENEEDRRVISLQLDRDHHALFVAFSSCVVRIPLS 465
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
65-524 2.12e-179

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 525.44  E-value: 2.12e-179
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  65 LNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRyQRKLTWRSNpsDINVCRMKGKQEGECRNFVKVLLLRDESTLFVC 144
Cdd:cd11270   9 LDFQRMLRINHMVYIAARDHVFAINLSASLERIVP-QQKLTWKTK--DVEKCTVRGKNSDECYNYIKVLVPRNDETLFAC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 145 GSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDR-PTLRTVKHDS 223
Cdd:cd11270  86 GTNAFNPTCRNYKMSSLEQDGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGESsPVLRTVKYDS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 224 KWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFN 303
Cdd:cd11270 166 KWLREPHFLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDSFFYFD 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 304 VLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPG- 382
Cdd:cd11270 246 VLQSLTNVMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPDEAVPKPRPGSCAGDGp 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 383 -MQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLvrp 461
Cdd:cd11270 326 aAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFKLTQIAVDTAAGPYKNYTVVFLGSENGHVLKVL--- 402
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19718780 462 NASTSGTSGLSVFLEEFETYRPDRCGRPgggETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11270 403 ASMHPNSSYSTQVLEDIDVYNPNKCNVR---GEDRRILGLELDKDHHALFVAFTGCVIRVPLS 462
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
76-524 1.23e-177

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 520.04  E-value: 1.23e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVELEpptstELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCAN 155
Cdd:cd11235  14 TLYVGARDRVYLVDLD-----SLYTEQKVAWPSSPDDVDTCYLKGKSKDDCRNFIKVLEKNSDDSLLVCGTNAFNPSCRN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 YSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV 235
Cdd:cd11235  89 YNVETFELVGKEESGRGKCPYDPDHNSTALFADGELYSGTSADFLGTDPVIYRTLGHNPPLRTEYHDSKWLNEPQFVGAF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 236 EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLG 315
Cdd:cd11235 169 DIGDYVYFFFREIAVEYINCGKAVYSRVARVCKNDQGGS-RSLEKKWTTFLKARLNCSVPGEFPFYFNELQDVFDLPSPS 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 316 -GRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCaapgmqYNASSALPDD 394
Cdd:cd11235 248 nKEKIFYAVFTTPYNSIPGSAVCAYSLSDIEAVFNGPFKEQHSSNSAWLPVPDERVPEPRPGTC------VDDSSPLPDD 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 395 ILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVD-VGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSgtsgLSV 473
Cdd:cd11235 322 TLNFIKSHPLMDEAVTPILNRPLFIKTDVNYRFTKIAVDrVQAKLGQTYDVLFVGTDRGIILKVVSLPEQGLQ----ASN 397
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 19718780 474 FLEEFETYRPDrcgrpgggetgQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11235 398 ILEEMPVGPPP-----------EPIQTMQLSRKRRSLYVGSETGVLQVPLA 437
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
65-524 3.70e-158

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 471.11  E-value: 3.70e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  65 LNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTE-LRYQRKLTWRSNpsDINVCRMKGKQEGECRNFVKVLLLRDESTLFV 143
Cdd:cd11268   9 LDFQRFLTLNRTLLVAARDHVFSFDLQAEEEGEgLVPNKYLTWRSQ--DVENCAVRGKLTDECYNYIRVLVPWDSQTLLA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 144 CGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDS 223
Cdd:cd11268  87 CGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 224 KWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFN 303
Cdd:cd11268 167 KWLREPHFVQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFD 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 304 VLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPG- 382
Cdd:cd11268 247 VLQALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGg 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 383 -MQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPwILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLvRP 461
Cdd:cd11268 327 aALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQP-LLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVL-PP 404
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19718780 462 NASTSGTSglSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11268 405 GGRSGGPE--PILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLS 465
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
76-526 1.03e-144

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 435.61  E-value: 1.03e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVELEpptstELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCAN 155
Cdd:cd11237  16 SLLVGARNAVYNISLS-----DLTENQRIEWPSSDAHREMCLLKGKSEDDCQNYIRVLAKKSAGRLLVCGTNAYKPLCRE 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 YsidTLQPVGDNI----SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSlgdrpTLRTVKHDSKWFKEPYF 231
Cdd:cd11237  91 Y---TVKDGGYRVerefDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYRE-----PLRTERYDLKQLNAPNF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 232 VHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGsPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGV 311
Cdd:cd11237 163 VSSFAYGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGG-PHPFRDRWTSFLKARLNCSVPGEYPFYFNEIQSTSDI 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 312 VS--LGGR--PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAapgmqyNA 387
Cdd:cd11237 242 VEggYGGKsaKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSNKVPEPRPGQCV------ND 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 388 SSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQT--VVFLGSEAGTVLKFLVRPNAST 465
Cdd:cd11237 316 SRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYRFTQIAVDPQVKALDGKYydVLFIGTDDGKVLKAVNIASADT 395
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19718780 466 SGTsGLSVFLEEFETYRPdrcgrpgggETGQRLLSLELDAASGGLLAAFPRCVVRVPVARC 526
Cdd:cd11237 396 VDK-VSPVVIEETQVFPR---------GVPIRNLLIVRGKDDGRLVVVSDDEIVSIPLHRC 446
Sema smart00630
semaphorin domain;
65-483 1.31e-143

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 430.64  E-value: 1.31e-143
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780     65 LNIQRVLRVNRTLFIGDRDNLYRVELepptSTELRYQRKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLLLRDESTLFV 143
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSL----NLILEAELKTGPVLSSPDCEECVSKGKdPPTDCVNYIRLLLDYNEDRLLV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    144 CGSNAFNPVCANYSIdtlqpvgdnisgmarcpydpkhanvalfsdGMLFTATVTDFLAIDAVIYRSLGDRP-------TL 216
Cdd:smart00630  77 CGTNAFQPVCRLRNL------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSL 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    217 RTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGsPRVLEKQWTSFLKARLNCSVPG 296
Cdd:smart00630 127 RTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGG-PRSLDKKWTSFLKARLECSVPG 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    297 DSHFYFNVLQAVT-GVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRP 375
Cdd:smart00630 206 EDPFYFNELQAAFlLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRP 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780    376 GCCAAPGMQynaSSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPwGNQTVVFLGSEAGTVL 455
Cdd:smart00630 286 GTCPNKPPS---SKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYLLTSIAVDRVATD-GNYTVLFLGTSDGRIL 361
                          410       420
                   ....*....|....*....|....*...
gi 19718780    456 KFLVRPnastSGTSGLSVFLEEFETYRP 483
Cdd:smart00630 362 KVVLSE----SSSSSESVVLEEISVFPD 385
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
76-524 1.16e-109

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 344.78  E-value: 1.16e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVELEPPTSTelrYQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLLRDESTLFVCGSNAFNPVCA 154
Cdd:cd11240  20 TLYVGAREALFALNVSDISTE---LKDKIKWEASEDKKKECANKGKDnQTDCFNFIRILQFYNSTHLYVCGTFAFSPRCT 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 155 NYSIDTLQ-PVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVkHDSKWFKEPYFVH 233
Cdd:cd11240  97 YINLSDFSlSSIKFEDGKGRCPFDPAQRYTAIMVDGELYSATVNNFLGSEPVISRNHSEGNVLKTE-NTLRWLNEPAFVG 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 234 AV---EWGSH-------VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPgDSHFYFN 303
Cdd:cd11240 176 SAhirESIDSpdgdddkIYFFFTETAVEYDFYEKVTVSRVARVCKGDLGGQ-RTLQKKWTTFLKAQLVCSQP-DSGLPFN 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 304 VLQAvtgVVSLGGR----PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRPRPGCC- 378
Cdd:cd11240 254 VLRD---VFVLSPDswdaTIFYGVFTSQWNVSGLSAVCAYSLEDIKKVFSGKYKEFNRETSKWSRY-TGPVPDPRPGACi 329
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 379 --AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGhAPWILRTLMRHqlTRVAVDVGAGPWGNQ-TVVFLGSEAGTVL 455
Cdd:cd11240 330 tnSARSQGITSSLNLPDNVLTFVKDHPLMDEQVHPIN-RPLLVKSGVNY--TRIAVHRVQALDGQTyTVLFLGTEDGFLH 406
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19718780 456 KflvrpnaSTSGTSGLSVfLEEFETYRPDrcgrpgggetgQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11240 407 K-------AVSLDGGMHI-IEEIQLFDQP-----------QPVKNLLLSSSKGVLYVGSSSGVVQVPLS 456
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
77-482 4.08e-105

