NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|302318952|ref|NP_115528|]
View 

PML-RARA-regulated adapter molecule 1 [Homo sapiens]

Protein Classification

FYN-binding protein 1( domain architecture ID 11234975)

FYN-binding protein 1 acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
hSH3 pfam14603
Helically-extended SH3 domain; This domain is the 70 C-terminal residues of ADAP - Adhesion ...
 576-655 8.71e-42

Helically-extended SH3 domain; This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent. It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered. The binding partners of the hSH3 domains are still unknown.


:

Pssm-ID: 464216  Cd Length: 89  Bit Score: 146.29  E-value: 8.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  576 FRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDV 655
Cdd:pfam14603   1 FRKKFKYDGEIKVLYSMTVDPNLTIKKWGGKDLPVKPGEVLDVIQKTDDTKVLCRNEEGKYGYVLRSNLLQNDGEIYDDI 80
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 56-412 1.12e-12

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   56 PKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTdlPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLG 135
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH--APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  136 ATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQ--------- 206
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAapappavpa 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  207 -PELSTFPKKPAQPEFNVYPKKPPQPQV-GGLPKKSVPQPEFSEAAQTPLWKPQSSEPK------------RDSSAFPKK 272
Cdd:PHA03247 2747 gPATPGGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPAdppaavlapaaaLPPAASPAG 2826

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  273 ASQPPLSDFPKKPPQPElgDLTRTSSEPEVSVLP-----KRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQ 347
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPP--GPPPPSLPLGGSVAPggdvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302318952  348 PERRGPPRKFSQPEPSAVLKRHPQPEffgDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA 412
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGA 2966
 
Name Accession Description Interval E-value
hSH3 pfam14603
Helically-extended SH3 domain; This domain is the 70 C-terminal residues of ADAP - Adhesion ...
 576-655 8.71e-42

Helically-extended SH3 domain; This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent. It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered. The binding partners of the hSH3 domains are still unknown.


Pssm-ID: 464216  Cd Length: 89  Bit Score: 146.29  E-value: 8.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  576 FRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDV 655
Cdd:pfam14603   1 FRKKFKYDGEIKVLYSMTVDPNLTIKKWGGKDLPVKPGEVLDVIQKTDDTKVLCRNEEGKYGYVLRSNLLQNDGEIYDDI 80
hSH3_ADAP cd11867
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor ...
 570-646 3.69e-17

Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein; ADAP, also called Fyn T-binding protein (FYB) or SLP-76-associated protein (SLAP), is expressed mainly in hematopoietic cells but not in B cells. It is required for the proliferation of mature T-cells and plays an important role in T-cell activation, TCR-induced integrin clustering, and T-cell adhesion. ADAP has been shown to bind many partners including SLP-76, Fyn, Src, SKAP1, SKAP2, dynein, Ena/VASP, Carma1, among others. It is connected to cytoskeleton via its binding to Ena and VASP, which impacts actin cytoskeletal remodeling upon TCR ligation. The SH3 domain of ADAP adopts an altered fold referred to as a helically extended SH3 (hSH3) domain characterized by clusters of positive charges. The hSH3 domain can no longer bind conventional proline-rich peptides, instead, it functions as a novel lipid interaction domain and can bind acidic lipids such as phosphatidylserine, phosphatidylinositol, phosphatidic acid, and polyphosphoinositides.


Pssm-ID: 212801  Cd Length: 77  Bit Score: 76.41  E-value: 3.69e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302318952 570 EKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLP 646
Cdd:cd11867    1 EKEEKEFRKKFKYNGEIKVLYSTTVLQTLTIKKFGSKDLQVKPGESLEVIQHTDDTKVLCRNEEGKYGYVLRSNLEP 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
 56-412 1.12e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   56 PKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTdlPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLG 135
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH--APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  136 ATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQ--------- 206
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAapappavpa 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  207 -PELSTFPKKPAQPEFNVYPKKPPQPQV-GGLPKKSVPQPEFSEAAQTPLWKPQSSEPK------------RDSSAFPKK 272
Cdd:PHA03247 2747 gPATPGGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPAdppaavlapaaaLPPAASPAG 2826

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  273 ASQPPLSDFPKKPPQPElgDLTRTSSEPEVSVLP-----KRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQ 347
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPP--GPPPPSLPLGGSVAPggdvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302318952  348 PERRGPPRKFSQPEPSAVLKRHPQPEffgDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA 412
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGA 2966
ftsN TIGR02223
cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a ...
 71-252 6.92e-04

cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. The N-terminal 30 residue region tends to by Lys/Arg-rich, and is followed by a membrane-spanning region. This is followed by an acidic low-complexity region of variable length and a well-conserved C-terminal domain of two tandem regions matched by pfam05036 (Sporulation related repeat), found in several cell division and sporulation proteins. The role of FtsN as a suppressor for other cell division mutations is poorly understood; it may involve cell wall hydrolysis. [Cellular processes, Cell division]


Pssm-ID: 274041 [Multi-domain]  Cd Length: 298  Bit Score: 42.37  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   71 PPPPEVTDLPKKPPPPEVTDLPKKPPPPE-----VTDLPKkpPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQ 145
Cdd:TIGR02223  52 KQANEPETLQPKNQTENGETAADLPPKPEerwsyIEELEA--REVLINDPEEPSNGGGVEESAQLTAEQRQLLEQMQADM 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  146 pevgEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKsgafprklwqpeagEATPRSPQPELSTFPKKPAQPEFNVYP 225
Cdd:TIGR02223 130 ----RAAEKVLATAPSEQTVAVEARKQTAEKKPQKARTA--------------EAQKTPVETEKIASKVKEAKQKQKALP 191

                         170       180
                  ....*....|....*....|....*..
gi 302318952  226 KKPPQPQVGGLPKKSVPQPEFSEAAQT 252
Cdd:TIGR02223 192 KQTAETQSNSKPIETAPKADKADKTKP 218
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 49-416 2.98e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   49 QPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPevtdlpkKPPPPEVTDLPKKPSKLELSDLS 128
Cdd:pfam03154 164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA-------TSQPPNQTQSTAAPHTLIQQTPT 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  129 KKFPQLgatPFPRKPLQPevgeaplkasLPEPGAPARKPLQ--PDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQ 206
Cdd:pfam03154 237 LHPQRL---PSPHPPLQP----------MTQPPPPSQVSPQplPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQ 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  207 PELSTFPkkpaqpefnvypkKPPQPQVGGLPKKSVPQPefseaaqTPLWKPQSSEPKRDSSAFPKKASQPPLSDfPKKPP 286
Cdd:pfam03154 304 SSQSQVP-------------PGPSPAAPGQSQQRIHTP-------PSQSQLQSQQPPREQPLPPAPLSMPHIKP-PPTTP 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  287 QPELGDLTRTSSEPEVSVlpkrprPAEFKALSKKPPQPELGGL-------PRTSSEPEFNSLPR-KLLQPERRGPPRKFS 358
Cdd:pfam03154 363 IPQLPNPQSHKHPPHLSG------PSPFQMNSNLPPPPALKPLsslsthhPPSAHPPPLQLMPQsQQLPPPPAQPPVLTQ 436

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 302318952  359 QPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTP 416
Cdd:pfam03154 437 SQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP 494
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 28-288 4.65e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.14  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  28 EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP----PPPEVTDL 103
Cdd:NF033839 256 EIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPqlekPKPEVKPQ 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 104 PKKPPPpEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAParkplQPDELSHPARPPSEP 183
Cdd:NF033839 336 PEKPKP-EVKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKP-----KPEVKPQPEKPKPEV 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 184 KsgafPRKLWQPEAGEATPRSPQPELSTFPKKPaQPEFNVYPKKpPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPK 263
Cdd:NF033839 410 K----PQPEKPKPEVKPQPEKPKPEVKPQPEKP-KPEVKPQPEK-PKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPK 483

                        250       260
                 ....*....|....*....|....*
gi 302318952 264 RDSSAFPKKASQPPLSDFPKKPPQP 288
Cdd:NF033839 484 PDNSKPQADDKKPSTPNNLSKDKQP 508
 
Name Accession Description Interval E-value
hSH3 pfam14603
Helically-extended SH3 domain; This domain is the 70 C-terminal residues of ADAP - Adhesion ...
 576-655 8.71e-42

Helically-extended SH3 domain; This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent. It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered. The binding partners of the hSH3 domains are still unknown.


Pssm-ID: 464216  Cd Length: 89  Bit Score: 146.29  E-value: 8.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  576 FRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLPLETEVYDDV 655
Cdd:pfam14603   1 FRKKFKYDGEIKVLYSMTVDPNLTIKKWGGKDLPVKPGEVLDVIQKTDDTKVLCRNEEGKYGYVLRSNLLQNDGEIYDDI 80
hSH3_ADAP cd11867
Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor ...
 570-646 3.69e-17

Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein; ADAP, also called Fyn T-binding protein (FYB) or SLP-76-associated protein (SLAP), is expressed mainly in hematopoietic cells but not in B cells. It is required for the proliferation of mature T-cells and plays an important role in T-cell activation, TCR-induced integrin clustering, and T-cell adhesion. ADAP has been shown to bind many partners including SLP-76, Fyn, Src, SKAP1, SKAP2, dynein, Ena/VASP, Carma1, among others. It is connected to cytoskeleton via its binding to Ena and VASP, which impacts actin cytoskeletal remodeling upon TCR ligation. The SH3 domain of ADAP adopts an altered fold referred to as a helically extended SH3 (hSH3) domain characterized by clusters of positive charges. The hSH3 domain can no longer bind conventional proline-rich peptides, instead, it functions as a novel lipid interaction domain and can bind acidic lipids such as phosphatidylserine, phosphatidylinositol, phosphatidic acid, and polyphosphoinositides.


Pssm-ID: 212801  Cd Length: 77  Bit Score: 76.41  E-value: 3.69e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302318952 570 EKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSNEEMLCRDPKGKYGYVPRTALLP 646
Cdd:cd11867    1 EKEEKEFRKKFKYNGEIKVLYSTTVLQTLTIKKFGSKDLQVKPGESLEVIQHTDDTKVLCRNEEGKYGYVLRSNLEP 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
 56-412 1.12e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   56 PKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTdlPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLG 135
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH--APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  136 ATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQ--------- 206
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAapappavpa 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  207 -PELSTFPKKPAQPEFNVYPKKPPQPQV-GGLPKKSVPQPEFSEAAQTPLWKPQSSEPK------------RDSSAFPKK 272
Cdd:PHA03247 2747 gPATPGGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPAdppaavlapaaaLPPAASPAG 2826

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  273 ASQPPLSDFPKKPPQPElgDLTRTSSEPEVSVLP-----KRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQ 347
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPP--GPPPPSLPLGGSVAPggdvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302318952  348 PERRGPPRKFSQPEPSAVLKRHPQPEffgDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGA 412
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGA 2966
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 24-373 5.62e-12

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 69.33  E-value: 5.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  24 ASQPEPSDLPKKPPKPEFgklkkfsqPELSEHPKKaplPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDL 103
Cdd:PTZ00449 564 AKEHKPSKIPTLSKKPEF--------PKDPKHPKD---PEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKS 632

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 104 PKKPPPPEVTDLPKKPSklelsdlSKKFPQLgatpfPRKPLQPEVgeaplkaslpePGAPARKPLQPDELSHPARPPSEP 183
Cdd:PTZ00449 633 PKRPPPPQRPSSPERPE-------GPKIIKS-----PKPPKSPKP-----------PFDPKFKEKFYDDYLDAAAKSKET 689

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 184 KSGAFPRKLWQPEAGEATPRSPQPELSTF----PKKPAQPEFNVYP-KKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKP- 257
Cdd:PTZ00449 690 KTTVVLDESFESILKETLPETPGTPFTTPrplpPKLPRDEEFPFEPiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPl 769

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 258 ---------------QSSEP----KRDSSafPKKASQPPLSDFPKKPPQPELGD---LTRTSSEPEVSVLPKRP------ 309
Cdd:PTZ00449 770 pdilaeefkeedihaETGEPdeamKRPDS--PSEHEDKPPGDHPSLPKKRHRLDglaLSTTDLESDAGRIAKDAsgkivk 847

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302318952 310 --RPAEFKALSKKPPQPELGGLPR----------TSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPE 373
Cdd:PTZ00449 848 lkRSKSFDDLTTVEEAEEMGAEARkivvdddgteADDEDTHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPD 923
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-334 6.03e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.03  E-value: 6.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952    5 LPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPP 84
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP 2767

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   85 PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSdlskkFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPA 164
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP-----AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  165 RKPLQPDELSHPARPPSEPKSGAFPRKlwQPEAGEATPrsPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQP 244
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAPGGDVRRRPPSR--SPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  245 EFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSkkPPQP 324
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS--TPPL 2996

                         330
                  ....*....|
gi 302318952  325 ELGGLPRTSS 334
Cdd:PHA03247 2997 TGHSLSRVSS 3006
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 81-390 1.13e-08

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 58.55  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  81 KKPPPPEVTDLPKKPPPPEVTDL----PKKPPPPEVTDLPKKPSKLelSDLSKKFPQlgatpfPRKPLQPEVGEAPlkas 156
Cdd:PTZ00449 494 KKLAPIEEEDSDKHDEPPEGPEAsglpPKAPGDKEGEEGEHEDSKE--SDEPKEGGK------PGETKEGEVGKKP---- 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 157 lpepgAPARKPlQPDELSHPARPPSEPKSGAFPRKlwqpeageatPRSPQPelstfPKKPAQPEFNVYPKKPPQPQVGGL 236
Cdd:PTZ00449 562 -----GPAKEH-KPSKIPTLSKKPEFPKDPKHPKD----------PEEPKK-----PKRPRSAQRPTRPKSPKLPELLDI 620

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 237 PkKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSdfPKKPPQPEL-----GDLTRTSSEPEVSVLPKRPRP 311
Cdd:PTZ00449 621 P-KSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKS--PKPPFDPKFkekfyDDYLDAAAKSKETKTTVVLDE 697

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 312 AEFKALskKPPQPELGGLPRTSSEPEFNSLPRKLLQPERrgPPRKFSQPEPSAVLKRHPQPE---FFGDLPRKPPLPSSA 388
Cdd:PTZ00449 698 SFESIL--KETLPETPGTPFTTPRPLPPKLPRDEEFPFE--PIGDPDAEQPDDIEFFTPPEEertFFHETPADTPLPDIL 773


                 ..
gi 302318952 389 SE 390
Cdd:PTZ00449 774 AE 775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 59-394 1.45e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   59 APLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLP-KKPPPPEV-----------TDLPKKPPPPEVTDLPKKPsklelSD 126
Cdd:PHA03247 2491 AAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPvGEPVHPRMltwirgleelaSDDAGDPPPPLPPAAPPAA-----PD 2565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  127 LSKKFPQLGATPF----------PRKPLQPEVGEAPLKASLPEPGAPARKPLQPDElSHPARPPSEPKSGAFPRKLWQPE 196
Cdd:PHA03247 2566 RSVPPPRPAPRPSepavtsrarrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT-HAPDPPPPSPSPAANEPDPHPPP 2644

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  197 AGEATPR---SPQPELSTFPKKPAQPEFNVYPKKPPQ--------PQVGGLPKKSVPQPEFSEAAQTPlwKPQSSEPKRD 265
Cdd:PHA03247 2645 TVPPPERprdDPAPGRVSRPRRARRLGRAAQASSPPQrprrraarPTVGSLTSLADPPPPPPTPEPAP--HALVSATPLP 2722

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  266 SSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKL 345
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPW 2802

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 302318952  346 LQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLP 394
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 228-396 1.22e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.53  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 228 PPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSE----PKRDSSAFPKKASQPPLSDFPKKPP----QPELGDLTRTSSE 299
Cdd:PTZ00449 511 PEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKeggkPGETKEGEVGKKPGPAKEHKPSKIPtlskKPEFPKDPKHPKD 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 300 PEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKfsqPEPSAVLKRhPQPEFFGDLP 379
Cdd:PTZ00449 591 PEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPER---PEGPKIIKS-PKPPKSPKPP 666

                        170
                 ....*....|....*..
gi 302318952 380 RKPPLPSSASESSLPAA 396
Cdd:PTZ00449 667 FDPKFKEKFYDDYLDAA 683
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
56-278 1.28e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  56 PKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLP-KKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPaRRSPAPEALAAARQASARGPGGAPAPAPAP 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 135 GATPFP--RKPLQPEVGEAPLKASLPEPGAPARKPLQPDElshpARPPSEPKSGAFPrklwQPEAGEATPRSPQPELSTF 212
Cdd:PRK12323 455 AAAPAAaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADD----DPPPWEELPPEFA----SPAPAQPDAAPAGWVAESI 526

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302318952 213 PKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFseAAQTPLWKPQSSEPKRDSSAFPKKASQPPL 278
Cdd:PRK12323 527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPV--VAPRPPRASASGLPDMFDGDWPALAARLPV 590
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 55-253 6.51e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 6.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  55 HPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 135 GATPFPRKPLQPEVGEAPlkaslPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPK 214
Cdd:PRK07764 670 PAKAGGAAPAAPPPAPAP-----AAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 302318952 215 KPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTP 253
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 151-421 1.48e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  151 APLKASLPEPGAPARKPL--QPDELSHPARPPSEPKSGAFPR-KLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKK 227
Cdd:PRK10263  335 APVEPVTQTPPVASVDVPpaQPTVAWQPVPGPQTGEPVIAPApEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQ 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  228 PPQ-PQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQP------PLSDFPKKPPQPELGDLTRTSSEP 300
Cdd:PRK10263  415 PAQqPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTeqtyqqPAAQEPLYQQPQPVEQQPVVEPEP 494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  301 EV-SVLPKRPRPAEFKALSKKppqpelgglpRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAvlkrhPQPEFFGDLP 379
Cdd:PRK10263  495 VVeETKPARPPLYYFEEVEEK----------RAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSV-----AAVPPVEAAA 559

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 302318952  380 RKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSG 421
Cdd:PRK10263  560 AVSPLASGVKKATLATGAAATVAAPVFSLANSGGPRPQVKEG 601
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 27-433 1.73e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   27 PEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDlPKKPPPPEVTDLPKK------------ 94
Cdd:PHA03307   71 PPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP-PASPPPSPAPDLSEMlrpvgspgpppa 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   95 --PPPPEVtdlpkkPPPPEVTDLpkkPSKLELSDLSKKFPQLGATPFPRKPlqpevgEAPLKASLPEPGAPARKPLQPDE 172
Cdd:PHA03307  150 asPPAAGA------SPAAVASDA---ASSRQAALPLSSPEETARAPSSPPA------EPPPSTPPAAASPRPPRRSSPIS 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  173 LSHPARPPSEPKSGAFPRklwqpeageatPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPKKSVPQPEfSEAAQT 252
Cdd:PHA03307  215 ASASSPAPAPGRSAADDA-----------GASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWN-GPSSRP 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  253 PLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKP----PQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGG 328
Cdd:PHA03307  283 GPASSSSSPRERSPSPSPSSPGSGPAPSSPRASssssSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  329 lPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAavagfssRHPL-- 406
Cdd:PHA03307  363 -SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYA-------RYPLlt 434

                         410       420       430
                  ....*....|....*....|....*....|..
gi 302318952  407 ---SPGFGAAGTP--RWRSGGLvhsGGARPGL 433
Cdd:PHA03307  435 psgEPWPGSPPPPpgRVRYGGL---GDSRPGL 463
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
149-354 1.93e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 149 GEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKP 228
Cdd:PRK12323 370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 229 PQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKR 308
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDP 529

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 302318952 309 PRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPP 354
Cdd:PRK12323 530 ATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PHA03247 PHA03247
large tegument protein UL36; Provisional
 141-573 2.06e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  141 RKPLQPEVGEAPLKASLPEPGAPArkplQPDELShPARPPSEPKSGAFPRKLWQ-----PEAGEATPRSPQPELSTFPKk 215
Cdd:PHA03247 2487 RFPFAAGAAPDPGGGGPPDPDAPP----APSRLA-PAILPDEPVGEPVHPRMLTwirglEELASDDAGDPPPPLPPAAP- 2560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  216 PAQPEFNVYPKKP-PQPqvgglpkksvPQPEFSEAAQTPLWKPQSSEPK-----RDSSAFPKKASQPPLSDFPKKPPQPE 289
Cdd:PHA03247 2561 PAAPDRSVPPPRPaPRP----------SEPAVTSRARRPDAPPQSARPRapvddRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  290 LGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRH 369
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEP 2710

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  370 PQPEFFGDLPrKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASS 449
Cdd:PHA03247 2711 APHALVSATP-LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  450 LGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGL----HFQDRQPEDIPQVPDEIYELYDDVEPRDDSSPSPKGR 525
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 302318952  526 DEAPSVQQAAR-------RPPQDPALRKEKDPQPQQLPPMDPKLLKQLRKAEKAE 573
Cdd:PHA03247 2870 SPAAKPAAPARppvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924
ftsN TIGR02223
cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a ...
 71-252 6.92e-04

cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. The N-terminal 30 residue region tends to by Lys/Arg-rich, and is followed by a membrane-spanning region. This is followed by an acidic low-complexity region of variable length and a well-conserved C-terminal domain of two tandem regions matched by pfam05036 (Sporulation related repeat), found in several cell division and sporulation proteins. The role of FtsN as a suppressor for other cell division mutations is poorly understood; it may involve cell wall hydrolysis. [Cellular processes, Cell division]


Pssm-ID: 274041 [Multi-domain]  Cd Length: 298  Bit Score: 42.37  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   71 PPPPEVTDLPKKPPPPEVTDLPKKPPPPE-----VTDLPKkpPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQ 145
Cdd:TIGR02223  52 KQANEPETLQPKNQTENGETAADLPPKPEerwsyIEELEA--REVLINDPEEPSNGGGVEESAQLTAEQRQLLEQMQADM 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  146 pevgEAPLKASLPEPGAPARKPLQPDELSHPARPPSEPKsgafprklwqpeagEATPRSPQPELSTFPKKPAQPEFNVYP 225
Cdd:TIGR02223 130 ----RAAEKVLATAPSEQTVAVEARKQTAEKKPQKARTA--------------EAQKTPVETEKIASKVKEAKQKQKALP 191

                         170       180
                  ....*....|....*....|....*..
gi 302318952  226 KKPPQPQVGGLPKKSVPQPEFSEAAQT 252
Cdd:TIGR02223 192 KQTAETQSNSKPIETAPKADKADKTKP 218
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 40-147 8.97e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 8.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  40 EFGKLKKFSQPELSEHP---KKAPLPEFGAVSLKPPP--PEVTDL-PKKPPPPEVTDLPKK-PPPPEVTDLPKKPPPPEV 112
Cdd:PRK14954 372 ELVRNDGGVAPSPAGSPdvkKKAPEPDLPQPDRHPGPakPEAPGArPAELPSPASAPTPEQqPPVARSAPLPPSPQASAP 451

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 302318952 113 TDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPE 147
Cdd:PRK14954 452 RNVASGKPGVDLGSWQGKFMNFTRNGSRKQPVQAS 486
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
73-313 1.12e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  73 PPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSklelsdlskkfPQLGATPFPRK--PLQPEVGE 150
Cdd:PRK12323 380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS-----------PAPEALAAARQasARGPGGAP 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 151 APLKASLPEPGAPARKPLQPdelshpARPPsepksgafprklwqPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPq 230
Cdd:PRK12323 449 APAPAPAAAPAAAARPAAAG------PRPV--------------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA- 507

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 231 pqvgglpkksVPQPEFSEAAQTPLwkpqssepkrDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPR 310
Cdd:PRK12323 508 ----------SPAPAQPDAAPAGW----------VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567


                 ...
gi 302318952 311 PAE 313
Cdd:PRK12323 568 ASA 570
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
16-131 1.57e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 41.49  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  16 RSIKAKFQASQPEPSDLPKKPPKPefgklkkfsQPELSEHPKKAPLPEFGAVSLKPPPPEvtdlpkkPPPPEVTDLPKKP 95
Cdd:PRK14948 504 RSIKLNLESQSGSASNTAKTPPPP---------QKSPPPPAPTPPLPQPTATAPPPTPPP-------PPPTATQASSNAP 567

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 302318952  96 PPPEVTDLPKKPPPPEVTDLPKKPSKLE-LSDLSKKF 131
Cdd:PRK14948 568 AQIPADSSPPPPIPEEPTPSPTKDSSPEeIDKAAKNL 604
SH3_Eps8 cd11764
Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar ...
 606-647 1.81e-03

Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins; This group is composed of Eps8 and Eps8-like proteins including Eps8-like 1-3, among others. These proteins contain N-terminal Phosphotyrosine-binding (PTB), central SH3, and C-terminal effector domains. Eps8 binds either Abi1 (also called E3b1) or Rab5 GTPase activating protein RN-tre through its SH3 domain. With Abi1 and Sos1, it becomes part of a trimeric complex that is required to activate Rac. Together with RN-tre, it inhibits the internalization of EGFR. The SH3 domains of Eps8 and similar proteins recognize peptides containing a PxxDY motif, instead of the classical PxxP motif. SH3 domains are protein interaction domains that usually bind to proline-rich ligands with moderate affinity and selectivity. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212698 [Multi-domain]  Cd Length: 54  Bit Score: 36.86  E-value: 1.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302318952 606 KHLGIRRGEILEVIEfTSNEEMLCRDPKGKYGYVPRTALLPL 647
Cdd:cd11764   14 KELSVLKGEYLEVLD-DSRQWWKVRNSRGQVGYVPHNILEPY 54
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
72-286 2.24e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  72 PPPEVTDLPKKPPPPEVTDLPKKPPPPevtdlPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRK--PLQPEVG 149
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAP-----AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQasARGPGGA 447

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 150 EAPLKASLPEPGAPARKPLQpdelshPARPPSEPKSGAFPRKlwQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPP 229
Cdd:PRK12323 448 PAPAPAPAAAPAAAARPAAA------GPRPVAAAAAAAPARA--APAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 302318952 230 QPQVGGLPKKSVPQPEFSEAAQTPLwKPQSSEPKRDSSAFPKKASQPPLSDFPKKPP 286
Cdd:PRK12323 520 GWVAESIPDPATADPDDAFETLAPA-PAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
48-183 2.52e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  48 SQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPP-PEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSD 126
Cdd:PRK12323 446 GAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAaPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 302318952 127 LSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPSEP 183
Cdd:PRK12323 526 IPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWP 582
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 49-416 2.98e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952   49 QPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPevtdlpkKPPPPEVTDLPKKPSKLELSDLS 128
Cdd:pfam03154 164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA-------TSQPPNQTQSTAAPHTLIQQTPT 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  129 KKFPQLgatPFPRKPLQPevgeaplkasLPEPGAPARKPLQ--PDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQ 206
Cdd:pfam03154 237 LHPQRL---PSPHPPLQP----------MTQPPPPSQVSPQplPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQ 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  207 PELSTFPkkpaqpefnvypkKPPQPQVGGLPKKSVPQPefseaaqTPLWKPQSSEPKRDSSAFPKKASQPPLSDfPKKPP 286
Cdd:pfam03154 304 SSQSQVP-------------PGPSPAAPGQSQQRIHTP-------PSQSQLQSQQPPREQPLPPAPLSMPHIKP-PPTTP 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  287 QPELGDLTRTSSEPEVSVlpkrprPAEFKALSKKPPQPELGGL-------PRTSSEPEFNSLPR-KLLQPERRGPPRKFS 358
Cdd:pfam03154 363 IPQLPNPQSHKHPPHLSG------PSPFQMNSNLPPPPALKPLsslsthhPPSAHPPPLQLMPQsQQLPPPPAQPPVLTQ 436

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 302318952  359 QPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTP 416
Cdd:pfam03154 437 SQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP 494
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
23-189 3.74e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  23 QASQPEPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPE--------FGAVSLKPPPPEVTDLP---------KKPPP 85
Cdd:PRK12323 393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALaaarqasaRGPGGAPAPAPAPAAAPaaaarpaaaGPRPV 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  86 PEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPePGAPAR 165
Cdd:PRK12323 473 AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAP-AAAPAP 551

                        170       180
                 ....*....|....*....|....
gi 302318952 166 KPLQPDELSHPARPPSEPKSGAFP 189
Cdd:PRK12323 552 RAAAATEPVVAPRPPRASASGLPD 575
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 28-288 4.65e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.14  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  28 EPSDLPKKPPKPEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKP----PPPEVTDL 103
Cdd:NF033839 256 EIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPqlekPKPEVKPQ 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 104 PKKPPPpEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAParkplQPDELSHPARPPSEP 183
Cdd:NF033839 336 PEKPKP-EVKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKP-----KPEVKPQPEKPKPEV 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952 184 KsgafPRKLWQPEAGEATPRSPQPELSTFPKKPaQPEFNVYPKKpPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPK 263
Cdd:NF033839 410 K----PQPEKPKPEVKPQPEKPKPEVKPQPEKP-KPEVKPQPEK-PKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPK 483

                        250       260
                 ....*....|....*....|....*
gi 302318952 264 RDSSAFPKKASQPPLSDFPKKPPQP 288
Cdd:NF033839 484 PDNSKPQADDKKPSTPNNLSKDKQP 508
PHA03247 PHA03247
large tegument protein UL36; Provisional
 160-565 7.50e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  160 PGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPR-------------------------------SPQPE 208
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAilpdepvgepvhprmltwirgleelasddagDPPPP 2554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  209 LSTFPkKPAQPEFNVYPKKP-PQPqvgglpkksvPQPEFSEAAQTPLWKPQSSEPK-----RDSSAFPKKASQPPLSDFP 282
Cdd:PHA03247 2555 LPPAA-PPAAPDRSVPPPRPaPRP----------SEPAVTSRARRPDAPPQSARPRapvddRGDPRGPAPPSPLPPDTHA 2623

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  283 KKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLPRKLLQPERRGPPRKFSQPEP 362
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  363 SAVLKRHPQPEFFGDLPrKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRR 442
Cdd:PHA03247 2704 PPPTPEPAPHALVSATP-LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  443 PLPPASSLGHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGL----HFQDRQPEDIPQVPDEIYELYDDVEPRDDS 518
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGDV 2862

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 302318952  519 SPSPKGRdEAPSVQQAARRPP--QDPALRKEKDPQPQQLPPMDPKLLKQ 565
Cdd:PHA03247 2863 RRRPPSR-SPAAKPAAPARPPvrRLARPAVSRSTESFALPPDQPERPPQ 2910
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 56-173 9.76e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.93  E-value: 9.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318952  56 PKKAPL-PEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPkkPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
Cdd:PRK14951 377 EKKTPArPEAAAPAAAPVAQAAAAPAPAAAPAAAASAP--AAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQ 454

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 302318952 135 GATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDEL 173
Cdd:PRK14951 455 AAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH