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Conserved domains on  [gi|19113899|ref|NP_592987|]
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peptide chain release factor [Schizosaccharomyces pombe]

Protein Classification

peptide chain release factor 1( domain architecture ID 1907968)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

CATH:  3.30.160.20|3.30.70.1660|1.10.287.4000
Gene Ontology:  GO:0003747|GO:0016149
SCOP:  4002864|4002570

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 58-390 1.68e-134

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 388.97  E-value: 1.68e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  58 DQSAMTndtDLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAQESDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQ- 136
Cdd:COG0216  28 DQKRFR---KLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARLEELEEELKILLLPKd 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 137 -ADSYalPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGV 215
Cdd:COG0216 105 pNDDK--NVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASE-GELGGYKEVIFRISGEGVYSRLKFESGV 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 216 HRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDS 295
Cdd:COG0216 182 HRVQRVPETESQGRIHTSAATVAVLPEA--EEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 296 RSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRVTDHRIGLSMHDLSTFMQGEekFD 375
Cdd:COG0216 260 RSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LD 337

                       330
                ....*....|....*
gi 19113899 376 EFLEKIRIWNREQLL 390
Cdd:COG0216 338 ELIDALIAEDQAEKL 352
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 58-390 1.68e-134

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 388.97  E-value: 1.68e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  58 DQSAMTndtDLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAQESDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQ- 136
Cdd:COG0216  28 DQKRFR---KLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARLEELEEELKILLLPKd 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 137 -ADSYalPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGV 215
Cdd:COG0216 105 pNDDK--NVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASE-GELGGYKEVIFRISGEGVYSRLKFESGV 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 216 HRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDS 295
Cdd:COG0216 182 HRVQRVPETESQGRIHTSAATVAVLPEA--EEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 296 RSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRVTDHRIGLSMHDLSTFMQGEekFD 375
Cdd:COG0216 260 RSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LD 337

                       330
                ....*....|....*
gi 19113899 376 EFLEKIRIWNREQLL 390
Cdd:COG0216 338 ELIDALIAEDQAEKL 352
prfA PRK00591
peptide chain release factor 1; Validated
 58-390 6.90e-134

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 387.51  E-value: 6.90e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   58 DQSAMTNdtdLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAQESDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQ- 136
Cdd:PRK00591  30 DQKRFRK---LSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEELKELEERLEELEEELKILLLPKd 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  137 -ADSYalPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGV 215
Cdd:PRK00591 107 pNDDK--NVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASE-GELGGYKEVIAEISGDGVYSKLKFESGV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  216 HRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDS 295
Cdd:PRK00591 184 HRVQRVPATESQGRIHTSAATVAVLPEA--EEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDE 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  296 RSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRVTDHRIGLSMHDLSTFMQGEekFD 375
Cdd:PRK00591 262 RSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LD 339

                        330
                 ....*....|....*
gi 19113899  376 EFLEKIRIWNREQLL 390
Cdd:PRK00591 340 ELIDALIAEDQAEKL 354
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 37-390 1.68e-114

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 338.21  E-value: 1.68e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899    37 LIEKARSLSSEYLQFHQVNNKDQsaMTNDTD----LAKRIARLRRVHNAYSKFKSLSEQISDLKQMeAQESDAEVKMMAV 112
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPE--VISDQDklrkLSKEYSQLEEIVDCYREYQQAQEDIKEAKEI-LEESDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   113 TEINEISNKIPKSIEDLENTLLPQADSYALPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSaVQGLEA 192
Cdd:TIGR00019  82 EELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSAN-ETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   193 ITEAIFSIEGEGAYGHLMLEGGVHRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHV 272
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPEL--EEVEVDINPADLRIDTFRSSGAGGQHV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   273 NRTESAVRLTHIPTGITVSMQDSRSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRV 352
Cdd:TIGR00019 239 NTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRV 318

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 19113899   353 TDHRIGLSMHDLSTFMQGeeKFDEFLEKIRIWNREQLL 390
Cdd:TIGR00019 319 TDHRINLTLYKLDEVLEG--DLDELIEALIAEDQAQQL 354
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 66-237 9.03e-57

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 184.51  E-value: 9.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899    66 TDLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAqesDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQaDSY-ALPA 144
Cdd:pfam03462  25 QKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKRLEELEEELKLLLLPK-DPNdDKNA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   145 LIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGVHRVQRTPAT 224
Cdd:pfam03462 101 ILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSE-TEAGGIKEATFEISGEGAYGRLKFESGVHRVQRVPPT 179

                         170
                  ....*....|...
gi 19113899   225 ETKGRVHTSTASV 237
Cdd:pfam03462 180 ESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
97-212 9.08e-31

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 113.71  E-value: 9.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899     97 QMEAQESDAEVKMMAVTEINEISNKIPKSIEDLE-NTLLPQADSYALPALIEIRPGVGGTEAAIFANELVEMYFQYANFK 175
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEEELEELLkLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 19113899    176 GWNCKFISKSAvqGLEA-ITEAIFSIEGEGAYGHLMLE 212
Cdd:smart00937  81 GWKVEVLDESE--GELGgIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 58-390 1.68e-134

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 388.97  E-value: 1.68e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  58 DQSAMTndtDLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAQESDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQ- 136
Cdd:COG0216  28 DQKRFR---KLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARLEELEEELKILLLPKd 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 137 -ADSYalPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGV 215
Cdd:COG0216 105 pNDDK--NVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASE-GELGGYKEVIFRISGEGVYSRLKFESGV 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 216 HRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDS 295
Cdd:COG0216 182 HRVQRVPETESQGRIHTSAATVAVLPEA--EEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 296 RSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRVTDHRIGLSMHDLSTFMQGEekFD 375
Cdd:COG0216 260 RSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LD 337

                       330
                ....*....|....*
gi 19113899 376 EFLEKIRIWNREQLL 390
Cdd:COG0216 338 ELIDALIAEDQAEKL 352
prfA PRK00591
peptide chain release factor 1; Validated
 58-390 6.90e-134

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 387.51  E-value: 6.90e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   58 DQSAMTNdtdLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAQESDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQ- 136
Cdd:PRK00591  30 DQKRFRK---LSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEELKELEERLEELEEELKILLLPKd 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  137 -ADSYalPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGV 215
Cdd:PRK00591 107 pNDDK--NVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASE-GELGGYKEVIAEISGDGVYSKLKFESGV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  216 HRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDS 295
Cdd:PRK00591 184 HRVQRVPATESQGRIHTSAATVAVLPEA--EEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDE 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  296 RSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRVTDHRIGLSMHDLSTFMQGEekFD 375
Cdd:PRK00591 262 RSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LD 339

                        330
                 ....*....|....*
gi 19113899  376 EFLEKIRIWNREQLL 390
Cdd:PRK00591 340 ELIDALIAEDQAEKL 354
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 37-390 1.68e-114

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 338.21  E-value: 1.68e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899    37 LIEKARSLSSEYLQFHQVNNKDQsaMTNDTD----LAKRIARLRRVHNAYSKFKSLSEQISDLKQMeAQESDAEVKMMAV 112
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPE--VISDQDklrkLSKEYSQLEEIVDCYREYQQAQEDIKEAKEI-LEESDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   113 TEINEISNKIPKSIEDLENTLLPQADSYALPALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSaVQGLEA 192
Cdd:TIGR00019  82 EELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSAN-ETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   193 ITEAIFSIEGEGAYGHLMLEGGVHRVQRTPATETKGRVHTSTASVIVLPQVsnDESSSLYDSSEVKIEVMRSRGAGGQHV 272
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPEL--EEVEVDINPADLRIDTFRSSGAGGQHV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   273 NRTESAVRLTHIPTGITVSMQDSRSQHQNKEKAFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQNRV 352
Cdd:TIGR00019 239 NTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRV 318

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 19113899   353 TDHRIGLSMHDLSTFMQGeeKFDEFLEKIRIWNREQLL 390
Cdd:TIGR00019 319 TDHRINLTLYKLDEVLEG--DLDELIEALIAEDQAQQL 354
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 67-384 3.75e-65

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 211.94  E-value: 3.75e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899    67 DLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAQESDAEVKMMAVTEINEISnkipKSIEDLENTLLPQADSYALPALI 146
Cdd:TIGR00020  53 AVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKALE----KKLAELELRTMLSGEYDANNAYL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   147 EIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFI--SKSAVQGLEAITeaiFSIEGEGAYGHLMLEGGVHRVQRTPAT 224
Cdd:TIGR00020 129 TIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIdySEGEEAGIKSVT---ILIKGPYAYGYLKSEQGVHRLVRISPF 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   225 ETKGRVHTSTASVIVLPQVsNDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDSRSQHQNKEK 304
Cdd:TIGR00020 206 DANGRRHTSFASVFVMPEV-DDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDS 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   305 AFLVLNSRLAALNAAKENEAERLKRKNQVTSSDRSEkLRTYNFN-QNRVTDHRIGLSMHDLSTFMQGEekFDEFLEKIRI 383
Cdd:TIGR00020 285 AMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ-IRSYVLHpYSMVKDLRTGYETGNVQAVLDGD--IDQFIEAYLK 361


                  .
gi 19113899   384 W 384
Cdd:TIGR00020 362 W 362
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 66-237 9.03e-57

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 184.51  E-value: 9.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899    66 TDLAKRIARLRRVHNAYSKFKSLSEQISDLKQMEAqesDAEVKMMAVTEINEISNKIPKSIEDLENTLLPQaDSY-ALPA 144
Cdd:pfam03462  25 QKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKRLEELEEELKLLLLPK-DPNdDKNA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   145 LIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSAvQGLEAITEAIFSIEGEGAYGHLMLEGGVHRVQRTPAT 224
Cdd:pfam03462 101 ILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSE-TEAGGIKEATFEISGEGAYGRLKFESGVHRVQRVPPT 179

                         170
                  ....*....|...
gi 19113899   225 ETKGRVHTSTASV 237
Cdd:pfam03462 180 ESQGRIHTSFATV 192
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 93-379 1.20e-55

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 185.63  E-value: 1.20e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   93 SDLKQMEAQESDAEvkmMAVTEINEIsNKIPKSIEDLENTLLPQADSYALPALIEIRPGVGGTEAAIFANELVEMYFQYA 172
Cdd:PRK08787  20 GELLDLAESEQDED---TALAVIADL-DKYQAHVEKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLRMYLRWA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  173 NFKGWNCKFISKSAVQgLEAITEAIFSIEGEGAYGHLMLEGGVHRVQRTPATETKGRVHTSTASVIVLPQVsNDESSSLY 252
Cdd:PRK08787  96 ESRGWKTELMEVSGGE-VAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEV-DDNIEIDI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  253 DSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDSRSQHQNKEKAFLVLNSRLAALNAAKENeAErlKRKNQ 332
Cdd:PRK08787 174 NPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRN-AE--KDALE 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 19113899  333 VTSSD--RSEKLRTYNFNQNRVTDHRIGLSMHDLSTFMQGEekFDEFLE 379
Cdd:PRK08787 251 ATKSDigWGSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGD--LDEFVE 297
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 253-356 1.28e-49

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 162.98  E-value: 1.28e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   253 DSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDSRSQHQNKEKAFLVLNSRLAALnAAKENEAERLKRKNQ 332
Cdd:pfam00472   8 DPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYEL-EEEKEEEKKRRIKSQ 86

                          90       100
                  ....*....|....*....|....*
gi 19113899   333 VTSSDRSEKLRTYNFN-QNRVTDHR 356
Cdd:pfam00472  87 VGSGDRSEQIRTYNFKpQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 64-371 1.06e-47

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 164.98  E-value: 1.06e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   64 NDTDLAKRIArlrrvhnaySKFKSLSEQISDLKQMEAQESDAEV-KMMAVTEINEISNKIPKSIEDLENtllpQADSYAL 142
Cdd:PRK05589   8 NDIKEAQEIT---------SEEKYLKDKLDKYNHLRNRIEDIEVlCEMMSEEDDEMKKEIISEVKNIKE----EIDRFKI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  143 P-----------ALIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISksAVQGLEA-ITEAIFSIEGEGAYGHLM 210
Cdd:PRK05589  75 EtllsgeydrnnAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIID--LLEGDEAgIKSVTLKITGEFAYGYLK 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  211 LEGGVHRVQRTPATETKGRVHTSTASVIVLPQVSNDESSSLyDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITV 290
Cdd:PRK05589 153 AEKGIHRLVRISPFNANGKRQTSFASVEVLPELTDDQDIEI-RSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  291 SMQDSRSQHQNKEKAFLVLNSRLAALN-AAKENEAERLkrKNQVTSSDRSEKLRTYNFNQ-NRVTDHRIGLSMHDLSTFM 368
Cdd:PRK05589 232 QCQNERSQHSNKETAMKMLKSKLVELKeRAHKEKIEDL--TGELKDMGWGSQIRSYVFHPyNLVKDHRTGVETSNVDSVM 309


                 ...
gi 19113899  369 QGE 371
Cdd:PRK05589 310 DGD 312
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 55-379 3.47e-45

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 158.89  E-value: 3.47e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   55 NNKDQSAMTNDTDLAKRIARLR-RVHNAYSKFKSLSEQISD---LKQMEAQESDAEVKMMAVTEINEISNKIPK-SIEDL 129
Cdd:PRK07342   1 NKAEDPSLWNDAQEAQKLMRERqQLDDSINGINHLEQTLNDnieLIAMGEEEGDKSIVEDAEKTIRDLKDEIDRrQIDAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  130 ENTLLPQADSYalpalIEIRPGVGGTEAAIFANELVEMYFQYANFKGWNCKFISKSavQGLEA-ITEAIFSIEGEGAYGH 208
Cdd:PRK07342  81 LSGEADANDTY-----LEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVH--DGEEAgIKSATILVKGHNAYGW 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  209 LMLEGGVHRVQRTPATETKGRVHTSTASVIVLPqVSNDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGI 288
Cdd:PRK07342 154 LKTESGVHRLVRISPYDSNARRHTSFASIWVYP-VIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  289 TVSMQDSRSQHQNKEKAFLVLNSRLAALNAAKENEAerlkrKNQVTSSD---------RSEKLRTYNFnqnrVTDHRIGL 359
Cdd:PRK07342 233 VVQCQQERSQHKNRAKAWSMLRARLYEEELKKREEA-----TNAAAASKtdigwghqiRSYVLQPYQL----VKDLRTGV 303

                        330       340
                 ....*....|....*....|
gi 19113899  360 SMHDLSTFMQGEekFDEFLE 379
Cdd:PRK07342 304 ESTNPQDVLDGD--LNEFME 321
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 87-379 5.85e-36

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 134.09  E-value: 5.85e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   87 SLSEQISDLKQMEAQESDAEVKMMAVTEinEISNKIPKSIEDLENTLLPQADSYAL-----------PALIEIRPGVGGT 155
Cdd:PRK06746  22 ALKDMVGKFRQLDETFENLEITHELLKE--EYDEDLHEELESEVKGLIQEMNEYELqlllsdpydknNAILELHPGAGGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  156 EAAIFANELVEMYFQYANFKGWNCKFISksAVQGLEA-ITEAIFSIEGEGAYGHLMLEGGVHRVQRTPATETKGRVHTST 234
Cdd:PRK06746 100 ESQDWGSMLLRMYTRWAEKRGFKVETVD--YLPGDEAgIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSF 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  235 ASVIVLPQVsNDESSSLYDSSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDSRSQHQNKEKAFLVLNSRLA 314
Cdd:PRK06746 178 VSCEVVPEF-NDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLY 256

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113899  315 AlNAAKENEAERLKRKNQVTSSDRSEKLRTYNFNQ-NRVTDHRIGLSMHDLSTFMQGEekFDEFLE 379
Cdd:PRK06746 257 Q-KKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPySLVKDHRTNTEVGNVQAVMDGE--IDPFID 319
PCRF smart00937
This domain is found in peptide chain release factors;
97-212 9.08e-31

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 113.71  E-value: 9.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899     97 QMEAQESDAEVKMMAVTEINEISNKIPKSIEDLE-NTLLPQADSYALPALIEIRPGVGGTEAAIFANELVEMYFQYANFK 175
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEEELEELLkLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 19113899    176 GWNCKFISKSAvqGLEA-ITEAIFSIEGEGAYGHLMLE 212
Cdd:smart00937  81 GWKVEVLDESE--GELGgIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 253-356 4.61e-25

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 99.05  E-value: 4.61e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899 253 DSSEVKIEVMRSRGAGGQHVNRTESAVRLTH------------IPTGITVSMQDSRSQHQNKEKAFLVLNSRLAalnaak 320
Cdd:COG1186  24 PESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLY------ 97

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19113899 321 enEAERLKRKNQVTSSDRSEKLRTYNFNQNR--VTDHR 356
Cdd:COG1186  98 --EAELEPKERRATKPTRGSKKRRLWGKQIRsmVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 254-333 7.62e-25

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 100.62  E-value: 7.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899   254 SSEVKIEVMRSRGAGGQHVNRTESAVRLTHIPTGITVSMQDSRSQHQNKEKAFLVLNSRLAALN--AAKENEAERLKRKN 331
Cdd:TIGR03072 105 EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQqeQAAALRAERRTAHH 184


                  ..
gi 19113899   332 QV 333
Cdd:TIGR03072 185 QI 186
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
253-316 5.25e-08

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 51.31  E-value: 5.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113899  253 DSSEVKIEVMRSRGAGGQHVNRTESAVRL------THIP---------------TG---ITVSMQDSRSQHQNKEKAFlv 308
Cdd:PRK09256  11 PENELEWRFIRASGPGGQNVNKVSTAVELrfdiaaSSLPefykerllalaghriTKdgvIVIKAQEFRSQERNREDAL-- 88


                 ....*...
gi 19113899  309 lnSRLAAL 316
Cdd:PRK09256  89 --ERLVAL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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