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Conserved domains on  [gi|53988387|ref|NP_443101|]
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protein tweety homolog 2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tweety_N super family cl12141
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
 1-115 4.09e-41

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


The actual alignment was detected with superfamily member pfam04906:

Pssm-ID: 472281  Cd Length: 429  Bit Score: 144.42  E-value: 4.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53988387     1 MQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAAL 80
Cdd:pfam04906 312 MQDQVQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCYDGLEGLLYLLLFSLLTAL 391

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 53988387    81 AFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQ 115
Cdd:pfam04906 392 AFSSIVCSDPHAWIYFQKRDRDYDDIDEEDPFNPQ 426
 
Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
 1-115 4.09e-41

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


Pssm-ID: 461475  Cd Length: 429  Bit Score: 144.42  E-value: 4.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53988387     1 MQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAAL 80
Cdd:pfam04906 312 MQDQVQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCYDGLEGLLYLLLFSLLTAL 391

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 53988387    81 AFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQ 115
Cdd:pfam04906 392 AFSSIVCSDPHAWIYFQKRDRDYDDIDEEDPFNPQ 426
Tweety_N cd07912
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
 1-101 7.27e-36

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


Pssm-ID: 143653  Cd Length: 418  Bit Score: 130.14  E-value: 7.27e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53988387   1 MQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAAL 80
Cdd:cd07912 318 MQSQVQGLLREAVFEFPTAEDNLLSLQGDLNSTEINLHQLTALLDCRGLHKDYVEALRGLCYDGLEGLLYLLLFSLLAAL 397

                        90       100
                ....*....|....*....|.
gi 53988387  81 AFSTMICAGPRAWKHFTTRNR 101
Cdd:cd07912 398 LFTILVCVDSHTWIYIRKRDD 418
 
Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
 1-115 4.09e-41

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


Pssm-ID: 461475  Cd Length: 429  Bit Score: 144.42  E-value: 4.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53988387     1 MQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAAL 80
Cdd:pfam04906 312 MQDQVQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCYDGLEGLLYLLLFSLLTAL 391

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 53988387    81 AFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQ 115
Cdd:pfam04906 392 AFSSIVCSDPHAWIYFQKRDRDYDDIDEEDPFNPQ 426
Tweety_N cd07912
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
 1-101 7.27e-36

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


Pssm-ID: 143653  Cd Length: 418  Bit Score: 130.14  E-value: 7.27e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53988387   1 MQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAAL 80
Cdd:cd07912 318 MQSQVQGLLREAVFEFPTAEDNLLSLQGDLNSTEINLHQLTALLDCRGLHKDYVEALRGLCYDGLEGLLYLLLFSLLAAL 397

                        90       100
                ....*....|....*....|.
gi 53988387  81 AFSTMICAGPRAWKHFTTRNR 101
Cdd:cd07912 398 LFTILVCVDSHTWIYIRKRDD 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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