NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|160707919|ref|NP_598590|]
View 

major facilitator superfamily domain-containing protein 6 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 71-625 1.79e-170

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 495.95  E-value: 1.79e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  71 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGI 150
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 151 GFVkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrr 230
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 231 pqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASSVT 310
Cdd:cd17335   84 ---------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVP 106

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 311 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIdvlidgkgckppeYRNYQIVFIVFGVLMTMALIVAT 390
Cdd:cd17335  107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLAL 173

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 391 QFRFRYNHfnnsdgkgkeveipqverdnstesseetptaatHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 470
Cdd:cd17335  174 KFPFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 471 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTH 550
Cdd:cd17335  221 LFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160707919 551 AAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 625
Cdd:cd17335  301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
PHA03381 super family cl31824
tegument protein VP22; Provisional
 666-779 2.97e-04

tegument protein VP22; Provisional


The actual alignment was detected with superfamily member PHA03381:

Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.46  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 666 PRVEARLPPKKTKH--QEEQEDVNKPAWGVSSSPwvtfvyalyqvKELIQLTRESRASEIQP-LQGTSENREASPAGGAQ 742
Cdd:PHA03381  47 GAGQARGRSQAERRfhHYDEARADYPYYTGSSSE-----------DERPADPRPSRRPHAQPeASGPGPARGARGPAGSR 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 160707919 743 RAPRETHSASPRNQPSP--------------DTAASQTQSSPAHP--SATPHG 779
Cdd:PHA03381 116 GRGRRAESPSPRDPPNPkgasaprgrksacaDSAALLDAPAPAAPkrQKTPAG 168
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 71-625 1.79e-170

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 495.95  E-value: 1.79e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  71 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGI 150
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 151 GFVkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrr 230
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 231 pqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASSVT 310
Cdd:cd17335   84 ---------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVP 106

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 311 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIdvlidgkgckppeYRNYQIVFIVFGVLMTMALIVAT 390
Cdd:cd17335  107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLAL 173

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 391 QFRFRYNHfnnsdgkgkeveipqverdnstesseetptaatHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 470
Cdd:cd17335  174 KFPFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 471 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTH 550
Cdd:cd17335  221 LFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160707919 551 AAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 625
Cdd:cd17335  301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 69-607 1.35e-71

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 238.68  E-value: 1.35e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919   69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNL 148
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  149 GIGFVKPatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltsept 228
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  229 rrpqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASS 308
Cdd:pfam12832  88 -----------------------------------------------------------SLTFWWLALLVVLFSFFWNAI 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  309 VTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLidgkgckppeyrnYQIVFIVFGVLMTMALIV 388
Cdd:pfam12832 109 LPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  389 ATQFRFrynhfnnsdgkgkeveipqverdnstesseetPTAATHSQAFNfwDLIKLLCSVQYGSVLFVAWFMGFGYGFVF 468
Cdd:pfam12832 176 PLAPPE--------------------------------MEYESKGGSKA--VFWNLLKQPEVIIFFLAAFLLGFSHGPFY 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  469 TFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQG 547
Cdd:pfam12832 222 TFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHA 301

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  548 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 607
Cdd:pfam12832 302 ISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
453-630 2.71e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.17  E-value: 2.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:COG2814   14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 611
Cdd:COG2814   94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                        170
                 ....*....|....*....
gi 160707919 612 ACLVILLLFALIQWLAVPD 630
Cdd:COG2814  169 VNAVLALLALLLLLRLLPE 187
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
77-141 1.57e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.91  E-value: 1.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160707919  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADrfRKG-KIVLLFSLL 141
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLAD--RKGrKIMLLRSAL 92
PHA03381 PHA03381
tegument protein VP22; Provisional
 666-779 2.97e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.46  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 666 PRVEARLPPKKTKH--QEEQEDVNKPAWGVSSSPwvtfvyalyqvKELIQLTRESRASEIQP-LQGTSENREASPAGGAQ 742
Cdd:PHA03381  47 GAGQARGRSQAERRfhHYDEARADYPYYTGSSSE-----------DERPADPRPSRRPHAQPeASGPGPARGARGPAGSR 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 160707919 743 RAPRETHSASPRNQPSP--------------DTAASQTQSSPAHP--SATPHG 779
Cdd:PHA03381 116 GRGRRAESPSPRDPPNPkgasaprgrksacaDSAALLDAPAPAAPkrQKTPAG 168
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 71-625 1.79e-170

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 495.95  E-value: 1.79e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  71 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGI 150
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 151 GFVkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrr 230
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 231 pqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASSVT 310
Cdd:cd17335   84 ---------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVP 106

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 311 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIdvlidgkgckppeYRNYQIVFIVFGVLMTMALIVAT 390
Cdd:cd17335  107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLAL 173

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 391 QFRFRYNHfnnsdgkgkeveipqverdnstesseetptaatHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 470
Cdd:cd17335  174 KFPFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 471 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTH 550
Cdd:cd17335  221 LFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160707919 551 AAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 625
Cdd:cd17335  301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 69-607 1.35e-71

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 238.68  E-value: 1.35e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919   69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNL 148
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  149 GIGFVKPatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltsept 228
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  229 rrpqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASS 308
Cdd:pfam12832  88 -----------------------------------------------------------SLTFWWLALLVVLFSFFWNAI 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  309 VTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLidgkgckppeyrnYQIVFIVFGVLMTMALIV 388
Cdd:pfam12832 109 LPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  389 ATQFRFrynhfnnsdgkgkeveipqverdnstesseetPTAATHSQAFNfwDLIKLLCSVQYGSVLFVAWFMGFGYGFVF 468
Cdd:pfam12832 176 PLAPPE--------------------------------MEYESKGGSKA--VFWNLLKQPEVIIFFLAAFLLGFSHGPFY 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  469 TFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQG 547
Cdd:pfam12832 222 TFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHA 301

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  548 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 607
Cdd:pfam12832 302 ISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 72-621 1.77e-44

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 164.40  E-value: 1.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  72 SKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLgig 151
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 152 fvkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppklLQKRdvqlsetepnisdidlvstaltltseptrrp 231
Cdd:cd17479   78 ---------------------------------------------LYHQ------------------------------- 81

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 232 qteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqeveaIFLIILVVVIIGEFFSASSVTI 311
Cdd:cd17479   82 ----------------------------------------------------------IFLLVLLVIIIWELLSAPLEKV 103

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 312 VDTVTLQYLGKHR--DRYGLQRMWGSLGwgLAMLSVGIGidythidVLIDGKGCKPPEYRN-YQIVFIVFGVLMTMALIV 388
Cdd:cd17479  104 ADDSLYEYLDFVDatERYGKLKVWSALG--AAFGPCGIT-------LLVDNLDCFLPPKISrILLHFYTYGGFMILTFLL 174

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 389 ATQFrfrynhfnnsdgkgkeveiPQVERDNSTESSEEtptaathSQAFNFwdlikLLCSVQ---YGSVLFVawfMGFGYG 465
Cdd:cd17479  175 SFFY-------------------PIPVPKKEEHSSKV-------VKGLRL-----LGGDGRailYALTVFL---VGFVGS 220

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 466 FVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVL 545
Cdd:cd17479  221 TVQNFLFWLMQDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELL 300

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707919 546 QGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFA 621
Cdd:cd17479  301 HAFSNGALWWAVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 74-625 1.26e-31

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 127.54  E-value: 1.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  74 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd06174    3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 154 KPatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrrpqt 233
Cdd:cd06174   82 PS------------------------------------------------------------------------------ 83

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 234 eaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqeveaiFLIILVVVIIGEFFSASSVTIVD 313
Cdd:cd06174   84 ---------------------------------------------------------FWLLLLGRFLLGLGSGLIDPAVL 106

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 314 TVTLQYLGKHR--DRYGLQRMWGSLGWGLAMLSVGIGIDYThidvlidgkgckppeyrnYQIVFIVFGVLMTMALIVATQ 391
Cdd:cd06174  107 ALIADLFPERErgRALGLLQAFGSVGGILGPLLGGILASSL------------------GFGWRAVFLIAAALALLAAIL 168

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 392 FRFRYNHFNNSDGKGKEVEipqverdnstesseetptaathSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFL 471
Cdd:cd06174  169 LLLVVPDPPESARAKNEEA----------------------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLL 226

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 472 YWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIE-LIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVT 549
Cdd:cd06174  227 PLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160707919 550 HAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIGGVLVNYFGAAAT-FRGIGMACLVILLLFALIQW 625
Cdd:cd06174  307 LGGLLPLSFALIAELFPPEIRGTAFGL-----LNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-623 3.03e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 87.25  E-value: 3.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLfnlgigfvkpa 156
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAV----------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 157 tlrclpkipptahptnvshpVTVLpmnsstVAFFSTPPKLlqkrdvqlsetepnisdidlvstaltltseptrrpqteai 236
Cdd:cd17325   74 --------------------STLL------FAFATSYWQL---------------------------------------- 87

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 237 thpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqeveaIFLIILVVVIIGEFFSASSVTIVDTVT 316
Cdd:cd17325   88 -----------------------------------------------------LLARFLQGLASAAVWPAAMALIADIAP 114

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 317 LQYLGKhrdRYGLQRMWGSLGWGLAMLSVGIGIDYTHidvlidgkgckppeyrnYQIVFIVFGVLMTMALIVATQFRfry 396
Cdd:cd17325  115 PEERGR---AMGIFSSAIGLGFLIGPLLGGLLADALG-----------------YRAPFLVCAALALLALVLALLLL--- 171

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 397 nhfnnsdgkgkeveipqverdnstESSEETPTAATHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLE 476
Cdd:cd17325  172 ------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 477 DLNGTTT-----LFGVcSVLSHVseLTAYFFShKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 551
Cdd:cd17325  228 ELGGLSPaqiglLFGA-QGLASA--LSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLG 303

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 160707919 552 AIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 623
Cdd:cd17325  304 LVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
453-630 2.71e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.17  E-value: 2.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:COG2814   14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 611
Cdd:COG2814   94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                        170
                 ....*....|....*....
gi 160707919 612 ACLVILLLFALIQWLAVPD 630
Cdd:COG2814  169 VNAVLALLALLLLLRLLPE 187
MFS_1 pfam07690
Major Facilitator Superfamily;
453-633 1.37e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 79.00  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  453 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGaaatFRGIGM 611
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLLASLFG----WRAAFL 155

                         170       180
                  ....*....|....*....|..
gi 160707919  612 ACLVILLLFALIQWLAVPDEEE 633
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 453-633 5.09e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.45  E-value: 5.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigMA 612
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSA-IGLGFLIGPLLGGLLADALGYRAPF----LV 155

                        170       180
                 ....*....|....*....|.
gi 160707919 613 CLVILLLFALIQWLAVPDEEE 633
Cdd:cd17325  156 CAALALLALVLALLLLPEPRP 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 453-652 8.43e-12

