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Conserved domains on  [gi|27734755|ref|NP_116264|]
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F-box/LRR-repeat protein 20 isoform 1 [Homo sapiens]

Protein Classification

F-box/LRR-repeat protein( domain architecture ID 17778485)

F-box/LRR-repeat protein functions as the substrate-recognition component of a SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0005515|GO:0019005|GO:0016567|GO:0006511
PubMed:  11751054|31898225|11178263|7583641|14747988|10581972
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 220-394 8.70e-28

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 110.11  E-value: 8.70e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 220 CPELVTLNLQTCLQITDEGLITICrgCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCH 299
Cdd:cd09293  27 HSGLEWLELYMCPISDPPLDQLSN--CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 300 ELEKMDL---EECVQITDSTLIQLSIHCPRLQVLSLSHCElITDDGIRHLGNGaCAHdQLEVIELDNCPLITDASLEHLK 376
Cdd:cd09293 105 KLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASG-CSK-SLERLSLNNCRNLTDQSIPAIL 181

                       170       180
                ....*....|....*....|.
gi 27734755 377 SCHSLERI---ELYDCQQITR 394
Cdd:cd09293 182 ASNYFPNLsvlEFRGCPLITD 202
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 22-66 6.06e-27

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438887  Cd Length: 45  Bit Score: 101.73  E-value: 6.06e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 27734755  22 AVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQ 66
Cdd:cd22115   1 ALINKKLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 93-289 3.42e-24

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 100.09  E-value: 3.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755  93 LRKLSLRGClGVGDNALRTFaQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLE 172
Cdd:cd09293  30 LEWLELYMC-PISDPPLDQL-SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQ 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 173 QLNISWcdqvtkdgiqalvrgcgglkalfLKGCTQLEDEALKYIGAHCPELVTLNLQTClQITDEGLITICRGC-HKLQS 251
Cdd:cd09293 108 TINLGR-----------------------HRNGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCsKSLER 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 27734755 252 LCASGCSNITDAILNAL--GQNCPRLRILEVARCSQLTDV 289
Cdd:cd09293 164 LSLNNCRNLTDQSIPAIlaSNYFPNLSVLEFRGCPLITDF 203
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 220-394 8.70e-28

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 110.11  E-value: 8.70e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 220 CPELVTLNLQTCLQITDEGLITICrgCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCH 299
Cdd:cd09293  27 HSGLEWLELYMCPISDPPLDQLSN--CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 300 ELEKMDL---EECVQITDSTLIQLSIHCPRLQVLSLSHCElITDDGIRHLGNGaCAHdQLEVIELDNCPLITDASLEHLK 376
Cdd:cd09293 105 KLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASG-CSK-SLERLSLNNCRNLTDQSIPAIL 181

                       170       180
                ....*....|....*....|.
gi 27734755 377 SCHSLERI---ELYDCQQITR 394
Cdd:cd09293 182 ASNYFPNLsvlEFRGCPLITD 202
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 22-66 6.06e-27

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 101.73  E-value: 6.06e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 27734755  22 AVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQ 66
Cdd:cd22115   1 ALINKKLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 93-289 3.42e-24

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 100.09  E-value: 3.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755  93 LRKLSLRGClGVGDNALRTFaQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLE 172
Cdd:cd09293  30 LEWLELYMC-PISDPPLDQL-SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQ 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 173 QLNISWcdqvtkdgiqalvrgcgglkalfLKGCTQLEDEALKYIGAHCPELVTLNLQTClQITDEGLITICRGC-HKLQS 251
Cdd:cd09293 108 TINLGR-----------------------HRNGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCsKSLER 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 27734755 252 LCASGCSNITDAILNAL--GQNCPRLRILEVARCSQLTDV 289
Cdd:cd09293 164 LSLNNCRNLTDQSIPAIlaSNYFPNLSVLEFRGCPLITDF 203
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 28-69 1.39e-12

