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Conserved domains on  [gi|24762236|ref|NP_116253|]
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pre-mRNA-splicing factor 38A [Homo sapiens]

Protein Classification

PRP38 family protein( domain architecture ID 10505891)

pre-mRNA-splicing factor 38 (PRP38) family protein is involved in pre-mRNA splicing as a component of the spliceosome

Gene Ontology:  GO:0003723|GO:0000398
SCOP:  4007353

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 10-172 1.61e-91

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


:

Pssm-ID: 460901  Cd Length: 165  Bit Score: 269.31  E-value: 1.61e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762236    10 HSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAME-LRFVGG-VYGGNIKPTPFLCLTLKMLQIQPEKDII 87
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKENLFGLNAAELVDEIVEdVKYIGGwTYGGNRKPSPFLCLLLKLLQLQPTKEQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762236    88 VEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQK 167
Cdd:pfam03371  81 LEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYRKLRIRLLDGDYKLTHMDEFVDDLLTKDRVCGTILPRLPK 160


                  ....*
gi 24762236   168 RYVLE 172
Cdd:pfam03371 161 RIVLE 165
 
Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 10-172 1.61e-91

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


Pssm-ID: 460901  Cd Length: 165  Bit Score: 269.31  E-value: 1.61e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762236    10 HSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAME-LRFVGG-VYGGNIKPTPFLCLTLKMLQIQPEKDII 87
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKENLFGLNAAELVDEIVEdVKYIGGwTYGGNRKPSPFLCLLLKLLQLQPTKEQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762236    88 VEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQK 167
Cdd:pfam03371  81 LEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYRKLRIRLLDGDYKLTHMDEFVDDLLTKDRVCGTILPRLPK 160


                  ....*
gi 24762236   168 RYVLE 172
Cdd:pfam03371 161 RIVLE 165
 
Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 10-172 1.61e-91

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


Pssm-ID: 460901  Cd Length: 165  Bit Score: 269.31  E-value: 1.61e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762236    10 HSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAME-LRFVGG-VYGGNIKPTPFLCLTLKMLQIQPEKDII 87
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKENLFGLNAAELVDEIVEdVKYIGGwTYGGNRKPSPFLCLLLKLLQLQPTKEQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762236    88 VEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQK 167
Cdd:pfam03371  81 LEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYRKLRIRLLDGDYKLTHMDEFVDDLLTKDRVCGTILPRLPK 160


                  ....*
gi 24762236   168 RYVLE 172
Cdd:pfam03371 161 RIVLE 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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