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Conserved domains on  [gi|18700024|ref|NP_570954|]
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isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 [Mus musculus]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
46-379 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 507.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024    46 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIYTPMEyKGELA 125
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   126 SYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYAT 205
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   206 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 285
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   286 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGY 365
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 18700024   366 STTTDFIKSVIGHL 379
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 46-379 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 507.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024    46 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIYTPMEyKGELA 125
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   126 SYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYAT 205
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   206 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 285
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   286 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGY 365
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 18700024   366 STTTDFIKSVIGHL 379
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 49-379 1.61e-133

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 386.14  E-value: 1.61e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   49 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIYTPMeyKGELASYD 128
Cdd:PLN00123  32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  129 MQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYATKKG 208
Cdd:PLN00123 106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  209 RSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 288
Cdd:PLN00123 186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  289 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGY 365
Cdd:PLN00123 266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGS 345

                        330
                 ....*....|....
gi 18700024  366 STTTDFIKSVIGHL 379
Cdd:PLN00123 346 STTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 48-379 6.23e-108

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 320.42  E-value: 6.23e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  48 FPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIYTP- 117
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGPk 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 118 MEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRH-----NNLDLVIIREQTEGEYSSLEHESAKG----VIECLKIV 188
Cdd:COG0473  78 WDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 189 TRTKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVM 268
Cdd:COG0473 158 TRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 269 PNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMI 344
Cdd:COG0473 237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18700024 345 ADAVKKVIKAGkVRTRDMGGYSTTTDFIKSVIGHL 379
Cdd:COG0473 313 EAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
50-375 1.75e-94

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 286.11  E-value: 1.75e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024    50 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFKEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTPMEYKGEL 124
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   125 ASYD--MQLRRKLDLFANVVHVKSLPG------YKTRHNNLDLVIIREQTEGEYSSLEHE---SAKGVIECLKIVTRTKS 193
Cdd:pfam00180  82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   194 QRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 273
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   274 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRH-LNLEYHSSMIADAVKK 350
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319

                         330       340
                  ....*....|....*....|....*...
gi 18700024   351 VIKAGKvRTRDMGG---YSTTTDFIKSV 375
Cdd:pfam00180 320 VLESGI-RTGDLAGsatYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 46-379 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 507.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024    46 GAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIYTPMEyKGELA 125
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   126 SYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYAT 205
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   206 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 285
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   286 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGY 365
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 18700024   366 STTTDFIKSVIGHL 379
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 49-379 1.61e-133

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 386.14  E-value: 1.61e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   49 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIYTPMeyKGELASYD 128
Cdd:PLN00123  32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  129 MQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYATKKG 208
Cdd:PLN00123 106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  209 RSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 288
Cdd:PLN00123 186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  289 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGY 365
Cdd:PLN00123 266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGS 345

                        330
                 ....*....|....
gi 18700024  366 STTTDFIKSVIGHL 379
Cdd:PLN00123 346 STTQEVVDAVIANL 359
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 15-379 1.24e-130

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 379.22  E-value: 1.24e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   15 LAARNSGAWRGLGTSTAHAASQSQAQDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSE-----VQN 89
Cdd:PLN00118   9 LLGNRLAQILGASSSSSGAFSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTtvdprTGS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   90 MASEEKLEqvlsSMKENKVAIIGKIYTPMEyKGElASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGE 169
Cdd:PLN00118  89 FLTWESLE----SVRRNKVGLKGPMATPIG-KGH-RSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  170 YSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMII 249
Cdd:PLN00118 163 YSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVII 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  250 DNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVP-GESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLS 327
Cdd:PLN00118 243 DNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPsCNIGENGLALAE--AVHGSAPDIaGKNLANPTALLLS 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 18700024  328 ATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRDMGGYSTTTDFIKSVIGHL 379
Cdd:PLN00118 321 AVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 48-379 6.23e-108

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 320.42  E-value: 6.23e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  48 FPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIYTP- 117
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGPk 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 118 MEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRH-----NNLDLVIIREQTEGEYSSLEHESAKG----VIECLKIV 188
Cdd:COG0473  78 WDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 189 TRTKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVM 268
Cdd:COG0473 158 TRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 269 PNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMI 344
Cdd:COG0473 237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18700024 345 ADAVKKVIKAGkVRTRDMGGYSTTTDFIKSVIGHL 379
Cdd:COG0473 313 EAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 50-379 5.56e-107

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 317.82  E-value: 5.56e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   50 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFKehhLSEVQNMASEEKLE----QVLSSMKENKVAIIGKIYTPMeykGE-L 124
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYE---FADAGLTALEKHGEllpqRTLDLIEKNKIALKGPLTTPV---GEgF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  125 ASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHE-SAKG-VIECLKIVTRTKSQRIAKFAFD 202
Cdd:PRK08997  79 TSINVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  203 YATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAG 282
Cdd:PRK08997 159 LARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  283 LVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVRTRD 361
Cdd:PRK08997 239 LVGGLGMAPGANIGRDAAIFE--AVHGSAPDIaGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRD 316

                        330
                 ....*....|....*...
gi 18700024  362 MGGYSTTTDFIKSVIGHL 379
Cdd:PRK08997 317 LGGTHGTTDFTQAVIDRL 334
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
50-375 1.75e-94

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 286.11  E-value: 1.75e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024    50 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFKEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTPMEYKGEL 124
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   125 ASYD--MQLRRKLDLFANVVHVKSLPG------YKTRHNNLDLVIIREQTEGEYSSLEHE---SAKGVIECLKIVTRTKS 193
Cdd:pfam00180  82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   194 QRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 273
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   274 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRH-LNLEYHSSMIADAVKK 350
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319

                         330       340
                  ....*....|....*....|....*...
gi 18700024   351 VIKAGKvRTRDMGG---YSTTTDFIKSV 375
Cdd:pfam00180 320 VLESGI-RTGDLAGsatYVSTSEFGEAV 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
49-379 3.96e-93

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 287.17  E-value: 3.96e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   49 PVTMLPGDGVGPELMHAVKEVFKAAAVPVE----------FKEHHLSEVqnmaSEEKLEqvlsSMKENKVAIIGKIYTPM 118
Cdd:PRK09222   6 PITVAYGDGIGPEIMEAVLKILEAAGAPLEietieigekvYKKGWTSGI----SPSAWE----SIRRTKVLLKAPITTPQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  119 E--YKgelaSYDMQLRRKLDLFANVVHVKSL-PGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQR 195
Cdd:PRK09222  78 GggYK----SLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  196 IAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNI 275
Cdd:PRK09222 154 IIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  276 IDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKA 354
Cdd:PRK09222 234 LSDIAAEISGSVGLAGSANIGEEYAMFE--AVHGSAPDIaGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLED 311

                        330       340       350
                 ....*....|....*....|....*....|.
gi 18700024  355 GkVRTRDMGGYST------TTDFIKSVIGHL 379
Cdd:PRK09222 312 G-IHTADIYNEGVskkkvgTKEFAEAVIENL 341
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 50-379 8.58e-84

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 258.53  E-value: 8.58e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   50 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFkehhlseVQNMASEEKLEQVLSSMKENKVAIIGKI-YTPMEYKGELA-SY 127
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHVLEATGLPFEF-------VYAEAGDEVFEKTGKALPEETIEAAKEAdAVLFGAAGETAaDV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  128 DMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYATKK 207
Cdd:PRK14025  77 IVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKRR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  208 ----GRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 283
Cdd:PRK14025 157 kkmgKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  284 VGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVrTRDM 362
Cdd:PRK14025 237 VGGLGLAPSANIGDKYGLFE--PVHGSApDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLT-TPDL 313

                        330
                 ....*....|....*..
gi 18700024  363 GGYSTTTDFIKSVIGHL 379
Cdd:PRK14025 314 GGNLSTMEMAEEVAKRV 330
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 50-379 2.40e-58

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 193.39  E-value: 2.40e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   50 VTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEHHLS-----EVQNMASEEKLEQVLSSMkenkvAII-GKIYTPme 119
Cdd:PRK00772   5 IAVLPGDGIGPEVMAEAVKVLDAVAekfgFDFEFEEALVGgaaidAHGVPLPEETLEACRAAD-----AVLlGAVGGP-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  120 yKGELASYDMQ-------LRRKLDLFANVVHVKSLPGYKT-------RHNNLDLVIIREQTEGEYS------SLEHESAK 179
Cdd:PRK00772  78 -KWDNLPPDVRpergllaLRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFgeprgrEGLGGEER 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  180 GVIEClkIVTRTKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 259
Cdd:PRK00772 157 AFDTM--VYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  260 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFETGarHPFA-QAVGRNIANPTAMLLSATNMLRH-LN 336
Cdd:PRK00772 233 PKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI--HGSApDIAGKGIANPIATILSAAMMLRYsLG 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 18700024  337 LEYHSSMIADAVKKVIKAGkVRTRDM---GGYSTTTDFIKSVIGHL 379
Cdd:PRK00772 311 LEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAAL 355
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 52-368 3.23e-45

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 158.94  E-value: 3.23e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   52 MLPGDGVGPELMH-AVKeVFKAAA---VPVEFKEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIYTP------MEy 120
Cdd:PRK03437   9 VIPGDGIGPEVVAeALK-VLDAVAaggPGVETTEYDLGARRYLRTGETLpDSVLAELRQHDAILLGAIGDPsvpsgvLE- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  121 KGELasydMQLRRKLDLFANVVHVKSLPGYKTRHNN---LDLVIIREQTEGEYSS--------LEHESAKGVieclKIVT 189
Cdd:PRK03437  87 RGLL----LKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----SVNT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  190 RTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 269
Cdd:PRK03437 159 AFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  270 NLYGNIIDNLAAGLVGGAGVVPGESYSAEYA---VFE-TGARHPfaQAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIA 345
Cdd:PRK03437 239 NLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEpVHGSAP--DIAGQGIADPTAAILSVALLLDHLGEEDAAARIE 316

                        330       340
                 ....*....|....*....|...
gi 18700024  346 DAVKKVikagkVRTRDMGGYSTT 368
Cdd:PRK03437 317 AAVEAD-----LAERGKMGRSTA 334
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 48-379 9.14e-44

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 155.26  E-value: 9.14e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   48 FPVTMLPGDGVGPELMHAVKEVFKAAA-----VPVEFKEHHLS-----EVQNMASEEKLEQvlssMKENKVAIIGKIYTP 117
Cdd:PRK08194   4 FKIAVIPGDGVGKEVVPAAVRVLKAVAevhggLKFEFTEFPWSceyylEHGEMMPEDGLEQ----LKQFDAIFLGAVGNP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  118 MEYKGELASYDM--QLRRKLDLFANVVHVKSLPGYK---TRHNNLDLVIIREQTEGEYSSL-------EHESAkgVIECl 185
Cdd:PRK08194  80 KLVPDHISLWGLliKIRREFEQVINIRPAKQLRGIKsplANPKDFDLLVVRENSEGEYSEVggrihrgEDEIA--IQNA- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  186 kIVTRTKSQRIAKFAFDYATKKgRSKVTAVHKAN----IMKLGDGLFlqccEEVAELYPKIKFETMIIDNCCMQLVQNPY 261
Cdd:PRK08194 157 -VFTRKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRPE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  262 QFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE--Y-AVFEtgARHPFA-QAVGRNIANPTAMLLSATNMLRHLNL 337
Cdd:PRK08194 231 EFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNgkYpSMFE--PVHGSApDIAGKGIANPIGQIWTAKLMLDHFGE 308

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 18700024  338 EYHSSMIADAVKKVIKAGkVRTRDMGGYSTTTDFIKSVIGHL 379
Cdd:PRK08194 309 EELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 55-380 1.12e-41

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 151.03  E-value: 1.12e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  55 GDGVGPELMHAVKEVFKAA-------AVPVEFKEHHLSEvqnMASEEKLEQV----LSSMKENKVAIIGKIYTPMEykGE 123
Cdd:COG0538  26 GDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDAGE---KARDETGDWLpdetAEAIKEYGVGIKGPLTTPVG--GG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 124 LASYDMQLRRKLDLFAN---VVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHES----AKGVIECL----------- 185
Cdd:COG0538 101 WRSLNVTIRQILDLYVCrrpVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAgspeALKLIFFLedemgvtvirf 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 186 --------KIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAE--------------LYP--- 240
Cdd:COG0538 181 pedsgigiKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEeefgdkfitegpweKYKgpk 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024 241 ---KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGE--SYSAeYAVFE----TGARHpfa 311
Cdd:COG0538 261 pagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGAniGDDG-GAEFEathgTAPKY--- 336

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18700024 312 qaVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVrTRD----MGG--YSTTTDFIKSVIGHLH 380
Cdd:COG0538 337 --AGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDlarlMEGatELSTSEFGDAIIENLD 408
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
55-376 4.37e-41

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 149.60  E-value: 4.37e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   55 GDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASE--EKL------EQVLSSMKENKVAIIGKIYTPMEyKGeLAS 126
Cdd:PRK06451  31 GDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDkaEKLtgnrfpKESEELIEKYRVLLKGPLETPIG-KG-WKS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  127 YDMQLRRKLDLFANVVHVKSLPGYKT--RH-NNLDLVIIREQTEGEYSSLEH----ESAKGVIECL-------------- 185
Cdd:PRK06451 109 INVAIRLMLDLYANIRPVKYIPGIESplKNpEKIDLIIFRENTDDLYRGIEYpydsEEAKKIRDFLrkelgveveddtgi 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  186 --KIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCC---------------EEVAELYP------KI 242
Cdd:PRK06451 189 giKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAyevalkefrdyvvteEEVTKNYNgvppsgKV 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  243 KFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANP 321
Cdd:PRK06451 269 IINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AIHGTApKYAGKNVANP 346

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  322 TAMLLSATNMLRHLNLEYHSSMIADAVKKVIKAGKVrTRDMGGYS-----TTTDFIKSVI 376
Cdd:PRK06451 347 TGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDLARFMgvralSTTEYTDELI 405
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 55-361 1.81e-37

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 139.81  E-value: 1.81e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   55 GDGVGPELMHAVKEVFKAAavpVEF-----KEHHLSEVqnMASEEKL----------EQVLSSMKENKVAIIGKIYTPMe 119
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAA---VEKaykgeRKISWMEI--YAGEKATkvygedvwlpEETLDLIREYRVAIKGPLTTPV- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  120 yKGELASYDMQLRRKLDLFA---NVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHES----AKGVIECL------- 185
Cdd:PRK07006 101 -GGGIRSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvk 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  186 ------------KIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAEL-----------YPKI 242
Cdd:PRK07006 180 kirfpetsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelidggpWDKI 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  243 K---------FETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII-DNLAAGlVGGAGVVPGESYSAEYAVFEtgARHPFA- 311
Cdd:PRK07006 260 KnpetgkeiiVKDSIADAFLQQILLRPAEYDVIATMNLNGDYIsDALAAQ-VGGIGIAPGANINDGHAIFE--ATHGTAp 336

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 18700024  312 QAVGRNIANPTAMLLSATNMLRHLNLEYHSSMIADAVKKVIkAGKVRTRD 361
Cdd:PRK07006 337 KYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTI-ASKTVTYD 385
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 44-362 5.21e-28

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 113.63  E-value: 5.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   44 VEGAFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFKEHHLSEVQ-NMASEEKLEQVLSSMKENKVAIIGKI---- 114
Cdd:PLN02329  43 GKKRYNIALLPGDGIGPEVISVAKNVLQKAGslegLEFDFQEMPVGGAAlDLVGVPLPEETFTAAKQSDAILLGAIggyk 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  115 --YTPMEYKGELASydMQLRRKLDLFANVVHVKSLPGY-------KTRHNNLDLVIIREQTEGEYSSLE-----HESAKG 180
Cdd:PLN02329 123 wdKNEKHLRPEMAL--FYLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPrgitiNENGEE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  181 VIECLKIVTRTKSQRIAKFAFDYATKKgRSKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNP 260
Cdd:PLN02329 201 VGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDP 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  261 YQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRH-LNLEY 339
Cdd:PLN02329 279 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEK 358

                        330       340
                 ....*....|....*....|...
gi 18700024  340 HSSMIADAVKKVIKAGkVRTRDM 362
Cdd:PLN02329 359 AAKRIEDAVVDALNKG-FRTGDI 380
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
55-362 2.07e-20

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 92.47  E-value: 2.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024   55 GDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEKL----------EQVLSSMKENKVAIIGKIYTPMeyKGEL 124
Cdd:PRK07362  36 GDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACdlygtyqylpEDTLEAIREYGVAIKGPLTTPI--GGGI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  125 ASYDMQLRRKLDLFANVVHVKSLPGYKTRHNN---LDLVIIREQTEGEYSSLEHES----AKGVIECL------------ 185
Cdd:PRK07362 114 RSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNpekLDVIVYRENTEDIYMGIEWEAgdeiGDKLIKHLneevipaspelg 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  186 ------------KIVTRTKSQRIAKFAFDYATK--KGRSKVTAVHKANIMKLGDGLF----------------------- 228
Cdd:PRK07362 194 krqiplgsgigiKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvteresw 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  229 --------------------------------LQCCEEVAELYPKI-------KFETMII------DNCCMQLVQNPYQF 263
Cdd:PRK07362 274 ilsnkeknpnisiednarmiepgydsltpekkAAICAEVKEVLDSIwsshgngKWKEKVLvddriaDSIFQQIQTRPQEY 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700024  264 DVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSATNMLRHLNLEYHSS 342
Cdd:PRK07362 354 SILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE--ATHGTApKHAGLDRINPGSVILSGVMMLEYLGWQEAAD 431

                        410       420
                 ....*....|....*....|
gi 18700024  343 MIADAVKKVIKAGKVrTRDM 362
Cdd:PRK07362 432 LITKGLSAAIANKQV-TYDL 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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