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 333.56  E-value: 4.08e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELEPPTstelRYQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLLRDESTLFVCGSNAFNPVCAn 155
Cdd:cd11239  22 LYVGGKDHILSLSLDNIN----QDPKKIYWPASPERIEECKMAGKDpNTECANFVRVLQPYNRTHLYACGTGAFHPICA- 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 ySIDTLQPVGDNI---------SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWF 226
Cdd:cd11239  97 -FINVGRRLEDPIfklddssleSGRGKCPFDPNQPFASVLIDGELYSGTAIDFMGRDAAIFRSLGHRHYIRTEQYDSRWL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 227 KEPYFVHAV-------EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGD-- 297
Cdd:cd11239 176 NEPKFVGAYlipdsdnPDDDKVYFFFREKAVEAEGSGKAIYSRVGRICKNDVGGQ-RSLVNKWSTFLKARLVCSVPGPdg 254
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 298 SHFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRPRPG 376
Cdd:cd11239 255 IDTYFDELEDVFLLPTRDPKnPLIYGVFTTSSNVFKGSAVCVYSMADIRAAFNGPFAHKEGPNYQWVEY-QGKVPYPRPG 333
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAP--GMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTV 454
Cdd:cd11239 334 TCPSKtyGPLYKSTKDFPDDVISFARSHPLMYNPVYPLHGRPLLIRTNVPYRLTQIAVDRVEAEDGQYDVLFIGTDSGTV 413
                       410       420
                ....*....|....*....|....*...
gi 19718780 455 LKFLVRPNASTSGTsglSVFLEEFETYR 482
Cdd:cd11239 414 LKVVSLPKENWEME---EVILEELQVFK 438
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
76-456 2.20e-102

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 325.53  E-value: 2.20e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVELEPPTSTELRYQRK-LTwrSNPSDINVCRMKGK-QEGECRNFVKVLLLR-DESTLFVCGSNAFNPv 152
Cdd:cd11238  14 ALYVGAMDRVFRLNLYNINDTGNNCARDeLT--LSPSDVSECVSKGKdEEYECRNHVRVIQPMgDGQTLYVCSTNAMNP- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 153 cANYSID-----TLQPVGDNISGMARCPYDPKHANVALFSDG-------MLFTATVTDFLAIDAVIYRS-----LGDR-- 213
Cdd:cd11238  91 -KDRVLDanllhLPEYVPGPGNGIGKCPYDPDDNSTAVWVEWgnpgdlpALYSGTRTEFTKANTVIYRPplynnTKGRhe 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 214 PTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCS 293
Cdd:cd11238 170 SFMRTLKYDSKWLDEPNFVGSFDIGDYVYFFFRETAVEYINCGKVVYSRVARVCKKDTGGK-NVLRQNWTTFLKARLNCS 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 294 VPGDSHFYFNVLQAVTGVVSlGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVF-EGRFREQKSPESIWTPVPEDQVPR 372
Cdd:cd11238 249 ISGEFPFYFNEIQSVYKVPG-RDDTLFYATFTTSENGFTGSAVCVFTLSDINAAFdTGKFKEQASSSSAWLPVLSSEVPE 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 373 PRPGCCAapgmqyNASSALPDDILNFVKTHPLMDEAVpslGHAPWILrTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAG 452
Cdd:cd11238 328 PRPGTCV------NDSATLSDTVLHFARTHPLMDDAV---SHGPPLL-YLRDVVFTHLVVDKLRIDDQEYVVFYAGSNDG 397

                ....
gi 19718780 453 TVLK 456
Cdd:cd11238 398 KVYK 401
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
68-461 1.06e-101

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 323.27  E-value: 1.06e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  68 QRVLRVNRTLFI-GDRDNLYRVELepptsTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDEStLFVCGS 146
Cdd:cd11265  11 QMLFDVARNQVIvGARDNLYRLSL-----DGLELLERASWPAAESKVALCQNKGQSEEDCHNYVKVLLSYGKQ-LFACGT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 147 NAFNPVCANYSIDTLQPVGDNISGMARCPYDPkHANVA--LFSDGMLFTATVTDFLAIDAVIYRSLG--DRPTLRTVKHD 222
Cdd:cd11265  85 NAFSPRCSWREMENLTSVTEWDSGVAKCPYSP-HANITalLSSSGQLFVGSPTDFSGSDSAIYRTLGtsNKSFLRTKQYN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 223 SKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYF 302
Cdd:cd11265 164 SKWLNEPQFVGSFETGNFVYFLFRESAVEYMNCGKVIYSRIARVCKNDVGGGTMLLKDNWTTFLKARLNCSLPGEYPFYF 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 303 NVLQAVTGVVSLGgrpVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQvpRPRPGCCaapg 382
Cdd:cd11265 244 DEIQGMTYLPDEG---ILYATFTTPENSIAGSAVCAFNLSSINAAFDGPFKHQESSGAAWERVNVNH--RDHFNQC---- 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 383 mqynaSSALPDDILNFVKtHPLMDEAVPSLGHAPWILRTLMRhqLTRVAVDVGA-GPWGNQTVVFLGSEAGTVLKFLVRP 461
Cdd:cd11265 315 -----SSSSSSHLLESSR-YQLMDEAVQPITLEPLHHAKLER--FSHIAVDVIPtKIHQSVHVLYVATTGGLIKKISVLP 386
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
77-489 1.13e-101

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 323.35  E-value: 1.13e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELEPPTSTELryqrkLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDEStLFVCGSNAFNPVCANY 156
Cdd:cd11241  21 LIVGARNYLFRLRLQSLSLLQA-----VPWNSDEDTKRQCQSKGKSVEECQNYVRVLLVVGKN-LFTCGTYAFSPVCTIR 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 157 SIDTLQPVGDNISGMARCPYDPKHANVALFS-DGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV 235
Cdd:cd11241  95 KLSNLTQILDTISGVARCPYSPAHNSTALISaSGELYAGTVYDFSGRDPAIYRSLGGKPPLRTAQYNSKWLNEPNFVGSY 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 236 EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQavtGVVSLG 315
Cdd:cd11241 175 EIGNHTYFFFRENAVEHQDCGKTVYSRIARVCKNDIGGR-FLLEDTWTTFMKARLNCSLPGEFPFYYNEIQ---GTFYLP 250
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 316 GRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPedqVPRPRPgCCAAPGMQYNASSALPDDI 395
Cdd:cd11241 251 ETDLIYAVFTTNVNGIAGSAICAFNLSAINQAFNGPFKYQENNGSAWLPTP---NPHPNF-QCTTSIDRGQPANTTERDL 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 396 LNFVKtHPLMDEAVPSLGHAPWILRTLMRhqLTRVAVDVGAGPWGNQ-TVVFLGSEAGTVLKFLVRPNASTSGTsglsvf 474
Cdd:cd11241 327 QDAQK-YQLMAEVVQPVTKIPLVTMDDVR--FSKLAVDVVQGRGTQLvHIFYVGTDYGTILKMYQPHRSQKSCT------ 397
                       410
                ....*....|....*
gi 19718780 475 LEEFETYrPDRCGRP 489
Cdd:cd11241 398 LEEIKIL-PAMKGEP 411
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
76-524 1.60e-98

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 313.37  E-value: 1.60e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLL-LRDESTLFVCGSNAFNPVCA 154
Cdd:cd09295  13 TIYVGAIARIYKVDGGGTRLLLSCISPELNFGFNEDQKAFCPLRRGKWTECINYIKVLQqKGDLDILAVCGSNAAQPSCG 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 155 NYSIDTLQPVGDN--ISGMARCPYDPKHANVALFSDGMLFTATVTDFL-AIDAVIYRSLGDRPTLRTVKHDSKWFKEPYF 231
Cdd:cd09295  93 SYRLDVLVELGKVrwPSGRPRCPIDNKHSNMGVNVDSKLYSATDHDFKdGDRPALSRRSSNVHYLRIVVDSSTGLDEITF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 232 VHAVEWGS---HVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPgDSHFYFNVLQAV 308
Cdd:cd09295 173 VYAFVSGDdddEVYFFFRQEPVEYLKKGMVYVPRIARVCKLDVGGC-HRLKKKLTSFLKADLNCSRP-QSGFAFNLLQDA 250
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 309 TGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFegrfreqkspesiwtpvpedqvprprpgccaapgmqynas 388
Cdd:cd09295 251 TGDTKNLIQDVKFAIFSSCLNKSVESAVCAYLFTDINNVF---------------------------------------- 290
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 389 salpddilnfvkthplmDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRpNASTSGt 468
Cdd:cd09295 291 -----------------DDPVEAINNRPLYAHQNQRSRLTSIAVDATKQKSVGYQVVFLGLKLGSLGKALAF-FFLYKG- 351
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19718780 469 sglsVFLEEFETYRPDrcgrpgggetgQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd09295 352 ----HIIEEWKVFKDS-----------SRITNLDLSRPPLYLYVGSESGVLGVPVQ 392
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
59-523 5.53e-97

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 310.81  E-value: 5.53e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  59 AEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEpptstELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDE 138
Cdd:cd11263   3 AENAVDFSQLTFDPGQKELIVGARNYLFRLQLE-----DLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGD 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 139 StLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALF-SDGMLFTATVTDFLAIDAVIYRSLGDRPTLR 217
Cdd:cd11263  78 R-LFTCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLtSSGELYAATAMDFPGRDPAIYRSLGILPPLR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 218 TVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNyLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGD 297
Cdd:cd11263 157 TAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGE 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 298 SHFYFNVLQavtGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEdqvPRPRPGC 377
Cdd:cd11263 235 IPFYYNELQ---STFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPN---PNPNFQC 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 378 CAA-PGMQYNASSALPDDILNFVkthpLMDEAVPSLGHAPWILRTLMRhqLTRVAVDVGAGPWGNQTVVFLGSEAGTVLK 456
Cdd:cd11263 309 GTMdQGLYVNLTERNLQDAQKFI----LMHEVVQPVTPVPYFMEDNSR--FSHVAVDVVQGKDMLFHIIYLATDYGTIKK 382
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19718780 457 FLVRPNASTSgtsglSVFLEEFETYrPDRCGRPgggetgqrLLSLELDAASGGLLAAFPRCVVRVPV 523
Cdd:cd11263 383 VLAPLNQSSS-----SCLLEEIELF-PKRQREP--------IRSLQILHSQSVLFVGLQEHVIKIPL 435
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
61-524 3.09e-95

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 306.14  E-value: 3.09e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  61 GADDLNiQRVLRVNRT-LFIGDRDNLYRVELepptsTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLrDES 139
Cdd:cd11264   5 GVRDFS-QLALDLNRNqLIVGARNYLFRLSL-----HNVSLIQATEWGSDEDTRRSCQSKGKTEEECQNYVRVLIV-YGK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 140 TLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSD-GMLFTATVTDFLAIDAVIYRSLGDRPTLRT 218
Cdd:cd11264  78 KVFTCGTNAFSPVCTSRQVGNLSKVIERINGVARCPYDPRHNSTAVITSrGELYAATVIDFSGRDPAIYRSLGSVPPLRT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 219 VKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNyLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGDS 298
Cdd:cd11264 158 AQYNSKWLNEPNFIAAYDIGLFTYFFFRENAVEHD-CGKTVYSRVARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEI 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 299 HFYFNVLQAvtgVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEdqvPRPRPGCC 378
Cdd:cd11264 236 PFYYNELQS---TFYLPEQDLIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLPTAN---PIPNFQCG 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 379 AAPGMQYNASsaLPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRhqLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFL 458
Cdd:cd11264 310 TLSDDSPNEN--LTERSLQDAQRLFLMNDVVQPVTVDPLVTQDSVR--FSKLVVDIVQGKDTLYHVMYIGTEYGTILKAL 385
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19718780 459 vrpnaSTSGTSGLSVFLEEFETYRPdrcgrpgggetGQR--LLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11264 386 -----STTNRSLRSCYLEEMQILPP-----------GQRepIRSLQILHSDRSLFVGLNNGVLKIPLE 437
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
77-482 7.06e-86

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 283.43  E-value: 7.06e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELepptsTELRYQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLLRDESTLFVCGSNAFNPVCA- 154
Cdd:cd11249  44 LYVGAKDHIFSFNL-----VNIKDFQKIVWPVSPSRRDECKWAGKDiLKECANFIKVLKAYNQTHLYACGTGAFHPVCTy 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 155 ----NYSIDTLQPVGDNI--SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKE 228
Cdd:cd11249 119 ievgHHPEDNIFRLEDSHfeNGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLND 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 229 PYFV--HAVEWGSH-----VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPG----D 297
Cdd:cd11249 199 PRFIsaHLIPESDNpeddkIYFFFRENAIDGEHTGKATHARIGQLCKNDFGGH-RSLVNKWTTFLKARLICSVPGpngiD 277
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 298 SHfyFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRPRPG 376
Cdd:cd11249 278 TH--FDELQDVFLMNSKDPKnPIVYAVFTTSSNIFKGSAVCMYSMTDIRRVFLGPYAHRDGPNYQWVPF-QGRVPYPRPG 354
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAPGMQ-YNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVL 455
Cdd:cd11249 355 TCPSKTFGgFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIIIKTDVDYQFTQIVVDRVEAEDGQYDVMFIGTDMGTVL 434
                       410       420
                ....*....|....*....|....*..
gi 19718780 456 KFLVRPNASTSGTSglSVFLEEFETYR 482
Cdd:cd11249 435 KVVSIPKETWHDLE--EVLLEEMTVFR 459
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
69-482 1.74e-83

