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Conserved domains on  [gi|19115309|ref|NP_594397|]
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isocitrate dehydrogenase (NAD+) subunit 1 Idh1 [Schizosaccharomyces pombe]

Protein Classification

NAD-dependent isocitrate dehydrogenase( domain architecture ID 10015520)

NAD-dependent isocitrate dehydrogenase converts isocitrate to 2-oxoglutarate in an NAD-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 18-353 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


:

Pssm-ID: 272942  Cd Length: 333  Bit Score: 600.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    18 GGKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGmEKNNKSsgDALHEAIQSLKRNKVGLKGILFTPFEKGG 97
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSP-QTDGKT--EIPDEAVESIKRNKVALKGPLETPIGKGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    98 HTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDF 177
Cdd:TIGR00175  78 HRSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   178 ALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSAL 257
Cdd:TIGR00175 158 ARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   258 VGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKTLTKDLG 337
Cdd:TIGR00175 238 VGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317

                         330
                  ....*....|....*.
gi 19115309   338 GSASTGDFTHAILERM 353
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 18-353 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 600.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    18 GGKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGmEKNNKSsgDALHEAIQSLKRNKVGLKGILFTPFEKGG 97
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSP-QTDGKT--EIPDEAVESIKRNKVALKGPLETPIGKGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    98 HTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDF 177
Cdd:TIGR00175  78 HRSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   178 ALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSAL 257
Cdd:TIGR00175 158 ARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   258 VGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKTLTKDLG 337
Cdd:TIGR00175 238 VGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317

                         330
                  ....*....|....*.
gi 19115309   338 GSASTGDFTHAILERM 353
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 1-354 2.03e-136

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 392.31  E-value: 2.03e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    1 MFKSLVRKSSAFQPLKYGGKY----------TVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTG-MEKNNKssgd 69
Cdd:PLN00123   1 LLKRLLSNALGSKAQRRSVTYmprpgdgaprAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGdMKKVPE---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   70 alhEAIQSLKRNKVGLKGILFTPFeKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEH 149
Cdd:PLN00123  77 ---EVLESIRRNKVCLKGGLATPV-GGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEH 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  150 QSVPGVVESLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQ 229
Cdd:PLN00123 153 EVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQ 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  230 AVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGL---SITGRGEANPTAAILSACLML 306
Cdd:PLN00123 233 LVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVgneKLVEQKKANPVALLLSSAMML 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 19115309  307 RHLGLKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354
Cdd:PLN00123 313 RHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 20-353 3.19e-119

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 348.15  E-value: 3.19e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDV--TGMEKNnkssGDAL-HEAIQSLKRNKVGLKGILFTP 92
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIggAAYDKT----GTPLpDETLEALRKADAILLGAVGGP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  93 --FEKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRH-----DNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKI 161
Cdd:COG0473  77 kwDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309 162 ITEYKSKRIAQFAFDFALQNgRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLV 241
Cdd:COG0473 157 YTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309 242 MPNLYGSILSNIGSALVGGPGVIPGANFGRDY-ALFEPgcrhVGLS---ITGRGEANPTAAILSACLMLRHLGLKDYADL 317
Cdd:COG0473 236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEP----VHGSapdIAGKGIANPIATILSAAMMLRHLGEEEAADA 311

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 19115309 318 INAATYSVIEEGkTLTKDLGGSASTGDFTHAILERM 353
Cdd:COG0473 312 IEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
22-349 3.02e-92

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 279.56  E-value: 3.02e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    22 TVTLIPGDGIGRETSNAVTEIFKTAN----VPIEFEEIDVTGMEKNNksSGDAL-HEAIQSLKRNKVGLKGILFTP-FEK 95
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDE--TGEPLpDETLEACKKADAVLLGAVGGPkWDP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    96 GGHTSFN--VALRKELDIYASLVLIKNIPG------FKTRHDNVDFAIIRENTEGEYSGLEHQSVPG---VVESLKIITE 164
Cdd:pfam00180  79 AGVRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   165 YKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADgLFRRTFYDVANG-YDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243
Cdd:pfam00180 159 DEIERIARVAFELARKRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFDVIVTP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   244 NLYGSILSNIGSALVGGPGVIPGANFGRD-YALFEPgcrhVGLS---ITGRGEANPTAAILSACLMLRH-LGLKDYADLI 318
Cdd:pfam00180 238 NLFGDILSDEASMLTGSLGLLPSASLGANgFGIFEP----VHGSapdIAGKGIANPIATILSAAMMLRYsLGLEDAADKI 313

                         330       340       350
                  ....*....|....*....|....*....|....
gi 19115309   319 NAATYSVIEEGKtLTKDLGGSA---STGDFTHAI 349
Cdd:pfam00180 314 EAAVLKVLESGI-RTGDLAGSAtyvSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 18-353 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 600.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    18 GGKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGmEKNNKSsgDALHEAIQSLKRNKVGLKGILFTPFEKGG 97
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSP-QTDGKT--EIPDEAVESIKRNKVALKGPLETPIGKGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    98 HTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDF 177
Cdd:TIGR00175  78 HRSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   178 ALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSAL 257
Cdd:TIGR00175 158 ARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   258 VGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKTLTKDLG 337
Cdd:TIGR00175 238 VGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317

                         330
                  ....*....|....*.
gi 19115309   338 GSASTGDFTHAILERM 353
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 1-354 2.03e-136

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 392.31  E-value: 2.03e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    1 MFKSLVRKSSAFQPLKYGGKY----------TVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTG-MEKNNKssgd 69
Cdd:PLN00123   1 LLKRLLSNALGSKAQRRSVTYmprpgdgaprAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGdMKKVPE---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   70 alhEAIQSLKRNKVGLKGILFTPFeKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEH 149
Cdd:PLN00123  77 ---EVLESIRRNKVCLKGGLATPV-GGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEH 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  150 QSVPGVVESLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQ 229
Cdd:PLN00123 153 EVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQ 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  230 AVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGL---SITGRGEANPTAAILSACLML 306
Cdd:PLN00123 233 LVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVgneKLVEQKKANPVALLLSSAMML 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 19115309  307 RHLGLKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354
Cdd:PLN00123 313 RHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 9-353 3.10e-124

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 361.89  E-value: 3.10e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    9 SSAFQPLKYGGKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVtGMEKNNKSSGDALHEAIQSLKRNKVGLKGI 88
Cdd:PLN00118  30 SSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYV-GTTVDPRTGSFLTWESLESVRRNKVGLKGP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   89 LFTPFEKGgHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSK 168
Cdd:PLN00118 109 MATPIGKG-HRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  169 RIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGS 248
Cdd:PLN00118 188 RVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGD 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  249 ILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEE 328
Cdd:PLN00118 268 IISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAE 347

                        330       340
                 ....*....|....*....|....*
gi 19115309  329 GKTLTKDLGGSASTGDFTHAILERM 353
Cdd:PLN00118 348 GKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 20-353 3.19e-119

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 348.15  E-value: 3.19e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDV--TGMEKNnkssGDAL-HEAIQSLKRNKVGLKGILFTP 92
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIggAAYDKT----GTPLpDETLEALRKADAILLGAVGGP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  93 --FEKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRH-----DNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKI 161
Cdd:COG0473  77 kwDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309 162 ITEYKSKRIAQFAFDFALQNgRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLV 241
Cdd:COG0473 157 YTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309 242 MPNLYGSILSNIGSALVGGPGVIPGANFGRDY-ALFEPgcrhVGLS---ITGRGEANPTAAILSACLMLRHLGLKDYADL 317
Cdd:COG0473 236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEP----VHGSapdIAGKGIANPIATILSAAMMLRHLGEEEAADA 311

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 19115309 318 INAATYSVIEEGkTLTKDLGGSASTGDFTHAILERM 353
Cdd:COG0473 312 IEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 20-353 2.09e-102

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 305.10  E-value: 2.09e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   20 KYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDV--TGMEKNnkssGDAL-HEAIQSLKRNKVGLKGILFTPFeKG 96
Cdd:PRK08997   2 KQTITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAglTALEKH----GELLpQRTLDLIEKNKIALKGPLTTPV-GE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   97 GHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLeHQSVP---GVVESLKIITEYKSKRIAQF 173
Cdd:PRK08997  77 GFTSINVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGE-GQTVSedgETAEATSIITRKGAERIVRF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  174 AFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNI 253
Cdd:PRK08997 156 AYELARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  254 GSALVGGPGVIPGANFGRDYALFEpGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKTLT 333
Cdd:PRK08997 236 CAGLVGGLGMAPGANIGRDAAIFE-AVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTT 314

                        330       340
                 ....*....|....*....|
gi 19115309  334 KDLGGSASTGDFTHAILERM 353
Cdd:PRK08997 315 RDLGGTHGTTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
19-353 1.00e-100

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 305.66  E-value: 1.00e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   19 GKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVtGMEKNNK--SSGDAlHEAIQSLKRNKVGLKGILFTPfEKG 96
Cdd:PRK09222   3 EKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEI-GEKVYKKgwTSGIS-PSAWESIRRTKVLLKAPITTP-QGG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   97 GHTSFNVALRKELDIYAslvlikNI-------PGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKR 169
Cdd:PRK09222  80 GYKSLNVTLRKTLGLYA------NVrpcvsyhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  170 IAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSI 249
Cdd:PRK09222 154 IIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  250 LSNIGSALVGGPGVIPGANFGRDYALFEPgcrhVGLS---ITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVI 326
Cdd:PRK09222 234 LSDIAAEISGSVGLAGSANIGEEYAMFEA----VHGSapdIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTL 309

                        330       340       350
                 ....*....|....*....|....*....|...
gi 19115309  327 EEGkTLTKDLGGS------ASTGDFTHAILERM 353
Cdd:PRK09222 310 EDG-IHTADIYNEgvskkkVGTKEFAEAVIENL 341
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 21-353 7.45e-96

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 288.19  E-value: 7.45e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   21 YTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDvTGMEKNNKSsGDAL-HEAIQSLKRNKVGLkgilftpFEKGGHT 99
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAE-AGDEVFEKT-GKALpEETIEAAKEADAVL-------FGAAGET 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  100 SFN--VALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDF 177
Cdd:PRK14025  73 AADviVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEM 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  178 A----LQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNI 253
Cdd:PRK14025 153 AkrrkKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  254 GSALVGGPGVIPGANFGRDYALFEPgCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKTlT 333
Cdd:PRK14025 233 AAGLVGGLGLAPSANIGDKYGLFEP-VHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLT-T 310

                        330       340
                 ....*....|....*....|
gi 19115309  334 KDLGGSASTGDFTHAILERM 353
Cdd:PRK14025 311 PDLGGNLSTMEMAEEVAKRV 330
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
22-349 3.02e-92

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 279.56  E-value: 3.02e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    22 TVTLIPGDGIGRETSNAVTEIFKTAN----VPIEFEEIDVTGMEKNNksSGDAL-HEAIQSLKRNKVGLKGILFTP-FEK 95
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDE--TGEPLpDETLEACKKADAVLLGAVGGPkWDP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    96 GGHTSFN--VALRKELDIYASLVLIKNIPG------FKTRHDNVDFAIIRENTEGEYSGLEHQSVPG---VVESLKIITE 164
Cdd:pfam00180  79 AGVRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   165 YKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADgLFRRTFYDVANG-YDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243
Cdd:pfam00180 159 DEIERIARVAFELARKRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFDVIVTP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   244 NLYGSILSNIGSALVGGPGVIPGANFGRD-YALFEPgcrhVGLS---ITGRGEANPTAAILSACLMLRH-LGLKDYADLI 318
Cdd:pfam00180 238 NLFGDILSDEASMLTGSLGLLPSASLGANgFGIFEP----VHGSapdIAGKGIANPIATILSAAMMLRYsLGLEDAADKI 313

                         330       340       350
                  ....*....|....*....|....*....|....
gi 19115309   319 NAATYSVIEEGKtLTKDLGGSA---STGDFTHAI 349
Cdd:pfam00180 314 EAAVLKVLESGI-RTGDLAGSAtyvSTSEFGEAV 346
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 23-353 1.99e-74