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 61.73  E-value: 1.39e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 27734755    28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRID 69
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
170-390 2.68e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 2.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 170 LLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLedealkyigAHCPELVTLNLQTClQITDegLITICRGCHKL 249
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL---------SNLTNLESLDLSGN-QLTD--LPEELANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 250 QSLCASGCsNITDaILNALGqNCPRLRILEVARCsQLTDVGFTtlARNCHELEKMDLEECvQITDstlIQLSI-HCPRLQ 328
Cdd:COG4886 139 KELDLSNN-QLTD-LPEPLG-NLTNLKSLDLSNN-QLTDLPEE--LGNLTNLKELDLSNN-QITD---LPEPLgNLTNLE 208

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27734755 329 VLSLSHCELIT-DDGIRHLGNgacahdqLEVIELDNCPLitdASLEHLKSCHSLERIELYDCQ 390
Cdd:COG4886 209 ELDLSGNQLTDlPEPLANLTN-------LETLDLSNNQL---TDLPELGNLTNLEELDLSNNQ 261
FBOX smart00256
A Receptor for Ubiquitination Targets;
28-68 3.36e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.58  E-value: 3.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27734755     28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
324-349 8.53e-04

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 36.62  E-value: 8.53e-04
                           10        20
                   ....*....|....*....|....*.
gi 27734755    324 CPRLQVLSLSHCELITDDGIRHLGNG 349
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 220-394 8.70e-28

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 110.11  E-value: 8.70e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 220 CPELVTLNLQTCLQITDEGLITICrgCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCH 299
Cdd:cd09293  27 HSGLEWLELYMCPISDPPLDQLSN--CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 300 ELEKMDL---EECVQITDSTLIQLSIHCPRLQVLSLSHCElITDDGIRHLGNGaCAHdQLEVIELDNCPLITDASLEHLK 376
Cdd:cd09293 105 KLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASG-CSK-SLERLSLNNCRNLTDQSIPAIL 181

                       170       180
                ....*....|....*....|.
gi 27734755 377 SCHSLERI---ELYDCQQITR 394
Cdd:cd09293 182 ASNYFPNLsvlEFRGCPLITD 202
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 181-371 3.51e-27

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 108.18  E-value: 3.51e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 181 QVTKDGIQALVRG-CGGLKALFLKGCTQLeDEALKYIGaHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSN 259
Cdd:cd09293  13 QITQSNISQLLRIlHSGLEWLELYMCPIS-DPPLDQLS-NCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACEN 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 260 ITDAILNALGQNCPRLRILEVAR---CSQLTDVGFTTLARNCHELEKMDLEECvQITDSTLIQL-SIHCPRLQVLSLSHC 335
Cdd:cd09293  91 ITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELaSGCSKSLERLSLNNC 169

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 27734755 336 ELITDDGIRH-LGNGACAHdqLEVIELDNCPLITDAS 371
Cdd:cd09293 170 RNLTDQSIPAiLASNYFPN--LSVLEFRGCPLITDFS 204
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 22-66 6.06e-27

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 101.73  E-value: 6.06e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 27734755  22 AVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQ 66
Cdd:cd22115   1 ALINKKLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 93-289 3.42e-24

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 100.09  E-value: 3.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755  93 LRKLSLRGClGVGDNALRTFaQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLE 172
Cdd:cd09293  30 LEWLELYMC-PISDPPLDQL-SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQ 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 173 QLNISWcdqvtkdgiqalvrgcgglkalfLKGCTQLEDEALKYIGAHCPELVTLNLQTClQITDEGLITICRGC-HKLQS 251
Cdd:cd09293 108 TINLGR-----------------------HRNGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCsKSLER 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 27734755 252 LCASGCSNITDAILNAL--GQNCPRLRILEVARCSQLTDV 289
Cdd:cd09293 164 LSLNNCRNLTDQSIPAIlaSNYFPNLSVLEFRGCPLITDF 203
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 89-236 2.11e-22

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 95.09  E-value: 2.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755  89 CGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDL---ASCTSITNMSLKALS 165
Cdd:cd09293  50 NCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLgrhRNGHLITDVSLSALG 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27734755 166 EGCPLLEQLNISWCDqVTKDGIQALVRGCG-GLKALFLKGCTQLEDEALKYIGA--HCPELVTLNLQTCLQITD 236
Cdd:cd09293 130 KNCTFLQTVGFAGCD-VTDKGVWELASGCSkSLERLSLNNCRNLTDQSIPAILAsnYFPNLSVLEFRGCPLITD 202
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 28-69 1.39e-12

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 61.73  E-value: 1.39e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 27734755    28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRID 69
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 28-68 1.31e-11

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 59.31  E-value: 1.31e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22134   7 LPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRI 47
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 27-65 1.50e-11

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 58.89  E-value: 1.50e-11
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22118   3 SLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 28-68 9.48e-10

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 53.86  E-value: 9.48e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22147   5 LPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRM 45
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 31-68 9.29e-09

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 51.18  E-value: 9.29e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27734755  31 ELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22109   9 DALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 27-59 3.47e-08

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 48.98  E-value: 3.47e-08
                        10        20        30
                ....*....|....*....|....*....|...
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLA 59
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELA 34
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
 28-65 6.94e-08

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 48.48  E-value: 6.94e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22124   4 LPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 28-68 1.97e-07

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 47.37  E-value: 1.97e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22137   3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNL 43
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 26-65 2.41e-07

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 47.06  E-value: 2.41e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27734755  26 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22094   4 RVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELW 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
170-390 2.68e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 2.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 170 LLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLedealkyigAHCPELVTLNLQTClQITDegLITICRGCHKL 249
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL---------SNLTNLESLDLSGN-QLTD--LPEELANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 250 QSLCASGCsNITDaILNALGqNCPRLRILEVARCsQLTDVGFTtlARNCHELEKMDLEECvQITDstlIQLSI-HCPRLQ 328
Cdd:COG4886 139 KELDLSNN-QLTD-LPEPLG-NLTNLKSLDLSNN-QLTDLPEE--LGNLTNLKELDLSNN-QITD---LPEPLgNLTNLE 208

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27734755 329 VLSLSHCELIT-DDGIRHLGNgacahdqLEVIELDNCPLitdASLEHLKSCHSLERIELYDCQ 390
Cdd:COG4886 209 ELDLSGNQLTDlPEPLANLTN-------LETLDLSNNQL---TDLPELGNLTNLEELDLSNNQ 261
FBXL3_LRR-like cd23951
Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part ...
 142-341 2.72e-07

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.


Pssm-ID: 467830 [Multi-domain]  Cd Length: 349  Bit Score: 52.39  E-value: 2.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 142 CSKLRHLDLAScTSITNMSLKAL-SEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKgCTQLEDE--------- 211
Cdd:cd23951  93 SSSLSSLAIDD-TPVDDPSLQTLaSSSSDTLELLKMKSCPRVSPRGILAVADHCQHLRELSLN-YHLLSDDlllalssee 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 212 --ALKY--IGAHCPELVTLNLQTCLQITDEGLITicrgcH----------------KLQSLCAS---------GCSnITD 262
Cdd:cd23951 171 hvRLEHlrIDVVSENDGPMPLHQISKESWDALIK-----HspdvnlvmyffvledeDFDPFFRSytpvthlyfGRS-VPK 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 263 AILNALGQNCPRLRILEVARCS-QLTDVGFTTLARNCHELEKMDLEECvQITDSTLIQLSIHC-PRLQVLSLSHCELITD 340
Cdd:cd23951 245 AVLGRVGQHCPRLVELVVCANGnSPIDEELIRIAKNCKQLSSLGLGEC-EVSCSALVEFAKLCgPRLTELYVMEEVLVED 323