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 67.58  E-value: 8.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRtsaqGILQGLHlGLGRGCGAMIGGVLVNYFG-AAATFRGIGM 611
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR----GRVLGLY-STVLGLGFALGPLLLALVGtAGALPFLIAA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 160707919 612 ACLVILLLFALIQWLAVPDEEEDKTMLAERIpVPSSPVPIA 652
Cdd:cd17477  156 VLLLLALVPLLLTRRAAPEIEEAESISLRRL-LRIAPLALL 195
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
291-586 2.87e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.77  E-value: 2.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 291 FLIILVVVI---IGEFFSASSVTIVDTVTLQYLGKhrdRYGLQRMWGSLGWGLAMLSVGIGIDYThidvlidgkgckppe 367
Cdd:COG2814  100 LLLAARFLQglgAGALFPAALALIADLVPPERRGR---ALGLLGAGLGLGPALGPLLGGLLADLF--------------- 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 368 yrNYQIVFIVFGVLMTMALIVATQFrfrynhfnnsdgkgkeveIPqverdnstesseETPTAATHSQAFNFWDLIKllcS 447
Cdd:COG2814  162 --GWRWVFLVNAVLALLALLLLLRL------------------LP------------ESRPAARARLRGSLRELLR---R 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 448 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTAR 526
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 527 YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGR 586
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 424-623 2.07e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 63.36  E-value: 2.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 424 EETPTAATHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvsELT 498
Cdd:cd17474  174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPiiiglLFAGWSVLL---ALG 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 499 AYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ 578
Cdd:cd17474  251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 160707919 579 GLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 623
Cdd:cd17474  331 FV-RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
453-628 4.10e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.19  E-value: 4.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSVAAPPLqADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGM 611
Cdd:COG2271   94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG-PLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                        170
                 ....*....|....*..
gi 160707919 612 ACLVILLLFALIQWLAV 628
Cdd:COG2271  173 PGLLLALLRFWLLALAY 189
MFS_1 pfam07690
Major Facilitator Superfamily;
290-593 7.53e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.28  E-value: 7.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  290 IFLIILVVVIIGeFFSASSVTIVDTVTLQYLGK-HRDR-YGLQRMWGSLGWGLAMLSVGIGIDYThidvlidgkgckppe 367
Cdd:pfam07690  85 LWLLLVLRVLQG-LGAGALFPAALALIADWFPPeERGRaLGLVSAGFGLGAALGPLLGGLLASLF--------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  368 yrNYQIVFIVFGVLMTMALIVATqfrfrynhfnnsdgkgkeveIPQVERDNSTESSEETPTAATHSqafnfwdLIKLLCS 447
Cdd:pfam07690 149 --GWRAAFLILAILSLLAAVLLL--------------------LPRPPPESKRPKPAEEARLSLIV-------AWKALLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  448 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN---T 524
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilaA 279

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  525 ARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQglhlgLGRGCGAMIG 593
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN-----TAGSLGGALG 343
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 455-622 7.85e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.46  E-value: 7.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 455 FVAWFMGFGYGFVFTFLYWHLEDLNGTT-----TLFGVCSVLSHvseltayFFSHKLIELIGHIRVLYIGLACNTARYIY 529
Cdd:cd17489  201 LILFLASIAYGAISTFLPLYAAERGISNaglffTVYAIALLLSR-------PFSGKLSDRKGPKTVIIPGLLLLALGLLL 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 530 ISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGI 609
Cdd:cd17489  274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF-FDLGIGLGGLLLGLVAELFGYRAMFLLA 352

                        170
                 ....*....|...
gi 160707919 610 GMACLVILLLFAL 622
Cdd:cd17489  353 AVVVLLALVLYIF 365
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 460-619 1.34e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 60.70  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 460 MGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSE-LTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWT 538
Cdd:cd17490  207 QMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNaLASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 539 VLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILL 618
Cdd:cd17490  287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY-ALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365


                 .
gi 160707919 619 L 619
Cdd:cd17490  366 L 366
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 452-623 2.16e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.92  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 452 SVLFVawFMGFGYGFVFTFLYwhLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:cd17489    4 ANFFF--FLSFYLLLPVLPLY--AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGM 611
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY-GLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158

                        170
                 ....*....|..
gi 160707919 612 ACLVILLLFALI 623
Cdd:cd17489  159 LALLALLLVFLV 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 453-654 3.12e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 59.75  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGlhlglGRGCGAMIGGVLVNYFGAA--ATFRGIG 610
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQA-----FGSVGGILGPLLGGILASSlgFGWRAVF 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 160707919 611 MACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATI 654
Cdd:cd06174  156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV 199
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 453-623 5.78e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 58.78  E-value: 5.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd06173  214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMA 612
Cdd:cd06173  294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL-NSGAMPLGALLAGLLADALGLSAVFLLAGAL 372

                        170
                 ....*....|.
gi 160707919 613 CLVILLLFALI 623
Cdd:cd06173  373 LLLAALLLLLL 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
327-623 6.25e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.15  E-value: 6.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 327 YGLQRMWGSLGWGLAMLSVGIGIDYTHIDvlidgkgckppEYRNYQIVFIVFGVLMTMALIVAtqFRFRynhfnnsdgkg 406
Cdd:COG2211  149 SSWRFAFAGLGGLLASVLPPPLVAAFGGD-----------AALGYRLTALIFAVLGLLAFLLT--FFGT----------- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 407 KEVEIPQVERdnstesseetptaathsqaFNFWDLIKLLCSV-QYGSVLFVAWFMGFGYGFVFT-FLYWHLEDLNGTTTL 484
Cdd:COG2211  205 KERPVPEEEK-------------------VSLKESLKALLKNrPFLLLLLAYLLFFLALALVAAlLLYYFKYVLGLSAAL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 485 FGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI--YISYLENAWTVLPMEVLQGVTHAAIWAACISYLS 562
Cdd:COG2211  266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLllFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 160707919 563 AAVPP-ELRT--SAQGILQGLH---LGLGRGCGAMIGGVLVNYFG-------AAATFRGIGMACLVILLLFALI 623
Cdd:COG2211  346 DVVDYdEWKTgrRREGLYFGIFtfaIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLL 419
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 461-620 7.23e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 58.36  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 461 GFGYGFVFTFLYWHLEDLNGT----------TTLFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACNTARYIYI 530
Cdd:cd17330    9 ALGFGIVFPVLPFYVREFNKLgasgyyvgllQSSYSLGQFLA------SPLWG-RLSDRYGRKPVLLLSLAGSAVSYVLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 531 SYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATF---R 607
Cdd:cd17330   82 GLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII-SAAFGLGFILGPALGGFLSTPYGYALPFlvaA 159

                        170
                 ....*....|...
gi 160707919 608 GIGMACLVILLLF 620
Cdd:cd17330  160 ALALLNLVLVLFF 172
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 453-622 1.24e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.13  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVcsVLShvseltAYFFSH--------KLIELIGHIRVLYIGLACN 523
Cdd:COG0477   18 ALALGTFLeGLDFTIVNVALPSIAADLGASSAQLGW--IVS------AYLLGRaiglllfgRLGDRYGRKRVLLIGLLLF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 603
Cdd:COG0477   90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWR 168

                        170
                 ....*....|....*....
gi 160707919 604 ATFrGIGMACLVILLLFAL 622
Cdd:COG0477  169 WIF-LINAPLGLLALVLRL 186
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-153 1.59e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.19  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  74 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRkGKIVLLFSLLCWVLFNLGIGFV 153
Cdd:COG2271   17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG-RRRVLAIGLLLWGLATLLFGFA 95
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
453-622 1.67e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 57.58  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFmgfgyGFVFTFLYWHL---------EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN 523
Cdd:COG2223    6 VLLLATL-----AFFLAFGVWYLwsvlapplaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 603
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG-GNLGAAVAAFLAPLLIAAFGWR 159

                        170
                 ....*....|....*....
gi 160707919 604 ATFRGIGMACLVILLLFAL 622
Cdd:COG2223  160 NAFLILGILLLVVAVLAWL 178
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
69-158 4.03e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.45  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFFYSAYGSLYPLLPVYYkqLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNL 148
Cdd:COG2211  233 LLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLL 309

                         90
                 ....*....|
gi 160707919 149 GIGFVKPATL 158
Cdd:COG2211  310 LLFFLGPGNL 319
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 459-636 4.93e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 55.70  E-value: 4.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 459 FMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAW 537
Cdd:cd17329   10 LNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 538 TVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFgaaatFRGIGMACLVIL 617
Cdd:cd17329   90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL-YWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLF 163

                        170
                 ....*....|....*....
gi 160707919 618 LLFALIQWLAVPDEEEDKT 636
Cdd:cd17329  164 LLAALVLLFLLPETRPKRR 182
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 453-623 1.29e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.53  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACnTARYIYIS 531
Cdd:cd17316  182 LILLWFFISFGYYGLTTFLpTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL-SGILALPL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YL---ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAqgilqglhLGLGRGCGAMIGGVLVNYFGAAATFRG 608
Cdd:cd17316  261 FYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG--------VGLSYNLGRLGGGGAPPLIALLLASTG 332

                        170
                 ....*....|....*
gi 160707919 609 IGMACLVILLLFALI 623
Cdd:cd17316  333 GTGVPALILALLAIV 347
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 453-620 1.73e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 54.09  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYgFVFTFLYWHLEDLNGTTTLFGVCSVLSH-VSELTAYFFSHkLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:cd17370  205 YLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNlVYALAAYPAGR-LSDRIGRKKLLILGYLSLALAYLGFA 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIG----GVLVNYFGAAATFR 607
Cdd:cd17370  283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL-----FNTVVGIGWLLAsliaGYLWDLISPSAAFL 357

                        170
                 ....*....|....
gi 160707919 608 -GIGMACLVILLLF 620
Cdd:cd17370  358 fSAVLALIALLLLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 505-621 1.91e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 54.10  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 505 KLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGL 584
Cdd:cd17321   53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW-GAVVGI 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 160707919 585 GRGCGAMIGGVLVNYFGAAATF--------------RGIGMACLVILLLFA 621
Cdd:cd17321  132 GAALGPLLGGLLLELFGWRWIFlinvpiglvalllaRTFSGAVLAAFLLGA 182
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 63-158 2.67e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.58  E-value: 2.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  63 VKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGM-SPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLL 141
Cdd:cd06174  199 VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL 278

                         90
                 ....*....|....*..
gi 160707919 142 CWVLFNLGIGFVKPATL 158
Cdd:cd06174  279 LMALGLALLLLAPSLLL 295
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 290-624 2.94e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.39  E-value: 2.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 290 IFLIILVVVIIGE--FFSASSVTIVDTVTlqylGKHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYthidvlidgkgckpp 366
Cdd:cd17329   90 LFAIALVLTGFGGglFEPASEAMIADVTT----PENRTRaFSLLYWAINLGVAIGPLLGGLLLLY--------------- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 367 eyrNYQIVFIVFGVLMTM-ALIVATQFRFRYNHFNNSDGKGKEVEIPQVERDnstesseetptaathsQAFnfwdlikll 445
Cdd:cd17329  151 ---SFRLLFLAAAVLFLLaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD----------------RAF--------- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 446 csvqygsVLFVAWFMG--FGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvseLTAYFFSHKLIELIGHIRVLYI 518
Cdd:cd17329  203 -------LLFLLASFLisLIYFQLESTLPVYVVEILGLGEsllglLLALNALLI----VLLQFPVARLVERFRLRKILMI 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 519 GLACNTARYIyISYLENAWTVLPM--------EVLqGVTHAAIWAACISylsaavPPELRTSAQGiLQGLHLGLGRGCGA 590
Cdd:cd17329  272 GILLFAIGFA-VLAFANTLAVLILamivltlgEML-VFPAVQTLVAALA------PPDKRGSYMG-FYALAWGLGRAIGP 342

                        330       340       350
                 ....*....|....*....|....*....|....
gi 160707919 591 MIGGVLVNYFGAAATFRGIGMACLVILLLFALIQ 624
Cdd:cd17329  343 LVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 32-153 4.66e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.96  E-value: 4.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  32 REPEPPSNETPSSTETSAIPEEEIdwiekhcvKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQL-GMSPSQSGLLVGI 110
Cdd:cd17325  172 PEPRPPPNKRAVSAARLRSGLRLL--------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGA 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 160707919 111 RYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17325  244 QGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLA 285
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 453-624 5.35e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.58  E-value: 5.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLF--GVCSVLSHVSELTAYFFShKLIELIGHIRVLYIGLACNTARYIYI 530
Cdd:cd17473  202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALigLALAIASLAGAIGALLFG-RLKRRLGKRRLLAIGFALMALGFLLL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 531 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVN-YFGAAATFRGI 609
Cdd:cd17473  281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA-FFLGQFLSPLVLGPLVNlTGGLSGAFLIL 359

                        170
                 ....*....|....*
gi 160707919 610 GMACLVILLLFALIQ 624
Cdd:cd17473  360 GVLALVLAIVLLLLR 374
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 491-622 6.82e-07

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 52.25  E-value: 6.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 491 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYL---ENAWTVLPMEVLQGVTHAAIWAACISYLSA 563
Cdd:cd06177  242 LGQISEilfmLAIPFFLKRL----GIKKVMLIGMLAWVLRFGLFAYGdpsPGVWMLVLSIILHGVCYDFFFVTGYIYVDK 317

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160707919 564 AVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAAT---FRGI-----GMAcLVILLLFAL 622
Cdd:cd06177  318 KAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEGtkdWQTIwlvpaIYA-LVLAILFAL 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 506-630 1.01e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 51.78  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 506 LIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ-GLHLG- 583
Cdd:cd17324   57 LSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFsGLTLGl 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 160707919 584 -LGRgcgaMIGGVLVNYFGAAATFRGIGmaclVILLLFALIQWLAVPD 630
Cdd:cd17324  137 vLGR----PLGGLLGQLLGWRAAFLAIA----VLALLAALLLWRLLPS 176
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
69-158 1.30e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.42  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrKGKIVLLFSLLCWVLFNL 148
Cdd:COG2223    7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLL 85

                         90
                 ....*....|
gi 160707919 149 GIGFVKPATL 158
Cdd:COG2223   86 LLALAVSYWL 95
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-158 1.38e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  74 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-RKGKIVLLFSLLCWVLFNLGIG 151
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLA 266


                 ....*..
gi 160707919 152 FVKPATL 158
Cdd:COG2271  267 LLPSPAL 273
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
453-623 1.92e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWF-MGFGYGFVFTFLYWHLEDLNG--------TTTLFGVCSVlshVSELTAYFFSHKLIEliGHIRVLYIGLACN 523
Cdd:COG2271  184 LLALAYFlVYFALYGFLTWLPTYLVEVRGlslaqaglLLSLPFLAGI---VGSLLGGWLSDRLGR--RRKLVLAIGLLLA 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAA 603
Cdd:COG2271  259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLDATGYQ 337

                        170       180
                 ....*....|....*....|
gi 160707919 604 ATFrGIGMACLVILLLFALI 623
Cdd:COG2271  338 AAF-LLLAALALLAALLALL 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-153 2.17e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  74 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIV---LLFSLLCWVLFNLG 149
Cdd:COG2814  214 LLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLligLLLLALGLLLLALA 293


                 ....
gi 160707919 150 IGFV 153
Cdd:COG2814  294 GSLW 297
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 497-623 2.61e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 50.27  E-value: 2.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 497 LTAYF--------FSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPE 568
Cdd:cd17504   37 LTAYLlvgavstpILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPE 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 160707919 569 LRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 623
Cdd:cd17504  116 RVPVAQGILSAT-FGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
74-158 2.79e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.26  E-value: 2.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  74 VFYFFFYSA-YGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGIGF 152
Cdd:COG2807  221 TLFFGLQSLlYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300


                 ....*.
gi 160707919 153 VkPATL 158
Cdd:COG2807  301 A-PGSL 305
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 69-153 3.18e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFN 147
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILSGILA 257


                 ....*.
gi 160707919 148 LGIGFV 153
Cdd:cd17316  258 LPLFYL 263
MFS_1 pfam07690
Major Facilitator Superfamily;
34-157 3.91e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919   34 PEPPSNETPSSTETSAIPEEEIDWieKHCVKVNNDLLISKVFYFFFysAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYF 113
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAW--KALLRDPVLWLLLALLLFGF--AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 160707919  114 IEFCSAPFWGVVADRFRKGKIVLLFSLLCwVLFNLGIGFVKPAT 157
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTL 289
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 77-153 5.12e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 5.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707919  77 FFFYSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17329    9 FLNRLGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGFALLGFA 85
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 463-620 6.72e-06

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 49.27  E-value: 6.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 463 GYGFVFTFLYWHL---------EDLNGTTTLFGVcsvlsHVSELTAYFFSHKLIELIGHIRVLYIGLaCNTARYIYISYL 533
Cdd:cd17338    5 SFGFLLIFLAYSAlqnlqtslhENGLGSISLGIL-----YSSFAVSSFIAPLLVKLLGEKITLVLGG-LGYAIFIASNIF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 534 ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA-------ATF 606
Cdd:cd17338   79 PIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSI-FQLSQVFGNLISLALLNHSKGSsgttilfIVF 157

                        170
                 ....*....|....
gi 160707919 607 RGIgMACLVILLLF 620
Cdd:cd17338  158 MAI-MLVGIILLFF 170
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 84-152 1.06e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 1.06e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  84 GSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrKGKIVLLFSLLCWVLFNLGIGF 152
Cdd:cd17474   16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRF-GRKKVLLPGLLLFGIGGLLCGL 83
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 453-623 1.19e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.34  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGY-GFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAY-FFSHKLIELIGHIRVLYIGLACNTARYIYI 530
Cdd:cd17330  179 LLLVYFLIALAFaGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 531 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFrGIG 610
Cdd:cd17330  259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ-SLARIIGPLLAGPLYSFLGPGVPF-LLA 336

                        170
                 ....*....|...
gi 160707919 611 MACLVILLLFALI 623
Cdd:cd17330  337 AGLLLIALFLLSL 349
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
74-146 4.48e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 4.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 160707919  74 VFYFFFYSAYGSLYPLLPVYYK-QLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLF 146
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
491-622 4.87e-05

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 46.30  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  491 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYLEN------AWTVLPMeVLQGVTHAAIWAACISY 560
Cdd:pfam03825 251 LGQISEilfmLTLPFFLKRF----GIKNVMLIGIVAWALRFAFFAYGADptpfgtALLLLSM-IVHGVAYDFFNITGYIF 325

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  561 LSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR-------GIGMAcLVILLLFAL 622
Cdd:pfam03825 326 VDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDwqtvwlvFAGMA-LVLAVLFMA 393
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 77-153 5.51e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.10  E-value: 5.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIG 151
Cdd:cd17391    6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGR-KPMLLRASLGMAIVIGLMA 84


                 ..
gi 160707919 152 FV 153
Cdd:cd17391   85 FV 86
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 510-636 6.59e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 46.05  E-value: 6.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 510 IGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVthAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCG 589
Cdd:cd17472   59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI-GASIGIAFAIS 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 160707919 590 AMIGGVLVNYFGAAATFrgIGMACLVILLLFalIQWLAVPDEEEDKT 636
Cdd:cd17472  136 MVLGPLLAAHLGVSGLF--LITAILSLVSLL--ILLFFVPDPPKIVQ 178
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
289-623 8.23e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 8.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 289 AIFLIILV----VVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRM-WGSLGWGL-AMLSVGIGIdythidVLIDGKG 362
Cdd:COG0738   86 GLLLFALApsypLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnLLHAFFSLgALLGPLLGG------LLILLGL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 363 ckPPEYRnyqIVFIVFGVLMTMALIVATQFRFRynhfnnsdgkgkeveipqverDNSTESSEETPTAATHSQAFNFwdli 442
Cdd:COG0738  160 --SLSWH---LPYLILAVLLLLLALLFLRSKLP---------------------EIEEEEEEAAGSAASLKSLLKN---- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 443 kllcsvqygSVLFVAWFMGFGYGFV----FTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLY 517
Cdd:COG0738  210 ---------PRLLLGGLAIFLYVGAegaiGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 518 IGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPelRTSAQGilqGLHLGLGrGCGAMIG---- 593
Cdd:COG0738  281 LSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK--RTAAAV---SAVLIMG-IVGGAIGppli 354

                        330       340       350
                 ....*....|....*....|....*....|
gi 160707919 594 GVLVNYFGAAATFrGIGMACLVILLLFALI 623
Cdd:COG0738  355 GFLADAFGLRAAF-LVPLVCYLLILLLALA 383
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 455-642 8.27e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.68  E-value: 8.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 455 FVAWFMG-----FGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLyigLACNTAR--- 526
Cdd:cd06173    1 FRLLWLAqllsaLGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL---ILADLLRall 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 527 -----YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFG 601
Cdd:cd06173   78 aavlaLLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLA-TQLARIIGPALGGLLVALLG 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 160707919 602 AAATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERI 642
Cdd:cd06173  157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL 197
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 517-622 1.09e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 45.35  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 517 YIGLACNTARYIYISYLENAWTV---LPMEVLQGVT--HAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAM 591
Cdd:cd17386   67 LVGLLLSSLILVLIVYFTTVPSVwwfYLSAIPLALFggFTAFLSASFAYISDISSEKKRTYRMAILEVA-LGLGGFLGSL 145

                         90       100       110
                 ....*....|....*....|....*....|.
gi 160707919 592 IGGVLVNYFGAAATFrGIGMACLVILLLFAL 622
Cdd:cd17386  146 LSGHLFKALGYAWSF-SISAALLLIALLYIL 175
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 82-155 1.26e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.88  E-value: 1.26e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707919  82 AYGSLYPLLPVY---YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-RkgKIVLLFSLLCWVLFNLGIGFVKP 155
Cdd:cd17330   11 GFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYgR--KPVLLLSLAGSAVSYVLLGLSRN 86
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
77-141 1.57e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.91  E-value: 1.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160707919  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADrfRKG-KIVLLFSLL 141
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLAD--RKGrKIMLLRSAL 92
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 453-621 2.12e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.46  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 453 VLFVAWFMGFGYGF-VFTFLYWHLEDLNGTTT--------LFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACN 523
Cdd:cd17324  202 LAYLITFLLFGGFFaLYTYLAPFLTDVPGFSSsaiiglllLFGVAGVVG------SPLAG-RLADRGGRRALLIALLLLA 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPpelrtSAQGILQGLHLG---LGRGCGAMIGGVLVNYF 600
Cdd:cd17324  275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-----EARGLASSLYLAaynLGGALGAALGGLVLDHG 349

                        170       180
                 ....*....|....*....|.
gi 160707919 601 GAAATFRGIGMACLVILLLFA 621
Cdd:cd17324  350 GWAGVGWVGAALLLLALLLAL 370
PHA03381 PHA03381
tegument protein VP22; Provisional
 666-779 2.97e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.46  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 666 PRVEARLPPKKTKH--QEEQEDVNKPAWGVSSSPwvtfvyalyqvKELIQLTRESRASEIQP-LQGTSENREASPAGGAQ 742
Cdd:PHA03381  47 GAGQARGRSQAERRfhHYDEARADYPYYTGSSSE-----------DERPADPRPSRRPHAQPeASGPGPARGARGPAGSR 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 160707919 743 RAPRETHSASPRNQPSP--------------DTAASQTQSSPAHP--SATPHG 779
Cdd:PHA03381 116 GRGRRAESPSPRDPPNPkgasaprgrksacaDSAALLDAPAPAAPkrQKTPAG 168
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 77-138 4.67e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.30  E-value: 4.67e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 160707919  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLF 138
Cdd:cd17370    9 LFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIL 70
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 88-153 4.72e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 4.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160707919  88 PLLPVYYKQLGMSPSQSGLLVGIrYFIEFC-SAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17324   20 GLLPDIARDFGVSVAQAGLLVSA-YALGYAlGALLLGPLSDRIER-RRLLLVLLLLFILGNLLAALA 84
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
328-629 5.20e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 328 GLQRMWGSLGWGLAMLSVGigidythidVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFrfrynhfnnsdgkgk 407
Cdd:COG2223  132 GLAAGGGNLGAAVAAFLAP---------LLIAAFG--------WRNAFLILGILLLVVAVLAWLF--------------- 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 408 eveipqVERDNSTESSEETPTAATHSQAF---NFWdlikllcsvqygsVLFVAWFMGFGYGFVFTF---LYWHLE---DL 478
Cdd:COG2223  180 ------LRDPPAGAAAAAKASLRDQLEALrdpRFW-------------LLSLLYFGTFGSFIGFSSwlpPYLVDQfglSA 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 479 NGTTTLFGVCSVLSHVSELTAYFFSHKlielIGHIRVLYIGLACNTARYIYISY-LENAWTVLPMEVLQGVTHAAIWAAC 557
Cdd:COG2223  241 ATAGLLAALFALLGALGRPLGGWLSDR----IGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLFLLLGLALGGGNGAV 316

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 160707919 558 ISYLSAAVPPELRTSAQGILqglhlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVP 629
Cdd:COG2223  317 FALVPDIFPTKNAGAVYGLV-----GAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 69-152 5.56e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.88  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCS-APFWGVVADRF-RkgKIVLLFSLLCWVLF 146
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSA-YLLGRAIgLLLFGRLGDRYgR--KRVLLIGLLLFGLA 92


                 ....*.
gi 160707919 147 NLGIGF 152
Cdd:COG0477   93 SLLCGL 98
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 71-157 5.63e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 5.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  71 ISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrKGKIVLLFSLLCWVLFNLG 149
Cdd:cd17503  182 LGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF-GPRLLLLAGLLLLALGTLL 260


                 ....*...
gi 160707919 150 IGFVKPAT 157
Cdd:cd17503  261 LAFLTPDT 268
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
501-636 1.03e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 501 FFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLsAAVPPELRTSAQGILQGL 580
Cdd:COG0738   61 LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV-AALGPETAASRLNLLHAF 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919 581 HlGLGRGCGAMIGGVLVNYFGAAAT---FRGIGMACLVILLLFALIQWLAVPDEEEDKT 636
Cdd:COG0738  140 F-SLGALLGPLLGGLLILLGLSLSWhlpYLILAVLLLLLALLFLRSKLPEIEEEEEEAA 197
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 70-142 1.25e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 41.79  E-value: 1.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160707919  70 LISKVFYFFF-YSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLC 142
Cdd:PRK05122  17 IVSIVMFTFIsYLTIGLPLAVLPGYvHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGC 91
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 70-146 1.41e-03

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 1.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707919  70 LISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLF 146
Cdd:cd06172    2 WKFSLFFFLFFFIWSASFSFFPIWLTQiNHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLF 79
lacY PRK09528
galactoside permease; Reviewed
 66-131 1.50e-03

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 41.81  E-value: 1.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  66 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADR--FRK 131
Cdd:PRK09528   9 NPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDiNGLSGTDTGIIFSANSLFALLFQPLYGLISDKlgLKK 77
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 88-141 1.56e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 41.44  E-value: 1.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 160707919  88 PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLL 141
Cdd:cd17390   17 PLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGR-RPVLLICLL 69
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 69-158 1.85e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.37  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFFYSaygslYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKiVLLFSLLCWVLFNL 148
Cdd:cd17370  206 LLAVALFALGNFS-----FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYL 279

                         90
                 ....*....|
gi 160707919 149 GIGFVKPATL 158
Cdd:cd17370  280 GFALGSSLWL 289
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 77-153 1.93e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.38  E-value: 1.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  77 FFFYSAYGSLYPL-LPVYY-KQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKiVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17471  208 FTLLFAANSMYIIaMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR-LLLAGFLAGVLFYLGLALA 285
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 63-158 2.39e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.05  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  63 VKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLC 142
Cdd:cd17332  217 LLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGK-KKAFFIGLLL 295

                         90
                 ....*....|....*.
gi 160707919 143 WVLFNLGIGFVKPATL 158
Cdd:cd17332  296 AILGLLLLFFLPPGNL 311
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 81-146 2.44e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 41.05  E-value: 2.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  81 SAYGSLYPLLPVYYKQLGMSPSQSGL---LVGIRYFIefcSAPFWGVVADRFRKGKIVLLF-SLLCWVLF 146
Cdd:cd17385  215 VSLGFLDPTLSPHLRQFKLSPGQVGLmflILAGSYAI---SAPLWGWLSDKKKIPKWLMVIgSIITGVGF 281
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 74-153 2.49e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  74 VFYFFFYSAYGSLYPLLpVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-RkgKIVLLFSLLCWVLFNLGIGF 152
Cdd:cd17316    9 FFDAYDFFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIgR--KKALILTLLLFGLATLLIGL 85


                 .
gi 160707919 153 V 153
Cdd:cd17316   86 L 86
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 411-626 2.82e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 40.67  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 411 IPQVERDNSTESSEETPTAAThsqAFNFWDLIKLLCSVQYGSVLFVAWFMGFG---YGFVFTFL---YWHL--EDLNGTT 482
Cdd:cd17331  173 IPSNTKSKREKEAKESASPPS---VFNLKEILRLLRLPGVAFLLLVKLLSGLPigmFQSMFSLVamdFFGLtpEENGYLM 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 483 TLFGVCSVLSH---VSELTAYFFSHKLIEL-IGHIRVLYIGLA-CNTaryIYISYLenawTVLPMEVLQGVTHAAIWAAc 557
Cdd:cd17331  250 SYAGVLGMVVQgllVGPLTKRFGERSLLKLsVALLAIGYLLLAfVTT---VWQLLV----LLLPLVIGGSVLYTVITSL- 321

