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protein tweety homolog 2 isoform 2 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Tweety_N super family | cl12141 | N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ... |
1-115 | 4.09e-41 | |||
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins. The actual alignment was detected with superfamily member pfam04906: Pssm-ID: 472281 Cd Length: 429 Bit Score: 144.42 E-value: 4.09e-41
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Name | Accession | Description | Interval | E-value | |||
Tweety | pfam04906 | Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ... |
1-115 | 4.09e-41 | |||
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in. Pssm-ID: 461475 Cd Length: 429 Bit Score: 144.42 E-value: 4.09e-41
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Tweety_N | cd07912 | N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ... |
1-101 | 7.27e-36 | |||
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins. Pssm-ID: 143653 Cd Length: 418 Bit Score: 130.14 E-value: 7.27e-36
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Name | Accession | Description | Interval | E-value | |||
Tweety | pfam04906 | Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ... |
1-115 | 4.09e-41 | |||
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in. Pssm-ID: 461475 Cd Length: 429 Bit Score: 144.42 E-value: 4.09e-41
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Tweety_N | cd07912 | N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ... |
1-101 | 7.27e-36 | |||
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins. Pssm-ID: 143653 Cd Length: 418 Bit Score: 130.14 E-value: 7.27e-36
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