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Conserved domains on  [gi|154275765|ref|NP_443098|]
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ADAMTS-like protein 1 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 380-437 1.52e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.52e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 154275765  380 WEATPWTACSSSCGGGIQSRAVSCVEEDiqGHVTSVEEWkCMYTPKMPIAQPCNIFDC 437
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKG--GGSIVPDSE-CSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 87-185 4.26e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765   87 DFRAQQCSAHN-----DVKHHGQFYEW---LPVSNDpDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTE------SLDMC 152
Cdd:pfam19236   4 EFMSQQCARTDgqplrSSPGGASFYHWgaaVPHSQG-DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 154275765  153 ISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTC 185
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 440-492 2.27e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 2.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154275765  440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG---CSPKTKPHIKEECIVPtPC 492
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLK-PC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 36-82 3.03e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 47.20  E-value: 3.03e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 154275765    36 WDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCP 82
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 301-359 7.21e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 7.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765  301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYChyypeNIKPKP-KLQECNLDPC 359
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-----SAQKKPpETQSCNLKPC 55
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 204-296 6.36e-06

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 45.26  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765  204 TVVAIPYGSRHIRLVLKGPDHLYLETKTLQGT---KGENSLS-STGTFLVDNSSVDF-QKFPDKEILRMAGPLTADFIVK 278
Cdd:pfam05986  16 TFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKyilNGKGSISlNPTYPSLLGTVLEYrRSLPALEELHAPGPTQEDLEIQ 95

                          90       100
                  ....*....|....*....|
gi 154275765  279 I--RNSGSADSTVQFIFYQP 296
Cdd:pfam05986  96 VlrQYGKGTNPGITYEYFIP 115
 
Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 380-437 1.52e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.52e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 154275765  380 WEATPWTACSSSCGGGIQSRAVSCVEEDiqGHVTSVEEWkCMYTPKMPIAQPCNIFDC 437
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKG--GGSIVPDSE-CSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 87-185 4.26e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765   87 DFRAQQCSAHN-----DVKHHGQFYEW---LPVSNDpDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTE------SLDMC 152
Cdd:pfam19236   4 EFMSQQCARTDgqplrSSPGGASFYHWgaaVPHSQG-DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 154275765  153 ISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTC 185
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 440-492 2.27e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 2.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154275765  440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG---CSPKTKPHIKEECIVPtPC 492
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLK-PC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 36-82 3.03e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 47.20  E-value: 3.03e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 154275765    36 WDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCP 82
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 301-359 7.21e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 7.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765  301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYChyypeNIKPKP-KLQECNLDPC 359
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-----SAQKKPpETQSCNLKPC 55
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 204-296 6.36e-06

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 45.26  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765  204 TVVAIPYGSRHIRLVLKGPDHLYLETKTLQGT---KGENSLS-STGTFLVDNSSVDF-QKFPDKEILRMAGPLTADFIVK 278
Cdd:pfam05986  16 TFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKyilNGKGSISlNPTYPSLLGTVLEYrRSLPALEELHAPGPTQEDLEIQ 95

                          90       100
                  ....*....|....*....|
gi 154275765  279 I--RNSGSADSTVQFIFYQP 296
Cdd:pfam05986  96 VlrQYGKGTNPGITYEYFIP 115
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 428-506 1.53e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.57  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765 428 IAQPC----NIFDCPKWlaQEWSPCTVTCGQGLRYRvvlcidHRGMHTGGCSpktkPHIKEECiVPTPCYKPKEKLPVEA 503
Cdd:PTZ00441 227 IAKVCteveRTASCGPW--DEWTPCSVTCGKGTHSR------SRPILHEGCT----THMVEEC-EEEECPVEPEPLPVPA 293


                 ...
gi 154275765 504 KLP 506
Cdd:PTZ00441 294 PVP 296
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 380-438 7.77e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 7.77e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 154275765   380 WEATPWTACSSSCGGGIQSRAVSCVeediqGHVTSVEEWKCmyTPKMPIAQPCNIFDCP 438
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCC-----SPPPQNGGGPC--TGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 444-473 8.24e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 8.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 154275765   444 EWSPCTVTCGQGLRYRVVLCIDHRGMHTGG 473
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGG 35
TSP_1 pfam00090
Thrombospondin type 1 domain;
39-81 1.26e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 154275765   39 WGPWSECSRTCGGGASYSLRRCLS----SKSCEGRNIRYRTCSNVDC 81
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIETQACKMDKC 49
 
Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 380-437 1.52e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.52e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 154275765  380 WEATPWTACSSSCGGGIQSRAVSCVEEDiqGHVTSVEEWkCMYTPKMPIAQPCNIFDC 437
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKG--GGSIVPDSE-CSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 87-185 4.26e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765   87 DFRAQQCSAHN-----DVKHHGQFYEW---LPVSNDpDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTE------SLDMC 152
Cdd:pfam19236   4 EFMSQQCARTDgqplrSSPGGASFYHWgaaVPHSQG-DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 154275765  153 ISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTC 185
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 440-492 2.27e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 2.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154275765  440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG---CSPKTKPHIKEECIVPtPC 492
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPdseCSAQKKPPETQSCNLK-PC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 36-82 3.03e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 47.20  E-value: 3.03e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 154275765    36 WDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCP 82
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 301-359 7.21e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 7.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765  301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYChyypeNIKPKP-KLQECNLDPC 359
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-----SAQKKPpETQSCNLKPC 55
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 204-296 6.36e-06

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 45.26  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765  204 TVVAIPYGSRHIRLVLKGPDHLYLETKTLQGT---KGENSLS-STGTFLVDNSSVDF-QKFPDKEILRMAGPLTADFIVK 278
Cdd:pfam05986  16 TFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKyilNGKGSISlNPTYPSLLGTVLEYrRSLPALEELHAPGPTQEDLEIQ 95

                          90       100
                  ....*....|....*....|
gi 154275765  279 I--RNSGSADSTVQFIFYQP 296
Cdd:pfam05986  96 VlrQYGKGTNPGITYEYFIP 115
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 428-506 1.53e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.57  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154275765 428 IAQPC----NIFDCPKWlaQEWSPCTVTCGQGLRYRvvlcidHRGMHTGGCSpktkPHIKEECiVPTPCYKPKEKLPVEA 503
Cdd:PTZ00441 227 IAKVCteveRTASCGPW--DEWTPCSVTCGKGTHSR------SRPILHEGCT----THMVEEC-EEEECPVEPEPLPVPA 293


                 ...
gi 154275765 504 KLP 506
Cdd:PTZ00441 294 PVP 296
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 380-438 7.77e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 7.77e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 154275765   380 WEATPWTACSSSCGGGIQSRAVSCVeediqGHVTSVEEWKCmyTPKMPIAQPCNIFDCP 438
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCC-----SPPPQNGGGPC--TGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 444-473 8.24e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 8.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 154275765   444 EWSPCTVTCGQGLRYRVVLCIDHRGMHTGG 473
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGG 35
TSP_1 pfam00090
Thrombospondin type 1 domain;
39-81 1.26e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 154275765   39 WGPWSECSRTCGGGASYSLRRCLS----SKSCEGRNIRYRTCSNVDC 81
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 38-52 5.06e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 5.06e-03
                          10
                  ....*....|....*
gi 154275765   38 AWGPWSECSRTCGGG 52
Cdd:pfam19028   5 EWSEWSECSVTCGGG 19
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 36-52 9.82e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 34.35  E-value: 9.82e-03
                          10
                  ....*....|....*..
gi 154275765   36 WDAwGPWSECSRTCGGG 52
Cdd:pfam19030   1 WVA-GPWGECSVTCGGG 16
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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