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Conserved domains on  [gi|49410495|ref|NP_277047|]
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testis-specific Y-encoded-like protein 5 [Homo sapiens]

Protein Classification

NAP domain-containing protein( domain architecture ID 1637)

NAP domain-containing protein similar to Homo sapiens protein testis-specific Y-encoded protein and nucleosome assembly protein 1-like

CATH:  3.30.1120.90
Gene Ontology:  GO:0042393|GO:0003682|GO:0006334
PubMed:  16936827
SCOP:  4003454

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00007 super family cl08298
(NAP-L) nucleosome assembly protein -L; Provisional
213-382 4.08e-20

(NAP-L) nucleosome assembly protein -L; Provisional


The actual alignment was detected with superfamily member PTZ00008:

Pssm-ID: 471807  Cd Length: 185  Bit Score: 87.18  E-value: 4.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  213 ENMNAQadraylrlsRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLaSFLNSQEKEVLSYLNSLEVEElGLARLG- 291
Cdd:PTZ00008  10 EQMNIQ---------RQFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPAL-SYLVPEDIDILEHLKKIDLED-NLDNNGs 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  292 YKIKFYFDR--NPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHD-----LQSLSQGNPEN-NRSFFGWFSNHSSIESD 363
Cdd:PTZ00008  79 YKITLIFDEkaKEFMEPLVLVKHVIFKNNQEKVVEVTKIKWKEGKSpiaaaEKARSDLDDECiVWSIFEWFTEEEWQDRP 158
                        170
                 ....*....|....*....
gi 49410495  364 KIVEIINEELWPNPLQFYL 382
Cdd:PTZ00008 159 DVGEIIRREIWHAPLLYYL 177
 
Name Accession Description Interval E-value
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
213-382 4.08e-20

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 87.18  E-value: 4.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  213 ENMNAQadraylrlsRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLaSFLNSQEKEVLSYLNSLEVEElGLARLG- 291
Cdd:PTZ00008  10 EQMNIQ---------RQFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPAL-SYLVPEDIDILEHLKKIDLED-NLDNNGs 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  292 YKIKFYFDR--NPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHD-----LQSLSQGNPEN-NRSFFGWFSNHSSIESD 363
Cdd:PTZ00008  79 YKITLIFDEkaKEFMEPLVLVKHVIFKNNQEKVVEVTKIKWKEGKSpiaaaEKARSDLDDECiVWSIFEWFTEEEWQDRP 158
                        170
                 ....*....|....*....
gi 49410495  364 KIVEIINEELWPNPLQFYL 382
Cdd:PTZ00008 159 DVGEIIRREIWHAPLLYYL 177
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
205-373 6.72e-19

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 84.53  E-value: 6.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495   205 LENVQLKLENMNAQADRAYLRLSRKFgQLRLQHLerrnhliqnipgfwgqaFQNHPQLASFLNSQEKEVLSYLNSLEVEE 284
Cdd:pfam00956   6 LKKLQKEHEKLEAEFQEEVHELEKKY-AALYQPL-----------------YKNLPLLSEMITERDEPALKHLKDIKIEY 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495   285 LgLARLGYKIKFYFDRNPYFQNKVLIKEY--GCGPSGQVVSRS--TPIQWLPGHDL--------QSLSQGNP-------E 345
Cdd:pfam00956  68 P-LDEPGFTLEFHFAPNPYFTNTVLTKTYyyQDEPDGPEIIKAegTEIDWKEGKNVtvktvkkkQRNKGTGQtrtvtktV 146
                         170       180
                  ....*....|....*....|....*...
gi 49410495   346 NNRSFFGWFSNHSSIESDKIVEIINEEL 373
Cdd:pfam00956 147 PTESFFNFFSPPEVPEDEDEDDEEDEEL 174
 
Name Accession Description Interval E-value
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
213-382 4.08e-20

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 87.18  E-value: 4.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  213 ENMNAQadraylrlsRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLaSFLNSQEKEVLSYLNSLEVEElGLARLG- 291
Cdd:PTZ00008  10 EQMNIQ---------RQFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPAL-SYLVPEDIDILEHLKKIDLED-NLDNNGs 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  292 YKIKFYFDR--NPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHD-----LQSLSQGNPEN-NRSFFGWFSNHSSIESD 363
Cdd:PTZ00008  79 YKITLIFDEkaKEFMEPLVLVKHVIFKNNQEKVVEVTKIKWKEGKSpiaaaEKARSDLDDECiVWSIFEWFTEEEWQDRP 158
                        170
                 ....*....|....*....
gi 49410495  364 KIVEIINEELWPNPLQFYL 382
Cdd:PTZ00008 159 DVGEIIRREIWHAPLLYYL 177
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
205-373 6.72e-19

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 84.53  E-value: 6.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495   205 LENVQLKLENMNAQADRAYLRLSRKFgQLRLQHLerrnhliqnipgfwgqaFQNHPQLASFLNSQEKEVLSYLNSLEVEE 284
Cdd:pfam00956   6 LKKLQKEHEKLEAEFQEEVHELEKKY-AALYQPL-----------------YKNLPLLSEMITERDEPALKHLKDIKIEY 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495   285 LgLARLGYKIKFYFDRNPYFQNKVLIKEY--GCGPSGQVVSRS--TPIQWLPGHDL--------QSLSQGNP-------E 345
Cdd:pfam00956  68 P-LDEPGFTLEFHFAPNPYFTNTVLTKTYyyQDEPDGPEIIKAegTEIDWKEGKNVtvktvkkkQRNKGTGQtrtvtktV 146
                         170       180
                  ....*....|....*....|....*...
gi 49410495   346 NNRSFFGWFSNHSSIESDKIVEIINEEL 373
Cdd:pfam00956 147 PTESFFNFFSPPEVPEDEDEDDEEDEEL 174
PTZ00007 PTZ00007
(NAP-L) nucleosome assembly protein -L; Provisional
239-365 1.81e-13

(NAP-L) nucleosome assembly protein -L; Provisional


Pssm-ID: 240226 [Multi-domain]  Cd Length: 337  Bit Score: 70.98  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49410495  239 ERRNHLIQN---------IPGFWGQAFQNHPQLASFLNSQEKEVLSYLNSLEVEELG-LARLGYKIKFYFDRNPYFQNKV 308
Cdd:PTZ00007  81 KRKEALVQNggaeigtpgLPQFWLTAMKNNNTLGSAIEEHDEPILSYLSDISCEYTEpNKQEGFILVFTFAPNPFFSNTV 160
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49410495  309 LIKEYGC----GPSGQVVS--RSTPIQWLPGHDL---------------QSLSQGNPENNRSFFGWFSNHSSIESDKI 365
Cdd:PTZ00007 161 LTKTYHMkvldGDDEPLLSntVATEIDWKQGKDVtkkvvtkkqrhkktkETRTVTETVDRESFFNFFTSHEVPSDEEL 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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