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Conserved domains on  [gi|49355757|ref|NP_116129|]
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vesicle transport protein SFT2C [Homo sapiens]

Protein Classification

Got1/Sft2-like family vesicle transport protein( domain architecture ID 10514491)

Got1/Sft2-like family vesicle transport protein similar to vesicle transport protein SFT2A/2B/2C that may be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 77-171 1.83e-07

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


:

Pssm-ID: 461210  Cd Length: 110  Bit Score: 47.87  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49355757    77 LAAGGGCLLLAALCFGLAALYapVLLLRARKFALLWSLGSALALAGSALLRGGAA-CGRLLRCEEAPSrpALLYMAALGA 155
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFL--FVLAKPRKFALLYTLGNILFLGSTGFLIGPKKqLKHMFSKERLPF--TIAYLGSLLL 76

                          90
                  ....*....|....*.
gi 49355757   156 TLFAALGLRSTLLTVL 171
Cdd:pfam04178  77 TLYFALILKSYGLTLL 92
 
Name Accession Description Interval E-value
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 77-171 1.83e-07

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 47.87  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49355757    77 LAAGGGCLLLAALCFGLAALYapVLLLRARKFALLWSLGSALALAGSALLRGGAA-CGRLLRCEEAPSrpALLYMAALGA 155
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFL--FVLAKPRKFALLYTLGNILFLGSTGFLIGPKKqLKHMFSKERLPF--TIAYLGSLLL 76

                          90
                  ....*....|....*.
gi 49355757   156 TLFAALGLRSTLLTVL 171
Cdd:pfam04178  77 TLYFALILKSYGLTLL 92
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
70-170 3.74e-06

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227433  Cd Length: 201  Bit Score: 46.06  E-value: 3.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49355757  70 SVTRGQRLAAGGGCLLLAALCFGLAALYAPVLLLRARKFALLWSLGSALALAGSALLRGGAACGRLLRCEEapSRP-ALL 148
Cdd:COG5102  61 GLSRFERAVLFSACLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGLTSKE--RLPhSSW 138

                        90       100
                ....*....|....*....|..
gi 49355757 149 YMAALGATLFAALGLRSTLLTV 170
Cdd:COG5102 139 FFGTTLLTIYVVLKYKRTLLNI 160
 
Name Accession Description Interval E-value
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 77-171 1.83e-07

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 47.87  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49355757    77 LAAGGGCLLLAALCFGLAALYapVLLLRARKFALLWSLGSALALAGSALLRGGAA-CGRLLRCEEAPSrpALLYMAALGA 155
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFL--FVLAKPRKFALLYTLGNILFLGSTGFLIGPKKqLKHMFSKERLPF--TIAYLGSLLL 76

                          90
                  ....*....|....*.
gi 49355757   156 TLFAALGLRSTLLTVL 171
Cdd:pfam04178  77 TLYFALILKSYGLTLL 92
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
70-170 3.74e-06

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227433  Cd Length: 201  Bit Score: 46.06  E-value: 3.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49355757  70 SVTRGQRLAAGGGCLLLAALCFGLAALYAPVLLLRARKFALLWSLGSALALAGSALLRGGAACGRLLRCEEapSRP-ALL 148
Cdd:COG5102  61 GLSRFERAVLFSACLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGLTSKE--RLPhSSW 138

                        90       100
                ....*....|....*....|..
gi 49355757 149 YMAALGATLFAALGLRSTLLTV 170
Cdd:COG5102 139 FFGTTLLTIYVVLKYKRTLLNI 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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