NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|16950591|ref|NP_203527|]
View 

small ribosomal subunit protein uS12m precursor [Homo sapiens]

Protein Classification

30S ribosomal protein S12( domain architecture ID 10130119)

30S ribosomal protein S12 assists in rRNA folding and the binding of other proteins during small subunit assembly

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 32-138 4.31e-58

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


:

Pssm-ID: 239466  Cd Length: 108  Bit Score: 175.40  E-value: 4.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  32 TLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIVLV 110
Cdd:cd03368   1 TINQLIRKGRKKKKKKSKSPAlEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLV 80

                        90       100
                ....*....|....*....|....*...
gi 16950591 111 EGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:cd03368  81 RGGRVKDLPGVRYHIVRGVLDLAGVKNR 108
 
Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 32-138 4.31e-58

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 175.40  E-value: 4.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  32 TLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIVLV 110
Cdd:cd03368   1 TINQLIRKGRKKKKKKSKSPAlEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLV 80

                        90       100
                ....*....|....*....|....*...
gi 16950591 111 EGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:cd03368  81 RGGRVKDLPGVRYHIVRGVLDLAGVKNR 108
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 30-138 1.15e-41

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 134.56  E-value: 1.15e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  30 MATLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIV 108
Cdd:COG0048   1 MPTINQLVRKGRKKKKKKSKSPAlKGCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSVV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 16950591 109 LVEGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:COG0048  81 LVRGGRVKDLPGVRYHIVRGALDTAGVKGR 110
rpsL_bact TIGR00981
ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of ...
 30-138 7.40e-40

ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of Bacteria, mitochondria, and chloroplasts. The homologous ribosomal proteins of Archaea and Eukarya, termed S23 in Eukarya and S12 or S23 in Archaea, score below the trusted cutoff. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130054  Cd Length: 124  Bit Score: 129.91  E-value: 7.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591    30 MATLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIV 108
Cdd:TIGR00981   1 MPTINQLIRKGRKKKKKKSKSPAlEACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTAYIPGEGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 16950591   109 LVEGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:TIGR00981  81 LIRGGRVKDLPGVRYHIVRGALDTAGVKNR 110
rps12 CHL00051
ribosomal protein S12
 30-135 2.04e-34

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 115.90  E-value: 2.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591   30 MATLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIV 108
Cdd:CHL00051   1 MPTIKQLIRNTRQPIRNKTKSPAlRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVV 80

                         90       100
                 ....*....|....*....|....*..
gi 16950591  109 LVEGGRTQDLPGVKLTVVRGKYDCGHV 135
Cdd:CHL00051  81 LVRGGRVKDLPGVRYHIVRGTLDAVGV 107
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 42-127 9.37e-26

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 93.67  E-value: 9.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591    42 PKRPPRKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLST-GREAVCFIPGEG--HTLQEHQIVLVEGGRTQ-- 116
Cdd:pfam00164   3 LLGLKTKSPPLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIKnGKEVTAFIPGEGaiHFLQEHDEVLIRGGGGPgh 82

                          90
                  ....*....|....
gi 16950591   117 ---DLPGVKLTVVR 127
Cdd:pfam00164  83 avgDLPGVRYKVVR 96
 
Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 32-138 4.31e-58

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 175.40  E-value: 4.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  32 TLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIVLV 110
Cdd:cd03368   1 TINQLIRKGRKKKKKKSKSPAlEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLV 80

                        90       100
                ....*....|....*....|....*...
gi 16950591 111 EGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:cd03368  81 RGGRVKDLPGVRYHIVRGVLDLAGVKNR 108
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 30-138 1.15e-41

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 134.56  E-value: 1.15e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  30 MATLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIV 108
Cdd:COG0048   1 MPTINQLVRKGRKKKKKKSKSPAlKGCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSVV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 16950591 109 LVEGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:COG0048  81 LVRGGRVKDLPGVRYHIVRGALDTAGVKGR 110
rpsL_bact TIGR00981
ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of ...
 30-138 7.40e-40

ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of Bacteria, mitochondria, and chloroplasts. The homologous ribosomal proteins of Archaea and Eukarya, termed S23 in Eukarya and S12 or S23 in Archaea, score below the trusted cutoff. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130054  Cd Length: 124  Bit Score: 129.91  E-value: 7.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591    30 MATLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIV 108
Cdd:TIGR00981   1 MPTINQLIRKGRKKKKKKSKSPAlEACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTAYIPGEGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 16950591   109 LVEGGRTQDLPGVKLTVVRGKYDCGHVQKK 138
Cdd:TIGR00981  81 LIRGGRVKDLPGVRYHIVRGALDTAGVKNR 110
rps12 CHL00051
ribosomal protein S12
 30-135 2.04e-34

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 115.90  E-value: 2.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591   30 MATLNQMHRLGPPKRPPRKLGPT-EGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIV 108
Cdd:CHL00051   1 MPTIKQLIRNTRQPIRNKTKSPAlRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVV 80

                         90       100
                 ....*....|....*....|....*..
gi 16950591  109 LVEGGRTQDLPGVKLTVVRGKYDCGHV 135
Cdd:CHL00051  81 LVRGGRVKDLPGVRYHIVRGTLDAVGV 107
PTZ00115 PTZ00115
40S ribosomal protein S12; Provisional
 35-131 6.37e-31

40S ribosomal protein S12; Provisional


Pssm-ID: 240276  Cd Length: 290  Bit Score: 111.86  E-value: 6.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591   35 QMHRLGPPKRPPRKLgptEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIVLVEGGR 114
Cdd:PTZ00115 106 QVPKLKPKNRRSKWL---EGAPQKKGICVKVRVQTPRKPNSGLRKVARVRLSTGRTVTVYIPGIGHNLNTHSVVLVRGGR 182

                         90
                 ....*....|....*..
gi 16950591  115 TQDLPGVKLTVVRGKYD 131
Cdd:PTZ00115 183 CKDVPGCNYKAVRGVYD 199
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 42-127 9.37e-26

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 93.67  E-value: 9.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591    42 PKRPPRKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLST-GREAVCFIPGEG--HTLQEHQIVLVEGGRTQ-- 116
Cdd:pfam00164   3 LLGLKTKSPPLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIKnGKEVTAFIPGEGaiHFLQEHDEVLIRGGGGPgh 82

                          90
                  ....*....|....
gi 16950591   117 ---DLPGVKLTVVR 127
Cdd:pfam00164  83 avgDLPGVRYKVVR 96
Ribosomal_S12_like cd00319
Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, ...
 48-128 4.63e-18

Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding center. They play an important role in translocation during the peptide elongation step of protein synthesis. They are also involved in important RNA and protein interactions. Ribosomal protein S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. S23 interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes translocation. Mutations in S12 and S23 have been found to affect translational accuracy. Antibiotics such as streptomycin may also bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 238196  Cd Length: 95  Bit Score: 73.59  E-value: 4.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  48 KLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGREAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVR 127
Cdd:cd00319   5 KVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVR 84


                .
gi 16950591 128 G 128
Cdd:cd00319  85 G 85
Ribosomal_S23 cd03367
S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the ...
 47-127 4.66e-15

S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the large and small ribosomal subunits of eukaryotes, adjacent to the decoding center. It interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes the translocation of the growing peptidyl-tRNA to the P site to make room for the next aminoacyl-tRNA at the A (acceptor) site. Through its interaction with eEF2, S23 may play an important role in translocation. Also members of this subfamily are the archaeal 30S ribosomal S12 proteins. Prokaryotic S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as control element for the rRNA- and tRNA-driven movements of translocation. S12 and S23 are also implicated in translation accuracy. Antibiotics such as streptomycin bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 239465  Cd Length: 115  Bit Score: 66.14  E-value: 4.66e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591  47 RKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRL-STGREAVCFIPGEG--HTLQEHQIVLVEG----GRTQ-DL 118
Cdd:cd03367  11 YKADPLGGAPHAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPGDGclNFIDENDEVLVAGfgrkGRAVgDI 90


                ....*....
gi 16950591 119 PGVKLTVVR 127
Cdd:cd03367  91 PGVRFKVVK 99
rps12P PRK04211
30S ribosomal protein S12P; Reviewed
 47-126 1.08e-13

30S ribosomal protein S12P; Reviewed


Pssm-ID: 235257  Cd Length: 145  Bit Score: 63.43  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591   47 RKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRL-STGREAVCFIPGEG--HTLQEHQIVLVEG-----GRTQ-D 117
Cdd:PRK04211  37 EKADPLEGAPMARGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKQVTAFCPGDGaiNFIDEHDEVVIEGiggpkGRSMgD 116


                 ....*....
gi 16950591  118 LPGVKLTVV 126
Cdd:PRK04211 117 IPGVRYKVI 125
uS12_E_A TIGR00982
ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and ...
 47-127 4.95e-13

ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and archaeal forms of ribosomal protein uS12. This protein was known previously as S23 in eukaryotes and as either S12 or S23 in the Archaea. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273377  Cd Length: 139  Bit Score: 61.81  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591    47 RKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRL-STGREAVCFIPGEGHTL--QEHQIVLVEG-----GRTQ-D 117
Cdd:TIGR00982  31 EKADPLEGAPQARGIVLEKIGVEAKQPNSAIRKAVRVQLiKNGKVVTAFCPGDGAINfiDEHDEVIIEGiggpkGRSMgD 110

                          90
                  ....*....|
gi 16950591   118 LPGVKLTVVR 127
Cdd:TIGR00982 111 IPGVRYKVVK 120
PTZ00067 PTZ00067
40S ribosomal S23; Provisional
 48-127 1.79e-10

40S ribosomal S23; Provisional


Pssm-ID: 185422  Cd Length: 143  Bit Score: 55.13  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16950591   48 KLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRL-STGREAVCFIPGEG--HTLQEHQIVLVEG-GRT----QDLP 119
Cdd:PTZ00067  37 KANPFGGASHAKGIVVEKIGIEAKQPNSAIRKCVRVQLiKNGKKITAFVPNDGclNFINENDEVLVSGfGRSghavGDIP 116


                 ....*...
gi 16950591  120 GVKLTVVR 127
Cdd:PTZ00067 117 GVRFKVVK 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH