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Conserved domains on  [gi|288541297|ref|NP_570843|]
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leucine-rich repeat-containing protein 15 isoform b precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-443 5.69e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 5.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  44 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 123
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 124 LDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVL 202
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSgNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 203 RLYENRLTDIPMGtFDGLVNLQELALQQNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSvFMQLPQLNRLTLFGNSLK 282
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 283 ELsPGIFGpMPNLRELWLYDNHISSLPDNvfSNLRQLQVLILSRNQISFISPGAFNGLTELreLSLHTNALQDLDGNVFR 362
Cdd:COG4886  242 DL-PELGN-LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 442
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 .
gi 288541297 443 P 443
Cdd:COG4886  396 T 396
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-443 5.69e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 5.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  44 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 123
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 124 LDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVL 202
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSgNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 203 RLYENRLTDIPMGtFDGLVNLQELALQQNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSvFMQLPQLNRLTLFGNSLK 282
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 283 ELsPGIFGpMPNLRELWLYDNHISSLPDNvfSNLRQLQVLILSRNQISFISPGAFNGLTELreLSLHTNALQDLDGNVFR 362
Cdd:COG4886  242 DL-PELGN-LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 442
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 .
gi 288541297 443 P 443
Cdd:COG4886  396 T 396
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-401 1.95e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  75 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLQIqPAHFSQCSNLKE 153
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPI-PSSLGNLKNLQY 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 154 LQLHGNHLE-YIPDGAFDhLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT-DIPMGtFDGLVNLQELALQQN 231
Cdd:PLN00113 265 LFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSN 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 232 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDN 311
Cdd:PLN00113 343 KFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPS 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 312 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA----LQDLDGNvfrmlANLQNISLQNNRLRQLPGNIFAN 387
Cdd:PLN00113 423 EFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffggLPDSFGS-----KRLENLDLSRNQFSGAVPRKLGS 497

                        330
                 ....*....|....
gi 288541297 388 VNGLMAIQLQNNQL 401
Cdd:PLN00113 498 LSELMQLKLSENKL 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 145-351 3.29e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 145 FSQCSNLKELQLHGNHLEYIPDgaFDHLVGLTKLNLGKNSLTHIsprvfqhlgnlqvlrlyENrltdipmgtFDGLVNLQ 224
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-----------------EN---------LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 225 ELALQQNQIGLLSpGLfHNNHNLQRLYLSNNhisQLPPSvfmqlpqlNRLTLFGNSLKELSpgifgpmPNLRELWLYDNH 304
Cdd:cd21340   72 KLYLGGNRISVVE-GL-ENLTNLEELHIENQ---RLPPG--------EKLTFDPRSLAALS-------NSLRVLNISGNN 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 288541297 305 ISSLPDnvFSNLRQLQVLILSRNQISFISP--GAFNGLTELRELSLHTN 351
Cdd:cd21340  132 IDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
149-209 5.25e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.25e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541297  149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 396-467 5.56e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.61  E-value: 5.56e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288541297   396 LQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIII 467
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGI 73
LRRCT smart00082
Leucine rich repeat C-terminal domain;
423-462 1.57e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541297   423 NPWRCDSDILPLRNWLLLNQPRLGTDTvPVCFSPANVRGQ 462
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-443 5.69e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 5.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  44 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 123
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 124 LDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVL 202
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSgNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 203 RLYENRLTDIPMGtFDGLVNLQELALQQNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSvFMQLPQLNRLTLFGNSLK 282
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 283 ELsPGIFGpMPNLRELWLYDNHISSLPDNvfSNLRQLQVLILSRNQISFISPGAFNGLTELreLSLHTNALQDLDGNVFR 362
Cdd:COG4886  242 DL-PELGN-LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 442
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 .
gi 288541297 443 P 443
Cdd:COG4886  396 T 396
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-449 1.07e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 1.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 150 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLthisprvFQHLGNLQVLRLYENRLTDIPmGTFDGLVNLQELALQ 229
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 230 QNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSVFmQLPQLNRLTLFGNSLKELsPGIFGPMPNLRELWLYDNHISSLP 309
Cdd:COG4886  145 NNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 310 DNvFSNLRQLQVLILSRNQISFISpgAFNGLTELRELSLHTNALQDLDGNVFrmLANLQNISLQNNRLRQLPGNIFANVN 389
Cdd:COG4886  222 EP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLL 296

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDT 449
Cdd:COG4886  297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-423 1.19e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.19  E-value: 1.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  53 WNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLfqgldsleslll 132
Cdd:COG4886   65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL------------ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 133 ssnqllqiqpahfSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVLRLYENRLTDI 212
Cdd:COG4886  133 -------------ANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 213 PMgTFDGLVNLQELALQQNQIGLLSPGLfHNNHNLQRLYLSNNHISQLPpsVFMQLPQLNRLTLFGNSLKELSPgiFGPM 292
Cdd:COG4886  198 PE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANL 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 293 PNLRELWLYDNHISSLPDNVFSNLRQLQVLIL----SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 368
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLllllLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 288541297 369 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Cdd:COG4886  352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-360 1.64e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  57 SLQILNTHITELNEsPFLNISALIALRIEKNELSRItPGAFRNLGSLRYLSLANNKLQVLPiglfqgldsleslllssnq 136
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP------------------- 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 137 llqiqpAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHISprVFQHLGNLQVLRLYENRLTDIPmgT 216
Cdd:COG4886  199 ------EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 217 FDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLR 296
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288541297 297 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV 360
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-401 1.95e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  75 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLQIqPAHFSQCSNLKE 153
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPI-PSSLGNLKNLQY 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 154 LQLHGNHLE-YIPDGAFDhLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT-DIPMGtFDGLVNLQELALQQN 231
Cdd:PLN00113 265 LFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSN 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 232 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDN 311
Cdd:PLN00113 343 KFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPS 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 312 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA----LQDLDGNvfrmlANLQNISLQNNRLRQLPGNIFAN 387
Cdd:PLN00113 423 EFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffggLPDSFGS-----KRLENLDLSRNQFSGAVPRKLGS 497

                        330
                 ....*....|....
gi 288541297 388 VNGLMAIQLQNNQL 401
Cdd:PLN00113 498 LSELMQLKLSENKL 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 145-351 3.29e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 145 FSQCSNLKELQLHGNHLEYIPDgaFDHLVGLTKLNLGKNSLTHIsprvfqhlgnlqvlrlyENrltdipmgtFDGLVNLQ 224
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-----------------EN---------LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 225 ELALQQNQIGLLSpGLfHNNHNLQRLYLSNNhisQLPPSvfmqlpqlNRLTLFGNSLKELSpgifgpmPNLRELWLYDNH 304
Cdd:cd21340   72 KLYLGGNRISVVE-GL-ENLTNLEELHIENQ---RLPPG--------EKLTFDPRSLAALS-------NSLRVLNISGNN 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 288541297 305 ISSLPDnvFSNLRQLQVLILSRNQISFISP--GAFNGLTELRELSLHTN 351
Cdd:cd21340  132 IDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-401 1.24e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  77 SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL--QV-----------------------LPIGLFQGLDSLESLL 131
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIprelgqmkslkwiylgynnlsgeIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 132 LSSNQLLQIqPAHFSQCSNLKELQLHGNHLE-YIPDGAFDhLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT 210
Cdd:PLN00113 244 VYNNLTGPI-PSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 211 -DIPMG---------------TFDGLV--------NLQELALQQNQI------GLLSPG------LFHNN---------- 244
Cdd:PLN00113 322 gKIPVAltslprlqvlqlwsnKFSGEIpknlgkhnNLTVLDLSTNNLtgeipeGLCSSGnlfkliLFSNSlegeipkslg 401

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 245 --HNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHIS-SLPDnvFSNLRQLQV 321
Cdd:PLN00113 402 acRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD--SFGSKRLEN 479

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR-QLPGNiFANVNGLMAIQLQNNQ 400
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQ 558


                 .
gi 288541297 401 L 401
Cdd:PLN00113 559 L 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-401 4.87e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.27  E-value: 4.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  87 NELSRITPGA-FRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLqiqPAHFSQCSNLKELQLHGNHLE-Y 163
Cdd:PLN00113 103 NQLSGPIPDDiFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEI---PNDIGSFSSLKVLDLGGNVLVgK 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 164 IPdGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL-YENRLTDIPMgTFDGLVNLQELALQQNQIGLLSPGLFH 242
Cdd:PLN00113 180 IP-NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLSGEIPY-EIGGLTSLNHLDLVYNNLTGPIPSSLG 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 243 NNHNLQRLYLSNNHIS-QLPPSVFmQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQV 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDL-------DGNVFRMlanlqnISLQNNRLRQLPGNIFAnVNGLMAI 394
Cdd:PLN00113 337 LQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEipeglcsSGNLFKL------ILFSNSLEGEIPKSLGA-CRSLRRV 409


                 ....*..
gi 288541297 395 QLQNNQL 401
Cdd:PLN00113 410 RLQDNSF 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-375 1.11e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 175 LTKLNLGKNSLTHISprVFQHLGNLQVLRLYENRLTDIPmgtfdglvNLqelalqqnqigllspglfHNNHNLQRLYLSN 254
Cdd:cd21340    4 ITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--------NL------------------EFLTNLTHLYLQN 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 255 NHISQLPPsvFMQLPQLNRLTLFGNSLKELSpGIFGPmPNLRELwlydnHIS--------SL---PDNVFSNLRQLQVLI 323
Cdd:cd21340   56 NQIEKIEN--LENLVNLKKLYLGGNRISVVE-GLENL-TNLEEL-----HIEnqrlppgeKLtfdPRSLAALSNSLRVLN 126

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 288541297 324 LSRNQISFISPgaFNGLTELRELSLHTNALQDLD--GNVFRMLANLQNISLQNN 375
Cdd:cd21340  127 ISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
149-209 5.25e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.25e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541297  149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
174-233 5.56e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.56e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
293-353 8.55e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 8.55e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541297  293 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
198-257 1.57e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.57e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  198 NLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHI 257
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
222-281 4.08e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 4.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  222 NLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSL 281
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-422 5.51e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 5.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 139 QIQPAHFsQCSNLKELQLHGNHLEY-IPDGAFDHLVGLTKLNLGKNSLTHISPRVFqhLGNLQVLRLYENRLT-DIP--M 214
Cdd:PLN00113  84 KISSAIF-RLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSgEIPndI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 215 GTFDglvNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPN 294
Cdd:PLN00113 161 GSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTS 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 295 LRELWL-YDNHISSLPDNvFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQdldGNVFRMLANLQNISL- 372
Cdd:PLN00113 238 LNHLDLvYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS---GEIPELVIQLQNLEIl 313

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 288541297 373 ---QNNRLRQLPGNIfANVNGLMAIQLQNNQLENlplGIFDHLGKLCELRLYD 422
Cdd:PLN00113 314 hlfSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSG---EIPKNLGKHNNLTVLD 362
LRR_8 pfam13855
Leucine rich repeat;
317-377 1.12e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.12e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541297  317 RQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 144-279 1.59e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 144 HFSQCSNLKELQLHGNHLEYIPDgaFDHLVGLTKLNLGKNSLTHISPrvFQHLGNLQVLRLYENRLtdiPMG---TFD-- 218
Cdd:cd21340   41 NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL---PPGeklTFDpr 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288541297 219 ---GLVN-LQELALQQNQIGLLSPglFHNNHNLQRLYLSNNHISQLPP--SVFMQLPQLNRLTLFGN 279
Cdd:cd21340  114 slaALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-353 5.58e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 5.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  75 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLQIqPAHFSQCSNLKE 153
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSGEI-PKNLGKHNNLTV 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 154 LQLHGNHLE-YIPDGAFDHlVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT----------------DIPMGT 216
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyflDISNNN 439

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 217 FDGLVN--------LQELALQQNQIGLLSPGLFHNNhNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGI 288
Cdd:PLN00113 440 LQGRINsrkwdmpsLQMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE 518

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288541297 289 FGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 353
Cdd:PLN00113 519 LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
163-405 1.00e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 163 YIPDGafdhlvgLTKLNLGKNSLTHIsPRVFQhlGNLQVLRLYENRLTDIPMGTFDglvNLQELALQQNQIGLLSPglfH 242
Cdd:PRK15370 196 CIPEQ-------ITTLILDNNELKSL-PENLQ--GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE---R 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 243 NNHNLQRLYLSNNHISQLPPSvfmqLPQlnrltlfgnslkelspgifgpmpNLRELWLYDNHISSLPDNVFSNLRQLQVL 322
Cdd:PRK15370 260 LPSALQSLDLFHNKISCLPEN----LPE-----------------------ELRYLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 323 ilsRNQISFIsPGAFNglTELRELSLHTNALQDLDGNvfrMLANLQNISLQNNRLRQLPGNIFANVNGLmaiQLQNNQLE 402
Cdd:PRK15370 313 ---SNSLTAL-PETLP--PGLKTLEAGENALTSLPAS---LPPELQVLDVSKNQITVLPETLPPTITTL---DVSRNALT 380


                 ...
gi 288541297 403 NLP 405
Cdd:PRK15370 381 NLP 383
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
151-406 1.50e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.95  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 151 LKELQLHGNHLEYIPDGAfdhlVGLTKLNLGKNSLTHIsPRVFQHLGNLQVlrlYENRLTDIPMGTfdglVNLQELALQQ 230
Cdd:PRK15387 244 LRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHL-PALPSGLCKLWI---FGNQLTSLPVLP----PGLQELSVSD 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 231 NQIGLLsPGLfhnNHNLQRLYLSNNHISQLPpsvfmQLPQ-LNRLTLFGNSLKELSPgifgpMPN-LRELWLYDNHISSL 308
Cdd:PRK15387 312 NQLASL-PAL---PSELCKLWAYNNQLTSLP-----TLPSgLQELSVSDNQLASLPT-----LPSeLYKLWAYNNRLTSL 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 309 PdNVFSNLRQlqvLILSRNQISFIS--PgafnglTELRELSLHTNALQDLDgnvfRMLANLQNISLQNNRLRQLPGNIFa 386
Cdd:PRK15387 378 P-ALPSGLKE---LIVSGNRLTSLPvlP------SELKELMVSGNRLTSLP----MLPSGLLSLSVYRNQLTRLPESLI- 442

                        250       260
                 ....*....|....*....|
gi 288541297 387 NVNGLMAIQLQNNQLENLPL 406
Cdd:PRK15387 443 HLSSETTVNLEGNPLSERTL 462
LRR_8 pfam13855
Leucine rich repeat;
246-305 1.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  246 NLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHI 305
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 57-303 1.74e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.29  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  57 SLQILNTHITELNESP---------FLNISALIALRIEKNELSRITPGAFRNL---GSLRYLSLANNKLQVLPIGLfqgl 124
Cdd:cd00116   52 SLKELCLSLNETGRIPrglqsllqgLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRL---- 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 125 dsleslllssnqllqIQPAHFSQCSNLKELQLHGNHLEYIP----DGAFDHLVGLTKLNLGKNSLTHISPRV----FQHL 196
Cdd:cd00116  128 ---------------LAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaegLKAN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 197 GNLQVLRLYENRLTDIPM----GTFDGLVNLQELALQQNQIGL-----LSPGLFHNNHNLQRLYLSNNHISQlppSVFMQ 267
Cdd:cd00116  193 CNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITD---DGAKD 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 288541297 268 L-------PQLNRLTLFGNSLKE-----LSPGIFGPMPNLRELWLYDN 303
Cdd:cd00116  270 LaevlaekESLLELDLRGNKFGEegaqlLAESLLEPGNELESLWVKDD 317
LRR_8 pfam13855
Leucine rich repeat;
269-329 2.14e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.14e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541297  269 PQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQI 329
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 274-424 7.86e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 7.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 274 LTLFGNSLKELspGIFGPMPNLRELWLYDNHISSLP--------------DNV------FSNLRQLQVLILSRNQISFIS 333
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEnlefltnlthlylqNNQiekienLENLVNLKKLYLGGNRISVVE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 334 pgAFNGLTELRELSLhtnALQDLD-GNVF----RMLANLQNiSLQ-----NNRLRQLpgNIFANVNGLMAIQLQNNQLEN 403
Cdd:cd21340   85 --GLENLTNLEELHI---ENQRLPpGEKLtfdpRSLAALSN-SLRvlnisGNNIDSL--EPLAPLRNLEQLDASNNQISD 156

