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Conserved domains on  [gi|16945972|ref|NP_476502|]
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kelch domain-containing protein 3 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-308 4.78e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 127.19  E-value: 4.78e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  14 RVNHAAVAVGHRVYSFGGYCSGEDYETlrqidVHIFNAVSLRWTKLPPVksairgqaPVVPymRYGHSTVLIDDTVLLWG 93
Cdd:COG3055  13 RSEAAAALLDGKVYVAGGLSGGSASNS-----FEVYDPATNTWSELAPL--------PGPP--RHHAAAVAQDGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  94 GRNDTEGACNVL---YAFDVNTHKWftpRVSGTVPGARDGHSACVLGKIMYIFGGYeqQADCFSNDIHKLDTSTMTWTli 170
Cdd:COG3055  78 GFTGANPSSTPLndvYVYDPATNTW---TKLAPMPTPRGGATALLLDGKIYVVGGW--DDGGNVAWVEVYDPATGTWT-- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 171 cTKGSPARWRDFHSATMLGS-HMYVFGGRAdrfgpfhsnneiycnrirvFDTRTEAWLDCPPtpvLPEGRRSHSAFGYNG 249
Cdd:COG3055 151 -QLAPLPTPRDHLAAAVLPDgKILVIGGRN-------------------GSGFSNTWTTLAP---LPTARAGHAAAVLGG 207

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16945972 250 ELYIFGGYNArlnrHFHDLWKFNPVSFTWKKIepkGKGPCPRRRQCCCIVGDKIVLFGG 308
Cdd:COG3055 208 KILVFGGESG----FSDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGG 259
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-308 4.78e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 127.19  E-value: 4.78e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  14 RVNHAAVAVGHRVYSFGGYCSGEDYETlrqidVHIFNAVSLRWTKLPPVksairgqaPVVPymRYGHSTVLIDDTVLLWG 93
Cdd:COG3055  13 RSEAAAALLDGKVYVAGGLSGGSASNS-----FEVYDPATNTWSELAPL--------PGPP--RHHAAAVAQDGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  94 GRNDTEGACNVL---YAFDVNTHKWftpRVSGTVPGARDGHSACVLGKIMYIFGGYeqQADCFSNDIHKLDTSTMTWTli 170
Cdd:COG3055  78 GFTGANPSSTPLndvYVYDPATNTW---TKLAPMPTPRGGATALLLDGKIYVVGGW--DDGGNVAWVEVYDPATGTWT-- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 171 cTKGSPARWRDFHSATMLGS-HMYVFGGRAdrfgpfhsnneiycnrirvFDTRTEAWLDCPPtpvLPEGRRSHSAFGYNG 249
Cdd:COG3055 151 -QLAPLPTPRDHLAAAVLPDgKILVIGGRN-------------------GSGFSNTWTTLAP---LPTARAGHAAAVLGG 207

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16945972 250 ELYIFGGYNArlnrHFHDLWKFNPVSFTWKKIepkGKGPCPRRRQCCCIVGDKIVLFGG 308
Cdd:COG3055 208 KILVFGGESG----FSDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGG 259
PLN02153 PLN02153
epithiospecifier protein
 74-318 1.45e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 73.87  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   74 PYMRYGHSTVLIDDTVLLWGGRNDTEGACNV-LYAFDVNTHKWFTPRVSGTVPGARD-GHSACVLGKIMYIFGGYEQQAD 151
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGELKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRISClGVRMVAVGTKLYIFGGRDEKRE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  152 cfSNDIHKLDTSTMTWTLIcTK----GSPARwRDFHSATMLGSHMYVFGGRADrfGPFHSNNEIYcNRIRVFDTRTEAWL 227
Cdd:PLN02153 100 --FSDFYSYDTVKNEWTFL-TKldeeGGPEA-RTFHSMASDENHVYVFGGVSK--GGLMKTPERF-RTIEAYNIADGKWV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  228 DCpPTPVLPEGRRSHSAFGY-NGELYIFGGY------NARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG 300
Cdd:PLN02153 173 QL-PDPGENFEKRGGAGFAVvQGKIWVVYGFatsilpGGKSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVG 251

                        250
                 ....*....|....*....
gi 16945972  301 DKIVLFGGTS-PSPEEGLG 318
Cdd:PLN02153 252 KYIIIFGGEVwPDLKGHLG 270
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 128-168 5.60e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 43.09  E-value: 5.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 16945972   128 RDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWT 168
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWT 42
Kelch smart00612
Kelch domain;
191-244 9.86e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 33.69  E-value: 9.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16945972    191 HMYVFGGRadrfgpfhsNNEIYCNRIRVFDTRTEAWLDCPPtpvLPEGRRSHSA 244
Cdd:smart00612   1 KIYVVGGF---------DGGQRLKSVEVYDPETNKWTPLPS---MPTPRSGHGV 42
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-308 4.78e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 127.19  E-value: 4.78e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  14 RVNHAAVAVGHRVYSFGGYCSGEDYETlrqidVHIFNAVSLRWTKLPPVksairgqaPVVPymRYGHSTVLIDDTVLLWG 93
Cdd:COG3055  13 RSEAAAALLDGKVYVAGGLSGGSASNS-----FEVYDPATNTWSELAPL--------PGPP--RHHAAAVAQDGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  94 GRNDTEGACNVL---YAFDVNTHKWftpRVSGTVPGARDGHSACVLGKIMYIFGGYeqQADCFSNDIHKLDTSTMTWTli 170
Cdd:COG3055  78 GFTGANPSSTPLndvYVYDPATNTW---TKLAPMPTPRGGATALLLDGKIYVVGGW--DDGGNVAWVEVYDPATGTWT-- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 171 cTKGSPARWRDFHSATMLGS-HMYVFGGRAdrfgpfhsnneiycnrirvFDTRTEAWLDCPPtpvLPEGRRSHSAFGYNG 249
Cdd:COG3055 151 -QLAPLPTPRDHLAAAVLPDgKILVIGGRN-------------------GSGFSNTWTTLAP---LPTARAGHAAAVLGG 207

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16945972 250 ELYIFGGYNArlnrHFHDLWKFNPVSFTWKKIepkGKGPCPRRRQCCCIVGDKIVLFGG 308
Cdd:COG3055 208 KILVFGGESG----FSDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
11-260 9.60e-33

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 123.73  E-value: 9.60e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  11 GPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQiDVHIFNAVSLRWTKLPPVksairgqapvvPYMRYGHSTVLIDDTVL 90
Cdd:COG3055  58 GPPRHHAAAVAQDGKLYVFGGFTGANPSSTPLN-DVYVYDPATNTWTKLAPM-----------PTPRGGATALLLDGKIY 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  91 LWGGRNDtEGACNVLYAFDVNTHKWftpRVSGTVPGARDGHSACVL--GKImYIFGGYEQQAdcfsndihkldtSTMTWT 168
Cdd:COG3055 126 VVGGWDD-GGNVAWVEVYDPATGTW---TQLAPLPTPRDHLAAAVLpdGKI-LVIGGRNGSG------------FSNTWT 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 169 licTKGSPARWRDFHSATMLGSHMYVFGGRadrfGPFHSNNEIYcnrirvfDTRTEAWLdcpPTPVLPEGRRSHSAFGYN 248
Cdd:COG3055 189 ---TLAPLPTARAGHAAAVLGGKILVFGGE----SGFSDEVEAY-------DPATNTWT---ALGELPTPRHGHAAVLTD 251

                       250
                ....*....|..
gi 16945972 249 GELYIFGGYNAR 260
Cdd:COG3055 252 GKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
56-310 4.07e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.23  E-value: 4.07e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  56 WTKLPPVksairgqapvvPYMRYGHSTVLIDDTVLLWGGrNDTEGACNVLYAFDVNTHKWftpRVSGTVPGARDGHSACV 135
Cdd:COG3055   3 WSSLPDL-----------PTPRSEAAAALLDGKVYVAGG-LSGGSASNSFEVYDPATNTW---SELAPLPGPPRHHAAAV 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 136 L--GKImYIFGGYEQQAD--CFSNDIHKLDTSTMTWTlicTKGSPARWRDFHSATMLGSHMYVFGGRadrfgpfhsNNEI 211
Cdd:COG3055  68 AqdGKL-YVFGGFTGANPssTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGKIYVVGGW---------DDGG 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 212 YCNRIRVFDTRTEAWLdcpPTPVLPEGRRSHSA-FGYNGELYIFGGYNarlnrhfhdlwkFNPVSFTWKKIEPKgkgPCP 290
Cdd:COG3055 135 NVAWVEVYDPATGTWT---QLAPLPTPRDHLAAaVLPDGKILVIGGRN------------GSGFSNTWTTLAPL---PTA 196

                       250       260
                ....*....|....*....|
gi 16945972 291 RRRQCCCIVGDKIVLFGGTS 310
Cdd:COG3055 197 RAGHAAAVLGGKILVFGGES 216
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-197 5.23e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.50  E-value: 5.23e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYEtlrqiDVHIFNAVSLRWTKLPPvksairgqapvVPYMRYGHS- 81
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA-----WVEVYDPATGTWTQLAP-----------LPTPRDHLAa 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  82 TVLIDDTVLLWGGRNDTegacnvlyafdVNTHKWFTPrvsGTVPGARDGHSACVLGKIMYIFGGYEQqadcFSNDIHKLD 161
Cdd:COG3055 165 AVLPDGKILVIGGRNGS-----------GFSNTWTTL---APLPTARAGHAAAVLGGKILVFGGESG----FSDEVEAYD 226

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16945972 162 TSTMTWTLICTKGSParwRDFHSATMLGSHMYVFGG 197
Cdd:COG3055 227 PATNTWTALGELPTP---RHGHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
180-322 5.48e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.50  E-value: 5.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972 180 RDFHSATMLGSHMYVFGGradrfgpfhSNNEIYCNRIRVFDTRTEAWLdcpPTPVLPEGRRSHSA-FGYNGELYIFGGYN 258
Cdd:COG3055  13 RSEAAAALLDGKVYVAGG---------LSGGSASNSFEVYDPATNTWS---ELAPLPGPPRHHAAaVAQDGKLYVFGGFT 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16945972 259 ARLN--RHFHDLWKFNPVSFTWKKIEPkgkGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFD 322
Cdd:COG3055  81 GANPssTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYD 143
PLN02153 PLN02153
epithiospecifier protein
 74-318 1.45e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 73.87  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   74 PYMRYGHSTVLIDDTVLLWGGRNDTEGACNV-LYAFDVNTHKWFTPRVSGTVPGARD-GHSACVLGKIMYIFGGYEQQAD 151
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGELKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRISClGVRMVAVGTKLYIFGGRDEKRE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  152 cfSNDIHKLDTSTMTWTLIcTK----GSPARwRDFHSATMLGSHMYVFGGRADrfGPFHSNNEIYcNRIRVFDTRTEAWL 227
Cdd:PLN02153 100 --FSDFYSYDTVKNEWTFL-TKldeeGGPEA-RTFHSMASDENHVYVFGGVSK--GGLMKTPERF-RTIEAYNIADGKWV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  228 DCpPTPVLPEGRRSHSAFGY-NGELYIFGGY------NARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG 300
Cdd:PLN02153 173 QL-PDPGENFEKRGGAGFAVvQGKIWVVYGFatsilpGGKSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVG 251

                        250
                 ....*....|....*....
gi 16945972  301 DKIVLFGGTS-PSPEEGLG 318
Cdd:PLN02153 252 KYIIIFGGEVwPDLKGHLG 270
PLN02193 PLN02193
nitrile-specifier protein
 74-322 1.83e-14

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 74.61  E-value: 1.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   74 PYMRYGHSTVLIDDTVLLWGGR-NDTEGACNVLYAFDVNTHKWFTPRVSGTVPgardgHSACV------LGKIMYIFGGy 146
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGEfTPNQPIDKHLYVFDLETRTWSISPATGDVP-----HLSCLgvrmvsIGSTLYVFGG- 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  147 eQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRfgpfhsnneiycNRIRVFDTRT--- 223
Cdd:PLN02193 237 -RDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSAT------------ARLKTLDSYNivd 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  224 EAWLDCPpTPVlpegrRSHSAFG------YNGELYIFGGYNARlnrHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCC 297
Cdd:PLN02193 304 KKWFHCS-TPG-----DSFSIRGgaglevVQGKVWVVYGFNGC---EVDDVHYYDPVQDKWTQVETFGVRPSERSVFASA 374

                        250       260
                 ....*....|....*....|....*...
gi 16945972  298 IVGDKIVLFGG---TSPSPEEGLGDEFD 322
Cdd:PLN02193 375 AVGKHIVIFGGeiaMDPLAHVGPGQLTD 402
PLN02153 PLN02153
epithiospecifier protein
 9-198 5.48e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 69.24  E-value: 5.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972    9 EGGPR-RVNHAAVAVGHRVYSFGGYCSGEDYET---LRQIDVhiFNAVSLRWTKLPPVKSAI--RGQA--PVVP---YMR 77
Cdd:PLN02153 122 EGGPEaRTFHSMASDENHVYVFGGVSKGGLMKTperFRTIEA--YNIADGKWVQLPDPGENFekRGGAgfAVVQgkiWVV 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   78 YGHSTVLIDdtvllwGGRNDTEGacNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGyEQQAD------ 151
Cdd:PLN02153 200 YGFATSILP------GGKSDYES--NAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGG-EVWPDlkghlg 270

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 16945972  152 --CFSNDIHKLDTSTMTWTLICTKGSPAR---WRDFHSATMLGSH-MYVFGGR 198
Cdd:PLN02153 271 pgTLSNEGYALDTETLVWEKLGECGEPAMprgWTAYTTATVYGKNgLLMHGGK 323
PLN02193 PLN02193
nitrile-specifier protein
 167-330 4.22e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 64.21  E-value: 4.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  167 WTLICTKGSPARWRDFHSATMLGSHMYVFGGRadrFGPfhsnNEIYCNRIRVFDTRTEAWLDCPPTPVLPE----GRRSH 242
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGE---FTP----NQPIDKHLYVFDLETRTWSISPATGDVPHlsclGVRMV 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  243 SAfgyNGELYIFGGYNArlNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFD 322
Cdd:PLN02193 226 SI---GSTLYVFGGRDA--SRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYN 300


                 ....*...
gi 16945972  323 LIDHSDLH 330
Cdd:PLN02193 301 IVDKKWFH 308
PLN02153 PLN02153
epithiospecifier protein
 122-256 9.96e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.31  E-value: 9.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  122 GTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFH-SATMLGSHMYVFGGRAD 200
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRISCLGvRMVAVGTKLYIFGGRDE 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  201 R--FGPFHSnneiycnrirvFDTRTEAWLDCPPTPVL--PEGRRSHSAFGYNGELYIFGG 256
Cdd:PLN02153  97 KreFSDFYS-----------YDTVKNEWTFLTKLDEEggPEARTFHSMASDENHVYVFGG 145
PHA03098 PHA03098
kelch-like protein; Provisional
 77-308 2.08e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 62.09  E-value: 2.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   77 RYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFtprvsgTVP---GARDGHSACVLGKIMYIFGGYEQqaDCF 153
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWN------KVPeliYPRKNPGVTVFNNRIYVIGGIYN--SIS 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  154 SNDIHKLDTSTMTWT----LICTKGSParwrdfhSATMLGSHMYVFGGRadrfgpfhSNNEIYCNRIRVFDTRTEAWLDC 229
Cdd:PHA03098 357 LNTVESWKPGESKWReeppLIFPRYNP-------CVVNVNNLIYVIGGI--------SKNDELLKTVECFSLNTNKWSKG 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  230 PPTPVLPEGrrsHSAFGYNGELYIFGGYNARLNRH-FHDLWKFNPVSFTWKKIEPKGKgpcPRRRQCCCIVGDKIVLFGG 308
Cdd:PHA03098 422 SPLPISHYG---GCAIYHDGKIYVIGGISYIDNIKvYNIVESYNPVTNKWTELSSLNF---PRINASLCIFNNKIYVVGG 495
PHA03098 PHA03098
kelch-like protein; Provisional
 14-235 2.70e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.38  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   14 RVNHAAVAVGHRVYSFGGycsgedyetlrqIDVHIFNAVSLRWTklpPVKSAIRGQAPVVpYMRYGHSTVLIDDTVLLWG 93
Cdd:PHA03098 333 RKNPGVTVFNNRIYVIGG------------IYNSISLNTVESWK---PGESKWREEPPLI-FPRYNPCVVNVNNLIYVIG 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   94 GRNDTEGACNVLYAFDVNTHKWFTPRVSgtvPGARDGHSACVLGKIMYIFGG--YEQQADCFSNdIHKLDTSTMTWT--- 168
Cdd:PHA03098 397 GISKNDELLKTVECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGisYIDNIKVYNI-VESYNPVTNKWTels 472

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16945972  169 -LICTKGSParwrdfhSATMLGSHMYVFGGradrfgpfhSNNEIYCNRIRVFDTRTEAW-LDCPPTPVL 235
Cdd:PHA03098 473 sLNFPRINA-------SLCIFNNKIYVVGG---------DKYEYYINEIEVYDDKTNTWtLFCKFPKVI 525
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 128-168 5.60e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 43.09  E-value: 5.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 16945972   128 RDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWT 168
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWT 42
Kelch_3 pfam13415
Galactose oxidase, central domain;
137-186 6.61e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 6.61e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16945972   137 GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSParwRDFHSAT 186
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPP---RSGHSAT 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
86-136 1.15e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 1.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16945972    86 DDTVLLWGGRNDTEGAC-NVLYAFDVNTHKWFTPrvsGTVPGARDGHSACVL 136
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRlNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 125-164 1.36e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 41.78  E-value: 1.36e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 16945972   125 PGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTST 164
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPT 40
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 236-276 2.31e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 41.01  E-value: 2.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 16945972   236 PEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSF 276
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPTF 41
Kelch_6 pfam13964
Kelch motif;
14-61 2.38e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 2.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 16945972    14 RVNHAAVAVGHRVYSFGGYCSGEDYetlrQIDVHIFNAVSLRWTKLPP 61
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPA----LNKLEVYNPLTKSWEELPP 45
PLN02772 PLN02772
guanylate kinase
 81-145 2.87e-05

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 45.60  E-value: 2.87e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16945972   81 STVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL--GKIMYIFGG 145
Cdd:PLN02772  29 TSVTIGDKTYVIGGNHEGNTLSIGVQILDKITNNWVSPIVLGTGPKPCKGYSAVVLnkDRILVIKKG 95
Kelch_4 pfam13418
Galactose oxidase, central domain;
13-64 4.38e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.67  E-value: 4.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 16945972    13 RRVNHAAVAVG-HRVYSFGGYcsGEDYETLrqIDVHIFNAVSLRWTKLPPVKS 64
Cdd:pfam13418   1 PRAYHTSTSIPdDTIYLFGGE--GEDGTLL--SDLWVFDLSTNEWTRLGSLPS 49
PLN02193 PLN02193
nitrile-specifier protein
 8-203 4.65e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972    8 LEGGPR-RVNHAAVAVGHRVYSFGGYCSGEDYETLRQidvhiFNAVSLRW--TKLPPVKSAIRGQA--PVVP---YMRYG 79
Cdd:PLN02193 262 VEEGPTpRSFHSMAADEENVYVFGGVSATARLKTLDS-----YNIVDKKWfhCSTPGDSFSIRGGAglEVVQgkvWVVYG 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   80 HSTVLIDDtvllwggrndtegacnvLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGyEQQADC------- 152
Cdd:PLN02193 337 FNGCEVDD-----------------VHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG-EIAMDPlahvgpg 398

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16945972  153 -FSNDIHKLDTSTMTW----TLICTKGSPAR--WRDFHSATMLGSH-MYVFGGRA---DRFG 203
Cdd:PLN02193 399 qLTDGTFALDTETLQWerldKFGEEEETPSSrgWTASTTGTIDGKKgLVMHGGKAptnDRFD 460
PRK14131 PRK14131
N-acetylneuraminate epimerase;
155-268 6.40e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.62  E-value: 6.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  155 NDIHKLDTSTMT--WTLICTKGSPARwrDFHSATMLGSHMYVFGG--RADRFGPFHSNNEIYcnrirVFDTRTEAWLDCP 230
Cdd:PRK14131  50 TSWYKLDLNAPSkgWTKIAAFPGGPR--EQAVAAFIDGKLYVFGGigKTNSEGSPQVFDDVY-----KYDPKTNSWQKLD 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 16945972  231 PTPvlPEGRRSHSAFGYNG-ELYIFGGYNARL-NRHFHDL 268
Cdd:PRK14131 123 TRS--PVGLAGHVAVSLHNgKAYITGGVNKNIfDGYFEDL 160
Kelch_3 pfam13415
Galactose oxidase, central domain;
248-299 9.39e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 9.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16945972   248 NGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIepkgkGPCPRRRQCCCIV 299
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQI-----GDLPPPRSGHSAT 47
Kelch_6 pfam13964
Kelch motif;
239-283 9.69e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.63  E-value: 9.69e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16945972   239 RRSHSAFGYNGELYIFGGYNARLNRHFhDLWKFNPVSFTWKKIEP 283
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALN-KLEVYNPLTKSWEELPP 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 239-283 1.04e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.52  E-value: 1.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16945972   239 RRSHSAFGYNGELYIFGGYNArlNRHFHDLWKFNPVSFTWKKIEP 283
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG--NQSLNSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
77-125 1.06e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.52  E-value: 1.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16945972    77 RYGHSTVLI-DDTVLLWGGRNDTEGACNVLYAFDVNTHKWftpRVSGTVP 125
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW---TRLGSLP 48
Kelch_6 pfam13964
Kelch motif;
179-234 1.44e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 1.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16945972   179 WRDFHSATMLGSHMYVFGGRADRFGPFhsnneiycNRIRVFDTRTEAWLDCPPTPV 234
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPAL--------NKLEVYNPLTKSWEELPPLPT 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
238-284 2.42e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16945972   238 GRRSHSAFG-YNGELYIFGGYNA---RLNrhfhDLWKFNPVSFTWKKIEPK 284
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEdgtLLS----DLWVFDLSTNEWTRLGSL 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 13-61 5.43e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 5.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 16945972    13 RRVNHAAVAVGHRVYSFGGYCSGEdyetlRQIDVHIFNAVSLRWTKLPP 61
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQ-----SLNSVEVYDPETNTWSKLPS 44
Kelch_6 pfam13964
Kelch motif;
76-115 6.10e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 6.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 16945972    76 MRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKW 115
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSW 40
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 13-62 7.42e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.93  E-value: 7.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 16945972    13 RRVNHAAVAVGHRVYSFGGYCSGEDyetLRQIDVHIFNAVSLRWTKLPPV 62
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGD---LSSSDVLVYDPETNVWTEVPRL 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 127-170 8.98e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 8.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16945972   127 ARDGHSACVLGKIMYIFGGYEqqADCFSNDIHKLDTSTMTWTLI 170
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD--GNQSLNSVEVYDPETNTWSKL 42
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-110 9.30e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 40.52  E-value: 9.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  14 RVNHAAVAVGHRVYSFGGYCSGEDyetlrqiDVHIFNAVSLRWTKLPPVksairgqapvvPYMRYGHSTVLIDDTVLLWG 93
Cdd:COG3055 197 RAGHAAAVLGGKILVFGGESGFSD-------EVEAYDPATNTWTALGEL-----------PTPRHGHAAVLTDGKVYVIG 258

                        90
                ....*....|....*..
gi 16945972  94 GRNDTEGACNVLYAFDV 110
Cdd:COG3055 259 GETKPGVRTPLVTSAEV 275
PRK14131 PRK14131
N-acetylneuraminate epimerase;
106-197 1.35e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.38  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972  106 YAFDVNT-HKWFTPRvsGTVPG-ARDGHSACVLGKIMYIFGGYEQQADCFS----NDIHKLDTSTMTWTLICTKgSParw 179
Cdd:PRK14131  53 YKLDLNApSKGWTKI--AAFPGgPREQAVAAFIDGKLYVFGGIGKTNSEGSpqvfDDVYKYDPKTNSWQKLDTR-SP--- 126

                         90       100
                 ....*....|....*....|.
gi 16945972  180 RDF--HSATML-GSHMYVFGG 197
Cdd:PRK14131 127 VGLagHVAVSLhNGKAYITGG 147
PRK14131 PRK14131
N-acetylneuraminate epimerase;
10-96 2.37e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 39.61  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16945972   10 GGPRrvNHA-AVAVGHRVYSFGGycSG-EDYETLRQI--DVHIFNAVSLRWTKLPPvksairgQAPVvpyMRYGHSTVLI 85
Cdd:PRK14131  72 GGPR--EQAvAAFIDGKLYVFGG--IGkTNSEGSPQVfdDVYKYDPKTNSWQKLDT-------RSPV---GLAGHVAVSL 137

                         90
                 ....*....|..
gi 16945972   86 DDT-VLLWGGRN 96
Cdd:PRK14131 138 HNGkAYITGGVN 149
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 180-231 7.77e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.12  E-value: 7.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16945972   180 RDFHSATMLGSHMYVFGGRadrfgpfhsNNEIYCNRIRVFDTRTEAWLDCPP 231
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGF---------DGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_6 pfam13964
Kelch motif;
127-170 8.07e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 8.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16945972   127 ARDGHSACVLGKIMYIFGGYEQQADcFSNDIHKLDTSTMTWTLI 170
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASP-ALNKLEVYNPLTKSWEEL 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
127-170 9.11e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 9.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16945972   127 ARDGHSACVLGK-IMYIFGGYEQQADcFSNDIHKLDTSTMTWTLI 170
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGGEGEDGT-LLSDLWVFDLSTNEWTRL 44
Kelch smart00612
Kelch domain;
191-244 9.86e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 33.69  E-value: 9.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16945972    191 HMYVFGGRadrfgpfhsNNEIYCNRIRVFDTRTEAWLDCPPtpvLPEGRRSHSA 244
Cdd:smart00612   1 KIYVVGGF---------DGGQRLKSVEVYDPETNKWTPLPS---MPTPRSGHGV 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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