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 237.74  E-value: 1.99e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    23 VTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDV-TGMEKNNKSSGDAlHEAIQSLKRNKVGLKGILFTPfEKGGHTSF 101
Cdd:TIGR02924   3 ITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIgEKVYKKGWPSGIS-PSSWESIRRTKVLLKAPITTP-QGGGHKSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   102 NVALRKELDIYASL-VLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDFALQ 180
Cdd:TIGR02924  81 NVTLRKTLGLYANIrPCVSYHPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   181 NGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGG 260
Cdd:TIGR02924 161 HNRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   261 PGVIPGANFGRDYALFEpGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGkTLTKDLGGS- 339
Cdd:TIGR02924 241 VGLAGSANIGEEYAMFE-AVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLEDG-VHTADIYNEk 318

                         330
                  ....*....|....*....
gi 19115309   340 -----ASTGDFTHAILERM 353
Cdd:TIGR02924 319 tskqkVGTKEFAEAVTANL 337
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 26-355 9.22e-69

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 221.14  E-value: 9.22e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  26 IPGDGIGRETSNAVTEIFKTA-------NVPIEFEEIDVtGmEKNNKSSGDAL-HEAIQSLKRNKVGLKGILFTPFEkGG 97
Cdd:COG0538  24 IEGDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDA-G-EKARDETGDWLpDETAEAIKEYGVGIKGPLTTPVG-GG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  98 HTSFNVALRKELDIYASL---VLIKNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQS-VPGVVE---------------- 157
Cdd:COG0538 101 WRSLNVTIRQILDLYVCRrpvRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAgSPEALKliffledemgvtvirf 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309 158 ------SLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA------------------NGY 213
Cdd:COG0538 181 pedsgiGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAeeefgdkfitegpwekykGPK 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309 214 DA--ITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDY-ALFEP--GC--RHVGLS 286
Cdd:COG0538 261 PAgkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGgAEFEAthGTapKYAGKD 340

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115309 287 ITgrgeaNPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKtLTKDL-----GGSA-STGDFTHAILERMES 355
Cdd:COG0538 341 ST-----NPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGK-VTYDLarlmeGATElSTSEFGDAIIENLDK 409
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 20-356 3.16e-66

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 213.04  E-value: 3.16e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEE-------IDVTG-------MEKNNKSsgDA-LHEAI----- 75
Cdd:PRK00772   2 TYKIAVLPGDGIGPEVMAEAVKVLDAVaekfGFDFEFEEalvggaaIDAHGvplpeetLEACRAA--DAvLLGAVggpkw 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   76 QSLKRNKVGLKGILftpfekgghtsfnvALRKELDIYASLVLIKNIPGFKT-------RHDNVDFAIIRENTEGEYSGlE 148
Cdd:PRK00772  80 DNLPPDVRPERGLL--------------ALRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFG-E 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  149 HQSVPGVVESLK-----IITEYKSKRIAQFAFDFALQNGRKsVTCIHKANIMKlADGLFRRTFYDVANGYDAITPKDLIV 223
Cdd:PRK00772 145 PRGREGLGGEERafdtmVYTREEIERIARVAFELARKRRKK-VTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYV 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  224 DNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRD-YALFEPgcrhVGLS---ITGRGEANPTAAI 299
Cdd:PRK00772 223 DNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEP----IHGSapdIAGKGIANPIATI 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19115309  300 LSACLMLRH-LGLKDYADLINAATYSVIEEGKtLTKDL---GGSASTGDFTHAILERMESL 356
Cdd:PRK00772 299 LSAAMMLRYsLGLEEAADAIEAAVEKVLAQGY-RTADIaegGGKVSTSEMGDAILAALAEG 358
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
20-356 6.12e-56

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 188.12  E-value: 6.12e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   20 KYTVTLIPGDGIGRETSNAVTEIFKTA-----NVPIEFEEIDVTGMEKNNKSSGDAL-HEAIQSLKRNKVGLKGILFTPF 93
Cdd:PRK06451  23 KPIILYVEGDGIGPEITHAAMKVINKAvekayGSDREIKWVEVLAGDKAEKLTGNRFpKESEELIEKYRVLLKGPLETPI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   94 EKGgHTSFNVALRKELDIYASLVLIKNIPGFKT--RH-DNVDFAIIRENTEGEYSGLEH---------------QSVPGV 155
Cdd:PRK06451 103 GKG-WKSINVAIRLMLDLYANIRPVKYIPGIESplKNpEKIDLIIFRENTDDLYRGIEYpydseeakkirdflrKELGVE 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  156 VES-----LKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA---------------NGYDA 215
Cdd:PRK06451 182 VEDdtgigIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVAlkefrdyvvteeevtKNYNG 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  216 ITPK------DLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEpGCRHVGLSITG 289
Cdd:PRK06451 262 VPPSgkviinDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE-AIHGTAPKYAG 340

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115309  290 RGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEgKTLTKDLG-----GSASTGDFTHAILERMESL 356
Cdd:PRK06451 341 KNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQ-KKVTQDLArfmgvRALSTTEYTDELISIIDML 411
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 26-353 1.39e-52

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 179.10  E-value: 1.39e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   26 IPGDGIGRETSNAVTEIFKTA-------NVPIEFEEIdVTGmEKNNKSSGDAL---HEAIQSLKRNKVGLKGILFTPFeK 95
Cdd:PRK07006  25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEI-YAG-EKATKVYGEDVwlpEETLDLIREYRVAIKGPLTTPV-G 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   96 GGHTSFNVALRKELDIYASLVLI---KNIPGFKTRHDNVDFAIIRENTEGEYSGLEHQSvpGVVESLKII---------- 162
Cdd:PRK07006 102 GGIRSLNVALRQELDLYVCLRPVryfKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA--GSAEAKKVIkflqeemgvk 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  163 ---------------TEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA-----------NGYDA- 215
Cdd:PRK07006 180 kirfpetsgigikpvSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAeeefgdelidgGPWDKi 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  216 --------ITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEpgCRH-VGLS 286
Cdd:PRK07006 260 knpetgkeIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE--ATHgTAPK 337

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115309  287 ITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEgKTLTKD----LGGSA--STGDFTHAILERM 353
Cdd:PRK07006 338 YAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIAS-KTVTYDfarlMEGATevKCSEFGDALIKNM 409
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 20-353 1.29e-49

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 169.34  E-value: 1.29e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   20 KYTVTLIPGDGIGRETsnaVTEIFK------TANVPIEFEEIDVTGmeKNNKSSGDAL-HEAIQSLKRNKVGLKGILFTP 92
Cdd:PRK03437   4 TMKLAVIPGDGIGPEV---VAEALKvldavaAGGPGVETTEYDLGA--RRYLRTGETLpDSVLAELRQHDAILLGAIGDP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   93 ------FEKGghtsFNVALRKELDIYASLVLIKNIPGFKTRHDN---VDFAIIRENTEGEYSG--------LEHQsvpgV 155
Cdd:PRK03437  79 svpsgvLERG----LLLKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHE----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  156 VESLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQ 235
Cdd:PRK03437 151 ATEVSVNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPS 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  236 QFDVLVMPNLYGSILSNIGSALVGGPGVIPGANF---GRDYALFEPgcrhVGLS---ITGRGEANPTAAILSACLMLRHL 309
Cdd:PRK03437 231 RFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEP----VHGSapdIAGQGIADPTAAILSVALLLDHL 306

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 19115309  310 GLKDYADLINAATYSVIEEgktltkDLGGSASTGDFTHAILERM 353
Cdd:PRK03437 307 GEEDAAARIEAAVEADLAE------RGKMGRSTAEVGDRIAARL 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 20-356 3.48e-45

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 157.96  E-value: 3.48e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   20 KYTVTLIPGDGIGRETSNAVTEIFKTA-----NVPIEFEEIDVTG---MEKNNKSSGDALH-----EAI-------QSLK 79
Cdd:PRK08194   3 QFKIAVIPGDGVGKEVVPAAVRVLKAVaevhgGLKFEFTEFPWSCeyyLEHGEMMPEDGLEqlkqfDAIflgavgnPKLV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   80 RNKVGLKGILftpfekgghtsfnVALRKELDIYASLVLIKNIPGFKT----RHDnVDFAIIRENTEGEYS---GLEHQSV 152
Cdd:PRK08194  83 PDHISLWGLL-------------IKIRREFEQVINIRPAKQLRGIKSplanPKD-FDLLVVRENSEGEYSevgGRIHRGE 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  153 PGVVESLKIITEYKSKRIAQFAFDFAlQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVS 232
Cdd:PRK08194 149 DEIAIQNAVFTRKGTERAMRYAFELA-AKRRKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  233 RPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANF---GRDYALFEPgcrhVGLS---ITGRGEANPTAAILSACLML 306
Cdd:PRK08194 228 RPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEP----VHGSapdIAGKGIANPIGQIWTAKLML 303

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 19115309  307 RHLGLKDYADLINAATYSVIEEGkTLTKDLGGSASTGDFTHAILERMESL 356
Cdd:PRK08194 304 DHFGEEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRLKKL 352
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
75-352 2.42e-30

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 120.59  E-value: 2.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   75 IQSLKRNKVGLKGILFTPFeKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRH---DNVDFAIIRENTEGEYSGLEHQS 151
Cdd:PRK07362  91 LEAIREYGVAIKGPLTTPI-GGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHknpEKLDVIVYRENTEDIYMGIEWEA 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  152 ----------------VPGVVE------------SLKIITEYKSKRIAQFAFDFALQ-NGRKS-VTCIHKANIMKLADGL 201
Cdd:PRK07362 170 gdeigdklikhlneevIPASPElgkrqiplgsgiGIKPVSKTGSQRHIRRAIEHALRlPGDKRhVTLVHKGNIMKYTEGA 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  202 FRRTFYDVAN------------------------------------GYDAITPK-------------------------- 219
Cdd:PRK07362 250 FRDWGYELATtefrdecvtereswilsnkeknpnisiednarmiepGYDSLTPEkkaaicaevkevldsiwsshgngkwk 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  220 ------DLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEP----GCRHVGLSitg 289
Cdd:PRK07362 330 ekvlvdDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEAthgtAPKHAGLD--- 406

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  290 rgEANPTAAILSACLMLRHLGLKDYADLINAATYSVIEEGKtLTKDLG-------GSASTGDFTHAILER 352
Cdd:PRK07362 407 --RINPGSVILSGVMMLEYLGWQEAADLITKGLSAAIANKQ-VTYDLArlmeppvDPLSCSEFAEAIISH 473
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 8-329 3.31e-25

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 105.15  E-value: 3.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309    8 KSSAFQPLKygGKYTVTLIPGDGIGRETSNAVTEIFKTAN----VPIEFEEIDVTGMEKNNKSSGDALHEAIQSLKRNKV 83
Cdd:PLN02329  36 RCAAASPGK--KRYNIALLPGDGIGPEVISVAKNVLQKAGslegLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309   84 GLKGILFTPFEKG-GHTSFNVAL---RKELDIYASLVLIKNIPGF-------KTRHDNVDFAIIRENTEGEYSGLE---- 148
Cdd:PLN02329 114 LLGAIGGYKWDKNeKHLRPEMALfylRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPrgit 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  149 -HQSVPGVVESLKIITEYKSKRIAQFAFDFALQNgRKSVTCIHKANIMKlADGLFRRTFYDVANGYDAITPKDLIVDNAS 227
Cdd:PLN02329 194 iNENGEEVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAA 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115309  228 MQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRD-YALFEPgCRHVGLSITGRGEANPTAAILSACLML 306
Cdd:PLN02329 272 MQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEP-IHGSAPDIAGQDKANPLATILSAAMLL 350

                        330       340
                 ....*....|....*....|....
gi 19115309  307 RH-LGLKDYADLINAATYSVIEEG 329
Cdd:PLN02329 351 KYgLGEEKAAKRIEDAVVDALNKG 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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