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Conserved domains on  [gi|91598894|ref|NP_536706|]
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barttin [Mus musculus]

Protein Classification

Barttin domain-containing protein( domain architecture ID 10634547)

Barttin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Barttin pfam15462
Bartter syndrome, infantile, with sensorineural deafness (Barttin); Barttin is a family of ...
 27-241 1.61e-133

Bartter syndrome, infantile, with sensorineural deafness (Barttin); Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.


:

Pssm-ID: 464731  Cd Length: 223  Bit Score: 378.01  E-value: 1.61e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91598894    27 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALSLLETGLS-EVKSPQPPYVRLWEEAAYD 105
Cdd:pfam15462   1 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALGLLENGLAaEMKSPQPPYVRLWEEAAYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91598894   106 QSLPDFTHIQMKVMGYSEDPRPLLAPE---LKTGASSVREGEPRTAQAWMEAPVVVHRGSDENEGEKSHSQSSPSVG--P 180
Cdd:pfam15462  81 QSLPDFSHIQMKVMGYSEDPRPLLAPEqgqPQLGTSDGGEGGPRDAQAWVEAAVVVHRGSDEDEGERKPTQSRPGPPacP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 91598894   181 QGSAPLASFHDDLDVGSSEGSSLQPSP-NRDEPH--RQVPWASRGPLDRFSDFALIDDtPTSED 241
Cdd:pfam15462 161 QGPAPLASFQDDLDMGSSEGSSPNPSPpWGEEPNppPQEPWACRCQLDRFHDFALIDA-PTTED 223
 
Name Accession Description Interval E-value
Barttin pfam15462
Bartter syndrome, infantile, with sensorineural deafness (Barttin); Barttin is a family of ...
 27-241 1.61e-133

Bartter syndrome, infantile, with sensorineural deafness (Barttin); Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.


Pssm-ID: 464731  Cd Length: 223  Bit Score: 378.01  E-value: 1.61e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91598894    27 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALSLLETGLS-EVKSPQPPYVRLWEEAAYD 105
Cdd:pfam15462   1 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALGLLENGLAaEMKSPQPPYVRLWEEAAYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91598894   106 QSLPDFTHIQMKVMGYSEDPRPLLAPE---LKTGASSVREGEPRTAQAWMEAPVVVHRGSDENEGEKSHSQSSPSVG--P 180
Cdd:pfam15462  81 QSLPDFSHIQMKVMGYSEDPRPLLAPEqgqPQLGTSDGGEGGPRDAQAWVEAAVVVHRGSDEDEGERKPTQSRPGPPacP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 91598894   181 QGSAPLASFHDDLDVGSSEGSSLQPSP-NRDEPH--RQVPWASRGPLDRFSDFALIDDtPTSED 241
Cdd:pfam15462 161 QGPAPLASFQDDLDMGSSEGSSPNPSPpWGEEPNppPQEPWACRCQLDRFHDFALIDA-PTTED 223
 
Name Accession Description Interval E-value
Barttin pfam15462
Bartter syndrome, infantile, with sensorineural deafness (Barttin); Barttin is a family of ...
 27-241 1.61e-133

Bartter syndrome, infantile, with sensorineural deafness (Barttin); Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.


Pssm-ID: 464731  Cd Length: 223  Bit Score: 378.01  E-value: 1.61e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91598894    27 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALSLLETGLS-EVKSPQPPYVRLWEEAAYD 105
Cdd:pfam15462   1 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALGLLENGLAaEMKSPQPPYVRLWEEAAYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91598894   106 QSLPDFTHIQMKVMGYSEDPRPLLAPE---LKTGASSVREGEPRTAQAWMEAPVVVHRGSDENEGEKSHSQSSPSVG--P 180
Cdd:pfam15462  81 QSLPDFSHIQMKVMGYSEDPRPLLAPEqgqPQLGTSDGGEGGPRDAQAWVEAAVVVHRGSDEDEGERKPTQSRPGPPacP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 91598894   181 QGSAPLASFHDDLDVGSSEGSSLQPSP-NRDEPH--RQVPWASRGPLDRFSDFALIDDtPTSED 241
Cdd:pfam15462 161 QGPAPLASFQDDLDMGSSEGSSPNPSPpWGEEPNppPQEPWACRCQLDRFHDFALIDA-PTTED 223
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 9-48 1.15e-04

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 40.94  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 91598894     9 IGFIVLGLFLLSLGTFLMSHDRPQVYGTFYAMGSVMVIGG 48
Cdd:pfam04178   5 GICLLLGVLCFFLSFFLFVLAKPRKFALLYTLGNILFLGS 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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