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Conserved domains on  [gi|18087793|ref|NP_444370|]
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protocadherin beta-7 [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 4.58e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 147.67  E-value: 4.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    30 QLQYSVAEETERGTFLANLAKDLGLGLGELSAREARIVSDQNTRFLLLSPLTGELILNEKLDREELCGPTEPCVLTFQLL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 18087793   110 LE 111
Cdd:pfam08266  81 LE 82
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-769 1.46e-31

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 118.01  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   686 ELTLYLVIALASVSSLFLVSVLLFVGVRLCRRARAA----SPGVCFVPEEHFPGHlvdvSGAGTLSQNYQYEVCLTGGSG 761
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSAllqsSGNLCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 18087793   762 iTSEFKFL 769
Cdd:pfam16492  77 -KSEFKFL 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-343 1.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 247 YKVQSPENTPVGSLVVAVSARDLDTGSYGQIDYTFFYATEriLQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGGG 326
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 18087793 327 --LSGKCAVVVEVMDVNDN 343
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 1.50e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.50e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 455 SYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAI 534
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087793 535 DQGSPALSSQALVRVVILDDNDN 557
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 5.02e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.02e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 140 LKISESTTPGATLLLERAQDADVGTNSLSNYTISPND---YFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 18087793 217 GGSPPRSGTALVQILVLDINDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-664 2.76e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.76e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 571 PYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEP 650
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....
gi 18087793 651 PRSASVTLHVLLVD 664
Cdd:cd11304  81 PLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-447 1.68e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 356 IPENSQE-TVVAVFKIRDRDSGNNGKTLCSIAN---DLPFVLKPsveNFYTLVTEKPLDRESNTEYNITITVTDMGIPRL 431
Cdd:cd11304   6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087793 432 TTQHTITVQVSDINDN 447
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 4.58e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 147.67  E-value: 4.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    30 QLQYSVAEETERGTFLANLAKDLGLGLGELSAREARIVSDQNTRFLLLSPLTGELILNEKLDREELCGPTEPCVLTFQLL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 18087793   110 LE 111
Cdd:pfam08266  81 LE 82
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-769 1.46e-31

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 118.01  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   686 ELTLYLVIALASVSSLFLVSVLLFVGVRLCRRARAA----SPGVCFVPEEHFPGHlvdvSGAGTLSQNYQYEVCLTGGSG 761
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSAllqsSGNLCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 18087793   762 iTSEFKFL 769
Cdd:pfam16492  77 -KSEFKFL 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-343 1.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 247 YKVQSPENTPVGSLVVAVSARDLDTGSYGQIDYTFFYATEriLQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGGG 326
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 18087793 327 --LSGKCAVVVEVMDVNDN 343
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 1.50e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.50e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 455 SYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAI 534
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087793 535 DQGSPALSSQALVRVVILDDNDN 557
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 5.02e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.02e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 140 LKISESTTPGATLLLERAQDADVGTNSLSNYTISPND---YFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 18087793 217 GGSPPRSGTALVQILVLDINDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-664 2.76e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.76e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 571 PYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEP 650
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....
gi 18087793 651 PRSASVTLHVLLVD 664
Cdd:cd11304  81 PLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-447 1.68e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 356 IPENSQE-TVVAVFKIRDRDSGNNGKTLCSIAN---DLPFVLKPsveNFYTLVTEKPLDRESNTEYNITITVTDMGIPRL 431
Cdd:cd11304   6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087793 432 TTQHTITVQVSDINDN 447
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-240 8.49e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 8.49e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    156 RAQDADVGTNSLSNYTISPND---YFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALDGGSPPRSGTALVQILV 232
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 18087793    233 LDINDNSP 240
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 1.44e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    474 SATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAIDQGSPALSSQALVRVVILD 553
Cdd:smart00112   1 SATDADSGENGKVTYSI-LSGND----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 18087793    554 DNDNAP 559
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 2.45e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 2.45e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    265 SARDLDTGSYGQIDYTFFYATERILqtFQINSTSGELYLKRELNYEAIQTYSITIQARDGGG--LSGKCAVVVEVMDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL--FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 18087793    343 NPP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 371-449 1.20e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    371 RDRDSGNNGKTLCSIA---NDLPFVLKPSVEnfyTLVTEKPLDRESNTEYNITITVTDMGIPRLTTQHTITVQVSDINDN 447
Cdd:smart00112   3 TDADSGENGKVTYSILsgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 18087793    448 AP 449
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
456-552 2.45e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   456 YTMFVRENNSPALHIGTISATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAID 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGP----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 18087793   536 QGSPALSSQALVRVVIL 552
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-664 8.23e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 8.23e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18087793    590 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEPPRSASVTLHVLLVD 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
247-337 2.09e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   247 YKVQSPENTPVGSLVVAVSARDLDTGSYGQIDYTFfyATERILQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|...
gi 18087793   326 -GLSGKCAVVVEV 337
Cdd:pfam00028  79 pPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 2.09e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   142 ISESTTPGATLLLERAQDADVGTNSLSNYTIS---PNDYFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 18087793   219 SPPRSGTALVQILVL 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
572-662 2.47e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   572 YTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEPP 651
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 18087793   652 RSASVTLHVLL 662
Cdd:pfam00028  81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-441 7.21e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 7.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   356 IPENSQE-TVVAVFKIRDRDSGNNGKTLCSIANDLPFvlkpsvENFY------TLVTEKPLDRESNTEYNITITVTDMGI 428
Cdd:pfam00028   5 VPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPG------GNFRidpdtgDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|...
gi 18087793   429 PRLTTQHTITVQV 441
Cdd:pfam00028  79 PPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 1.75e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 49.65  E-value: 1.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793  33 YSVAEETERGTFLANLAKDlglgLGELSAREARIVS---DQNTRFLLLSPLTGELILNEKLDREELcgptepCVLTFQLL 109
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTD----LIASSGEIIKISAagkEALPSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                        90       100
                ....*....|....*....|....*
gi 18087793 110 LERPF-----QIYRAALHIKDINDN 129
Cdd:cd00031  74 AASLGanvpqTSSVFSIEVYDENDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 4.58e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 147.67  E-value: 4.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    30 QLQYSVAEETERGTFLANLAKDLGLGLGELSAREARIVSDQNTRFLLLSPLTGELILNEKLDREELCGPTEPCVLTFQLL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 18087793   110 LE 111
Cdd:pfam08266  81 LE 82
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-769 1.46e-31

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 118.01  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   686 ELTLYLVIALASVSSLFLVSVLLFVGVRLCRRARAA----SPGVCFVPEEHFPGHlvdvSGAGTLSQNYQYEVCLTGGSG 761
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSAllqsSGNLCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 18087793   762 iTSEFKFL 769
Cdd:pfam16492  77 -KSEFKFL 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-343 1.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 1.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 247 YKVQSPENTPVGSLVVAVSARDLDTGSYGQIDYTFFYATEriLQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGGG 326
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 18087793 327 --LSGKCAVVVEVMDVNDN 343
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 1.50e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.50e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 455 SYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAI 534
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087793 535 DQGSPALSSQALVRVVILDDNDN 557
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 5.02e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.02e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 140 LKISESTTPGATLLLERAQDADVGTNSLSNYTISPND---YFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 18087793 217 GGSPPRSGTALVQILVLDINDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-664 2.76e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.76e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 571 PYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEP 650
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....
gi 18087793 651 PRSASVTLHVLLVD 664
Cdd:cd11304  81 PLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-447 1.68e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793 356 IPENSQE-TVVAVFKIRDRDSGNNGKTLCSIAN---DLPFVLKPsveNFYTLVTEKPLDRESNTEYNITITVTDMGIPRL 431
Cdd:cd11304   6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087793 432 TTQHTITVQVSDINDN 447
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-240 8.49e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 8.49e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    156 RAQDADVGTNSLSNYTISPND---YFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALDGGSPPRSGTALVQILV 232
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 18087793    233 LDINDNSP 240
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 1.44e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    474 SATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAIDQGSPALSSQALVRVVILD 553
Cdd:smart00112   1 SATDADSGENGKVTYSI-LSGND----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 18087793    554 DNDNAP 559
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 2.45e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 2.45e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    265 SARDLDTGSYGQIDYTFFYATERILqtFQINSTSGELYLKRELNYEAIQTYSITIQARDGGG--LSGKCAVVVEVMDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL--FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 18087793    343 NPP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 371-449 1.20e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793    371 RDRDSGNNGKTLCSIA---NDLPFVLKPSVEnfyTLVTEKPLDRESNTEYNITITVTDMGIPRLTTQHTITVQVSDINDN 447
Cdd:smart00112   3 TDADSGENGKVTYSILsgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 18087793    448 AP 449
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
456-552 2.45e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   456 YTMFVRENNSPALHIGTISATDSDSGSNAHITYSLrLPHDPqlalDSLISINADNGQLFALRALDYEALQAFEFHVGAID 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGP----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 18087793   536 QGSPALSSQALVRVVIL 552
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-664 8.23e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 8.23e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18087793    590 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEPPRSASVTLHVLLVD 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
247-337 2.09e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   247 YKVQSPENTPVGSLVVAVSARDLDTGSYGQIDYTFfyATERILQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|...
gi 18087793   326 -GLSGKCAVVVEV 337
Cdd:pfam00028  79 pPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 2.09e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   142 ISESTTPGATLLLERAQDADVGTNSLSNYTIS---PNDYFHIHVHDGgegpiipELVLDKMLDREEIPEFTLTLTALDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 18087793   219 SPPRSGTALVQILVL 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
572-662 2.47e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   572 YTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEPP 651
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 18087793   652 RSASVTLHVLL 662
Cdd:pfam00028  81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-441 7.21e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 7.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793   356 IPENSQE-TVVAVFKIRDRDSGNNGKTLCSIANDLPFvlkpsvENFY------TLVTEKPLDRESNTEYNITITVTDMGI 428
Cdd:pfam00028   5 VPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPG------GNFRidpdtgDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|...
gi 18087793   429 PRLTTQHTITVQV 441
Cdd:pfam00028  79 PPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 1.75e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 49.65  E-value: 1.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793  33 YSVAEETERGTFLANLAKDlglgLGELSAREARIVS---DQNTRFLLLSPLTGELILNEKLDREELcgptepCVLTFQLL 109
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTD----LIASSGEIIKISAagkEALPSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                        90       100
                ....*....|....*....|....*
gi 18087793 110 LERPF-----QIYRAALHIKDINDN 129
Cdd:cd00031  74 AASLGanvpqTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 9.66e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 9.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087793  32 QYSVAEETERGTFLANL-AKDLGLGL-GELSARearIVSDQNTRFLLLSPLTGELILNEKLDREELCgptepcvlTFQLL 109
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGEnGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQS--------SYTLT 71

                        90       100
                ....*....|....*....|....*..
gi 18087793 110 LE-----RPFQIYRAALHIK--DINDN 129
Cdd:cd11304  72 VTatdggGPPLSSTATVTITvlDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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