                .
gi 27734755 341 D 341
Cdd:cd23951 324 E 324
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 75-332 4.74e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 4.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755  75 RDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALR----TFAQNCRNI---EVLNLNGCTKTTDAT---CTSLSKFCSK 144
Cdd:cd00116  59 SLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGpdgcGVLESLLRSsslQELKLNNNGLGDRGLrllAKGLKDLPPA 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 145 LRHLDLASCtSITNMSLKALSEGCP---LLEQLNISwCDQVTKDGIQALVRGcgglkalflkgctqledealkyiGAHCP 221
Cdd:cd00116 139 LEKLVLGRN-RLEGASCEALAKALRanrDLKELNLA-NNGIGDAGIRALAEG-----------------------LKANC 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 222 ELVTLNLQTClQITDEGLITIC---RGCHKLQSLCASGCsNITD----AILNALGQNCPRLRILEVArCSQLTDVGFTTL 294
Cdd:cd00116 194 NLEVLDLNNN-GLTDEGASALAetlASLKSLEVLNLGDN-NLTDagaaALASALLSPNISLLTLSLS-CNDITDDGAKDL 270

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 27734755 295 ARNCHE---LEKMDLEE-CVQITDSTLIQLSIHCPRLQVLSL 332
Cdd:cd00116 271 AEVLAEkesLLELDLRGnKFGEEGAQLLAESLLEPGNELESL 312
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 28-67 4.89e-07

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 46.12  E-value: 4.89e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQR 67
Cdd:cd22148   5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 28-56 5.45e-07

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 46.16  E-value: 5.45e-07
                        10        20
                ....*....|....*....|....*....
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWN 56
Cdd:cd22113   4 LPPEMSLRIFSQLDVQSLCRASQTCKTWN 32
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 26-59 7.26e-07

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 45.74  E-value: 7.26e-07
                        10        20        30
                ....*....|....*....|....*....|....
gi 27734755  26 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLA 59
Cdd:cd22172   7 RVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLT 40
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 27-68 1.15e-06

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 45.11  E-value: 1.15e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22091   3 ELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 26-56 1.16e-06

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 45.01  E-value: 1.16e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 27734755  26 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWN 56
Cdd:cd22131   4 KLLPLELSFYLLSFLDPESLLTCCLVSKQWN 34
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 27-67 1.22e-06

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 45.06  E-value: 1.22e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQR 67
Cdd:cd22149   3 RLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 27-65 2.35e-06

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 43.94  E-value: 2.35e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22114   3 SLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
 28-68 3.30e-06

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 43.91  E-value: 3.30e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22120   4 LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
28-68 3.36e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.58  E-value: 3.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27734755     28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXO10 cd22090
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ...
 28-70 3.62e-06

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438862  Cd Length: 50  Bit Score: 43.88  E-value: 3.62e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWN--VLALDGSNWQRIDL 70
Cdd:cd22090   5 LPLELWRLILAYLPVRDLCRCCQVCRAWYelILSLDSTRWKQLYL 49
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 28-65 4.44e-06

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 43.55  E-value: 4.44e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22173   6 LPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLW 43
F-box_JHDM cd22122
F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; ...
 28-67 6.28e-06

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438894  Cd Length: 43  Bit Score: 43.03  E-value: 6.28e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQR 67
Cdd:cd22122   4 LPREVWLPVFQYLSPKDLCVCMRVCKTWNRWCCDPSLWKR 43
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 28-68 8.09e-06

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 42.62  E-value: 8.09e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22139   4 LPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 26-68 1.43e-05

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 41.85  E-value: 1.43e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 27734755  26 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22093   2 ERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 27-67 2.42e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.37  E-value: 2.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 27734755    27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQR 67
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 27-69 2.99e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 41.16  E-value: 2.99e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRID 69
Cdd:cd22138   3 SLPVECQLKIFSFLSEVDKCLAATVCRSWSELIRSPRLWRTVD 45
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 27-68 3.08e-05