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 275.93  E-value: 1.74e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  69 RVLRVNRT---LFIGDRDNLYRVELEPPTSTELryqrKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLLLRDESTLFVC 144
Cdd:cd11254  11 RILLKDEDhdrMYVGSKDYVLSLDLHDINREPL----IIHWPASPQRIEECILSGKgSNGECGNFIRLIQPWNRTHLYVC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 145 GSNAFNPVC--------ANYSIDTLQPvGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTL 216
Cdd:cd11254  87 GTGAYNPVCayinrgrrAEDYMFRLEP-DKLESGKGKCPYDPKQDSVSALINGELYAGVYIDFMGTDAAIFRTMGKQPAM 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 217 RTVKHDSKWFKEPYFVHAV---EWGSH----VYFFFREIAMEFNyLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKAR 289
Cdd:cd11254 166 RTDQYNSRWLNDPAFVHAHlipDSSEKnddkLYFFFREKSLEAP-QSPAVLSRIGRVCLNDDGGH-CCLVNKWSTFLKAR 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 290 LNCSVPGDS--HFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVp 366
Cdd:cd11254 244 LVCSVPGADgiETHFDELRDVFIQPTQDTKnPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPY- 322
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 367 EDQVPRPRPGCCAA----PGMQynASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQ 442
Cdd:cd11254 323 TGKIPYPRPGTCPGgtftPSMK--STKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYRFTTIAVDQVDAADGRY 400
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 19718780 443 TVVFLGSEAGTVLKFLVRPNaSTSGTSGLSvfLEEFETYR 482
Cdd:cd11254 401 EVLFLGTDRGTVQKVIVLPK-DDLETEELT--LEEVEVFK 437
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
77-526 2.07e-83

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 276.02  E-value: 2.07e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELEPPTSTELR--YQRKLTWRSNpsdinvCRMKGKQEG-ECRNFVKVLLLRDESTLFVCGSNAFNPVC 153
Cdd:cd11250  22 LFVGAKNYLASLSLDNISKQEKKiyWPAPVEWREE------CNWAGKDINtDCMNYVKILHHYNRTHLYACGTGAFHPTC 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 154 AnySIDTLQPVGDNI---------SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSK 224
Cdd:cd11250  96 A--FVEVGQRMEDHVfrldpsrveDGKGKSPYDPRHTAASVLVGDELYSGVATDLMGRDFTIFRSLGQRPSLRTEQHDSR 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 225 WFKEPYFVhAVEW--------GSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPG 296
Cdd:cd11250 174 WLNEPKFV-KVFWipesenpdDDKIYFFFRETAVEAAGLGKQSYSRIGQICRNDMGGQ-RSLVNKWTTFLKARLVCSVPG 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 297 D--SHFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRP 373
Cdd:cd11250 252 NegGDTHFDELRDVFLLQTRDKRnPLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFLGPFAHKEGPNYQWVSY-QGKVPYP 330
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 374 RPGCCAAPGM-QYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAG 452
Cdd:cd11250 331 RPGMCPSKTFgSFESTKDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIPYTFTQIAVDRVAAADGHYDVMFIGTDVG 410
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19718780 453 TVLKFLVRPNASTSGTSGLsvFLEEFETYrpdrcgrpgggETGQRLLSLELDAASGGLLAAFPRCVVRVPVARC 526
Cdd:cd11250 411 SVLKVISVPKGSWPSNEEL--LLEELHVF-----------KDSSPITSMQISSKRQQLYVGSRSGVSQLPLHRC 471
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
76-524 1.64e-80

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 267.16  E-value: 1.64e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVELEPPTSTELRYQrkLTWRSNPSDINVCRMKGK-QEGECRNFVKVLLLRDESTLFVCGSNAFNPVCA 154
Cdd:cd11256  21 TLYVGARDNILALGIRTPGPIRLKHQ--IPWPANDSKISECAFKKKsNETECFNFIRVLVPVNGTHLYTCGTYAFSPACT 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 155 NYSID--TLQPVGDNI---SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTvKHDSKWFK-E 228
Cdd:cd11256  99 YIELDhfSLPPPNGTIitmDGKGQSPFDPQHNYTAILVDGELYTGTMNNFRGNEPIIFRNLGTKVSLKT-DGFLRWLNaD 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 229 PYFVHAV--EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGdsHFYFNVLQ 306
Cdd:cd11256 178 AVFVASFnpQGDSKVYFFFEETAREFDFFEKLTVARVARVCKNDVGGE-KLLQKKWTTFLKAQLTCSQQG--HFPFNVIH 254
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 307 -AVTGVVSLGGRPVVLAVFST--PSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTpVPEDQVPRPRPGCCAApgm 383
Cdd:cd11256 255 hVALLNQPDPNNSVFYAVFTSqwQLGGRRSSAVCAYKLNDIEKVFNGKYKELNKESSRWT-RYMGPVSDPRPGSCSG--- 330
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 384 qyNASSalpDDILNFVKTHPLMDEAVPSLGHAPWILRTLMrhQLTRVAVDVGAGPWG-NQTVVFLGSEAGtVLKFLVRPN 462
Cdd:cd11256 331 --GKSS---DKALNFMKDHFLMDEVVLPGAGRPLLVKSNV--QYTRIAVDSVQGVSGhNYTVMFLGTDKG-FLHKAVLMG 402
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19718780 463 ASTsgtsglSVFLEEFETYRPDRCGRpgggetgqrllSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11256 403 GSE------SHIIEEIELLTPPEPVE-----------NLLLAANEGVVYIGYSAGVWRVPLA 447
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
75-524 2.59e-79

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 264.80  E-value: 2.59e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  75 RTLFIGDRDNLYRVELEPPTSTElrYQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLLRDESTLFVCGSNAFNPVC 153
Cdd:cd11257  20 NMLYVGARETLFALSSNDISPTG--EQQELTWSADEEKKQECSFKGKDpQRDCQNYIKILLRLNSTHLFTCGTYAFSPIC 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 154 ANYSIDTLQPVGDNI------SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTvKHDSKWFK 227
Cdd:cd11257  98 TYIVMTNFSLERDEKgeplleDGKGRCPFDPEYKSTAIMVDGELYTGTVSNFQGNDPIIYRSLGSGTPLKT-ENSLNWLQ 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 228 EPYFV----------HAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGD 297
Cdd:cd11257 177 DPAFVgsayiqeslpKLVGDDDKIYFFFSETGKEFDFFENTIVSRIARVCKGDEGGE-RVLQKRWTTFLKAQLLCSLPDD 255
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 298 ShFYFNVLQAVTgVVSLGGR----PVVLAVFSTPSN--SIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEdQVP 371
Cdd:cd11257 256 G-FPFNVLQDVF-VLTPSPEdwkdTLFYGVFTSQWHkgTAGSSAVCVFTMDQVQRAFNGLYKEVNRETQQWYTYTH-PVP 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 372 RPRPGCC---AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSlghAPWILRTLMRHqlTRVAVDVGAGPWGNQTVVFLG 448
Cdd:cd11257 333 EPRPGACitnSARERKINSSLHMPDRVLNFVKDHFLMDGQVRS---QPLLLQPQVRY--TQIAVHRVKGLHKTYDVLFLG 407
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19718780 449 SEAGTVLKFLvrpnastsGTSGLSVFLEEFETYrpdrcgrpgggETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11257 408 TDDGRLHKAV--------SVGPMVHIIEELQIF-----------SEGQPVQNLLLDTHKGLLYASSHSGVVQVPVA 464
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
60-482 2.63e-79

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 264.79  E-value: 2.63e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  60 EGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTelryQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDES 139
Cdd:cd11253   5 FGFLDLHTMLLDEYQERLFVGGRDLLYSLSLERISAN----YKEIHWPSTQLQVEDCIMKGRDKPECANYIRVLHHYNRT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 140 TLFVCGSNAFNPVCAnySIDTLQPVGDNI---------SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSL 210
Cdd:cd11253  81 HLLACGTGAFDPVCA--FIRVGRGSEDHLfqlesdkfeRGRGRCPFDPNSSFISTLIGGELFVGLYSDYWGRDAAIFRTM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 211 GDRPTLRTVKHDSKWFKEPYFVhavewGSH------------VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVL 278
Cdd:cd11253 159 NHLAHIRTEHDDERLLKEPKFV-----GSYmipdnedpddnkVYFFFTEKALEAEGGNHAIYTRVGRVCANDQGGQ-RML 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 279 EKQWTSFLKARLNCSVPG----DSHFyfnvlQAVTGVVSLGGR----PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEG 350
Cdd:cd11253 233 VNKWSTFLKTRLICSVPGpngiDTHF-----DELEDVFLLRTRdnknPEIFGLFSTTSNIFKGYAICVYHMASIRAAFNG 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 351 RFREQKSPESIWTpVPEDQVPRPRPGCCAAP--GMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLT 428
Cdd:cd11253 308 PFAHKEGPEYHWS-VYEGKVPYPRPGSCASKvnGGHYGTTKDYPDEALRFARSHPLMYQAVKPVHKRPILVKTDGKYNLK 386
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 19718780 429 RVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSglSVFLEEFETYR 482
Cdd:cd11253 387 QIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQETETME--EVILEELQVFK 438
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
77-482 1.12e-77

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 260.61  E-value: 1.12e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELEPPTSTElryqRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLLRDESTLFVCGSNAFNPVCAn 155
Cdd:cd11255  22 LFLGGKDVLYSLRLDQTHPDA----KEIHWPPLPGQREECIRKGKDpETECANFVRVLQPFNRTHLLACGTGAFQPVCA- 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 ysIDTLQPVGDNI---------SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTvKHDSKWF 226
Cdd:cd11255  97 --LINVGHRGEHVfsldpttveSGRGRCPHEPKRPFASTFTGGELYTGLTADFLGRDSVIFRGFGTRSPLRT-ETDQRLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 227 KEPYFVHAV-------EWGSHVYFFFREIAMEFNYLE-KVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGDS 298
Cdd:cd11255 174 HEPRFVAAHlipdnadRDNDKVYFFFTERATETAEDDdGAIHSRVGRLCANDAGGQ-RVLVNKWSTFIKARLVCSVPGPH 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 299 --HFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRPRP 375
Cdd:cd11255 253 giQTHFDQLEDVFLLRTKDGKsPEIYALFSTISNVFQGFAVCVYSMADIWEVFNGPFAHKDGPDHQWGPY-EGKVPYPRP 331
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 376 GCC-----AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSE 450
Cdd:cd11255 332 GVCpskitAQPGRAFRSTKDYPDEVLQFARAHPLMWRPVYPSHRRPVLVKTGLPYRLTQIVVDRVEAEDGYYDVMFIGTD 411
                       410       420       430
                ....*....|....*....|....*....|..
gi 19718780 451 AGTVLKFLVRPNASTSgtSGLSVFLEEFETYR 482
Cdd:cd11255 412 SGSVLKVIVLQKGNSA--AGEEVTLEELQVFK 441
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
77-482 1.71e-76

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 257.13  E-value: 1.71e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELEPPTSTELryqrKLTWRSNPSDINVCRMKGKQEGE-CRNFVKVLLLRDESTLFVCGSNAFNPVCAN 155
Cdd:cd11251  22 IYVGSKDHILSLNINNISQDAL----SIFWPASASKVEECKMAGKDPTHgCGNFVRVIQPYNRTHLYVCGSGAFSPVCVY 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 -----------YSIDTlqpvgDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSK 224
Cdd:cd11251  98 vnrgrrseeqvFHIDS-----KAESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSK 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 225 WFKEPYFV--HAVEWGSH-----VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPGD 297
Cdd:cd11251 173 WLSEPIFVdaHLIPDGTDpndakLYFFLKERLTDNSGSTKQIHSMIARVCPNDTGGQ-RSLVNKWTTFLKARLVCSVMDE 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 298 --SHFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRPR 374
Cdd:cd11251 252 dgTETHFDELEDVFLLETDNPRtTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPNHQLIAY-QGRIPYPR 330
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 375 PGCCAA----PGMQynASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSE 450
Cdd:cd11251 331 PGTCPGgaftPNMQ--STKEFPDDVVTFIRNHPLMFNPIYPIGRRPLLVRTGTDYKYTKIAVDRVNAADGRYHVLFLGTD 408
                       410       420       430
                ....*....|....*....|....*....|...
gi 19718780 451 AGTVLKFLVRP-NASTSGtsglSVFLEEFETYR 482
Cdd:cd11251 409 KGTVQKVVVLPtNGSLSG----ELILEELEVFK 437
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
59-476 3.40e-76

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 255.97  E-value: 3.40e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  59 AEGADDLNIQRVLRVNRTLFIGDRDNLYRVELepPTSTElrYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDE 138
Cdd:cd11261   8 APHTYNYSVLLVDPASHTLYVGARDAIFALTL--PFSGE--RPRRIDWMVPEAHRQNCRKKGKKEAECHNFIRILAIANA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 139 STLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGD-RPTLR 217
Cdd:cd11261  84 SHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAIMAGGVLYAATVKNFLGTEPIISRAVGRaEEWIR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 218 TVKHDSkWFKEPYFVHAV-----EWG-----SHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLK 287
Cdd:cd11261 164 TETLPS-WLNAPAFVAAVflspaEWGdedgdDEIYFFFTETAREYDSYERIKVPRVARVCAGDLGGR-KTLQQRWTTFLK 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 288 ARLNCSVPgDSHFYFNVLQAVTGVVSL--GGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPV 365
Cdd:cd11261 242 ADLLCPGP-EHGRASSILQDVTTLRPLpgAGTPIFYGIFSSQWEGASISAVCAFRPQDIRRVMNGPFREFKHDCNRGLPV 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 366 PEDQVPRPRPGCCAAPGM---QYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQltRVAVDVGAGPWGNQ 442
Cdd:cd11261 321 MDSDVPQPRPGECITNNMkllGFGSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLLVTTDTAYL--RVAAHRVTSLSGKE 398
                       410       420       430
                ....*....|....*....|....*....|....*
gi 19718780 443 -TVVFLGSEAGTVLKfLVRPNASTSGTSGLSVFLE 476
Cdd:cd11261 399 yDVLYLGTEDGHLHR-AVRIGAQLSVLEDLALFPE 432
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
77-482 1.15e-75

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 255.22  E-value: 1.15e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELEPPTstelRYQRKLTWRSNPSDINVCRMKGKQEG-ECRNFVKVLLLRDESTLFVCGSNAFNPVCAN 155
Cdd:cd11252  22 LLLGAKDHIYLLDLVDLN----KNPKKIYWPAAKERVELCKLAGKDANtECANFIRVLHPYNRTHVYVCGTGAFHPTCGY 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 YSIDT------LQPVGDNI-SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLG---DRPTLRTVKHDSKW 225
Cdd:cd11252  98 IELGThkedriFLLDTQNLeSGRLKCPFDPQQPFASVMTDEYLYAGTASDFLGKDTTFTRSLGptpDHHYIRTDISEHYW 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 226 FKEPYFVhavewGSH------------VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCS 293
Cdd:cd11252 178 LNGAKFI-----GTFpipdtynpdddkIYFFFREASQDGSTSDKSVLSRVGRVCKNDVGGQ-RSLINKWTTFLKARLVCS 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 294 VPGD--SHFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQV 370
Cdd:cd11252 252 IPGPdgADTHFDELQDIFLLPTRDERnPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESPDHRWVQY-EGRI 330
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 371 PRPRPGCCaaPGMQYN----ASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVF 446
Cdd:cd11252 331 PYPRPGTC--PSKTYDplikSTKDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYRLTQIVVDHVAAEDGQYDVMF 408
                       410       420       430
                ....*....|....*....|....*....|....*.
gi 19718780 447 LGSEAGTVLKFLvrpNASTSGTSGLSVFLEEFETYR 482
Cdd:cd11252 409 LGTDIGTVLKVV---SITKEKWTMEEVVLEELQIFK 441
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
76-463 2.72e-74

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 251.31  E-value: 2.72e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  76 TLFIGDRDNLYRVEleppTSTELRYQRKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLLLRDESTLFVCGSNAFNPVCA 154
Cdd:cd11259  31 VLYVGAREAVFALN----ALNISEKQHELYWKVSEDKRTKCAVKGKsKQTECRNYIRVLQPLNDTFLYVCGTNAFQPTCD 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 155 NYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPtLRTvKHDSKWFKEPYFVHA 234
Cdd:cd11259 107 YLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISRNSSQSP-LRT-EYAIPWLNEPSFVFA 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 235 --VEWGSH--------VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPgDSHFYFNV 304
Cdd:cd11259 185 dvIRADPDspdgeddkIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSIP-DKNLVFNV 262
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 305 LQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVF-EGRFREQKSPESIWTPVPE--DQVPRPRPGCC-- 378
Cdd:cd11259 263 VNDVFILKSPTLKePVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFsKGKYMQSATVEQSHTKWVRynGEVPKPRPGACin 342
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 379 -AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHqlTRVAVD-VGAGPWGNQTVVFLGSEAGTVLK 456
Cdd:cd11259 343 nEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNY--TQIVVDrVQALDGTIYDVMFISTDRGALHK 420

                ....*..
gi 19718780 457 FLVRPNA 463
Cdd:cd11259 421 AISLENE 427
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
63-456 3.84e-69

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 236.73  E-value: 3.84e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  63 DDLNIqrvlrvnrtLFIGDRDNLYRVELEPPTSTelryQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLLRDESTL 141
Cdd:cd11260  16 EDLGL---------LVLGAREAVFALDLNDISVK----RAKVLWEVTEEKQKDCTNKGKHaDIDCHNYIRILHKMNDSRM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 142 FVCGSNAFNPVCA--NYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSlgDRPTLRTv 219
Cdd:cd11260  83 YVCGTNAFSPTCDyiSYDDGQLTLEGKQEDGKGKCPFDPFQRYSSVMVDQDLYSATSMNFLGSEPVIMRS--SPITIRT- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 220 KHDSKWFKEPYFVH--AVEWGSH--------VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKAR 289
Cdd:cd11260 160 EFKSSWLNEPNFIYmaAVPESEDspegdddkIYLFFSETAVEYDFYNKLVVSRVARVCKGDLGGQ-RTLQKKWTSFLKAR 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 290 LNCSVPGDSHFYfnVLQAVTGVVSLGGRPVVL-AVFSTPSNSIPGSAVCAFDLTQVAAVF-EGRFReqkspesiwTPVPE 367
Cdd:cd11260 239 LDCSVPEPSLPY--VIQDVFHVCHQDWRKCVFyAVFTSQSDSSQSSAVCAYNVTDISNVFsRGKFK---------TPVAV 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 368 D-----------QVPRPRPGCC---AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTlmRHQLTRVAVD 433
Cdd:cd11260 308 EtsfvkwvmysgELPVPRPGACinnAARTSGIKKSLNLPDKTLQFVKDKPLMDQAVHPITGKPLLVKR--GALFTRIVVD 385
                       410       420
                ....*....|....*....|....
gi 19718780 434 VGAGPWGNQ-TVVFLGSEAGTVLK 456
Cdd:cd11260 386 MVTAADGQSyPVMFIGTANGYVLK 409
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
77-460 7.90e-69

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 235.81  E-value: 7.90e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVElepPTSTELRYQRKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLLLRDESTLFVCGSNAFNPVCAN 155
Cdd:cd11262  22 LYVGARGAIFSLN---ASDISDSSALTIDWEASPEQKHQCLKKGKnNQTECFNHVRFLQRFNSTHLYTCGTHAFRPLCAY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 156 YSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFlaidaviyRSLGD------RPTLRTVKHDSKWFKEP 229
Cdd:cd11262  99 IDAERFTLSSQFEEGKEKCPYDPAKGYTGLIVDGQLYTASQYEF--------RSFPDirrnspQPTLRTEEAPTRWLNDA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 230 YFVHAV----EWGSHV------YFFFREIAME-FNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPgDS 298
Cdd:cd11262 171 DFVGSVlvreSMNSSVgdddkiYFFFTERSQEeTAYFSQSRVARVARVCKGDRGGK-KTLQRKWTSFLKARLVCYIP-EY 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 299 HFYFNVLQAVTGV-VSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVpEDQVPRPRPGC 377
Cdd:cd11262 249 EFLFNVLRSVFVLwGSTPQDTVFYGIFGLEWKNVKASAICRYSLSDIQTAFEGPYMEYQDSSSKWSRY-TGKVPEPRPGS 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 378 C---AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHqlTRVAVDVGAGPWGN-QTVVFLGSEAGT 453
Cdd:cd11262 328 CitdEHRSQGINSSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLLFKRNVIY--TKIAVQTVRGLDGRvYDVLFLGTDEGW 405

                ....*..
gi 19718780 454 VLKFLVR 460
Cdd:cd11262 406 LHKAVVI 412
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
75-483 1.81e-68

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 235.08  E-value: 1.81e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  75 RTLFIGDRDNLY-----RVELEPPTSTELRYQRKLTwrsnpsdinvCRMKGK-QEGECRNFVKVLLLRDESTLFVCGSNA 148
Cdd:cd11258  22 GLLYVGAREAIFalslsNIELQPPISWEAPAEKKTE----------CAQKGKsNQTECFNYIRFLQPYNQSHLYTCGTYA 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 149 FNPVCANYSIDTLQPVGDNIS-GMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTvKHDSKWFK 227
Cdd:cd11258  92 FQPKCAYINMLTFTLDRAEFEdGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNLGQHYSMKT-EYLAFWLN 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 228 EPYFV---HAVEW-GSH------VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSpRVLEKQWTSFLKARLNCSVPgD 297
Cdd:cd11258 171 EPHFVgsaFVPESvGSFtgdddkIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGA-RTLQKKWTTFLKARLLCSIP-E 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 298 SHFYFNVLQAVTGVVSLGGRPV-VLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPeDQVPRPRPG 376
Cdd:cd11258 249 WQLYFNQLKAVFTLEGASWRNTtFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRYT-DPVPSPRPG 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 377 CCAAPGMQ---YNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRtlMRHQLTRVAVD-VGAGPWGNQTVVFLGSEAG 452
Cdd:cd11258 328 SCINNWHRdhgYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVP--CNSNFTHVVWTrVLGLDGETYSVLFIGTLDG 405
                       410       420       430
                ....*....|....*....|....*....|.
gi 19718780 453 TVLKflvrpNASTSGTSGLSVFLEEFETYRP 483
Cdd:cd11258 406 WLIK-----AVSLGSWVHMIEELQVFDQEPP 431
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
305-483 2.72e-48

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 169.37  E-value: 2.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   305 LQAVTgVVSLGGR----PVVLAVFSTP-SNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPeDQVPRPRPGCCA 379
Cdd:pfam01403   1 LQDVF-VLKPGAGdaldTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYT-GKVPYPRPGTCI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   380 apgmQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRhqLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLV 459
Cdd:pfam01403  79 ----NDPLRLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVR--LTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVL 152
                         170       180
                  ....*....|....*....|....
gi 19718780   460 RPnastsgtSGLSVFLEEFETYRP 483
Cdd:pfam01403 153 VG-------SEESHIIEEIQVFPE 169
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
77-524 3.90e-36

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 141.91  E-value: 3.90e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  77 LFIGDRDNLYRVELepPTSTELryQRKLTWRSNPSDinvCRMKGKQEgECRNFVKVLLLRDEStLFVCGSNAFNPVCANY 156
Cdd:cd11243  16 VYVGGQGALYLLDF--TGSAVI--VKKIPDEKTEKD---CKKRATLD-DCENYITLIKKLDYR-LLVCGTNAGSPKCWFL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 157 SIDTLQPVGDNiSGMArcPYDPKHANVALFSDGMLFTATVTDFLAIdaVIYRSLGDRPTLRTvkHDSkWFKEPYFVHAV- 235
Cdd:cd11243  87 VNQTLVTLSAD-RGVA--PFLPDENSLVLIEGNNVYSTISGKKGNI--PRFRRYGGKKELYT--SDT-VMQKPQFVKATl 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 236 -----EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHfYFNVLQAVTG 310
Cdd:cd11243 159 lpedeQYQDKIYYFFREDNEDKGPEAEPNISRVARLCKEDQGGTSSLSTSKWSTFLKARLVCGDPATPM-NFNRLQDVFL 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 311 V-VSLGGRPVVLAVFSTPSNSipgSAVCAFDLTQVAAVFegrfreqkSPESIWT-PVPedqVPRPRPGCCAAPGmqynas 388
Cdd:cd11243 238 LpKEEWREAVVYGVFSNTWGS---SAVCSYSLGDIDKVF--------RTSSLKGySGS---LPNPRPGTCVPPE------ 297
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 389 SALPDDILNFVKTHPLMDEAVPSLGHAP-WILRTLMRHQltRVAVDVGAGPWGNQ-TVVFLGSEAGTVLKfLVRPNASTS 466
Cdd:cd11243 298 QTHPSETFSFADEHPELDDRIEPDEPRKlPVFQNKDHYQ--KVVVDEVRASDGVSyDVLYLATDKGKIHK-VVESKGQTH 374
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19718780 467 GTSGLSVFLEEFEtyrpdrcgrpgggetgqrLLSLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11243 375 NIMEIQPFKEQEP------------------IQSMILDAERSHLYVGTKAEVTRLPLD 414
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
231-464 1.08e-09

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 61.72  E-value: 1.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 231 FVHAVEWGSHVYFFFREiamefnYLEKVVVSR--VARVCKNDVGgsprvlekqWTSFLKARLNCSVPGDSHFYFN----- 303
Cdd:cd11276 192 FRYAFEDNNYVYFLFNQ------QLGHPDKNRtlIARLCENDHH---------YYSYTEMDLNCRDGANAYNKCQaayvs 256
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 304 ----VLQAVTGVVSLGGRpVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEgrfreqKSPESIWTPVPEDqvprprpgcca 379
Cdd:cd11276 257 tpgkELAQNYGNSILSDK-VLFAVFSRDEKDSGESALCMFPLKSINAKME------ANREACYTGTIDD----------- 318
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 380 aPGMQYNASSALPDDIL-----NFVKTHPLMDEAVPSL--------GHAPWILRTLMrhQLTRVAVDVGagpwGNQTVVF 446
Cdd:cd11276 319 -RDVFYKPFHSQKDIICgshqqKNSKSFPCGSEHLPYPlgsrdelaLTAPVLQRGGL--NLTAVTVAVE----NGHTVAF 391
                       250
                ....*....|....*...
gi 19718780 447 LGSEAGTVLKFLVRPNAS 464
Cdd:cd11276 392 LGTSDGRILKVHLSPDPE 409
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
128-524 1.83e-09

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 60.81  E-value: 1.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 128 NFVKVLLLRDEST-LFVCGSnAFNPVCANYSIDTLQPVGDNISgMARCPYDPKHANVALFSDG------MLFTATVTDFL 200
Cdd:cd11236  63 NYNKILLIDYSSGrLITCGS-LYQGVCQLRNLSNISVVVERSS-TPVAANDPNASTVGFVGPGpynnenVLYVGATYTNN 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 201 AID----AVIYRSL--------GDRPTLRTVKHDSKwFKEPY---FVHAVEWGSHVYFFFREiaMEFNYLEKVVVSRVAR 265
Cdd:cd11236 141 GYRdyrpAVSSRSLppdddfnaGSLTGGSAISIDDE-YRDRYsikYVYGFSSGGFSYFVTVQ--RKSVDDESPYISRLVR 217
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 266 VCKNDvggsprvleKQWTSFLKARLNCSVPGDSHfyFNVLQAV-------TGVVSLG---GRPVVLAVFS---TPSNSIP 332
Cdd:cd11236 218 VCQSD---------SNYYSYTEVPLQCTGGDGTN--YNLLQAAyvgkagsDLARSLGistDDDVLFGVFSkskGPSAEPS 286
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 333 G-SAVCAFDLTQVaavfEGRFREQkSPESIWTPVpedqvprprpgccaapgmqynASSALPDDILnfvkthplmdeavps 411
Cdd:cd11236 287 SkSALCVFSMKDI----EAAFNDN-CPLGGGVPI---------------------TTSAVLSDSL--------------- 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 412 lghapwilrtlmrhqLTRVAVDVgagpWGNQTVVFLGSEAGTVLKFLVrpNASTSGTSGLSVFLEEFETYRPDrcgrpgg 491
Cdd:cd11236 326 ---------------LTSVAVTT----TRNHTVAFLGTSDGQLKKVVL--ESSSSATQYETLLVDSGSPILPD------- 377
                       410       420       430
                ....*....|....*....|....*....|...
gi 19718780 492 getgqrllsLELDAASGGLLAAFPRCVVRVPVA 524
Cdd:cd11236 378 ---------MVFDPDGEHLYVMTPKKVTKVPVE 401
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
231-464 2.14e-07

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 54.17  E-value: 2.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 231 FVHAVEWGSHVYFFF--REIAMEFNYlekvvVSRVARVCKNDvggsprvleKQWTSFLKARLNCSVPGDSHFyfNVLQAV 308
Cdd:cd11245 186 FVYAFADNGYIYFLFsrRPGTADSTK-----RTYISRLCEND---------HHYYSYVELPLNCTVNQENTY--NLVQAA 249
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 309 ---TGVVSLGGRpVVLAVFSTPSNSIPG----SAVCAFDLTQVAAVFE--------GRFREQKSPESIWTPvpedqvprp 373
Cdd:cd11245 250 ylaKPGKVLNGK-VLFGVFSADEASTAApdgrSALCMYPLSSVDARFErtrescytGEGLEDDKPETAYIE--------- 319
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 374 rpgccaapgmqYNASS---ALPDDIlnfVKTHPLMDEAVPS-------LGHAPWILRTLMrhqLTRVAVDVGAGpwgnQT 443
Cdd:cd11245 320 -----------YNVKSickTLPDKN---VKAYPCGAEHTPSplasrypLAAKPILTRNDM---LTAVAVAVENG----HT 378
                       250       260
                ....*....|....*....|.
gi 19718780 444 VVFLGSEAGTVLKFLVRPNAS 464
Cdd:cd11245 379 IAFLGDSGGQLHKVYLDPNHT 399
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
173-546 4.49e-07

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 53.40  E-value: 4.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 173 RCPYDPKhanvalfSDGMLFTATVTDFLAidaviyrSLGDRP--TLRTVKHdskwfKEPYFVHAVEWGSHVYFFF----- 245
Cdd:cd11272 165 KLPRDPE-------SSAMLDYELHSDFVS-------SLIKIPsdTLALVSH-----FDIFYIYGFASGNFVYFLTvqpet 225
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 246 REIAMEFNYLEKVVVSRVARVCKNDvggsprvleKQWTSFLKARLNCsVPGDSHFyfNVLQAvtGVVSLGGR-------- 317
Cdd:cd11272 226 PEGVSINSAGDLFYTSRIVRLCKDD---------PKFHSYVSLPFGC-VRGGVEY--RLLQA--AYLSKPGEvlarslni 291
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 318 ----PVVLAVFSTPSNSI----PGSAVCAFDLTQVAAVFEGRFRE----QKSPESIWTPVPEDQvprprpgCCAAPgmqy 385
Cdd:cd11272 292 taqeDVLFAIFSKGQKQYhhppDDSALCAFPIRAINAQIKERLQScyqgEGNLELNWLLGKDVQ-------CTKAP---- 360
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 386 nassaLP-DDilNFVKthplMDEAVPSLGHAP---WILRTLMRHQLTRVAVDVgagpWGNQTVVFLGSEAGTVLKflVRP 461
Cdd:cd11272 361 -----VPiDD--NFCG----LDINQPLGGSTPvegVTLYTSSRDRLTSVASYV----YNGYSVVFVGTKSGKLKK--IRA 423
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 462 NASTSGtsGLsvfleEFETYRPDRCGRPGggetgQRLLSLELDAASggLLAAFPRCVVRVPVARCQQYSGCmKNCIGSQD 541
Cdd:cd11272 424 DGPPHG--GV-----QYEMVSVFKDGSPI-----LRDMAFSIDHKY--LYVMSERQVSRVPVESCEQYTTC-GECLSSGD 488

                ....*
gi 19718780 542 PYCGW 546
Cdd:cd11272 489 PHCGW 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
706-888 2.21e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   706 LLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTP--DGRLYAARPGRAS 783
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdTHAPDPPPPSPSP 2633
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   784 HGDFPLTPHASPD----------------RRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTH 847
Cdd:PHA03247 2634 AANEPDPHPPPTVppperprddpapgrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPH 2713
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 19718780   848 TFNSGEARPGDRHRGCHARPGTDLAHLLPyggADRTAPPVP 888
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPAAPAPP---AVPAGPATP 2751
PHA03378 PHA03378
EBNA-3B; Provisional
695-841 3.31e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 3.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  695 LQGGPHDLDSGLLPTPEQTP----LPQKRLPTPHPH---------PHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQ 761
Cdd:PHA03378 636 LRMQPITFNVLVFPTPHQPPqveiTPYKPTWTQIGHipyqpsptgANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQ 715
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  762 PPAPGE---PTPDGRLYAARPGRASHGDFPlTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPP--PTGSLRRPLG-- 834
Cdd:PHA03378 716 RPAAATgraRPPAAAPGRARPPAAAPGRAR-PPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPqaPPAPQQRPRGap 794
                        170
                 ....*....|..
gi 19718780  835 -----PHAPPAA 841
Cdd:PHA03378 795 tpqppPQAGPTS 806
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
525-554 6.71e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.15  E-value: 6.71e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19718780   525 RCQQYSGCMKnCIGSQDPYCGW-APDGSCIF 554
Cdd:pfam01437   1 RCSQYTSCSS-CLAARDPYCGWcSSEGRCVR 30
PHA03378 PHA03378
EBNA-3B; Provisional
676-866 1.07e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  676 PPEALLAPLMQNgWAKATLLQGGPHDLDSGLLPTPEQTPL---PQKRLPTPHPHPHALGPRAwdHGHPLLPASASSSLLL 752
Cdd:PHA03378 654 PPQVEITPYKPT-WTQIGHIPYQPSPTGANTMLPIQWAPGtmqPPPRAPTPMRPPAAPPGRA--QRPAAATGRARPPAAA 730
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  753 LAPARAPEQPPAPGEPtPDGRLYAARPGRASHGDFPlTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTG----- 827
Cdd:PHA03378 731 PGRARPPAAAPGRARP-PAAAPGRARPPAAAPGRAR-PPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGptsmq 808
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 19718780  828 -SLRRPLGPHAPPAATLRRTHTFNSGEARPGDRHRGCHAR 866
Cdd:PHA03378 809 lMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALER 848
PHA03378 PHA03378
EBNA-3B; Provisional
704-888 1.10e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  704 SGLLPTPEQTPLPqkrlPTPHPH-PHALGPRAWDHGHPLLPASASSSLLLL---APARAPEQPPAPgEPTPDGRLYAARP 779
Cdd:PHA03378 596 PWPVPHPSQTPEP----PTTQSHiPETSAPRQWPMPLRPIPMRPLRMQPITfnvLVFPTPHQPPQV-EITPYKPTWTQIG 670
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  780 grasHGDFPLTPHASPDRRRVVSAPTGPLDPASAadglPRPWSPP--PTGSLRRP---LGPHAPPAATLRRTHTFNS--G 852
Cdd:PHA03378 671 ----HIPYQPSPTGANTMLPIQWAPGTMQPPPRA----PTPMRPPaaPPGRAQRPaaaTGRARPPAAAPGRARPPAAapG 742
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 19718780  853 EARPGDRHRGCHARPGTDLAHLLPYGGADRTAPPVP 888
Cdd:PHA03378 743 RARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQP 778
PHA03247 PHA03247
large tegument protein UL36; Provisional
721-880 6.55e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   721 PTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEP-TPDGRLYAARPGRASHGDFPLTPH--ASPDR 797
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPaTPGGPARPARPPTTAGPPAPAPPAapAAGPP 2780
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   798 RRVVSAPTGPLDPASAAdgLPRPWSPPPtgslrrPLGPHAPPAATLRRTHTFNSGEARPGDRHRGCHARPGTDLAHLLPY 877
Cdd:PHA03247 2781 RRLTRPAVASLSESRES--LPSPWDPAD------PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                  ...
gi 19718780   878 GGA 880
Cdd:PHA03247 2853 GGS 2855
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
525-553 1.35e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 37.52  E-value: 1.35e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 19718780    525 RCQQYSGCmKNCIGSQDPYCGW-APDGSCI 553
Cdd:smart00423   1 RCSKYTSC-SECLLARDPYCAWcSSQGRCT 29
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
703-859 1.77e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   703 DSGLLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPE---QPPAPGEPTPDGRLYAARP 779
Cdd:PHA03307  238 DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSpspSPSSPGSGPAPSSPRASSS 317
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780   780 GRASHGDFPLTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAA------TLRRTHTFNSGE 853
Cdd:PHA03307  318 SSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAasagrpTRRRARAAVAGR 397

                  ....*.
gi 19718780   854 ARPGDR 859
Cdd:PHA03307  398 ARRRDA 403
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
711-841 2.28e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780  711 EQTPLPQKRLPTPHPHPHALGPRAwdhghpllpasassslLLLAPARAPEQPPAPGEPTPDGRLYAARPGRAShgdfPLT 790
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAA----------------AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS----PAP 430
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19718780  791 PHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAA 841
Cdd:PRK12323 431 EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA 481
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
231-465 5.70e-03

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 40.18  E-value: 5.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 231 FVHAVEWGSHVYFFFR----EIAMEFNylekvvvSRVARVCKNDVggsprvlekQWTSFLKARLNCSVPgdshfyFNVLQ 306
Cdd:cd11277 188 YVGAFAHNGYVYFLFRrrgaRAQAEYR-------TYVARVCLGDT---------NLYSYVEVPLVCQGG------YNLAQ 245
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 307 AVtgVVSLGGRPVVLAVFSTP---SNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVprprpgccaapgM 383
Cdd:cd11277 246 AA--YLAPGQGTLFVVFAAGQgstPTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEAT------------I 311
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718780 384 QYNASS---ALPDDILnfvKTHPLMDEAVPS--LGHAPWILRTLMR--HQLTRVAVDVGAGpwgnQTVVFLGSEAGTVLK 456
Cdd:cd11277 312 EYGVTSrcvNLPKDSP---ESYPCGDEHTPSpiASRQPLEAEPLLTltPPLTAVAALQEDG----HTIAFLGDTQGQLHK 384

                ....*....
gi 19718780 457 FLVRPNAST 465
Cdd:cd11277 385 VFLNGSAGQ 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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