                        170       180
                 ....*....|....*....|...
gi 288541297 404 LP--LGIFDHLGKLCELRLYDNP 424
Cdd:cd21340  157 LEelLDLLSSWPSLRELDLTGNP 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 151-377 1.83e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 151 LKELQLHGNHLEYIPDG------AFDHLVGLTKLNLGKNSLTHISPRVFQHLgnlqvLRLYenrltdipmgtfdglvNLQ 224
Cdd:cd00116   53 LKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESL-----LRSS----------------SLQ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 225 ELALQQNQIG-----LLSPGLFHNNHNLQRLYLSNNHISQLP----PSVFMQLPQLNRLTLFGNSLKElsPGI------F 289
Cdd:cd00116  112 ELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGD--AGIralaegL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 290 GPMPNLRELWLYDNHISSLPD----NVFSNLRQLQVLILSRNQISF-----ISPGAFNGLTELRELSLHTNALQDLDG-N 359
Cdd:cd00116  190 KANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAkD 269

                        250       260
                 ....*....|....*....|.
gi 288541297 360 VFRMLAN---LQNISLQNNRL 377
Cdd:cd00116  270 LAEVLAEkesLLELDLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
149-329 6.59e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.47  E-value: 6.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 149 SNLKELQLHGNHLEYIPDGAFDhlvGLTKLNLGKNSLTHIS---PRVFQHL---------------GNLQVLRLYENRLT 210
Cdd:PRK15370 220 GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPerlPSALQSLdlfhnkisclpenlpEELRYLSVYDNSIR 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 211 DIPMGTFDGLVnlqELALQQNQIGLLSPGLfhnNHNLQRLYLSNNHISQLPPSVFMQLPQL----NRLTLfgnsLKELSP 286
Cdd:PRK15370 297 TLPAHLPSGIT---HLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLdvskNQITV----LPETLP 366

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 288541297 287 gifgpmPNLRELWLYDNHISSLPDNVFSNLRQLQVlilSRNQI 329
Cdd:PRK15370 367 ------PTITTLDVSRNALTNLPENLPAALQIMQA---SRNNL 400
LRR_8 pfam13855
Leucine rich repeat;
54-113 3.53e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.53e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297   54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
61-346 1.65e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  61 LNTHITEL--NESPFLNISALIALRIEKNELS--RITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGldsleslllssnq 136
Cdd:PRK15370 218 LQGNIKTLyaNSNQLTSIPATLPDTIQEMELSinRITELPERLPSALQSLDLFHNKISCLPENLPEE------------- 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 137 llqiqpahfsqcsnLKELQLHGNHLEYIPdgafDHL-VGLTKLNLGKNSLTHIsPRVFQHlgNLQVLRLYENRLTDIPMG 215
Cdd:PRK15370 285 --------------LRYLSVYDNSIRTLP----AHLpSGITHLNVQSNSLTAL-PETLPP--GLKTLEAGENALTSLPAS 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 216 TFDGlvnLQELALQQNQIGLLSPGLfhnNHNLQRLYLSNNHISQLPPSV--FMQLPQLNRLTLFgnSLKELSPGIFGPMP 293
Cdd:PRK15370 344 LPPE---LQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLpaALQIMQASRNNLV--RLPESLPHFRGEGP 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 288541297 294 NLRELWLYDNHISslpDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 346
Cdd:PRK15370 416 QPTRIIVEYNPFS---ERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPL 465
LRR_8 pfam13855
Leucine rich repeat;
102-185 1.68e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  102 SLRYLSLANNKLQVLPIGLFQGldsleslllssnqllqiqpahfsqCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLG 181
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG------------------------LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 288541297  182 KNSL 185
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
366-424 2.49e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 288541297  366 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
82-161 2.89e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297   82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPiglfqgldsleslllssnqllqiqPAHFSQCSNLKELQLHGNHL 161
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS------------------------PGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 145-272 4.65e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 43.30  E-value: 4.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  145 FSQCsNLKELQLhGNHLEYIPDGAFDHLVGLTKLNLGkNSLTHISPRVFQHLgNLQVLRLYENrLTDIPMGTFDGLVNLQ 224
Cdd:pfam13306   8 FYNC-SLTSITI-PSSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 288541297  225 ELALQQN--QIGllsPGLFHNNhNLQRLYLSNNhISQLPPSVFMQLPQLN 272
Cdd:pfam13306  83 SITLPSNltSIG---SYAFSNC-SLKSITIPSS-VTTIGSYAFSNCSNLK 127
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 396-467 5.56e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.61  E-value: 5.56e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288541297   396 LQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIII 467
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGI 73
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 151-467 1.86e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.48  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  151 LKELQLHG-NHLEYIPDGAfdHLVGLTKLNLGKNSLTHISPRVFQhlgNLQVLRLYENRLTDIPMGTfdGLVNLQELALQ 229
Cdd:PLN03210  683 LEDLDMSRcENLEILPTGI--NLKSLYRLNLSGCSRLKSFPDIST---NISWLDLDETAIEEFPSNL--RLENLDELILC 755

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  230 QNQIG-------LLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFG-NSLKELSPGIfgpmpNLRELWLY 301
Cdd:PLN03210  756 EMKSEklwervqPLTPLMTMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENcINLETLPTGI-----NLESLESL 830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  302 D-NHISSL---PDnVFSNLRQlqvLILSRnqisfispgafnglTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
Cdd:PLN03210  831 DlSGCSRLrtfPD-ISTNISD---LNLSR--------------TGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKL 892

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  378 RQLPGNIFANVNGLMAIQLQNNQLE--NLPLGIFDHLGKLCELRLYdNPWRCDSDILpLRNWLLLNQPRLGTDTVPVCFS 455
Cdd:PLN03210  893 KHLETVDFSDCGALTEASWNGSPSEvaMATDNIHSKLPSTVCINFI-NCFNLDQEAL-LQQQSIFKQLILSGEEVPSYFT 970

                         330
                  ....*....|..
gi 288541297  456 PANVrGQSLIII 467
Cdd:PLN03210  971 HRTT-GASLTNI 981
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-263 1.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297  77 SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQvlpiglfqGLDSLESLLLSSNQLLQIQPAHF-------SQCS 149
Cdd:PLN00113 404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ--------GRINSRKWDMPSLQMLSLARNKFfgglpdsFGSK 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 150 NLKELQLHGNHL-EYIPDGaFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT-DIPMGtFDGLVNLQELA 227
Cdd:PLN00113 476 RLENLDLSRNQFsGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLD 553

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 288541297 228 LQQNQIGLLSPGLFHNNHNLQRLYLSNNHI-SQLPPS 263
Cdd:PLN00113 554 LSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPST 590
LRRCT smart00082
Leucine rich repeat C-terminal domain;
423-462 1.57e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541297   423 NPWRCDSDILPLRNWLLLNQPRLGTDTvPVCFSPANVRGQ 462
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP 39
LRR smart00370
Leucine-rich repeats, outliers;
292-315 1.95e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.95e-03
                           10        20
                   ....*....|....*....|....
gi 288541297   292 MPNLRELWLYDNHISSLPDNVFSN 315
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
292-315 1.95e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.95e-03
                           10        20
                   ....*....|....*....|....
gi 288541297   292 MPNLRELWLYDNHISSLPDNVFSN 315
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 293-334 3.43e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 288541297  293 PNLRELWLYDNHISSLPdnVFSNLRQLQVLILSRN-QISFISP 334
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 243-422 4.99e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 243 NNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPG-IFGPMPNLRELWLYDNHIS-SLPDNVFSNLRQLQ 320
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDdIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541297 321 vliLSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNrlrQLPGNIFANVNGLMAIQLQNNQ 400
Cdd:PLN00113 147 ---LSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN---QLVGQIPRELGQMKSLKWIYLG 220

                        170       180
                 ....*....|....*....|..
gi 288541297 401 LENLPLGIFDHLGKLCELRLYD 422
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLD 242
LRR smart00370
Leucine-rich repeats, outliers;
245-265 6.57e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.57e-03
                           10        20
                   ....*....|....*....|.
gi 288541297   245 HNLQRLYLSNNHISQLPPSVF 265
Cdd:smart00370   2 PNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
245-265 6.57e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.57e-03
                           10        20
                   ....*....|....*....|.
gi 288541297   245 HNLQRLYLSNNHISQLPPSVF 265
Cdd:smart00369   2 PNLRELDLSNNQLSSLPPGAF 22
LRR smart00370
Leucine-rich repeats, outliers;
316-339 8.65e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.65e-03
                           10        20
                   ....*....|....*....|....
gi 288541297   316 LRQLQVLILSRNQISFISPGAFNG 339
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
316-339 8.65e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.65e-03
                           10        20
                   ....*....|....*....|....
gi 288541297   316 LRQLQVLILSRNQISFISPGAFNG 339
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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