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Conserved domains on  [gi|120444906|ref|NP_573447|]
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solute carrier family 5 member 4A [Mus musculus]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 27-656 0e+00

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11486:

Pssm-ID: 444915  Cd Length: 636  Bit Score: 966.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11486    1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11486   81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIF 266
Cdd:cd11486  161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACV 346
Cdd:cd11486  241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 347 VPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAG 426
Cdd:cd11486  321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 427 RLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSY 506
Cdd:cd11486  401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 507 GTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLDAEDKEEN-GADD 585
Cdd:cd11486  481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETEDqDSNS 560

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120444906 586 RTEEDQTEKPRGCLKKTCDLFCGL-QRAEFKLTKVEEEA----LTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11486  561 MIETDEMREEPGCCKKAYNWFCGLdQGNAPKLTKEEEAAlkmkLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 27-656 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 966.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11486    1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11486   81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIF 266
Cdd:cd11486  161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACV 346
Cdd:cd11486  241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 347 VPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAG 426
Cdd:cd11486  321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 427 RLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSY 506
Cdd:cd11486  401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 507 GTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLDAEDKEEN-GADD 585
Cdd:cd11486  481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETEDqDSNS 560

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120444906 586 RTEEDQTEKPRGCLKKTCDLFCGL-QRAEFKLTKVEEEA----LTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11486  561 MIETDEMREEPGCCKKAYNWFCGLdQGNAPKLTKEEEAAlkmkLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 58-492 2.21e-154

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 451.41  E-value: 2.21e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906   58 FFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFG 137
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  138 GKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFI 217
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  218 LMVFAFVEVGGYESFTEKFMNAIPSVVegDNLTinsrcytpqPDSFHIFRDPVTGDIPWPGTAFGMPITalwywcinQVI 297
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  298 VQRCLCGKnlshvKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVPsecvKHCGVDVGCTNYAYPMLVLKLMPMG 377
Cdd:pfam00474 222 LQRCLAAK-----DAKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  378 LRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGqLVHYTE 457
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 120444906  458 AISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVG 492
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 61-492 2.39e-146

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 430.96  E-value: 2.39e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906   61 AGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKR 140
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFG-KR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  141 LQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMV 220
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  221 FAFVEVGGYESFTEKFMNAIPSVVEGDnltinsrcytpqpDSFHIFRDPVTGDIPWPGTAFGMPITALWYWcINQVIVQR 300
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTNPSPD-------------DLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  301 CLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMvacvVPSEcvkhCGVDVGCTNYAYPMLVLKLMPMGLRG 380
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDI----DPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  381 LMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVpiVEVSQGGQLVHYTEAIS 460
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 120444906  461 SYLGPPIAAVFLVAVFCKRANEQGAFWGLMVG 492
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 25-499 7.65e-141

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 418.01  E-value: 7.65e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  25 NAADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESH 104
Cdd:COG4146    4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 105 SFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFgGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:COG4146   84 AAIALIILALFFLPFYLKSGIYTMPEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesftekfmnaiPSVVEG-DNLTINSrcytpqPDSF 263
Cdd:COG4146  163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 264 HIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMV 343
Cdd:COG4146  225 NMIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 AcvvpsecvkhcgvdvgCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASEREL 422
Cdd:COG4146  305 D----------------NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKyFNPNASEKQL 368

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120444906 423 LIAGRLFVSVLIVTSILWVPIveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIR 499
Cdd:COG4146  369 VKVGRIATVVLAVIAILIAPL--IGNADGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
PRK10484 PRK10484
putative transporter; Provisional
 32-547 1.73e-71

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 240.55  E-value: 1.73e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  32 IVIYFVVVMAVGVWAMLKTNRSTVG---GFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFAL 108
Cdd:PRK10484   4 ILSFLGFTLLVAVISWWKTRKTDTSssdGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIyLSILFLFICVILTISADIFSGAIFIK----------LALGLNLY 178
Cdd:PRK10484  84 LIILALIFLPRYLKSGITTIPDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALALNslfhvsellgISYGAAIW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 179 LAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesftekfmnaipsvveGDNLTINSRCYTP 258
Cdd:PRK10484 163 LLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 259 QPDSFHIFrDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRIL 338
Cdd:PRK10484 226 HPEKLNSI-GGATDPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 339 YTDMVAcvvpsecvkhcgvdvgCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLY-TKIRKKA 417
Cdd:PRK10484 305 YGDGLP----------------NADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNA 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 418 SERELLIAGRLFVSVLIVTSILWVPIVEVSQGGqLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVmgl 497
Cdd:PRK10484 369 SEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGII--- 444

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 120444906 498 irmiaefSYGTGSCLAPSscpkiicGVHYLYFAIILFFVCILVILGVSYL 547
Cdd:PRK10484 445 -------LYIIINFVLKF-------DIHFLYVLAILFVINVVVMLIIGKI 480
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 27-656 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 966.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11486    1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11486   81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIF 266
Cdd:cd11486  161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACV 346
Cdd:cd11486  241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 347 VPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAG 426
Cdd:cd11486  321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 427 RLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSY 506
Cdd:cd11486  401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 507 GTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLDAEDKEEN-GADD 585
Cdd:cd11486  481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETEDqDSNS 560

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120444906 586 RTEEDQTEKPRGCLKKTCDLFCGL-QRAEFKLTKVEEEA----LTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11486  561 MIETDEMREEPGCCKKAYNWFCGLdQGNAPKLTKEEEAAlkmkLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
 27-656 0e+00

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 771.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11487    1 ADISVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11487   81 FVVLLLGWLFVPVYLTAGVITMPQYLKKRFGGQRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLT---INSRCYTPQPDSF 263
Cdd:cd11487  161 ITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTVSEDPAvgnISSSCYRPRPDSY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 264 HIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMV 343
Cdd:cd11487  241 HLLRDPVTGDLPWPALILGLTIVSSWYWCSDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYPDEV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 ACVVPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELL 423
Cdd:cd11487  321 ACVEPSVCLRVCGTEVGCSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDKELL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 424 IAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAE 503
Cdd:cd11487  401 LVGRVWVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGGLLMGLCRMVPE 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 504 FSYGTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLdaedkeenga 583
Cdd:cd11487  481 FSFGSGSCVAPSSCPAIICGVHYLYFAILLFFCSGLLVLIVSLCTPPIPRKHLHRLVFSLRHSKEEREDL---------- 550

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 120444906 584 ddrteedqtekprgclkktcdlfcglqraefkltkveeeaLTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11487  551 ----------------------------------------LPDISEDPKWARVVNLNALIMMAVAVFLWGFYA 583
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
 28-656 0e+00

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 736.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFA 107
Cdd:cd11488    1 DIAVVVVYFVFVLAVGIWSSIRASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNAAW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAI 187
Cdd:cd11488   81 VLIALGWIFVPVYIAAGVVTMPEYLKKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 188 TAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPsvvegdNLTI-NSRCYTPQPDSFHIF 266
Cdd:cd11488  161 TALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIP------ALTVpNTTCHLPRSDAFHIF 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACV 346
Cdd:cd11488  235 RDPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEVGCV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 347 VPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAG 426
Cdd:cd11488  315 DPDECQKICGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQELMVVG 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 427 RLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSY 506
Cdd:cd11488  395 RVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMIMEFVY 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 507 GTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLdaedkeengaddr 586
Cdd:cd11488  475 GAPSCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL------------- 541

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120444906 587 teedqtekprgCLKKTCDLFCGL-QRAEFKLTKVEEEA----LTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11488  542 -----------WWKRLGMWFCGLsQTPEQDLSEEERQAlekkLTSIEEDPLWRTVCNINALILLAINVFLWGYFA 605
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
 29-656 0e+00

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 707.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  29 ISVIVIYFVVVMAVGVWAMLKtNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFAL 108
Cdd:cd10329    1 IVIIAVYFVAVIAIGLWSSRK-KRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGNYEWNAAFV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGWIFVPIYIKAGVMTMPEYLKKRFGGkRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAIT 188
Cdd:cd10329   80 LLLLGWVFLPFYIRSGVSTMPEFLEKRFGG-RSRVYLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYLSIIVLLVIT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 189 AIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesFTEKFMNAIPSVVegdnltinsrcytpqpdSFHIFRD 268
Cdd:cd10329  159 AIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGG---GWSAYMAAIPSGT-----------------AFHLFRP 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 269 PVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVP 348
Cdd:cd10329  219 PDDPDLPWPGLLLGYPILGIWYWCTDQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVP 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 349 secvkhCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRL 428
Cdd:cd10329  299 ------CGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPEASEKELVRVGRI 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 429 FVSVLIVTSILWVPIVEvSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYGt 508
Cdd:cd10329  373 ATLVVVVISILWAPIIQ-AQGGSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYG- 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 509 gsclAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEeridldaedkeengaddrte 588
Cdd:cd10329  451 ----EPDTRPAIIGGIHFLYFAFLLFVVSVIVTVIVSLLTPPPPAEKLAGLTWSTRLTKE-------------------- 506

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 120444906 589 edqtekprgclkktcdlfcglqraefkltkveeealTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd10329  507 ------------------------------------TSTLERPPWYKNVRILAILLLALTIFLYGYFA 538
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
 28-656 0e+00

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 677.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFA 107
Cdd:cd11490    1 DIVVLVLYFLFVLAVGLWSMWKTKRSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAI 187
Cdd:cd11490   81 MVLVLAWLFLPIYIASRVTTMPEYLKKRFGGKRIQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDLYLAVVGLLGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 188 TAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGdnltiNSRCYTPQPDSFHIFR 267
Cdd:cd11490  161 TALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEALLEKYFQAIPSIRSP-----NSTCGIPREDAFHIFR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 268 DPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVV 347
Cdd:cd11490  236 DPVTSDLPWPGVLLGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACAD 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 348 PSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGR 427
Cdd:cd11490  316 PEVCKEICGNPSGCSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRPRASEWELMIVGR 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 428 LFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYG 507
Cdd:cd11490  396 VFVLVLVVVSILWIPLVQASQGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTRMVLDFIYV 475

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 508 TGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRnskeeridLDAEDKEENgaddrt 587
Cdd:cd11490  476 TPQCDQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLATEPPSKEMISRLTWFTR--------FDAVVESEE------ 541

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 120444906 588 eedqtekprgcLKKTCDLFCGLQ-RAEFKLTKVE--EEALTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11490  542 -----------LKKAILWLCGMEkQTEKSSSSPAppEAAMVSLEEEPLMKHVLNANLIICVSVAVFLWAYFA 602
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
 27-656 0e+00

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 663.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11489    3 ADIIVIGVYFALNVAVGIWSSCRVSRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWNAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11489   83 YALLALAWVFVPVYISSGIVTMPEYLQRRFGGERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSvvegdNLTINSRCYTPQPDSFHIF 266
Cdd:cd11489  163 VTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAYLQAVPS-----KIIPNTTCHLPRADAMHLF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACV 346
Cdd:cd11489  238 RDPVTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVACV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 347 VPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAG 426
Cdd:cd11489  318 DPEECLRVCGAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLLVG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 427 RLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSY 506
Cdd:cd11489  398 RLVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLTRMVLEFAH 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 507 GTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLC-WALRNSKEERIdldaedkeengadd 585
Cdd:cd11489  478 PAPRCGVPDTRPSVLRSMHYLHFAVALCALSGAVVVAGSLLTPPPQSVQIRNLTwWTLAQDTPLGI-------------- 543

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 120444906 586 rteedqtekPRGCLKKTCDLFCGLQRAEFKlTKVEEEALTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA 656
Cdd:cd11489  544 ---------KLGDGQTLSRRTDGCESVRFA-SGTPPPIIHSTTEHPFWARVCGVNAILLMCVNIFFYAYFA 604
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
 28-566 0e+00

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 611.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFA 107
Cdd:cd11491    1 DIAVVALYFILVMCIGIYAMWKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAI 187
Cdd:cd11491   81 LLQLLGWVFIPVYIRSGVYTLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVSIILLLGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 188 TAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSV----VEGDNLTINSRCYTPQPDSF 263
Cdd:cd11491  161 TALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVtsilLTYNLSNTNSCCVHPKKDAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 264 HIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMV 343
Cdd:cd11491  241 KLLRDPTDEDVPWPGFILGQTPASIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRILFPDDI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 ACVVPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELL 423
Cdd:cd11491  321 ACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKASSRELM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 424 IAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAE 503
Cdd:cd11491  401 IVGRIFVAVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLGAVRLILA 480

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 120444906 504 FSYGTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNS 566
Cdd:cd11491  481 FAYRAPECGQPDNRPGIIKDIHYMYFATALFWITGLITVIVSLLTPPPTKENIRTTTFWTKKS 543
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 58-492 2.21e-154

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 451.41  E-value: 2.21e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906   58 FFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFG 137
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  138 GKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFI 217
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  218 LMVFAFVEVGGYESFTEKFMNAIPSVVegDNLTinsrcytpqPDSFHIFRDPVTGDIPWPGTAFGMPITalwywcinQVI 297
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  298 VQRCLCGKnlshvKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVPsecvKHCGVDVGCTNYAYPMLVLKLMPMG 377
Cdd:pfam00474 222 LQRCLAAK-----DAKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  378 LRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGqLVHYTE 457
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 120444906  458 AISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVG 492
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 61-492 2.39e-146

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 430.96  E-value: 2.39e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906   61 AGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKR 140
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFG-KR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  141 LQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMV 220
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  221 FAFVEVGGYESFTEKFMNAIPSVVEGDnltinsrcytpqpDSFHIFRDPVTGDIPWPGTAFGMPITALWYWcINQVIVQR 300
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTNPSPD-------------DLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  301 CLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMvacvVPSEcvkhCGVDVGCTNYAYPMLVLKLMPMGLRG 380
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDI----DPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  381 LMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVpiVEVSQGGQLVHYTEAIS 460
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 120444906  461 SYLGPPIAAVFLVAVFCKRANEQGAFWGLMVG 492
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 25-499 7.65e-141

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 418.01  E-value: 7.65e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  25 NAADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESH 104
Cdd:COG4146    4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 105 SFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFgGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:COG4146   84 AAIALIILALFFLPFYLKSGIYTMPEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesftekfmnaiPSVVEG-DNLTINSrcytpqPDSF 263
Cdd:COG4146  163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 264 HIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMV 343
Cdd:COG4146  225 NMIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 AcvvpsecvkhcgvdvgCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASEREL 422
Cdd:COG4146  305 D----------------NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKyFNPNASEKQL 368

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120444906 423 LIAGRLFVSVLIVTSILWVPIveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIR 499
Cdd:COG4146  369 VKVGRIATVVLAVIAILIAPL--IGNADGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
 31-555 6.20e-81

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 265.71  E-value: 6.20e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  31 VIVIYFVVVMAVGVWAML--KTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFAL 108
Cdd:cd10325    2 IFIVYVILIIGLGLWVSRekKGGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIASYEWMAAIT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGWIFVPIYIKAGVMTMPEYLKKRFGGkRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAIT 188
Cdd:cd10325   82 LIIVAKFFLPIFLKNGIYTMPQFLEERYDG-RVRTIMAVFWLLLYVFVNLTSVLYLGALAIETITGIPLTYSIIGLALFA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 189 AIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESftekfmnaipsvvegdNLTINSRCYTPQPDSFHIFRD 268
Cdd:cd10325  161 AAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEG----------------VFAGFTLLAAEAPEHFHMILD 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 269 PVTG-----DIPWPGTAF-GMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDM 342
Cdd:cd10325  225 KSNPedaykDLPGIAVLLgGLWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASNL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 343 VACVVPSECVKhcgvdvgctNYAYPMLvLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASERE 421
Cdd:cd10325  305 LLPAATGIEKP---------DQAYPWL-LRNLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKyIPKKASEKQ 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 422 LLIAGRLFVSVLIVTSILWVPIveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMI 501
Cdd:cd10325  375 LVNVGRLAAVIALIIAALIAPP--LLGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSALFKF 452

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 120444906 502 AEFSygtgsclapsscpkiicgVHYLYFAIILFFVCILVILGVSYLTkPIPDVH 555
Cdd:cd10325  453 LLPE------------------LPFLDRMGYVFFICVVLIVLVSLLT-PKGKDD 487
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
25-559 4.23e-79

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 259.37  E-value: 4.23e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  25 NAADISVIVIYFVVVMAVGVWAMLKTNrsTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESH 104
Cdd:COG0591    2 STLDLIIIILYLLLLLGIGLYASRRTK--SLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 105 SFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLFICVILtISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:COG0591   80 YALGALLLALFFAPRLRRLGALTIPEFLEKRFG-RGLRLLAAIIILLFLLGY-LAAQLVALGKLLEALFGIPYWLGILIG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFmnaipsvvegdnltinsrcytPQPDSFH 264
Cdd:COG0591  158 ALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAAL---------------------PAPGLLS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 265 IFRDPvtgDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVA 344
Cdd:COG0591  217 LFPGL---GFTGWLAFLGLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPL 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 345 cvvpsecvkhcgvdvGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASERELL 423
Cdd:COG0591  294 ---------------ADPDLALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPfIKPKASDKQLL 358

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 424 IAGRLFVSVLIVTSILWVpiveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAE 503
Cdd:COG0591  359 RVSRLAVLVVGLLALLLA----LLFPSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLG 434

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 120444906 504 FSygtgsclapsscpkiICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRL 559
Cdd:COG0591  435 GP---------------LGPFGWLYPILPGLLVSLLVFVVVSLLTKPPSEEVLEEF 475
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-559 2.62e-72

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 241.81  E-value: 2.62e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNRStvGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIA-VTAFESHSF 106
Cdd:cd11478    2 DYLIVAVYFVFVLGIGFYLKRKVKTS--EDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIAtVHFYWIGAI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLFIcVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11478   80 PAMVFLGIVMMPFYYGSKVRSVPEYLKLRFN-KSTRLLNAVSFAVM-TILMSGINLYALALVLNVLLGWPLWLSIILSAA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKfmnaipsVVEGDNLTINSRCYTPQPDSFHIf 266
Cdd:cd11478  158 IVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEK-------IDANGPPGWNGLSWGPQGSQSTN- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 rdPVTgdiPWPGTAFGMP-ITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYtdmvac 345
Cdd:cd11478  230 --PMG---VNLGLVFGLGfVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLV------ 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 346 vvpSECVKHCGVDvgcTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLY-TKIRKKASERELLI 424
Cdd:cd11478  299 ---PELGASGGLD---YNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYqTYIVKDAPDKHYLK 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 425 AGRLFVSVLIVTSILWVPIveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMI-AE 503
Cdd:cd11478  373 VGRIATVVGVLISIGTAYI--ASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGlYE 450

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 120444906 504 FSYGT-GSCLAPSscpkiicgvhyLYFAIILFFVCILVILGVSYLTKPIPDVHLHRL 559
Cdd:cd11478  451 LGLIVyHSDMAPN-----------FYGAWWAFVVCFVVTVLVSLLTKPKPEKELAGL 496
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
 36-545 4.44e-72

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 240.52  E-value: 4.44e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  36 FVVVMA-VGVWAMLKT---NRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLV 111
Cdd:cd10328    1 FLLFTAlVALISWYKTrgdDLSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 112 LGWIFVPIYIKAGVMTMPEYLKKRFgGKRLQIYLSILFLFICVILTISADIFSGAIF------IKLALGLNLYLAILILL 185
Cdd:cd10328   81 LALVFLPRYLKGGITTIPEFLEERY-DETTRRIVSILFLLGYVVILLPIVLYSGALAlnslfdVSELLGISYFQALWLLV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 186 AIT----AIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesftekfmnaipsvveGDNLTINSRCYTPQPD 261
Cdd:cd10328  160 WLIgiigAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGD-----------------GSFLAGLDTLLTAHPE 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 262 SFHIFRDPvTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTD 341
Cdd:cd10328  223 KLNAIGGA-DSPVPFSTLFTGMLLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGD 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 342 mvacvvpsecvkhcgvDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASER 420
Cdd:cd10328  302 ----------------GLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPiINKNATDK 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 421 ELLIAGRLFVSVLIVTSILWVPIVEVSQGGqLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAfwglMVGLVMGLIrm 500
Cdd:cd10328  366 QLVKVGKIFGIVLALISMIIAPFIAYAPEG-LFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAA----KIALIFGVI-- 438

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 120444906 501 iaefSYGTGSCLAPSscpkiicGVHYLYFAIILFFVCILVILGVS 545
Cdd:cd10328  439 ----LYALLQFVFLV-------PIHFLHVLAILFVICVAIMLIIG 472
PRK10484 PRK10484
putative transporter; Provisional
 32-547 1.73e-71

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 240.55  E-value: 1.73e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  32 IVIYFVVVMAVGVWAMLKTNRSTVG---GFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFAL 108
Cdd:PRK10484   4 ILSFLGFTLLVAVISWWKTRKTDTSssdGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIyLSILFLFICVILTISADIFSGAIFIK----------LALGLNLY 178
Cdd:PRK10484  84 LIILALIFLPRYLKSGITTIPDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALALNslfhvsellgISYGAAIW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 179 LAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesftekfmnaipsvveGDNLTINSRCYTP 258
Cdd:PRK10484 163 LLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 259 QPDSFHIFrDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRIL 338
Cdd:PRK10484 226 HPEKLNSI-GGATDPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 339 YTDMVAcvvpsecvkhcgvdvgCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLY-TKIRKKA 417
Cdd:PRK10484 305 YGDGLP----------------NADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNA 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 418 SERELLIAGRLFVSVLIVTSILWVPIVEVSQGGqLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVmgl 497
Cdd:PRK10484 369 SEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGII--- 444

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 120444906 498 irmiaefSYGTGSCLAPSscpkiicGVHYLYFAIILFFVCILVILGVSYL 547
Cdd:PRK10484 445 -------LYIIINFVLKF-------DIHFLYVLAILFVINVVVMLIIGKI 480
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 28-545 2.10e-66

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 224.74  E-value: 2.10e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNrsTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFA 107
Cdd:cd10322    2 DLIIVVVYLALLLGIGLYASKKVK--SSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIyLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAI 187
Cdd:cd10322   80 GALLLALFLAPRLRRLGKTTIPETILERYYSKGLRL-LVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 188 TAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYesFTEKFMNAIPSvvegdnltinsrcytpqpdsfhIFR 267
Cdd:cd10322  159 VILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGG--GFSALAAALPA----------------------LLL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 268 DPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVAcvv 347
Cdd:cd10322  215 ALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLEN--- 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 348 psecvkhcgvdvgcTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASERELLIAG 426
Cdd:cd10322  292 --------------PDLALPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPlINPKASDKKLLRVS 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 427 RLFVSVLIVTSILWVPIVevsqgGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSy 506
Cdd:cd10322  358 RIAVVVVGVLALLLALLP-----PSILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLA- 431

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 120444906 507 gtgsclapsscpkiicGVHYLYFAIILFFVCILVILGVS 545
Cdd:cd10322  432 ----------------SPLGIDPIIPALLVSLIVFVVVS 454
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 28-545 2.90e-56

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 198.21  E-value: 2.90e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWamLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFEshsFA 107
Cdd:cd11494    2 DWIVLVGYLLGILVYGVY--KGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYY---FG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 L---LLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLfICVILTISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:cd11494   77 LplaMIFLCITFVPVFYKLKVYTAYEYLERRFG-LKTRLLTSILFL-ISRGLATGVTIYAPAIILSTILGWSLWLTILLI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyeSFTEKFMNAIPSvvegDNL-TINSrcytpqpdSF 263
Cdd:cd11494  155 GGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPV--GFVDALLVAGKS----GRLnALDF--------SF 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 264 HIFRDPVTgdipWPGTaFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMV 343
Cdd:cd11494  221 DLSDTYTF----WSGL-IGGFFLYLSYFGTDQSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLVFVFYQFNP 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 ACVVPSECVkhcgVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASEREL 422
Cdd:cd11494  296 FPVSFNPAE----DETKDTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRfFKKDASDEHY 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 423 LIAGRLFVSVLIVTSIlwVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIrmia 502
Cdd:cd11494  372 LKVSRLLTVFWGLLAI--VFALFAGLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIV---- 445

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 120444906 503 eFSYGTgsclapsscpkiicGVHYLYFAIILFFVCILVILGVS 545
Cdd:cd11494  446 -LWLFP--------------DVSWLWWNVIGCVVVIGVALLLS 473
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-558 1.49e-50

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 183.17  E-value: 1.49e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNRSTvGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVtAFESHSFA 107
Cdd:cd11477    2 DWLVIALYFLLMLGIGLWFSKRASKST-SDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAG-NWIWWLWA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLG-WIFVPIYIKAGVMTMPEYLKKRFGGK---RLQIYLSILFLFIcVILTISADIFSGAIFI-KLALGLNLYLAIL 182
Cdd:cd11477   80 VAGLIGaFVFARRWRRLRVLTDGEFPEERYGGRygaPLRQFYAVYFALL-SNVDILAWVFLAAIKVsAVFGPWDPWLTIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 183 ILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFmnaipsvvegdnltinsrcytpqpds 262
Cdd:cd11477  159 ILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQL-------------------------- 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 263 FHIFRDPVTGDIPWpgTAFGMPITALWYWCINQV--------IVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMI 334
Cdd:cd11477  213 PEGHLDLFGSGLGA--SGFYITFFFILFFGWYPLsysgggwyLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALA 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 335 SRILYTDMVACVVPSEcvkhcgvdvgctnYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-I 413
Cdd:cd11477  291 ALVLYPDLDDPEADFE-------------LAYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRfI 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 414 RKKASERELLIAGRLFVSVLIVTSILWVPIVEVSqgGQLVHYTEAISSYLGPPIaavfLVAVFCKRANEQGAFWGLMVGL 493
Cdd:cd11477  358 KPNASEKHLLKVGRLATVLFGLLSIVVALASDSI--GGAFWIVLALGAGLGGPL----ILPWLWWRFNAWTEIWAMIASI 431

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120444906 494 VMGLIrmiaefsygtgsclAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHR 558
Cdd:cd11477  432 IVGLV--------------VSVLLKVFGLPEDFLFSFLVPVLLSLVVWLAVTLLTPPTDEETLVA 482
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
 29-547 1.37e-40

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 154.59  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  29 ISVIVIYFVVVMAVGVWAMLKTNrsTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAvtafeshsfAL 108
Cdd:cd11475    1 LITFIVYLLLMLGIGIYSYRKTK--TLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLS---------AI 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGWIFVPIYI-------------KAGVMTMPEYLKKRFGGKRLQI-YLSILFLFICVILTISADIFSGAIFIKLALG 174
Cdd:cd11475   70 WIAIGLILGAYLNwlfvakrlrryteKNDSITLPDYLENRFRDKSKLLrILSALIILIFFTIYAAAQLVAGGKLFESLFG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 175 LNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSvvegdnltinsr 254
Cdd:cd11475  150 IDYSTGLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPG------------ 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 255 cytpqpdsfhiFRDPVTGDipwPGTAFGMPITALWYWCINQV----IVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVM 330
Cdd:cd11475  218 -----------LLSPFGGD---LGAGGLLAIISLLAWGLGYFgqphILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVL 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 331 PGMISRILYTDMVAcvVPSEcvkhcgvdvgctnYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLY 410
Cdd:cd11475  284 VGLLGRALFPDGLL--GDPE-------------TVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLY 348

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 411 TK-IRKKASERELLIAGRLfvSVLIVTSI-LWVPIVEVSQGGQLVHYTEA-ISSYLGPPIaavfLVAVFCKRANEQGAFW 487
Cdd:cd11475  349 KAfLRKEASDKELVWVSRL--AVLVIALIaLLIALNPPSSVFSLVSFAWAgLGAAFGPLL----LLSLYWKRTTRQGALA 422

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 488 GLMVGLVMGLIrmiaefsygtgsclapssCPKIICGVHYLYFAIILFFVCILVILGVSYL 547
Cdd:cd11475  423 GMIAGAVTVVV------------------WKLLGLGIFGLYEIVPGFLASLLAIVVVSLL 464
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 26-547 1.47e-40

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 154.62  E-value: 1.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  26 AADISVIVIYFVVVMAVGVWAMLKTNrsTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHS 105
Cdd:cd11495    3 WLDYLVLVIYLLAMLGIGLYFSKKQK--STDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 106 FALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILF-LFIcvILTISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:cd11495   81 IIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFG-PWARVYGSLLFiLFQ--LGRMGIVLYLPALALSAVTGINPYIIIILM 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyeSFTEKFMNAIpsvvEGDNLTINsrcytpqpDSFH 264
Cdd:cd11495  158 GVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPG--GFGEVFDIAI----ANGKFSLG--------DFSF 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 265 IFRDPVTgdipwPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKL------------LPLFFMVMPG 332
Cdd:cd11495  224 SLTESTI-----WVIFIGGIFNNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALpvallffgigtaLYVFYQQHPE 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 333 MISRILYTDMVacvvpsecvkhcgvdvgctnyaYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK 412
Cdd:cd11495  299 LLPAGINGDAV----------------------FPYFIVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKR 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 413 IRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAfwglMVG 492
Cdd:cd11495  357 LSPDPSDKQYLKVARLITLLVGLLGTLVALYLANAGVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGA----LVG 432

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 120444906 493 LVMGLIRMIAEFSYGTgsclapsscpkiicGVHYLYFAIILFFVCILVILGVSYL 547
Cdd:cd11495  433 IIVSIIVIFWISLLYT--------------PIHFFLYSVIGTLVCFVVGYVVSLL 473
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 29-552 2.35e-34

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 136.50  E-value: 2.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  29 ISVIVIYFVVVMAVGVWAMLKTNRSTVggFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFAL 108
Cdd:cd11474    1 LIGVILYYLLILGIGLWASRRVKSSED--FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAQDPFGYAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGWIFV--PIYiKAGVMTMPEYLKKRFGgKRLQIylsilflfICVILTISADIF-SGAIFIKLA------LGLNLYL 179
Cdd:cd11474   79 CLILGGLFFakPMR-RMGLLTLGDFFRQRYG-RRVEV--------LLSIPAVLSYLGwVAAQLVALGlvlsviLGLPVET 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 180 AILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFT---EKFMNAIPSVVEGDNLTINsrcy 256
Cdd:cd11474  149 GILISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIASaaaAGKLRFFPWLGTKSDWLIW---- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 257 tpqpdsFHIFRDPVTGDIPWpgtafgmpitalwywcinQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISR 336
Cdd:cd11474  225 ------IDAWLTLGLGSIPQ------------------QDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAA 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 337 ILYTDMVACVVPSEcvkhcgvdvgcTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLY-TKIRK 415
Cdd:cd11474  281 SIDPSLTQYGLEED-----------AQLILPLLLQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYkPPFRP 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 416 KASERELLIAGRlfVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSY-LGPPIAAVflvaVFCKRANEQGAFWGLMVGLV 494
Cdd:cd11474  350 KASDRELLWVMR--ISVVVFGAIATLMALTVESIYGLVELASDLVLVgLFVPLLAG----LYWKRANTYGALAAIIVGLV 423

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 120444906 495 mglIRMIAEFSYGTGSCLAPSScpkiicgvhylyfaIILFFVCILVILGVSYLTKPIP 552
Cdd:cd11474  424 ---LRLLGGELLLGLPADIPPQ--------------LQGFPFSTLAMVIGSLLPLAVS 464
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 28-545 4.98e-34

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 135.77  E-value: 4.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKtnRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFA 107
Cdd:cd10326    1 DWAVVVVYFLILLAISYYTSRR--NADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKrlqIYLSILFLFIC-------VILTISADIFSGAIFIklALGLNLYLA 180
Cdd:cd10326   79 GYLIIAFVLLPLYYRLNLTSIYEYLEDRFGVS---SRKTGAVFFLLsrilgagIRLYLVALVLQQFLFD--SLGIPFWLT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 181 ILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyeSFTEkfmnAIPSVVEGDNLTInsrcytpqp 260
Cdd:cd10326  154 VLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGL--GFGE----AISAAGESGYSRI--------- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 261 dsfhIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMisrILYT 340
Cdd:cd10326  219 ----FNFDDDNSRRTFWKQFLGGIFITIAMTGLDQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGV---LLYT 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 341 DMVACVVPsecvkhcgVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRK---KA 417
Cdd:cd10326  292 YAQKNGIA--------LPAKDSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRkseKK 363

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 418 SERELLIAGRLFVSVLIVTSILWvpiveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQ--GAFWGLMVGLVM 495
Cdd:cd10326  364 SERKYVHIAFSLTFVLGILVFGS-----ASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDkwVPLVGLLAPVLS 438

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 120444906 496 GLIRMIAEFSYgtgsclapsscpkiicGVHYLYFAIILFFVCILVILGVS 545
Cdd:cd10326  439 YLLVSNSEGFF----------------GYKFGFELLIINGLLTFLGLLLS 472
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
24-550 5.24e-34

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 135.74  E-value: 5.24e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  24 NNAADISVIVIYFVVVMAVGVWAMLKTNR-STVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGlaGTGAA--------- 93
Cdd:COG4145    2 MNLAILIPLLIYLLLVLGIGIYASRKRSKgSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIG--GPGAAykyglgwvl 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  94 -SGIAVTAfeshSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIY--LSILFLFICvilTISADIFSGAIFIK 170
Cdd:COG4145   80 lAMIQVPT----AFLTLGVLGKKFAILGRKYNAVTLADWLRARYQSKALVLLaaLLLLLFFIA---FMVAQFVGGARLLE 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 171 LALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNlt 250
Cdd:COG4145  153 TVTGISYTTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIENIMSTLAAIDPNLVSPTG-- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 251 insrcytpqPDSFhIFRDPVTGD-IPWPGTAFGMPitalwywcinQVIVqRCLCGKNLSHVKAACILCGYLKLLPLFFMV 329
Cdd:COG4145  231 ---------PDGF-LPRPFVISFwILVGFGVIGLP----------HTAV-RCMAYKDSKSLHRAMIIGTIVVGLLMFGMH 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 330 MPGMISRILYTDMVAcvvpsecvkhcgvdvgcTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDL 409
Cdd:COG4145  290 LIGVLGRAVLPDLTV-----------------PDQVIPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDL 352

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 410 YTK-IRKKAS--ERELLIAGRLFVSVLIVTSIL--WVP---IVEVSQ---GGqlvhyteaissylgppIAAVFLVAVFC- 477
Cdd:COG4145  353 YLNyINPKASenEKKLKRLSKLVTLVLGLIVFLlaLNPpdlIIWLNLfafGG----------------LEAAFFWPLVLg 416

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120444906 478 ---KRANEQGAFWGLMVGLVMGLIRMIAEFSygtgsclapsscpkiICGVHYLYFAIILFFVCILVilgVSYLTKP 550
Cdd:COG4145  417 lywKRANATGAIASMLVGVASYFLLYYGNPK---------------IFGFHAIVPSLLISLIAFLI---GSLLGKP 474
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 28-513 1.81e-33

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 134.26  E-value: 1.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTNRSTvgGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAvtaFESHSFA 107
Cdd:cd11493    1 DLAVIVLYLLGLPLLGLWLSGRQKSTA--DYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLT---FLQLALG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLL---VLGWIFVPIYIKAGVMTMPEYLKKRFGGKrLQIYLSILFLfICVILTISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:cd11493   76 YILgriIVAFVLLPRYFRGEVVSAYELLGQRFGGG-MQKTASVTFL-VTRLLADGVRLFAAAIPVSMILGADGVALSYIA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 -----LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTpq 259
Cdd:cd11493  154 siliiSVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPYT-- 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 260 pdsfhiFRDPVTGDIPWPGTAFGMpitalwywciNQVIVQRCLCGKNLSHVKAACILCGYLkLLPLFFMVMpgMISRILY 339
Cdd:cd11493  232 ------FWAAIIGGALLSMASHGT----------DQLMVQRLLACRNLRDAQKALIGSGVV-VFPQFALFL--LIGLLLY 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 340 TDMVACVVPSecvkhcgVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKI-RKKAS 418
Cdd:cd11493  293 VYYGGASLAA-------LGLGSPDEVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWkRRRLS 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 419 ERELLIAGRL----FVSVLIVTSILWvpiveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLV 494
Cdd:cd11493  366 DEKLLRASRLltlvWAVVLVGIALLF-----QYTDQPVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFL 440

                        490
                 ....*....|....*....
gi 120444906 495 MGLIRMIAEFSYGTGSCLA 513
Cdd:cd11493  441 VMLLLIFGVKFLGLLFALA 459
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 27-547 2.14e-27

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 116.43  E-value: 2.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVW-AMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSghfVGLAGTGAAS---GIAVTAFE 102
Cdd:cd11492    1 VDYVVFVAMLLISAAIGIYfGFFGGKQKTTEEYLLGGRNMSVFPVALSLIASFISG---ITLLGTPAEIyyyGTQYWLIV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 103 SHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLfICVILTISADIFSGAIFIKLALGLNLYLAIL 182
Cdd:cd11492   78 IAYVLVGPITAYIFLPVFYNLQLTSVYEYLELRFN-RRVRLLASFLFI-LQMLLYLPIVIYAPALALSQVTGINLHIIIL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 183 ILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGyesftekFMNAIPSVVEGDNLTINSrcYTPQPDS 262
Cdd:cd11492  156 VVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGG-------FSEVWEIAEEGGRLEFFN--FDPDPTV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 263 FHIFrdpvtgdipWpGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGylkllPLFFMVMpgmisrilytdM 342
Cdd:cd11492  227 RHTF---------W-SLVIGGTFTWLSLYGVNQTQVQRYLSLPSLKSAKKALWLNI-----VGLILIL-----------S 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 343 VACVvpsecvkhcgvdVGCTNYAY-------------------PMLVLKLMP--MGLRGLMLS-VMLASLmSSLTSVFNS 400
Cdd:cd11492  281 LCCF------------TGLVIYAKyhdcdpltaglikkpdqllPYFVMDVLGhlPGLPGLFVAgIFSAAL-STLSSGLNS 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 401 ASTLFTIDLYTKIRKK-ASERELLIAGRLFVSVLIVTSILWVPIVEvsQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKR 479
Cdd:cd11492  348 LAAVILEDFIKPFFKKkLSERQATNIMKLLVVVFGLLCIGLAFLVE--KLGGVLQLSLSIFGITGGPLLGIFTLGMFFPW 425

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 480 ANEQGAFWGLMVGLV-MGLIRMIAEFSYGTGScLAPSSCPKIICG-----------------------------VHYLYF 529
Cdd:cd11492  426 ANSKGALVGLLVGLIfMLWIGIGGQIAIAPGP-LSFPPLPTSTEGcnytntttittsttttttedesepfplyrISYLWY 504

                        570
                 ....*....|....*...
gi 120444906 530 AIILFFVCILVILGVSYL 547
Cdd:cd11492  505 SLIGFLITVVVGLIVSLL 522
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-552 1.96e-23

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 103.84  E-value: 1.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKTnrSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFA 107
Cdd:cd11479    2 DYGVIALYFAAMIAIGWWGMRRA--KTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 108 LLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILF---LFICVILTISAdifsGAIFIKLaLGLNLYLAILIL 184
Cdd:cd11479   80 GILALSLLLAKRIARLKVYTVSEVLELRYGPSARVISALVMLaytLMVAVTSTIAI----GTVFSVL-FGLPRTLSILVG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMV-FAFVEVGGYESFTEKFmnaipsvvegdnltinsrcytpqPDSF 263
Cdd:cd11479  155 GGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLpLALSKAGGLSGLQEKL-----------------------PASY 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 264 HIFrdpvtGDIPWpGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTdmv 343
Cdd:cd11479  212 FDL-----TSIGW-DTIVTYFLLYFFGILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLP--- 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 acvvpsecvkhcgvDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKK-ASEREL 422
Cdd:cd11479  283 --------------DLANPQNAFATMAQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKnESERSE 348

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 423 LIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLvavfcKRANEQGAFWGLMVGLVMGLIRMia 502
Cdd:cd11479  349 VRLSRLFTLLLGVVVIVIAVLVNDVVAALTIAYAILVGGLLVPILGGLFW-----KRATGAGALASMVAGSVVVLAGM-- 421

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 120444906 503 eFSYGTgsclaPSSCPkiicgvhyLYFAIIlffVCILVILGVSYLTKPIP 552
Cdd:cd11479  422 -AVDGL-----LANTP--------IYYGLA---VSLVAFVAVSLLTRPTP 454
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
 27-516 3.75e-20

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 94.17  E-value: 3.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  27 ADISVIVIYFVVVMAVGVW-AMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHS 105
Cdd:cd11504    4 ADYVVFSLLLVISAGIGLYyACTGGKQKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQYWFLGCSY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 106 FALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLFICVILtISADIFSGAIFIKLALGLNLYLAILILL 185
Cdd:cd11504   84 FLGLLIPAHVFIPVFYRLELTSAYEYLELRFN-KTVRICGTVTFIFQMVIY-MGVVLYAPALALNAVTGFNLWISVLAMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 186 AITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAipSVVEGDNLtinsrcyTPQPDSFHI 265
Cdd:cd11504  162 VVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEAGGIARVWRVAAES--DRIDGFNL-------SPDPTIRHT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 266 FrdpvtgdipWPgTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILY-----T 340
Cdd:cd11504  233 F---------WT-LVVGGVFNMLALYGVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARYhecdpL 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 341 DMVACVVPSECVKHcgvdvgctnyaYPMLVLKLMPmGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASER 420
Cdd:cd11504  303 KNGIVARSDQLVPY-----------FVMDVLDGLP-GLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPKFPDMTEE 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 421 ELLIAGRLFVSVLIVTSILWVPIveVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRM 500
Cdd:cd11504  371 RATLLSKGLAVGYGLLCLLMAYL--ASTMGQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLLAGLFMAFWIG 448

                        490
                 ....*....|....*.
gi 120444906 501 IAEFSYGTGSCLAPSS 516
Cdd:cd11504  449 IGSKVFPPYSPTKSTP 464
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
 29-552 9.65e-20

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 92.65  E-value: 9.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  29 ISVIVIYFVVVMAVGVWAMLKTNRSTvGGF----FLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASG--------I 96
Cdd:cd10327    2 LLPIIIYLVILLGIGFYARRSKKRRS-GDFleeyFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGlgwvllamI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  97 AVTAfeshSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIyLSILFLFICVILTISADIFSGAIFIKLALGLN 176
Cdd:cd10327   81 QVPT----GFLTLGVLGKKFAIIARKINAVTIIDYLRARYNSKALVV-LSSLALIVFFIAAMVAQFIGGARLLEAVTGLS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 177 LYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVE---GDNLTIns 253
Cdd:cd10327  156 YVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAEIDPNLLTpfgPGFLSP-- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 254 rcytPQPDSFHIFRDPVTgdipwpgtaFGMPITAlwywcinqvivQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGM 333
Cdd:cd10327  234 ----PYILSFWVLVGFGV---------IGLPQTA-----------VRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGV 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 334 ISRILYTDMvacvvpsecvkhcgvDVGctNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKI 413
Cdd:cd10327  290 LGRAVLPDL---------------EVP--DKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNY 352

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 414 R---KKASEREL----LIAGRLFVSVLIVTSI----LWVPIVEVSQGGQlvhyteaISSYLGPpiaavFLVAVFCKRANE 482
Cdd:cd10327  353 KnkeKKTSEKKVkrisLIITIILGLLVFLLAInppdLIVWLNLFAFGGL-------EAAFFWP-----LVLGLYWKRANA 420

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 483 QGAFWGLMVGLVmglirmiaefSYgtgscLAPSSCPKIICGVHYLYFAIILFFVCILVilgVSYLTKPIP 552
Cdd:cd10327  421 TGALASMVVGLV----------SY-----ILITYLKIKILGLHPIVPSLLLSLIAFII---VSLATKKPD 472
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
 28-506 2.47e-18

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 88.79  E-value: 2.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVW-AMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11505    8 DYVVFAAMLFISAGIGIYyAFAGGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIFAFAYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLfICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11505   88 FVVLISSEVFLPVFYRLGITSTYEYLELRFN-KPVRLAGTVLFI-VQTILYTGIVIYAPALALNQVTGFDLWGAVVATGV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNaipsvveGDNLTINSrcYTPQPDSFHIF 266
Cdd:cd11505  166 VCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQGGIHNILNDSYN-------GSRLNFWD--FDPNPLRRHTF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVTGdipwpGTafgmpITALWYWCINQVIVQRCLCGKNLSHVKAACilcgYLKLLPLFFM----VMPGMISRILYTDm 342
Cdd:cd11505  237 WTITVG-----GT-----FTWTGIYGVNQSQVQRYISCKTRFQAKLSL----YFNLLGLWAIlvcaVFSGLAMYSHYKD- 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 343 vacvvpseCVKHCGVDVGCTNYAYPMLVLKL---MPmGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASE 419
Cdd:cd11505  302 --------CDPWTAKIVSAPDQLMPYLVLDIladYP-GLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSE 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 420 REL--------LIAGRLFVSVLIVTSILwvpivevsqgGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMV 491
Cdd:cd11505  373 KLSswiskglsLLYGAMCIGMAVAASLM----------GGLLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLT 442

                        490
                 ....*....|....*
gi 120444906 492 GLVMGLIRMIAEFSY 506
Cdd:cd11505  443 GFAISLWVGIGAQIY 457
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
 26-548 3.04e-17

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 85.29  E-value: 3.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  26 AADISVIVIYFVVVMAVGVWAMLKT-NRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESH 104
Cdd:cd11520    6 AWDYVVFAGLFLVSSGIGVFFAIKErKKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 105 SFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFggKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILIL 184
Cdd:cd11520   86 YTFVIIFTSELFLPVFYRSGITSTYEYLELRF--NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 185 LAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNaipsvveGDNLTInsrcytpqpdsFH 264
Cdd:cd11520  164 GIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNGGFTNVWETAYN-------GSRLNI-----------FD 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 265 IFRDPVTGDIPWPgTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACilcgYLKLLPLFFMVMPGMIS-RILYTDMV 343
Cdd:cd11520  226 FDVDPLRRHTFWT-ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLAL----YLNLLGLWIILVCAVFSgLIMYSHYK 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 344 AC--------VVPSECVKHcgvdvgctnyaYPMLVLKLMPmGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRK 415
Cdd:cd11520  301 DCdpwtsgfiSAPDQLMPY-----------FVMEIFSTMP-GLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFP 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 416 KASER--ELLIAGRLFVSVLIVTSIlwvpIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGL 493
Cdd:cd11520  369 HLSEKlsTWISKGLCILFGVMCTSM----AVAASLMGGVVQAALSIHGMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGI 444

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 494 VMGLIRMIAEFSY------------GTGSC-------LAPSSCPKIIC----------GVHYLYFAIILFFVCILVILGV 544
Cdd:cd11520  445 TLSFWVGIGAFIYpapssktlplelSTAGCilanstaTPTPATPILTSdrplladtwySLSYLYYSAVGCLGCIAAGLLI 524


                 ....
gi 120444906 545 SYLT 548
Cdd:cd11520  525 SFLT 528
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
 28-497 2.60e-16

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 82.20  E-value: 2.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVWAMLKT-NRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11503    2 DYGVFAAMLLVSTGIGLFVGLARgGQRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLfICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11503   82 LNSLMTAVLFMPVFYRLGITSTYQYLEMRFS-RAVRLCGTLQFI-VATMLYTGIVIYAPALILNQVTGLDIWASLFSTGI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEkfmnaipsvVEGDNLTINSRCYTPQPDSFHIF 266
Cdd:cd11503  160 ICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILVGGPRRVLE---------IAQNHSRINFMDFDPDPRRRYTF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 rdpvtgdipWpgtAFGMPITALW--YWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDmva 344
Cdd:cd11503  231 ---------W---TFVVGGTLVWlsMYGVNQAQVQRYVACRTEKQAKLALLVNQVGLCLIVSSAATCGIVMFVYYSN--- 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 345 cvvpseCVKHCGVDVGCTNYAYPMLVLKLMPM--GLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASEREL 422
Cdd:cd11503  296 ------CDPLLIGRISAPDQYMPYLVLDIFEDlpGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLPTIAPRKL 369

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120444906 423 LIAGRlFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGL 497
Cdd:cd11503  370 VFISK-GLSLIYGSACITVAALSSLLGGGVLQGSFTVMGVISGPLLGAFALGMFLPACNTPGVFSGLAVGLALSL 443
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
 36-498 1.03e-15

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 80.32  E-value: 1.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  36 FVVVMAVGVWAMLKTNR--STVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVtAFESHSFALLLVLG 113
Cdd:cd11476   11 FALLMVFITRLLKRYRGknQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSG-PFWYASGATLQILL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 114 WIFVPIYIKA---GVMTMPEYLKKRFGGKRLQIYLsiLFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAI 190
Cdd:cd11476   90 FAPLAIRIKRlapNAHTLLEIVRARYGTAAHLVFL--VFALFTNVIVLAMLLLGGSAVVNALTGMPIVAASFLIPLGVLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 191 FTITGGLASVIYTDTVQAVIMLVGSFILMVFAFV--EVGGYESFTEKFMNAIPSVVEGDNltinsrcytpqPDSFHIFRD 268
Cdd:cd11476  168 YTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTssDIGSPSKVYDLLQEAAPDLPVEGN-----------QGSYLTFKS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 269 PvtgdipwPGTAFGMP--ITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDmvacv 346
Cdd:cd11476  237 K-------AGLIFGIIniVGNFGTVFLDQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALALGLN----- 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 347 vpsecVKHCGVDVGctnYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLY-TKIRKKASERELLIA 425
Cdd:cd11476  305 -----PTFEEVSAG---LVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYrTYINPNATGKQLLRV 376

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 120444906 426 GRLFVSVL-IVTSILWVPIVEVsqGGQLVHYTEAISSYLGPPIAAVFLvAVFCKRANEQGAFWGLMVGLVMGLI 498
Cdd:cd11476  377 SRIAVIGFgLFMGGLAVGLNYI--GISLGWLLLFMGILIGSAVFPVAL-GLYWRRQTGTAAVVSPIAGLVAGLA 447
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
 28-497 1.08e-14

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 77.20  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  28 DISVIVIYFVVVMAVGVW-AMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF 106
Cdd:cd11519    8 DYVVFAGMLLISAGIGIYyAFAGGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 107 ALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGgKRLQIYLSILFLfICVILTISADIFSGAIFIKLALGLNLYLAILILLA 186
Cdd:cd11519   88 IVVVISAEVFLPVFYRLGITSTYEYLELRFN-KCVRLIGTSLFI-VQTALYTGIVIYAPALALNQVTGFDLWGAVVATGV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 187 ITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNaipsvveGDNLtiNSRCYTPQPDSFHIF 266
Cdd:cd11519  166 VCTFYCTLGGLKAVIWTDVFQVGIMVAGFVSVIIRAVVLQGGIGTILNDSYY-------GGRL--NFWDFDPNPLQRHTF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 267 RDPVT-GDIPWPGTafgmpitalwyWCINQVIVQRCLCGKNLSHVKaaciLCGYLKLLPLFFMVMPGMISRI-LYTdmva 344
Cdd:cd11519  237 WTIVIgGTFTWTSI-----------YGVNQSQVQRYISCKTRFQAK----MSLYVNLVGLWAILSCAVLSGLaMYS---- 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 345 cvVPSECVKHCGVDVGCTNYAYPMLVLKLMP--MGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASEREL 422
Cdd:cd11519  298 --IYKDCDPWTAKDVSAPDQLMPYLVLDILAdyPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQL 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 423 --------LIAGRLFVSVLIVTSILwvpivevsqgGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLV 494
Cdd:cd11519  376 swismgmsVFYGALCIGMAGLASLM----------GALLQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSGFA 445


                 ...
gi 120444906 495 MGL 497
Cdd:cd11519  446 ISL 448
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 29-547 1.38e-12

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 70.23  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  29 ISVIVIYFVVVMAVGVWAMLKTnrSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIavtafeshsFAL 108
Cdd:cd11480    1 IGLFFVFVTITLYITIWAARRT--RSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGY---------DGL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 109 LLVLGW--------IFVPIYI-KAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTIsADIFSGAIFIKLALGLNLYL 179
Cdd:cd11480   70 AYAIGWtggyvlllLLVAEPLrNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLV-AQMVGAGLLLSLLLGIPYEV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 180 AILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYeSFTEKFMNAIPSVVEGDNLTinsrcytpq 259
Cdd:cd11480  149 GVVVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGN-PLGAGPGLLGLAAAAASGAG--------- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 260 pdsFHIFRDPVTGDIPWP----------GTAfGMPitalwywcinQVIVqRCLCGKNlshVKAA-------CILCGYLKL 322
Cdd:cd11480  219 ---EAYLAPGLLLTDPLDvisltlalmlGTA-GLP----------HVLM-RFYTVPD---ARAArksvvwaLGFIGLFYL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 323 LPLFFmvmpGMISRIL-YTDMVACVVPSECVKHcgvdvgcTNYAYPMLVLKL-MPMGLRGLMLSVMLASLMSSLTSVFNS 400
Cdd:cd11480  281 LAPAL----GFGARALvGPDVIGAPIAGELDGG-------GDMAVLLLPEIAgLGDLLLALVAAGAFAAILATVAGLLLA 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 401 ASTLFTIDLYTK-IRKKASERELLIAGRLFVSVLIVTSI---LWVPIVEVsqgGQLVHYTEAI--SSylgppIAAVFLVA 474
Cdd:cd11480  350 AASALAHDLYAGvIRPGASERREVRVARIAAVVVGVIAIllaLLFPPQNV---AFLVALAFAIaaSA-----FFPVLVLG 421

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 120444906 475 VFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYGTGSCLAPSScpkiicGVHYLYFAIILFFVCILVILGVSYL 547
Cdd:cd11480  422 IFWRRFTTRGAIAGMLVGLLVSLVLIVLSPAVSGAPPGHDFA------GFPLTNPGLVSVPLGFLVAIVVSLL 488
PRK15419 PRK15419
sodium/proline symporter PutP;
58-508 4.39e-10

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 62.34  E-value: 4.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906  58 FFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGI-----AVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYL 132
Cdd:PRK15419  35 YILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGIseswiAIGLTLGAWINWKLVAGRLRVHTEYNNNALTLPDYF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 133 KKRFGGK-RLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIM 211
Cdd:PRK15419 115 TGRFEDKsRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLM 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 212 LVGSFILMVFAFVEVGGY----ESFTEKFMNAIpSVVEGDNLTinsrcytpqpdsfhifrdPVTGDIPWPGTAFGMPita 287
Cdd:PRK15419 195 IFALILTPVIVIISVGGFgdslEVIKQKSIENV-DMLKGLNFV------------------AIISLMGWGLGYFGQP--- 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 288 lwywcinqVIVQRCLCGKNLSHVKAAcilcgylkllplffmvmpgmiSRILYTDMVACVVPSECVKHCGV--------DV 359
Cdd:PRK15419 253 --------HILARFMAADSHHSIVHA---------------------RRISMTWMILCLAGAVAVGFFGIayfnehpaVA 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 360 GCTNYAYPMLVLKLMPM----GLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK-IRKKASERELLIAGRLFVSVLI 434
Cdd:PRK15419 304 GAVNQNAERVFIELAQIlfnpWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAfLRKHASQKELVWVGRVMVLVVA 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444906 435 VTSILWVPIVEVSQGGQLVHYTEAISSYLGPpiaaVFLVAVFCKRANEQGAFWGLMVGLV----------MGLIRMIAEF 504
Cdd:PRK15419 384 LVAIALAANPENRVLGLVSYAWAGFGAAFGP----VVLFSVMWSRMTRNGALAGMIIGALtvivwkqfgwLGLYEIIPGF 459


                 ....
gi 120444906 505 SYGT 508
Cdd:PRK15419 460 IFGS 463
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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