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 41.15  E-value: 3.08e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22151   2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENA 43
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 26-71 5.14e-05

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 40.30  E-value: 5.14e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 27734755  26 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLF 71
Cdd:cd22117   2 DLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKELNLQ 47
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 25-160 6.16e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 44.24  E-value: 6.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755  25 NKKLPKELLLRIFSF---LDVVTLCRCAQVSRAwNVLALdGSNWQRIDLFDFQRDIEGRVVENISKRCGG----FLRKLS 97
Cdd:cd09293  62 SKLIDDEGLIALAQScpnLQVLDLRACENITDS-GIVAL-ATNCPKLQTINLGRHRNGHLITDVSLSALGknctFLQTVG 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27734755  98 LRGClGVGDNALRTFAQNC-RNIEVLNLNGCTKTTDATCTSL--SKFCSKLRHLDLASCTSITNMS 160
Cdd:cd09293 140 FAGC-DVTDKGVWELASGCsKSLERLSLNNCRNLTDQSIPAIlaSNYFPNLSVLEFRGCPLITDFS 204
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 197-405 1.12e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 197 LKALFLKGCTqLEDEALKYIG---AHCPELVTLNLQT--------CLQITDEGLITICrgchKLQSLCASGCSNITD--A 263
Cdd:cd00116  25 LQVLRLEGNT-LGEEAAKALAsalRPQPSLKELCLSLnetgriprGLQSLLQGLTKGC----GLQELDLSDNALGPDgcG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 264 ILNALGQNcPRLRILEVARCSqLTDVGFTTLAR----NCHELEKMDLEECvQITDSTLIQLS---IHCPRLQVLSLSHCE 336
Cdd:cd00116 100 VLESLLRS-SSLQELKLNNNG-LGDRGLRLLAKglkdLPPALEKLVLGRN-RLEGASCEALAkalRANRDLKELNLANNG 176

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27734755 337 lITDDGIRHLGNGACAHDQLEVIELDNCPL--ITDASLEH-LKSCHSLERIELYDCqQITRAGIKRLRTHLP 405
Cdd:cd00116 177 -IGDAGIRALAEGLKANCNLEVLDLNNNGLtdEGASALAEtLASLKSLEVLNLGDN-NLTDAGAAALASALL 246
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 28-66 1.23e-04

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 39.72  E-value: 1.23e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQ 66
Cdd:cd22133  21 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 28-65 1.87e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 38.87  E-value: 1.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22123   4 LPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLW 41
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 27-66 3.26e-04

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 38.39  E-value: 3.26e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 27734755  27 KLPKELLLRIFSFL-----DVVTLCRCAQVSRAWNVLALDGSNWQ 66
Cdd:cd22119   3 RLPPEILVKIFQFAvategAVPLLCRLSRVCRLWREVALDPSLWT 47
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 26-59 6.15e-04

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 37.22  E-value: 6.15e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 27734755  26 KKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLA 59
Cdd:cd22136   3 RCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALT 36
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 28-67 7.05e-04

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 37.24  E-value: 7.05e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQR 67
Cdd:cd22084   4 LPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKR 43
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
324-349 8.53e-04

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 36.62  E-value: 8.53e-04
                           10        20
                   ....*....|....*....|....*.
gi 27734755    324 CPRLQVLSLSHCELITDDGIRHLGNG 349
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 28-68 1.19e-03

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 36.42  E-value: 1.19e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd20090   5 LPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRI 45
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 28-65 1.44e-03

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 36.51  E-value: 1.44e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNW 65
Cdd:cd22087   4 LPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLW 41
FBXL3_LRR cd23957
Leucine-rich repeat domain of F-box/LRR-repeat protein 3; FBXL3 (F-box/LRR-repeat protein 3), ...
 260-341 1.52e-03

Leucine-rich repeat domain of F-box/LRR-repeat protein 3; FBXL3 (F-box/LRR-repeat protein 3), together with SKP1 (S-phase-kinase-associated protein-1) and cullin subunit CUL1, forms a Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complex that ubiquitinates CRY repressor proteins and mediates their degradation. FBXL21 also ubiquitinates the cryptochromes (CRYs) but counteracts FBXL3. This plays an important role in regulating oscillation of the circadian clock.


Pssm-ID: 467832 [Multi-domain]  Cd Length: 350  Bit Score: 40.42  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 260 ITDAILNALGQNCPRLriLEVARCS---QLTDVGFTTLARNCHELEKMDLEECvQITDSTLIQLSIHC-PRLQVLSLSHC 335
Cdd:cd23957 241 VSKEVLGRVGMNCPRL--VELVVCAnglRPLDEELIRIAERCKNLTAIGLGEC-EVSCSAFVEFVKMCgGRLSQLSIMEE 317


                ....*.
gi 27734755 336 ELITDD 341
Cdd:cd23957 318 VLIPDQ 323
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
 27-72 1.55e-03

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 36.23  E-value: 1.55e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFD 72
Cdd:cd22085   5 HLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFLLRD 50
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 27-68 1.76e-03

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 36.01  E-value: 1.76e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22106   3 RLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKI 44
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 27-68 2.91e-03

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 35.67  E-value: 2.91e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 27734755  27 KLPKELLLRIF----SFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22089   5 ALPSEILLYILrwvvSDLDLRSLEQLSLVCRKFYLLARDPSIWRLA 50
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 27-58 3.47e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 34.95  E-value: 3.47e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 27734755  27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVL 58
Cdd:cd22111   3 RLPSRVLEVIFSYLDLPDLRNCSLVCKSWYRL 34
FBXL3_LRR-like cd23951
Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part ...
 104-280 3.90e-03

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.


Pssm-ID: 467830 [Multi-domain]  Cd Length: 349  Bit Score: 39.29  E-value: 3.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 104 VGDNALRTFAQNCRN-IEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLaSCTSITNMSLKALS-EGCPLLEQLNIS-WCD 180
Cdd:cd23951 106 VDDPSLQTLASSSSDtLELLKMKSCPRVSPRGILAVADHCQHLRELSL-NYHLLSDDLLLALSsEEHVRLEHLRIDvVSE 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734755 181 --------QVTKDGIQALVRGCG--GLKALFLKgctqLEDE------------------------ALKYIGAHCPELVTL 226
Cdd:cd23951 185 ndgpmplhQISKESWDALIKHSPdvNLVMYFFV----LEDEdfdpffrsytpvthlyfgrsvpkaVLGRVGQHCPRLVEL 260

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 27734755 227 NL-QTCLQITDEGLITICRGCHKLQSLCASGCSnITDAILNALGQNC-PRLRILEV 280
Cdd:cd23951 261 VVcANGNSPIDEELIRIAKNCKQLSSLGLGECE-VSCSALVEFAKLCgPRLTELYV 315
F-box_FBXL14 cd22125
F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also ...
 31-66 5.87e-03

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438897  Cd Length: 41  Bit Score: 34.37  E-value: 5.87e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 27734755  31 ELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQ 66
Cdd:cd22125   6 EILAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVWR 41
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
 28-70 6.99e-03

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 34.70  E-value: 6.99e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQ-VSRAWNVLALDGSNWQRIDL 70
Cdd:cd22092   5 LPDSILLKIFSYLSLQERCLSASlVCKYWRDLCLDSQFWKQIDL 48
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 28-68 7.42e-03

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 34.46  E-value: 7.42e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22141   4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKL 44
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 28-68 7.45e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 34.51  E-value: 7.45e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 27734755  28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
Cdd:cd22132   4 LPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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