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919 558 isyLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGaaatFRGIGMACLVILLLFALIQWL 626
Cdd:cd17331  322 ---LTKAVPPEDTGTALGLSHALF-SLVRTVSPTIGGALLQAYG----FPSFGLLGAAINGLLTVYLLL 382
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 466-622 3.09e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 40.67  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 466 FVFTFLYW------------HLEDLNGTTTLFGVCsvlshvseLTAYFFSHKLIEL-IG--------HIRVLYIGLACNT 524
Cdd:cd17490    2 LIIVFLFWfsqyvyvpflspYAESLGASLSMIGII--------LGAYGISQMLLRIpLGilsdrigkRKLFIIIGLLFTV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 525 ARYIYISYLENAWTVLPMEVLQGVThAAIWAACISYLSAAVPPELRTSAQGILQgLHLGLGRGCGAMIGGVLVNYFGAAA 604
Cdd:cd17490   74 LASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLIN-LVNNLGQLIAFLIGGLIAEHFGMRA 151

                        170
                 ....*....|....*....
gi 160707919 605 TFR-GIGMACLVILLLFAL 622
Cdd:cd17490  152 PFLlAALAGVLGFILSLFI 170
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 79-154 3.13e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 40.64  E-value: 3.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  79 FYSAYGS--LYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCSAP-FWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFVK 154
Cdd:cd17323    9 FVVTFGSsiYSPALPQIAEDFHVSEEVANLGVSL-FVLGFGLGPlIWAPLSELYGR-RPVYLVSLFIFVIFQIGCALAP 85
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 477-624 3.44e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 477 DLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAA 556
Cdd:cd17391  234 DASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPA 313

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707919 557 CISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAAATFRGIGmaclvILLLFALIQ 624
Cdd:cd17391  314 INSLLAKITPKEVAGRIFGYNQSFQY-LGNVAGPLLGSAIAAHFGYRAVFVVTA-----LLVLLNAIW 375
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 283-584 3.53e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 40.69  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 283 DQQEVEAIFLIILVVVIIgEFFSAssvtIVDTVTLQYLG-----KHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYTHIDV 356
Cdd:cd17313   98 DGPRTWALVLFVLGIVLL-DFAMN----VCQGPVRALLPdlvppEQRSKaNGIINFMGGLGGVLGYLLGAILWDHNWFGF 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 357 LIDGkgckppeyrNYQIVFIVFGVLMTMALIVaTQFRFRynhfnnsdgkgkeveipqvERDNSTESSEETPTAATHSQAF 436
Cdd:cd17313  173 ALGG---------NLKVPFYIGAIILLVCVLV-TLFFVK-------------------EPPLSPEAGEHSENPSLGEVLK 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 437 NFWDLIK-------LLCSVQygsvLFvaWFMGFGYGFVFTFLYWHLEDLNGTTTL------------FGVCsVLSHVSEL 497
Cdd:cd17313  224 SLLKLLKimprsllRLLLVI----FF--WWIAFFPFELFFTDYMGEEVYHGTSAAsshygagvrmgaWGLL-IFSLAFLI 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 498 TAyFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTsaqgil 577
Cdd:cd17313  297 FS-LPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRG------ 369


                 ....*..
gi 160707919 578 QGLHLGL 584
Cdd:cd17313  370 QGTDTGL 376
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 476-619 3.89e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 476 EDLNGTTT----LFGVCSVLshvsELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 551
Cdd:cd17471  228 NELGGSESwvglLFGLAAAL----EIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG 303

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 160707919 552 AIWAACISYLSAAVPPE------LRTSAQGIlqglhlglgrgcGAMIGGVLVNYFGAAATFRGIGMACLVILLL 619
Cdd:cd17471  304 ITAGLGISYFQDLMPGQpglattLYSNASRI------------GSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 84-162 3.92e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 3.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160707919  84 GSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFVKPATLRCLP 162
Cdd:cd17477  205 GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRVLLGCALLGALAALLLPLVPGLPLALLV 282
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 454-650 4.36e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 454 LFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVL-YIGLACNTARYIYIS 531
Cdd:cd17471    2 LLATLLTGLAGAFVLPYLsLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLiLLALLAGALGYLLFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919 532 YLENAWTVLpmevLQGVTHAAIWAACISYLSA-------AVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAA 604
Cdd:cd17471   82 FLRNYWVLL----LVGVVLLSLGAAAFPQLFAlareyadRSSGRDATLFNSVLRAA-FSLAWVIGPPLAFLLLDVLGFTG 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 160707919 605 TFRGIGmaclVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVP 650
Cdd:cd17471  157 LFLLAA----LLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVN 198
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
69-153 5.37e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrkG-KIVLLFSLLCWVLFN 147
Cdd:COG0738   10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GyKRGLLLGLLLMALGL 87


                 ....*.
gi 160707919 148 LGIGFV 153
Cdd:COG0738   88 LLFALA 93
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 69-158 5.77e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707919  69 LLISKVFYFFfysaygSLY---PLLPVYYKQLGMSPSQSGLLVG--------IRYFIefcsapfwGVVADRFRKGKIVLL 137
Cdd:cd17490    1 FLIIVFLFWF------SQYvyvPFLSPYAESLGASLSMIGIILGaygisqmlLRIPL--------GILSDRIGKRKLFII 66

                         90       100
                 ....*....|....*....|.
gi 160707919 138 FSLLCWVLFNLGIGFVKPATL 158
Cdd:cd17490   67 IGLLFTVLASLIMILFPSPWG 87
PRK11128 PRK11128
3-phenylpropionate MFS transporter;
76-116 6.25e-03

3-phenylpropionate MFS transporter;


Pssm-ID: 236856 [Multi-domain]  Cd Length: 382  Bit Score: 39.88  E-value: 6.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 160707919  76 YFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 116
Cdd:PRK11128  13 YFGYFFAYGVFLPFWSVWLKGQGYTPETIGLLLGAGLVARF 53
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 79-153 7.16e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 7.16e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160707919  79 FYSayGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLfSLLCWVLFNLGIGFV 153
Cdd:cd17478   10 FYQ--GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPL-GPLLTGLGLSLLGFA 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH