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Conserved domains on  [gi|17981699|ref|NP_523240|]
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cyclin-dependent kinase 4 inhibitor C [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-161 1.68e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.87  E-value: 1.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17981699  88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-161 1.68e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.87  E-value: 1.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17981699  88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
46-128 1.75e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    46 KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFqADVNIEDNeGNLPLHLAAKEGHLRVVEFLVKH 125
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ...
gi 17981699   126 TAS 128
Cdd:pfam12796  84 GAD 86
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-159 6.95e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 65.37  E-value: 6.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   45 MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
Cdd:PHA02874 132 IKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLID 211

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 17981699  125 HTaSNVGHRNHKGDTACDLARLYGRNeVVSLMQAN 159
Cdd:PHA02874 212 HG-NHIMNKCKNGFTPLHNAIIHNRS-AIELLINN 244
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 102-128 1.08e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*..
gi 17981699    102 EGNLPLHLAAKEGHLRVVEFLVKHTAS 128
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-161 1.68e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.87  E-value: 1.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17981699  88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-161 5.53e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 92.32  E-value: 5.53e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   7 NELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTAL-QVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDT 85
Cdd:COG0666  56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLhAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17981699  86 LQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-167 1.11e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 1.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699  88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-161 1.46e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.21  E-value: 1.46e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQT 88
Cdd:COG0666  26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17981699  89 LLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:COG0666 106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177
Ank_2 pfam12796
Ankyrin repeats (3 copies);
46-128 1.75e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    46 KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFqADVNIEDNeGNLPLHLAAKEGHLRVVEFLVKH 125
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ...
gi 17981699   126 TAS 128
Cdd:pfam12796  84 GAD 86
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-161 5.85e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 5.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    74 IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVghrNHKGDTACDLARLYGRNEVV 153
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIV 77


                  ....*...
gi 17981699   154 SLMQANGA 161
Cdd:pfam12796  78 KLLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-159 6.95e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 65.37  E-value: 6.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   45 MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
Cdd:PHA02874 132 IKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLID 211

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 17981699  125 HTaSNVGHRNHKGDTACDLARLYGRNeVVSLMQAN 159
Cdd:PHA02874 212 HG-NHIMNKCKNGFTPLHNAIIHNRS-AIELLINN 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 49-160 2.99e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.44  E-value: 2.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   49 NPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA- 127
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAy 182

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17981699  128 SNVghRNHKGDTACDLARLYGRNEVVSLMQANG 160
Cdd:PHA02874 183 ANV--KDNNGESPLHNAAEYGDYACIKLLIDHG 213
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-140 1.96e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 1.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLaAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17981699  88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTA 140
Cdd:COG0666 237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 53-126 2.61e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 2.61e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17981699   53 ARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHT 126
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 42-161 1.31e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.03  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPL-------H------ 108
Cdd:PLN03192 530 LTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakHhkifri 609

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17981699  109 ------------------LAAKEGHLRVVEFLVKHtASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:PLN03192 610 lyhfasisdphaagdllcTAAKRNDLTAMKELLKQ-GLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-123 1.36e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 1.36e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17981699    73 VIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
12-100 1.98e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIArRLLLRGANPDLKDRtGFAVIHDAARAGFLDTLQTLL 90
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIV-KLLLEHADVNLKDN-GRTALHYAARSGHLEIVKLLL 81

                          90
                  ....*....|
gi 17981699    91 EFQADVNIED 100
Cdd:pfam12796  82 EKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 7-161 9.68e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 9.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    7 NELASAAARGDLEQLTSLLQNNV-NVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLD 84
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKfADDVFYKDGMTPLHLaTILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17981699   85 TLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKhTASNVGHRNHKGD-TACDLARLYGRNEVVSLMQANGA 161
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGA 226
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 46-161 1.90e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.36  E-value: 1.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   46 KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGF--LDTLQTLLEFQADVNIE----------------DNEGNLPL 107
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKnrvnyllsygvpinikDVYGFTPL 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17981699  108 HLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:PHA03100 197 HYAVYNNNPEFVKYLLDLGA-NPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-161 2.82e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.88  E-value: 2.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699  41 ALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE 120
Cdd:COG0666  25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 17981699 121 FLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:COG0666 105 LLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 55-128 3.62e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 3.62e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17981699   55 RLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA03095 PHA03095
ankyrin-like protein; Provisional
 36-142 4.77e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.48  E-value: 4.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   36 GFGRTALQV-MKLGNP---EIARRLLLRGANPDLKDRTGFAVIHDAARAGF-LDTLQTLLEFQADVNIEDNEGNLPLH-- 108
Cdd:PHA03095  45 EYGKTPLHLyLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvy 124

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17981699  109 LAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACD 142
Cdd:PHA03095 125 LSGFNINPKVIRLLLRKGA-DVNALDLYGMTPLA 157
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 49-128 7.66e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.57  E-value: 7.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   49 NPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAkeGHLR---VVEFLVKH 125
Cdd:PHA02878 180 DQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCKdydILKLLLEH 257


                 ...
gi 17981699  126 TAS 128
Cdd:PHA02878 258 GVD 260
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 51-161 2.17e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   51 EIARRLLLRGANPDLKDR-TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHtASN 129
Cdd:PHA02878 148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN-GAS 226

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17981699  130 VGHRNHKGDTACDLARLYGRN-EVVSLMQANGA 161
Cdd:PHA02878 227 TDARDKCGNTPLHISVGYCKDyDILKLLLEHGV 259
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 89-156 1.16e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 1.16e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17981699   89 LLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLM 156
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA-DPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 67-161 1.28e-05

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 42.94  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   67 DRTGFAVIHDAARAGFLD---TLQTLLEFQADVNIEDN-EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACD 142
Cdd:PHA02736  52 NRHGKQCVHIVSNPDKADpqeKLKLLMEWGADINGKERvFGNTPLHIAVYTQNYELATWLCNQPGVNMEILNYAFKTPYY 131

                         90       100
                 ....*....|....*....|.
gi 17981699  143 LArlYGRNE--VVSLMQANGA 161
Cdd:PHA02736 132 VA--CERHDakMMNILRAKGA 150
PHA03095 PHA03095
ankyrin-like protein; Provisional
 37-144 1.45e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   37 FGRTALQVMKLG---NPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDT--LQTLLEFQADVNIEDNEGNLPLHLAA 111
Cdd:PHA03095 186 RFRSLLHHHLQSfkpRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAA 265

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17981699  112 KEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLA 144
Cdd:PHA03095 266 VFNNPRACRRLIALGA-DINAVSSDGNTPLSLM 297
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-155 1.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   38 GRTALQVM-KLG-NPEIARRLLLRGANPDLKDRTGFAVIHDAARAG-FLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEG 114
Cdd:PHA02876 307 GETPLYLMaKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRN 386

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 17981699  115 HLRVVEFLVKHTAsNVGHRNHKGDTACDLArLYGRNEVVSL 155
Cdd:PHA02876 387 NVVIINTLLDYGA-DIEALSQKIGTALHFA-LCGTNPYMSV 425
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 9-152 1.94e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG----------------- 70
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAaSKGYEDCVLVLLKHACNVHIRDANGntalwnaisakhhkifr 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   71 ----FAVIHD----------AARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHK 136
Cdd:PLN03192 609 ilyhFASISDphaagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDD 688

                        170
                 ....*....|....*.
gi 17981699  137 GDTACDLARLYGRNEV 152
Cdd:PLN03192 689 DFSPTELRELLQKREL 704
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-144 2.38e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 2.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17981699    89 LLE-FQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHkGDTACDLA 144
Cdd:pfam13857   1 LLEhGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEE-GLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 49-127 7.41e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   49 NPEIARRLLLRGANPDLKDRTGFAVIHDAARAGF-----LDTLQTLLEFQADVNIEDNEGNLPLHLAA--KEGHLRVVEF 121
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEY 126


                 ....*.
gi 17981699  122 LVKHTA 127
Cdd:PHA03100 127 LLDNGA 132
Ank_5 pfam13857
Ankyrin repeats (many copies);
59-110 8.61e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 8.61e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 17981699    59 RGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLA 110
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 8-127 2.39e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.36  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699    8 ELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTL 86
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLaMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 17981699   87 QTLLE---FQADVNIEDneGNLPLHLAAKEGHLRVVEFLVKHTA 127
Cdd:PHA02875  85 EELLDlgkFADDVFYKD--GMTPLHLATILKKLDIMKLLIARGA 126
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-161 3.94e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 3.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   48 GNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQA--DVNIEDNEGnlPLHLAAKEGHLRVVEFLVKH 125
Cdd:PHA02875  13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEELLDL 90

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 17981699  126 T--ASNVGHRnhKGDTACDLARLYGRNEVVSLMQANGA 161
Cdd:PHA02875  91 GkfADDVFYK--DGMTPLHLATILKKLDIMKLLIARGA 126
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-156 5.36e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17981699   103 GNLPLHLAAKEGHLRVVEFLVKHTAsNVGHRNHKGDTACDLARLYGRNEVVSLM 156
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 102-128 1.08e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*..
gi 17981699    102 EGNLPLHLAAKEGHLRVVEFLVKHTAS 128
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 67-161 1.23e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 37.49  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   67 DRTGFAVIHDAA---RAGFLDTLQTLLEFQADVNI-EDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACD 142
Cdd:PHA02743  54 DHHGRQCTHMVAwydRANAVMKIELLVNMGADINArELGTGNTLLHIAASTKNYELAEWLCRQLGVNLGAINYQHETAYH 133

                         90
                 ....*....|....*....
gi 17981699  143 LARLYGRNEVVSLMQANGA 161
Cdd:PHA02743 134 IAYKMRDRRMMEILRANGA 152
Ank_4 pfam13637
Ankyrin repeats (many copies);
38-90 1.59e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 1.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17981699    38 GRTALQV-MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLL 90
Cdd:pfam13637   1 ELTALHAaAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02741 PHA02741
hypothetical protein; Provisional
 72-157 3.98e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 36.17  E-value: 3.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   72 AVIHDAARAgfLDTLQTLLEFQADVNIEDN-EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLygrN 150
Cdd:PHA02741  68 AEKHEAQLA--AEIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLAEWLCCQPGIDLHFCNADNKSPFELAID---N 142


                 ....*..
gi 17981699  151 EVVSLMQ 157
Cdd:PHA02741 143 EDVAMMQ 149
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 37-113 7.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 36.01  E-value: 7.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981699   37 FGRTALQ--VMKLGNPEIARRLLLRGANPDLKDRT-GFAVIHDAARAGflDTLQTLLEFQADVNIEDNEGNLPLHLAAKE 113
Cdd:PHA02878 233 CGNTPLHisVGYCKDYDILKLLLEHGVDVNAKSYIlGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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