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Conserved domains on  [gi|19114450|ref|NP_593538|]
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transcription factor [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_PLM2-like cd22699
forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein ...
 68-175 1.55e-26

forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; This subfamily includes two homologs PLM2 and TOS4 (also called target of SBF protein 4), which are predicted to be chromatin-associated proteins. They bind to the promoters of genes with functions important for the G1/S (start) transition. PLM2 targets primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division, and transcription. TOS4 targets primarily genes involved in pheromone response, polarized growth, and transcription. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438751 [Multi-domain]  Cd Length: 122  Bit Score: 104.42  E-value: 1.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114450  68 RREPLSPM--SFVRMRSH--RVNKIGRSSQQCDHVLStVDKAISRVHAIVTCTQDR--MIIECVGWNGMIVSDKMRKSVF 141
Cdd:cd22699   1 LKSPSSHEatITIVLPSSdtAPVTIGRSSQSCDYISR-KNKQISRVHATIQYDPDRneLEITCLGWNGVTVDIPGQLKGY 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19114450 142 HMKKNDR----IVLVRPNSDACPVLDVfGYRVLLGWPS 175
Cdd:cd22699  80 KLKVNKTlnlsKELQKDEDFHNFVLDV-GERVLFPGVG 116
 
Name Accession Description Interval E-value
FHA_PLM2-like cd22699
forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein ...
 68-175 1.55e-26

forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; This subfamily includes two homologs PLM2 and TOS4 (also called target of SBF protein 4), which are predicted to be chromatin-associated proteins. They bind to the promoters of genes with functions important for the G1/S (start) transition. PLM2 targets primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division, and transcription. TOS4 targets primarily genes involved in pheromone response, polarized growth, and transcription. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438751 [Multi-domain]  Cd Length: 122  Bit Score: 104.42  E-value: 1.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114450  68 RREPLSPM--SFVRMRSH--RVNKIGRSSQQCDHVLStVDKAISRVHAIVTCTQDR--MIIECVGWNGMIVSDKMRKSVF 141
Cdd:cd22699   1 LKSPSSHEatITIVLPSSdtAPVTIGRSSQSCDYISR-KNKQISRVHATIQYDPDRneLEITCLGWNGVTVDIPGQLKGY 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19114450 142 HMKKNDR----IVLVRPNSDACPVLDVfGYRVLLGWPS 175
Cdd:cd22699  80 KLKVNKTlnlsKELQKDEDFHNFVLDV-GERVLFPGVG 116
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 70-151 2.47e-03

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 40.43  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114450    70 EPLSPMSFVRMR-SHRVNKIGRSsQQCDHVLSTVDKAISRVHAIVTCTQDRMIIECVGWNGMIVSDK---MRKSVFH-MK 144
Cdd:TIGR03354   9 HQLTPGIAAQKTfGTNGGTIGRS-EDCDWVLPDPERHVSGRHARIRYRDGAYLLTDLSTNGVFLNGSgspLGRGNPVrLE 87


                  ....*..
gi 19114450   145 KNDRIVL 151
Cdd:TIGR03354  88 QGDRLRL 94
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 87-126 3.62e-03

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 35.62  E-value: 3.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19114450     87 KIGRSSQQCDHVLStvDKAISRVHAIVTCTQDRMI-IECVG 126
Cdd:smart00240   2 TIGRSSEDCDIQLD--GPSISRRHAVIVYDGGGRFyLIDLG 40
 
Name Accession Description Interval E-value
FHA_PLM2-like cd22699
forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein ...
 68-175 1.55e-26

forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; This subfamily includes two homologs PLM2 and TOS4 (also called target of SBF protein 4), which are predicted to be chromatin-associated proteins. They bind to the promoters of genes with functions important for the G1/S (start) transition. PLM2 targets primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division, and transcription. TOS4 targets primarily genes involved in pheromone response, polarized growth, and transcription. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438751 [Multi-domain]  Cd Length: 122  Bit Score: 104.42  E-value: 1.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114450  68 RREPLSPM--SFVRMRSH--RVNKIGRSSQQCDHVLStVDKAISRVHAIVTCTQDR--MIIECVGWNGMIVSDKMRKSVF 141
Cdd:cd22699   1 LKSPSSHEatITIVLPSSdtAPVTIGRSSQSCDYISR-KNKQISRVHATIQYDPDRneLEITCLGWNGVTVDIPGQLKGY 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19114450 142 HMKKNDR----IVLVRPNSDACPVLDVfGYRVLLGWPS 175
Cdd:cd22699  80 KLKVNKTlnlsKELQKDEDFHNFVLDV-GERVLFPGVG 116
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 84-151 4.48e-04

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 39.57  E-value: 4.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19114450  84 RVNKIGRSSQqCDHVLStvDKAISRVHAIVTCTQDRMIIECVGW-NGMIVSDKMRKSVFHMKKNDRIVL 151
Cdd:cd00060  19 GVVTIGRSPD-CDIVLD--DPSVSRRHARIEVDGGGVYLEDLGStNGTFVNGKRITPPVPLQDGDVIRL 84
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 70-151 2.47e-03

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 40.43  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114450    70 EPLSPMSFVRMR-SHRVNKIGRSsQQCDHVLSTVDKAISRVHAIVTCTQDRMIIECVGWNGMIVSDK---MRKSVFH-MK 144
Cdd:TIGR03354   9 HQLTPGIAAQKTfGTNGGTIGRS-EDCDWVLPDPERHVSGRHARIRYRDGAYLLTDLSTNGVFLNGSgspLGRGNPVrLE 87


                  ....*..
gi 19114450   145 KNDRIVL 151
Cdd:TIGR03354  88 QGDRLRL 94
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 87-126 3.62e-03

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 35.62  E-value: 3.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19114450     87 KIGRSSQQCDHVLStvDKAISRVHAIVTCTQDRMI-IECVG 126
Cdd:smart00240   2 TIGRSSEDCDIQLD--GPSISRRHAVIVYDGGGRFyLIDLG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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