|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
252-1043 |
3.08e-122 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 396.76 E-value: 3.08e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPI---LSEeqvIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMN--LSQ 326
Cdd:COG1643 10 LPVsavLPE---LLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIG-MLEPRRLAARAAAERMAEELGepVGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 327 RVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIvtLRAKRnlP-LKLL 405
Cdd:COG1643 86 TV-GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL--QPALR--PdLKLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 406 IMSATLRVEDFTqnpRLFAkPPPVIKVESRQFPVTVHFNKRTPLE-DYSGECFRKVCKIHRMlPAGGILVFLTGQAEVHA 484
Cdd:COG1643 161 VMSATLDAERFA---RLLG-DAPVIESSGRTYPVEVRYRPLPADErDLEDAVADAVREALAE-EPGDILVFLPGEREIRR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 485 LCRRLRKAFPPSrarpqekdddqkdsveemrkfkksrarakkaraevlpqinldhysvlpagegdedreaevdeeegald 564
Cdd:COG1643 236 TAEALRGRLPPD-------------------------------------------------------------------- 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 565 sdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 644
Cdd:COG1643 248 -----------------------TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIP 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 645 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRrpvEDL---ILQMKALNVEKVI 721
Cdd:COG1643 305 RYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILR---ADLaslILELAAWGLGDPE 381
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 722 NFPFPTPPSveallaaeelliaLGALqppqkAERVKQLQE-------NRlscpITALGRTMATFPVAPRYAKMLALSRQH 794
Cdd:COG1643 382 DLPFLDPPP-------------ARAI-----ADARALLQElgaldadGR----LTPLGRALARLPLDPRLARMLLAAAEL 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 795 GCLPYAITIVASMTVRELFeeldRPAASDEELTRLKSKRARVAQMKrtwagqgaslklgdlmvllgavgaceyasctpqf 874
Cdd:COG1643 440 GCLREAAILAALLSERDPR----RGAAGSDLLARLNLWRRLREQQR---------------------------------- 481
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 875 ceaNGLRYKAMMEIRRLRGQLTTAVNavcpeaelfvdpkmQPPTESQVTYLR--QIVTAGLGDHLARRVQseemledkwr 952
Cdd:COG1643 482 ---EFLSYLRLREWRDLARQLRRLLG--------------EGANEEPADYEAigLLLALAYPDRIARRRG---------- 534
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 953 nayktpllDDPVF---------IHPSSVLFKElpEFVVYQEIVET---TKMYMkgVSSVEVQWIPALLPSYCQfdkplEE 1020
Cdd:COG1643 535 --------EGGRYllargrgaaLFPGSPLAKK--EWLVAAELVGGaaeARIRL--AAPIDPEWLEELAAHLIK-----RY 597
|
810 820
....*....|....*....|...
gi 29029601 1021 PAPTYCPERGRVLCHRASVFYRV 1043
Cdd:COG1643 598 SEPHWDKKRGRVVARERVRLGAL 620
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
252-432 |
3.52e-119 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 365.52 E-value: 3.52e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDS----IIGVTEPRRVAAVAMSQRVAKEMNLSQR 327
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESdnpgMIGITQPRRVAAVSMAKRVAEELNVFGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 328 VVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAK------RNLP 401
Cdd:cd17982 81 EVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqTVKP 160
|
170 180 190
....*....|....*....|....*....|.
gi 29029601 402 LKLLIMSATLRVEDFTQNPRLFAKPPPVIKV 432
Cdd:cd17982 161 LKLVIMSATLRVEDFTENKLLFPRPPPVIKV 191
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
252-1041 |
4.52e-97 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 337.13 E-value: 4.52e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:TIGR01967 66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSH-GLIGHTQPRRLAARTVAQRIAEELGTPlGEKVG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSAT 410
Cdd:TIGR01967 145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPDLKIIITSAT 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 411 LRVEDFTqnpRLFAKpPPVIKVESRQFPVTVHFNkrtPLEDYSGE--------CFRKVCKIHRMLPaGGILVFLTGQAEV 482
Cdd:TIGR01967 221 IDPERFS---RHFNN-APIIEVSGRTYPVEVRYR---PLVEEQEDddldqleaILDAVDELFAEGP-GDILIFLPGEREI 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 483 halcrrlrkafppsrarpqekdddqKDSVEEMRKfkksrarakkaraevlpqINLDHysvlpagegdedreaevdeeega 562
Cdd:TIGR01967 293 -------------------------RDAAEILRK------------------RNLRH----------------------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 563 ldsdldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKppPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVK 642
Cdd:TIGR01967 307 -------------------------TEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTAR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 643 KRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVIN 722
Cdd:TIGR01967 360 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAA 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 723 FPFPTPPSVEALLAAEELLIALGAlqppqkaervkqLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAIT 802
Cdd:TIGR01967 440 FPFIEAPDPRAIRDGFRLLEELGA------------LDDDEAEPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLI 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 803 IVASMTVRELFEE-LDRPAASDEELTRLKSKRARVAQMKRTWAGqgaslklgdlmvllgaVGACEYASCTPQFCEANGLR 881
Cdd:TIGR01967 508 IASALSIQDPRERpMEKQQAADQAHARFKDPRSDFLSRVNLWRH----------------IEEQRQALSANQFRNACRKQ 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 882 YKAMMEIRRLRgQLTTAVNAVCPEAELFVDpkmQPPTESQVtyLRQIVTAGLGDHLARRVQSEEMleDKWRNAyktplld 961
Cdd:TIGR01967 572 YLNYLRVREWQ-DIYRQLTQVVKELGLKLN---EEPADYDA--IHKALLSGLLSQIGMKDEKHEY--DGARGR------- 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 962 dPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQfDKPLEepaPTYCPERGRVLCHRASVFY 1041
Cdd:TIGR01967 637 -KFHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIK-KNYFE---PHWEKKRGQVMAYEKVTLY 711
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
252-1007 |
3.71e-93 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 325.86 E-value: 3.71e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK-GLIGHTQPRRLAARTVANRIAEELETElGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSAT 410
Cdd:PRK11131 152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD----LKVIITSAT 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 411 LRVEDFTqnpRLFAKpPPVIKVESRQFPVTVHFNKRTPLEDYSGE-----CFRKVCKIHRMLPaGGILVFLTGQAEVhal 485
Cdd:PRK11131 228 IDPERFS---RHFNN-APIIEVSGRTYPVEVRYRPIVEEADDTERdqlqaIFDAVDELGREGP-GDILIFMSGEREI--- 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 486 crrlrkafppsrarpqekdddqKDSveemrkfkksrarakkarAEVLPQINLDHysvlpagegdedreaevdeeegalds 565
Cdd:PRK11131 300 ----------------------RDT------------------ADALNKLNLRH-------------------------- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 566 dldldlgdggqdggeqpdaslpLHVLPLYSLLAPEKQAQVFKppPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRY 645
Cdd:PRK11131 314 ----------------------TEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISR 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 646 YDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPF 725
Cdd:PRK11131 370 YSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPF 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 726 PTPPSVEALLAAEELLIALGALQPPQKaERVKQLqenrlscpiTALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVA 805
Cdd:PRK11131 450 VEAPDKRNIQDGVRLLEELGAITTDEQ-ASAYKL---------TPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITS 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 806 SMTVRELFEE-LDRPAASDEELTRLKSKRARVAqmkrtwagqgASLKLGDLmvllgaVGACEYASCTPQF---CEANGLR 881
Cdd:PRK11131 520 ALSIQDPRERpMDKQQASDEKHRRFADKESDFL----------AFVNLWNY------LQEQQKALSSNQFrrlCRTDYLN 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 882 YKAMMEIRRLRGQLTTAVNavcpeaelfvdpKMQPPTESQVTYLRQIVTA---GLGDHLARRvQSEEMLEDKWRNAYktp 958
Cdd:PRK11131 584 YLRVREWQDIYTQLRQVVK------------ELGIPVNSEPAEYREIHTAlltGLLSHIGMK-DAEKQEYTGARNAR--- 647
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 29029601 959 llddpVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPAL 1007
Cdd:PRK11131 648 -----FSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPL 691
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
268-432 |
6.56e-66 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 219.25 E-value: 6.56e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 268 HPIVIVCGETGSGKTTQVPQFLYEAGFSS-EDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVSYQIRYEGNVTEETRI 345
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKgGKGRIVCTQPRRIAAISVAERVAEERGEKlGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 346 KFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSATLRVEDFTQnprlFAK 425
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLL----RKRPDLKVILMSATLDAEKFSS----YFG 152
|
....*..
gi 29029601 426 PPPVIKV 432
Cdd:cd17917 153 GAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
252-418 |
1.22e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 216.45 E-value: 1.22e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSsEDSIIGVTEPRRVAAVAMSQRVAKEMN--LSQrVV 329
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFA-RGGMIGITQPRRVAAVSVAKRVAEEMGveLGQ-LV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNL-PLKLLIMS 408
Cdd:cd17978 79 GYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQKLsPLKVIIMS 158
|
170
....*....|
gi 29029601 409 ATLRVEDFTQ 418
Cdd:cd17978 159 ATLDADLFSE 168
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
437-684 |
1.73e-59 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 201.61 E-value: 1.73e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 437 FPVTVHFNKRT----------PLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKafppsraRPQEKDdd 506
Cdd:cd18791 1 FPVEVYYLEDIlellgissekEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLRE-------ELLSPD-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 507 qkdsveemrkfkksrarakkaraevlpqinldhysvlpagegdedreaevdeeegaldsdldldlgdggqdggeqpdaSL 586
Cdd:cd18791 72 ------------------------------------------------------------------------------LG 73
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 587 PLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASAD 666
Cdd:cd18791 74 KLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAE 153
|
250
....*....|....*...
gi 29029601 667 QRAGRAGRTEPGHCYRLY 684
Cdd:cd18791 154 QRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
252-414 |
5.20e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 186.21 E-value: 5.20e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSsEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS-QHGMIGVTQPRRVAAISVAQRVAEEMKCTlGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRN-LPLKLLIMSA 409
Cdd:cd17984 80 YQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRkEHLKVVVMSA 159
|
....*
gi 29029601 410 TLRVE 414
Cdd:cd17984 160 TLELA 164
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
252-416 |
1.02e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 182.67 E-value: 1.02e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEM--NLSQRvV 329
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMgaVLGHE-V 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 330 SYQIRYEGNVTE-ETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIvtlRAKRNlPLKLLIMS 408
Cdd:cd17980 80 GYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKI---QKKRG-DLRLIVAS 155
|
....*...
gi 29029601 409 ATLRVEDF 416
Cdd:cd17980 156 ATLDAEKF 163
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
252-795 |
2.00e-50 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 192.45 E-value: 2.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPIlseEQVI---MEAVAEHPIVIVCGETGSGKTTQVP-QFLYEAGFSSEdsIIgVTEPRRVAAVAMSQRVAKEMN--LS 325
Cdd:PRK11664 4 LPV---AAVLpelLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGINGK--II-MLEPRRLAARNVAQRLAEQLGekPG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 326 QRVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVT-LRAKrnlpLKL 404
Cdd:PRK11664 78 ETV-GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDD----LKL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 405 LIMSATLrvedftQNPRLFAKPP--PVIKVESRQFPVTVHF---NKRTPLEDysgecfrKVCK-IHRML--PAGGILVFL 476
Cdd:PRK11664 153 LIMSATL------DNDRLQQLLPdaPVIVSEGRSFPVERRYqplPAHQRFDE-------AVARaTAELLrqESGSLLLFL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 477 TGQAEVHALCRRLRkafppsrarpqekdddqkDSVEEmrkfkksrarakkaraevlpqinldhysvlpagegdedreaEV 556
Cdd:PRK11664 220 PGVGEIQRVQEQLA------------------SRVAS-----------------------------------------DV 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 557 DeeegaldsdldldlgdggqdggeqpdaslplhVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVV 636
Cdd:PRK11664 241 L--------------------------------LCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVV 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 637 DCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLIL------ 710
Cdd:PRK11664 289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLellqwg 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 711 -----QMKALNvekvinfpfpTPPSVeallaaeellialgALQppQKAERVKQL----QENRLscpiTALGRTMATFPVA 781
Cdd:PRK11664 369 chdpaQLSWLD----------QPPAA--------------ALA--AAKRLLQQLgaldGQGRL----TARGRKMAALGND 418
|
570
....*....|....
gi 29029601 782 PRYAKMLALSRQHG 795
Cdd:PRK11664 419 PRLAAMLVAAKEDD 432
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
240-418 |
2.52e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 176.07 E-value: 2.52e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 240 NRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFS-SEDSIIGVTEPRRVAAVAMSQRV 318
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPhQPKKLVACTQPRRVAAMSVAQRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 319 AKEMNLS-QRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAK 397
Cdd:cd17973 81 AEEMDVKlGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160
|
170 180
....*....|....*....|.
gi 29029601 398 rnlpLKLLIMSATLRVEDFTQ 418
Cdd:cd17973 161 ----LKLIVMSATLDAGKFQK 177
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
252-417 |
2.52e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 175.38 E-value: 2.52e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKlGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSAT 410
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD----LKLLISSAT 156
|
....*..
gi 29029601 411 LRVEDFT 417
Cdd:cd17974 157 MDAEKFS 163
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
247-418 |
1.88e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 173.05 E-value: 1.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 247 EERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMN--L 324
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSR-GKIGCTQPRRVAAMSVAKRVAEEFGccL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 325 SQRVvSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKL 404
Cdd:cd17971 80 GQEV-GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTV----QKRPDLKL 154
|
170
....*....|....
gi 29029601 405 LIMSATLRVEDFTQ 418
Cdd:cd17971 155 IVTSATLDAVKFSQ 168
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
252-417 |
2.99e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 172.26 E-value: 2.99e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSeDSIIGVTEPRRVAAVAMSQRVAKEMN--LSQRVv 329
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTD-YGMIGCTQPRRVAAMSVAKRVSEEMGveLGEEV- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSA 409
Cdd:cd17983 79 GYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD----LKLIVTSA 154
|
....*...
gi 29029601 410 TLRVEDFT 417
Cdd:cd17983 155 TMDADKFA 162
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
252-417 |
5.45e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 165.69 E-value: 5.45e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSedsiIGVTEPRRVAAVAMSQRVAKEmNLSQ--RVV 329
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFE-SLNQygSKV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMSA 409
Cdd:cd17979 76 AYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD----LKLILMSA 151
|
....*...
gi 29029601 410 TLRVEDFT 417
Cdd:cd17979 152 TINIELFS 159
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
252-432 |
1.77e-46 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 164.55 E-value: 1.77e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEdSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVS 330
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIR-GLIGHTQPRRLAARSVAERIAEELKTElGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIMSAT 410
Cdd:cd17989 80 YKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPDLKVIITSAT 155
|
170 180
....*....|....*....|..
gi 29029601 411 LRVEDFTQNprlFAKpPPVIKV 432
Cdd:cd17989 156 IDAERFSRH---FNN-APIIEV 173
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
252-417 |
7.50e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 140.05 E-value: 7.50e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYE----AGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-- 325
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCEsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 326 ----QRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlp 401
Cdd:cd17975 81 pggkNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD---- 156
|
170
....*....|....*.
gi 29029601 402 LKLLIMSATLRVEDFT 417
Cdd:cd17975 157 LHLILMSATVDCEKFS 172
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
252-418 |
1.21e-36 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 136.51 E-value: 1.21e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLY----EAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMNLSQ- 326
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILddaiERGKGSSCRIV-CTQPRRISAISVAERVAAERAESCg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 327 --RVVSYQIRYEGNVT-EETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRakrnLPLK 403
Cdd:cd17981 80 lgNSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFR----SDLK 155
|
170
....*....|....*
gi 29029601 404 LLIMSATLRVEDFTQ 418
Cdd:cd17981 156 VILMSATLNAEKFSD 170
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
252-418 |
1.86e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 127.26 E-value: 1.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFS---SEDSIIGVTEPRRVAAVAMSQRVAKEMnlSQRV 328
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQgppLPVANIICTQPRRISAISVAERVAQER--AERV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 329 ---VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLL 405
Cdd:cd17985 79 gqsVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPD----LKVI 154
|
170
....*....|...
gi 29029601 406 IMSATLRVEDFTQ 418
Cdd:cd17985 155 LMSATLNAELFSD 167
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
252-432 |
2.69e-33 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 126.85 E-value: 2.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQF-LYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQ-RVV 329
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFiLDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLgSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 330 SYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRnlpLKLLIMSA 409
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRH---VKIILMSA 157
|
170 180
....*....|....*....|...
gi 29029601 410 TLRVEDFTQNPRLFAKPPPVIKV 432
Cdd:cd17988 158 TISCKEFADYFTTPNNPAYVFEV 180
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
252-432 |
1.78e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 124.52 E-value: 1.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSS---EDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QR 327
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRgrgARCNVVITQPRRISAVSVAQRVAHELGPNlRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 328 VVSYQIRYEGNVTEE-TRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLI 406
Cdd:cd17976 81 NVGYQVRLESRPPPRgGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE----LRVVL 156
|
170 180
....*....|....*....|....*.
gi 29029601 407 MSATLRVEDFTQnprlFAKPPPVIKV 432
Cdd:cd17976 157 MSATGDNQRLSR----YFGGCPVVRV 178
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
252-432 |
7.64e-31 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 119.93 E-value: 7.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSI-IGVTEPRRVAAVAMSQRVAKEM--NLSQrV 328
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPCrIFCTQPRRLAAIAVAERVAAERgeKIGQ-T 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 329 VSYQIRYEGNVTEETRIKFMTDGVLLKEIQ-KDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVtlraKRNLPLKLLIM 407
Cdd:cd17987 80 VGYQIRLESRVSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDIL----QKHPNLKLILS 155
|
170 180
....*....|....*....|....*
gi 29029601 408 SATLRVEDFTqnpRLFAKpPPVIKV 432
Cdd:cd17987 156 SAALDVNLFI---RYFGS-CPVIYI 176
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
252-414 |
5.50e-29 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 114.35 E-value: 5.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVP-QFLYEAGFssEDSIIGVTEPRRVAAVAMSQRVAKEMNlsQRV-- 328
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPlALLAELWI--AGGKIIVLEPRRVAARAAARRLATLLG--EAPge 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 329 -VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRivtLRAKRNLPLKLLIM 407
Cdd:cd17990 77 tVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLE---VQQLLRDDLRLLAM 153
|
....*..
gi 29029601 408 SATLRVE 414
Cdd:cd17990 154 SATLDGD 160
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
252-409 |
4.79e-27 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 108.76 E-value: 4.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSS--EDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRV 328
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAhyQHGVVVCTQVHKQTAVWLALRVADEMDVNiGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 329 VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIMS 408
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE----LKLVIIT 156
|
.
gi 29029601 409 A 409
Cdd:cd17977 157 C 157
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
247-432 |
1.16e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 109.54 E-value: 1.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 247 EERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSE---DSIIGVTEPRRVAAVAMSQRVAKEMN 323
Cdd:cd17972 54 QERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDraaECNIVVTQPRRISAVSVAERVAFERG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 324 LS-QRVVSYQIRYEGNVTE-ETRIKFMTDGVLLKEIQKDFLLLRYkvVIIDEAHERSVYTDILIGLLSRIVtlRAKRNlp 401
Cdd:cd17972 134 EEvGKSCGYSVRFESVLPRpHASILFCTVGVLLRKLEAGIRGISH--VIVDEIHERDINTDFLLVVLRDVV--QAYPD-- 207
|
170 180 190
....*....|....*....|....*....|.
gi 29029601 402 LKLLIMSATLRVEDFTQnprlFAKPPPVIKV 432
Cdd:cd17972 208 LRVILMSATIDTSMFCE----YFFNCPVIEV 234
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
768-858 |
4.71e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 103.47 E-value: 4.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 768 ITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQG 847
Cdd:pfam04408 17 LTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRRRRAADEKARAKFARLD 96
|
90
....*....|.
gi 29029601 848 aslKLGDLMVL 858
Cdd:pfam04408 97 ---LEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
258-418 |
3.65e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 101.41 E-value: 3.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 258 EQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVV-------S 330
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVvglyggdS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 331 YQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLL-RYKVVIIDEAHERS--VYTDILIGLLSRIvtlrakrNLPLKLLIM 407
Cdd:smart00487 94 KREQLRKLESGKTDILVTTPGRLLDLLENDKLSLsNVDLVILDEAHRLLdgGFGDQLEKLLKLL-------PKNVQLLLL 166
|
170
....*....|...
gi 29029601 408 SATL--RVEDFTQ 418
Cdd:smart00487 167 SATPpeEIENLLE 179
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
252-432 |
3.91e-24 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 100.74 E-value: 3.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 252 LPILSEEQVIMEAV-AEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDS--IIGVTEPRRVAAVAMSQRVAKEMNLS-QR 327
Cdd:cd17986 1 LPIWAAKFTFLEQLeSPSGIVLVSGEPGSGKSTQVPQWCAEFALSRGFQkgQVTVTQPHPLAARSLALRVADEMDLNlGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 328 VVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKrnlpLKLLIm 407
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPE----LRVVV- 155
|
170 180
....*....|....*....|....*..
gi 29029601 408 satlrVEDFTQNPRL--FAKPPPVIKV 432
Cdd:cd17986 156 -----VTSPALEPKLraFWGNPPVVHV 177
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
925-1011 |
3.80e-22 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 91.55 E-value: 3.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 925 LRQIVTAGLGDHLARRVQSeemledkwRNAYKTPLLDDPVFIHPSSVLFKEL---PEFVVYQEIVETTKMYMKGVSSVEV 1001
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPK--------GKGYTTLSDNQRVFIHPSSVLFNEKtfpPEWVVYQELVETTKVYIRTVTAISP 72
|
90
....*....|
gi 29029601 1002 QWIPALLPSY 1011
Cdd:pfam07717 73 EWLLLFAPHI 82
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
768-859 |
7.36e-16 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 73.46 E-value: 7.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 768 ITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEeldrpaasdeeltrlKSKRARVAQMKRTWAGQG 847
Cdd:smart00847 11 LTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRP---------------KEKREDADAARRRFADPE 75
|
90
....*....|..
gi 29029601 848 aslklGDLMVLL 859
Cdd:smart00847 76 -----SDHLTLL 82
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
585-674 |
9.91e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 61.84 E-value: 9.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 585 SLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGkvkkryydrvtgvssfrvTWVSQAS 664
Cdd:smart00490 9 ELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWSPAS 70
|
90
....*....|
gi 29029601 665 ADQRAGRAGR 674
Cdd:smart00490 71 YIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
588-674 |
2.56e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 55.68 E-value: 2.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 588 LHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDcgkvkkryYDRVTGVSSFRvtwvsqasadQ 667
Cdd:pfam00271 39 IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVIN--------YDLPWNPASYI----------Q 100
|
....*..
gi 29029601 668 RAGRAGR 674
Cdd:pfam00271 101 RIGRAGR 107
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
271-411 |
1.01e-08 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 55.71 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 271 VIVCGETGSGKTT--QVPqFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSY-----QIRYEGNVTEET 343
Cdd:pfam00270 17 VLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASllggdSRKEQLEKLKGP 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 344 RIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSV--YTDILIGLLSRivtLRAKRnlplKLLIMSATL 411
Cdd:pfam00270 96 DILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDmgFGPDLEEILRR---LPKKR----QILLLSATL 158
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
258-420 |
2.88e-08 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 58.07 E-value: 2.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 258 EQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYE-----AGFSSEDSIIGVTEPR-------RVAAV-AMSQRVAKEMNL 324
Cdd:PHA02653 169 QLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLWfnylfGGFDNLDKIDPNFIERpivlslpRVALVrLHSITLLKSLGF 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 325 SQRVVS-YQIRYeGNVTEETR-IKFMTDGVLLK----EIQKdflLLRYKVVIIDEAHERSVYTDILIGLlsrivtLRAKR 398
Cdd:PHA02653 249 DEIDGSpISLKY-GSIPDELInTNPKPYGLVFSthklTLNK---LFDYGTVIIDEVHEHDQIGDIIIAV------ARKHI 318
|
170 180
....*....|....*....|....*..
gi 29029601 399 NLPLKLLIMSATL-----RVEDFTQNP 420
Cdd:PHA02653 319 DKIRSLFLMTATLeddrdRIKEFFPNP 345
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
271-410 |
3.47e-08 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 53.56 E-value: 3.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 271 VIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRY-----EGNVTEETRI 345
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALQTAERLRELFGPGIRVAVLVGGSsaeerEKNKLGDADI 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29029601 346 KFMTDGVLLKEIQKD--FLLLRYKVVIIDEAHERSVYTDiliGLLSRIVTLRAKRNLPLKLLIMSAT 410
Cdd:cd00046 83 IIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSR---GALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
259-425 |
1.73e-05 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 46.49 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 259 QVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRvaavAMSQRVAKEMN-LSQRVVSYQIRYEG 337
Cdd:cd17921 8 EALRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAV-YIAPTR----ALVNQKEADLReRFGPLGKNVGLLTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 338 NVTE------ETRIKFMT----DGVLLKEIQKDFLLLRYkvVIIDEAH-----ERSVytdILIGLLSRIvtLRAKRNlpL 402
Cdd:cd17921 83 DPSVnklllaEADILVATpeklDLLLRNGGERLIQDVRL--VVVDEAHligdgERGV---VLELLLSRL--LRINKN--A 153
|
170 180
....*....|....*....|...
gi 29029601 403 KLLIMSATLrvedftQNPRLFAK 425
Cdd:cd17921 154 RFVGLSATL------PNAEDLAE 170
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
617-677 |
2.81e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 2.81e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29029601 617 VVATNVAETSLTIPGIKYVVDCGKVKkryydrvtgvssfrvtwvSQASADQRAGRAGRTEP 677
Cdd:cd18785 26 LVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGGK 68
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
277-410 |
4.29e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 42.15 E-value: 4.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 277 TGSGKTTQVPQFLYEAGFSSEDSIIgVTEPRRVAAVAMSQRvakemnLSQRVVSYQIryeGNVTEETR----IKFMTDGV 352
Cdd:cd17931 10 PGAGKTTRVLPQIIREAIKKRLRTL-VLAPTRVVAAEMYEA------LRGLPIRYRT---GAVKEEHGgneiVDYMCHGT 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 29029601 353 LLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRnlplkLLIMSAT 410
Cdd:cd17931 80 FTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRVEMGEAA-----VIFMTAT 132
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
270-438 |
1.39e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 42.42 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 270 IVIVCGETGSGKTTQVPQF-LYEAGFSSEDSIIgVTEPRRVAAVAMSQRvAKEMnLSQRVVSYQI----RYEGNVTEE-- 342
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWaLHSLKSQKADRVI-IALPTRATINAMYRR-AKEA-FGETGLYHSSilssRIKEMGDSEef 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 343 ----------------TRIKFMTDGVLLKEIQKDF-------LLLRYKVVIIDEAHERSVYTDILIgllsrIVTLRAKRN 399
Cdd:cd09639 78 ehlfplyihsndtlflDPITVCTIDQVLKSVFGEFghyeftlASIANSLLIFDEVHFYDEYTLALI-----LAVLEVLKD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 29029601 400 LPLKLLIMSATL--RVEDFTQN--PRLFAKPPPVIKVESRQFP 438
Cdd:cd09639 153 NDVPILLMSATLpkFLKEYAEKigYVEENEPLDLKPNERAPFI 195
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
268-416 |
1.47e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 40.43 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 268 HPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRvaavamsqrvakEMNLSQRVVSYQIRYEGNVTEETRIKf 347
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDIL------------EEVLDQLLLIIVGGKKASGSGELRLR- 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29029601 348 mtdgVLLKEIQKdfllLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDF 416
Cdd:smart00382 69 ----LALALARK----LKPDVLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDL 129
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
270-375 |
2.06e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 39.63 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 270 IVIVCGETGSGKTTQVPQFLYEAGfSSEDSIIGVTEPRRVAAVAMSQRVAKEmnlsqrvvsYQIRYEGNVTEETRIKFMT 349
Cdd:pfam13401 7 ILVLTGESGTGKTTLLRRLLEQLP-EVRDSVVFVDLPSGTSPKDLLRALLRA---------LGLPLSGRLSKEELLAALQ 76
|
90 100
....*....|....*....|....*.
gi 29029601 350 DgvLLKEIQkdflllRYKVVIIDEAH 375
Cdd:pfam13401 77 Q--LLLALA------VAVVLIIDEAQ 94
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
270-522 |
3.41e-03 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 41.29 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 270 IVIVCGETGSGKTTQVPQF-LYEAGFSSEDSIIgVTEPRRVAAVAMSQRvAKEMNLSQRVV----SYQIRYEGNVTEE-- 342
Cdd:TIGR01587 1 LLVIEAPTGYGKTEAALLWaLHSIKSQKADRVI-IALPTRATINAMYRR-AKELFGSELVGlhhsSSFSRIKEMGDSEef 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 343 ----------------TRIKFMTDGVLLKEIQKDF-------LLLRYKVVIIDEAHERSVYTDILIgllsrIVTLRAKRN 399
Cdd:TIGR01587 79 ehlfplyihsndklflDPITVCTIDQVLKSVFGEFghyeftlASIANSLLIFDEVHFYDEYTLALI-----LAVLEVLKD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029601 400 LPLKLLIMSATL--RVEDFTQN--PRLFAKPPPVIkvesrqfPVTVHFNKRTPL-EDYSGECFRKVCKIHRMLPAGG-IL 473
Cdd:TIGR01587 154 NDVPILLMSATLpkFLKEYAEKigYVEFNEPLDLK-------EERRFENHRFILiESDKVGEISSLERLLEFIKKGGsIA 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 29029601 474 VFLTGQAEVHALCRRLRKAFPPSR-----ARPQEKDDDQKDsVEEMRKFKKSRA 522
Cdd:TIGR01587 227 IIVNTVDRAQEFYQQLKEKAPEEEiilyhSRFTEKDRAKKE-AELLREMKKSNE 279
|
|
| |
