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Conserved domains on  [gi|74315957|ref|NP_444328|]
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leiomodin-2 [Mus musculus]

Protein Classification

Tropomodulin and PPP1R42 superfamily-containing protein( domain architecture ID 1903313)

Tropomodulin and PPP1R42 superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tropomodulin super family cl12276
Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of ...
 6-85 1.12e-14

Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.


The actual alignment was detected with superfamily member pfam03250:

Pssm-ID: 460862  Cd Length: 142  Bit Score: 71.16  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957     6 YRRGLSKYESIDEDELLASLSPEELKELERELEDIEPDRN-LPVGLRQKSLTEKTPTGNFSREALMAYWEKesQKLLEKE 84
Cdd:pfam03250   1 YKKDLKKYDDIDEDELLKKLSEEELEQLDELLEELDPDNAlLPAGQRQRDQTKKEPTGPFDREKLLHHLEK--QALEPKD 78


                  .
gi 74315957    85 R 85
Cdd:pfam03250  79 R 79
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-339 7.51e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.88  E-value: 7.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 230 NITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELr 309
Cdd:COG5238 219 PIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSL- 297

                        90       100       110
                ....*....|....*....|....*....|
gi 74315957 310 FHNQRHImGSQVEMEIVKLLKENTTLLRLG 339
Cdd:COG5238 298 DLSVNRI-GDEGAIALAEGLQGNKTLHTLN 326
 
Name Accession Description Interval E-value
Tropomodulin pfam03250
Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of ...
 6-85 1.12e-14

Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.


Pssm-ID: 460862  Cd Length: 142  Bit Score: 71.16  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957     6 YRRGLSKYESIDEDELLASLSPEELKELERELEDIEPDRN-LPVGLRQKSLTEKTPTGNFSREALMAYWEKesQKLLEKE 84
Cdd:pfam03250   1 YKKDLKKYDDIDEDELLKKLSEEELEQLDELLEELDPDNAlLPAGQRQRDQTKKEPTGPFDREKLLHHLEK--QALEPKD 78


                  .
gi 74315957    85 R 85
Cdd:pfam03250  79 R 79
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-339 7.51e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.88  E-value: 7.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 230 NITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELr 309
Cdd:COG5238 219 PIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSL- 297

                        90       100       110
                ....*....|....*....|....*....|
gi 74315957 310 FHNQRHImGSQVEMEIVKLLKENTTLLRLG 339
Cdd:COG5238 298 DLSVNRI-GDEGAIALAEGLQGNKTLHTLN 326
 
Name Accession Description Interval E-value
Tropomodulin pfam03250
Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of ...
 6-85 1.12e-14

Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.


Pssm-ID: 460862  Cd Length: 142  Bit Score: 71.16  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957     6 YRRGLSKYESIDEDELLASLSPEELKELERELEDIEPDRN-LPVGLRQKSLTEKTPTGNFSREALMAYWEKesQKLLEKE 84
Cdd:pfam03250   1 YKKDLKKYDDIDEDELLKKLSEEELEQLDELLEELDPDNAlLPAGQRQRDQTKKEPTGPFDREKLLHHLEK--QALEPKD 78


                  .
gi 74315957    85 R 85
Cdd:pfam03250  79 R 79
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-339 7.51e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.88  E-value: 7.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 230 NITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELr 309
Cdd:COG5238 219 PIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSL- 297

                        90       100       110
                ....*....|....*....|....*....|
gi 74315957 310 FHNQRHImGSQVEMEIVKLLKENTTLLRLG 339
Cdd:COG5238 298 DLSVNRI-GDEGAIALAEGLQGNKTLHTLN 326
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-340 1.69e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 223 VNLNNIEnITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHN 302
Cdd:COG5238 185 VYLGCNQ-IGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNN 263

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74315957 303 TVLTELRF-HNQrhiMGSQVEMEIVKLLKENTTL--LRLGY 340
Cdd:COG5238 264 TTVETLYLsGNQ---IGAEGAIALAKALQGNTTLtsLDLSV 301
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-338 2.15e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 230 NITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELr 309
Cdd:COG5238 275 QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSL- 353

                        90       100       110
                ....*....|....*....|....*....|...
gi 74315957 310 fhnqrHIMGSQVEME----IVKLLKENTTLLRL 338
Cdd:COG5238 354 -----DLSDNQIGDEgaiaLAKYLEGNTTLREL 381
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 209-357 8.02e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 8.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 209 ALEKIRNNDPDTTEVNLNNIeNITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFIT 288
Cdd:COG5238 283 ALAKALQGNTTLTSLDLSVN-RIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIG 361

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315957 289 GKGILAIMRALQHNTVLTELrfHNQRHIMGSQVEMEIVKLLKENT-TLLRLGYHFELPGPRMSMTSILTR 357
Cdd:COG5238 362 DEGAIALAKYLEGNTTLREL--NLGKNNIGKQGAEALIDALQTNRlHTLILDGNLIGAEAQQRLEQLLER 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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