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Conserved domains on  [gi|20070408|ref|NP_613061|]
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glycine dehydrogenase (decarboxylating), mitochondrial precursor [Mus musculus]

Protein Classification

aminomethyl-transferring glycine dehydrogenase( domain architecture ID 1004953)

aminomethyl-transferring glycine dehydrogenase is part of the glycine cleavage system that catalyzes the degradation of glycine

EC:  1.4.4.2
PubMed:  4585091

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02414 super family cl31876
glycine dehydrogenase (decarboxylating)
 56-1014 0e+00

glycine dehydrogenase (decarboxylating)


The actual alignment was detected with superfamily member PLN02414:

Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1500.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    56 RLLERLLPRH------------DDFSRRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRlKRPLKME---DPICENE 120
Cdd:PLN02414   11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLSkydEGLTESQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   121 ILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANAS 200
Cdd:PLN02414   90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   201 LLDEATAAAEAMQLCHRHN--KRKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSGKDVCGVLFQYPDTEGKV 278
Cdd:PLN02414  170 LLDEGTAAAEAMAMCNNILkgKKKKFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQYPATDGEV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   279 EDFTELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTR 358
Cdd:PLN02414  250 LDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSV 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   359 DATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDL 438
Cdd:PLN02414  330 DSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLP 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   439 FFDTLKVQCGcSVKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSF 518
Cdd:PLN02414  410 FFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIPSSL 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   519 KRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQ 598
Cdd:PLN02414  489 ARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQE 568

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   599 LFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRY 678
Cdd:PLN02414  569 MFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAK 648

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   679 GNIDVAHLKAMVDQHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLH 758
Cdd:PLN02414  649 GNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLH 728

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   759 KTFCIPHGGGGPGMGPIGVKKHLSPFLPSHPVI---SIKPTEGTWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEAT 835
Cdd:PLN02414  729 KTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLTDAS 808

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   836 EIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTES 915
Cdd:PLN02414  809 KIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTES 888

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   916 EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKpENKFWPTIARID 995
Cdd:PLN02414  889 ESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTGRVD 967

                         970
                  ....*....|....*....
gi 20070408   996 DIYGDQHLVCTCPPMEVYE 1014
Cdd:PLN02414  968 NVYGDRNLVCTLPSAAEEE 986
 
Name Accession Description Interval E-value
PLN02414 PLN02414
glycine dehydrogenase (decarboxylating)
 56-1014 0e+00

glycine dehydrogenase (decarboxylating)


Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1500.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    56 RLLERLLPRH------------DDFSRRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRlKRPLKME---DPICENE 120
Cdd:PLN02414   11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLSkydEGLTESQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   121 ILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANAS 200
Cdd:PLN02414   90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   201 LLDEATAAAEAMQLCHRHN--KRKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSGKDVCGVLFQYPDTEGKV 278
Cdd:PLN02414  170 LLDEGTAAAEAMAMCNNILkgKKKKFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQYPATDGEV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   279 EDFTELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTR 358
Cdd:PLN02414  250 LDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSV 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   359 DATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDL 438
Cdd:PLN02414  330 DSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLP 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   439 FFDTLKVQCGcSVKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSF 518
Cdd:PLN02414  410 FFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIPSSL 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   519 KRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQ 598
Cdd:PLN02414  489 ARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQE 568

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   599 LFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRY 678
Cdd:PLN02414  569 MFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAK 648

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   679 GNIDVAHLKAMVDQHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLH 758
Cdd:PLN02414  649 GNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLH 728

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   759 KTFCIPHGGGGPGMGPIGVKKHLSPFLPSHPVI---SIKPTEGTWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEAT 835
Cdd:PLN02414  729 KTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLTDAS 808

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   836 EIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTES 915
Cdd:PLN02414  809 KIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTES 888

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   916 EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKpENKFWPTIARID 995
Cdd:PLN02414  889 ESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTGRVD 967

                         970
                  ....*....|....*....
gi 20070408   996 DIYGDQHLVCTCPPMEVYE 1014
Cdd:PLN02414  968 NVYGDRNLVCTLPSAAEEE 986
gcvP TIGR00461
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ...
 71-1007 0e+00

glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273089 [Multi-domain]  Cd Length: 939  Bit Score: 1320.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408     71 RHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYNCSVPQ 150
Cdd:TIGR00461    1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    151 TILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRK--KFFVDP 228
Cdd:TIGR00461   81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKanAFFVAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    229 RCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSgKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCILR 308
Cdd:TIGR00461  161 DCHPQTIEVIKTRANPFGIEVIVGDHHTFSFS-TDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLLT 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    309 PPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICT 388
Cdd:TIGR00461  240 PPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNICT 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    389 AQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCG-CSVKEVLGRAAQRQINFRL 467
Cdd:TIGR00461  320 AQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGeQSAPAILKAAEGRGINLRP 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    468 FDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLE 547
Cdd:TIGR00461  400 LVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQLE 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    548 NKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGE 627
Cdd:TIGR00461  480 SKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQGE 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    628 YAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKAMVDQHKENLAAIMITYPST 707
Cdd:TIGR00461  560 YAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPST 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    708 NGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLSPFLPS 787
Cdd:TIGR00461  640 HGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLPR 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    788 HPVISIKPTEG-TWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEATEIAILNANYMAKRLEKHYRVLFRGARGYVAH 866
Cdd:TIGR00461  720 HSLNSTAELQGeDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVAH 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    867 EFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPR 946
Cdd:TIGR00461  800 ECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDPA 879

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20070408    947 VNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKpENKFWPTIARIDDIYGDQHLVCTC 1007
Cdd:TIGR00461  880 DNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 70-493 0e+00

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 766.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408     70 RRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYNCSVP 149
Cdd:pfam02347    1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    150 QTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRK--KFFVD 227
Cdd:pfam02347   81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    228 PRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSG-KDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCI 306
Cdd:pfam02347  161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTDlKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    307 LRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNI 386
Cdd:pfam02347  241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    387 CTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCG-CSVKEVLGRAAQRQINF 465
Cdd:pfam02347  321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400

                          410       420
                   ....*....|....*....|....*...
gi 20070408    466 RLFDDGTLGISLDETVTEKDLDDLLWIF 493
Cdd:pfam02347  401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
GcvP2 COG1003
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ...
 513-1006 0e+00

Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440627  Cd Length: 468  Bit Score: 741.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  513 LLGSSFKRTSPflthqVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQ 592
Cdd:COG1003   13 LLPEALLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPFQPEET 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  593 AQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQP 672
Cdd:COG1003   88 VQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAGFKVVV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  673 VEVDRYGNIDVAHLKAMVDqhkENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDV 752
Cdd:COG1003  168 VKSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGDMGFDV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  753 SHLNLHKTFCIphggggpgmgpigVKKHLSPFLPSHPVIsikPTEGTWPVGT-------VSAAPWGSSSILPISWAYIKM 825
Cdd:COG1003  245 CHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVV---KDGDKYRLDYdrpksigRSAAFYGNAGVLVRAYAYIRM 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  826 MGGKGLKEATEIAILNANYMAKRLEKHYRVLFRGaRGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWP-- 903
Cdd:COG1003  322 MGAEGLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYFPli 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  904 VAGTLMIEPTESEDKAELDRFCDAMISIRQEIADieegriDPrvNPLKMSPHSLtcvtsscwdrpysrevaafplpfvkp 983
Cdd:COG1003  401 VPETLMIEPTESESKEELDRFIDAMIAIREEARE------DP--EPLKNAPHTT-------------------------- 446

                        490       500
                 ....*....|....*....|...
gi 20070408  984 enkfwpTIARIDDIYGDQHLVCT 1006
Cdd:COG1003  447 ------PVRRLDEVYADRNLVLT 463
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 118-493 3.36e-176

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 519.10  E-value: 3.36e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  118 ENEILETLHAIASKNQIWR---SYIGMGYYNCSVPQTILRNLLENsGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGL 194
Cdd:cd00613    1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  195 DMANASLLDEATAAAEAMQLCHRHNK--RKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEM---------DFSGKD 263
Cdd:cd00613   80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  264 VCGVLFQYPDTEGKVEDF-TELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVK 342
Cdd:cd00613  160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  343 ENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLI 422
Cdd:cd00613  240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20070408  423 LSEGLKRAGHQLQ-HDLFFDTLKVQCGC---SVKEVLGRAAQRQINFR----LFDDGTLGISLDETVTEKDLDDLLWIF 493
Cdd:cd00613  320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPlygIRAEDLAKALIDGGFHAptmyLPVDGTLMIEPTETETKEELDALLEAL 398
 
Name Accession Description Interval E-value
PLN02414 PLN02414
glycine dehydrogenase (decarboxylating)
 56-1014 0e+00

glycine dehydrogenase (decarboxylating)


Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1500.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    56 RLLERLLPRH------------DDFSRRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRlKRPLKME---DPICENE 120
Cdd:PLN02414   11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLSkydEGLTESQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   121 ILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANAS 200
Cdd:PLN02414   90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   201 LLDEATAAAEAMQLCHRHN--KRKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSGKDVCGVLFQYPDTEGKV 278
Cdd:PLN02414  170 LLDEGTAAAEAMAMCNNILkgKKKKFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQYPATDGEV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   279 EDFTELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTR 358
Cdd:PLN02414  250 LDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSV 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   359 DATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDL 438
Cdd:PLN02414  330 DSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLP 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   439 FFDTLKVQCGcSVKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSF 518
Cdd:PLN02414  410 FFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIPSSL 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   519 KRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQ 598
Cdd:PLN02414  489 ARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQE 568

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   599 LFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRY 678
Cdd:PLN02414  569 MFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAK 648

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   679 GNIDVAHLKAMVDQHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLH 758
Cdd:PLN02414  649 GNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLH 728

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   759 KTFCIPHGGGGPGMGPIGVKKHLSPFLPSHPVI---SIKPTEGTWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEAT 835
Cdd:PLN02414  729 KTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLTDAS 808

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   836 EIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTES 915
Cdd:PLN02414  809 KIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTES 888

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   916 EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKpENKFWPTIARID 995
Cdd:PLN02414  889 ESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTGRVD 967

                         970
                  ....*....|....*....
gi 20070408   996 DIYGDQHLVCTCPPMEVYE 1014
Cdd:PLN02414  968 NVYGDRNLVCTLPSAAEEE 986
gcvP TIGR00461
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ...
 71-1007 0e+00

glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273089 [Multi-domain]  Cd Length: 939  Bit Score: 1320.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408     71 RHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYNCSVPQ 150
Cdd:TIGR00461    1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    151 TILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRK--KFFVDP 228
Cdd:TIGR00461   81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKanAFFVAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    229 RCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSgKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCILR 308
Cdd:TIGR00461  161 DCHPQTIEVIKTRANPFGIEVIVGDHHTFSFS-TDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLLT 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    309 PPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICT 388
Cdd:TIGR00461  240 PPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNICT 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    389 AQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCG-CSVKEVLGRAAQRQINFRL 467
Cdd:TIGR00461  320 AQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGeQSAPAILKAAEGRGINLRP 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    468 FDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLE 547
Cdd:TIGR00461  400 LVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQLE 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    548 NKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGE 627
Cdd:TIGR00461  480 SKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQGE 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    628 YAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKAMVDQHKENLAAIMITYPST 707
Cdd:TIGR00461  560 YAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPST 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    708 NGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLSPFLPS 787
Cdd:TIGR00461  640 HGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLPR 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    788 HPVISIKPTEG-TWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEATEIAILNANYMAKRLEKHYRVLFRGARGYVAH 866
Cdd:TIGR00461  720 HSLNSTAELQGeDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVAH 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    867 EFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPR 946
Cdd:TIGR00461  800 ECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDPA 879

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20070408    947 VNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKpENKFWPTIARIDDIYGDQHLVCTC 1007
Cdd:TIGR00461  880 DNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 70-493 0e+00

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 766.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408     70 RRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYNCSVP 149
Cdd:pfam02347    1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    150 QTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRK--KFFVD 227
Cdd:pfam02347   81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    228 PRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSG-KDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCI 306
Cdd:pfam02347  161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTDlKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    307 LRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNI 386
Cdd:pfam02347  241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    387 CTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCG-CSVKEVLGRAAQRQINF 465
Cdd:pfam02347  321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400

                          410       420
                   ....*....|....*....|....*...
gi 20070408    466 RLFDDGTLGISLDETVTEKDLDDLLWIF 493
Cdd:pfam02347  401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
GcvP2 COG1003
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ...
 513-1006 0e+00

Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440627  Cd Length: 468  Bit Score: 741.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  513 LLGSSFKRTSPflthqVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQ 592
Cdd:COG1003   13 LLPEALLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPFQPEET 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  593 AQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQP 672
Cdd:COG1003   88 VQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAGFKVVV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  673 VEVDRYGNIDVAHLKAMVDqhkENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDV 752
Cdd:COG1003  168 VKSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGDMGFDV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  753 SHLNLHKTFCIphggggpgmgpigVKKHLSPFLPSHPVIsikPTEGTWPVGT-------VSAAPWGSSSILPISWAYIKM 825
Cdd:COG1003  245 CHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVV---KDGDKYRLDYdrpksigRSAAFYGNAGVLVRAYAYIRM 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  826 MGGKGLKEATEIAILNANYMAKRLEKHYRVLFRGaRGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWP-- 903
Cdd:COG1003  322 MGAEGLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYFPli 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  904 VAGTLMIEPTESEDKAELDRFCDAMISIRQEIADieegriDPrvNPLKMSPHSLtcvtsscwdrpysrevaafplpfvkp 983
Cdd:COG1003  401 VPETLMIEPTESESKEELDRFIDAMIAIREEARE------DP--EPLKNAPHTT-------------------------- 446

                        490       500
                 ....*....|....*....|...
gi 20070408  984 enkfwpTIARIDDIYGDQHLVCT 1006
Cdd:COG1003  447 ------PVRRLDEVYADRNLVLT 463
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 66-494 0e+00

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 659.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   66 DDFSRRHIGPGDKDRREMLQALGLASIDELIEKtVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYN 145
Cdd:COG0403    1 DEFAMRYIPPTEEDRAEMLAAIGVDSLDELFDD-IPAEIRLKRPLDLPEALSEAELLRHLRALAAKNKVLTSFIGAGYYD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  146 CSVPQTIlRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKR-KKF 224
Cdd:COG0403   80 HYVPAVV-RNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRsNKV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  225 FVDPRCHPQTIAVVQTRAKYRGV-LVELKLPH-EMDFS------GKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTC 296
Cdd:COG0403  159 LVSEDVHPQTRAVLKTYAEPLGIeVVEVPDEDgVTDLEalkallDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  297 CATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQH 376
Cdd:COG0403  239 VAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQH 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  377 IRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQ-HDLFFDTLKVQCGCSVKEVL 455
Cdd:COG0403  319 IRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVPfNGPFFDEFVVRLPKPAAEIN 398

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 20070408  456 GRAAQRQI----NFRLFDDGTLGISLDETVTEKDLDDLLWIFG 494
Cdd:COG0403  399 AALLEKGIlgglNLRRVDDDTLLVAVTETTTKEDIDALVEALA 441
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 118-493 3.36e-176

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 519.10  E-value: 3.36e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  118 ENEILETLHAIASKNQIWR---SYIGMGYYNCSVPQTILRNLLENsGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGL 194
Cdd:cd00613    1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  195 DMANASLLDEATAAAEAMQLCHRHNK--RKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEM---------DFSGKD 263
Cdd:cd00613   80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  264 VCGVLFQYPDTEGKVEDF-TELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVK 342
Cdd:cd00613  160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  343 ENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLI 422
Cdd:cd00613  240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20070408  423 LSEGLKRAGHQLQ-HDLFFDTLKVQCGC---SVKEVLGRAAQRQINFR----LFDDGTLGISLDETVTEKDLDDLLWIF 493
Cdd:cd00613  320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPlygIRAEDLAKALIDGGFHAptmyLPVDGTLMIEPTETETKEELDALLEAL 398
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 536-928 1.41e-158

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 473.64  E-value: 1.41e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  536 ETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWR-EFANIHPFVPLDQAQGYQQLFQGLEKDLCEITGYD 614
Cdd:cd00613    1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILEnEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  615 --RVSFQPNSGAQGEYAGLATIRAYLdqkgerHRTVCLIPKSAHGTNPASAHMA----GMKIQPVEVDRYGNIDvahLKA 688
Cdd:cd00613   81 vaNASLQDEATAAAEAAGLAAIRAYH------KRNKVLVPDSAHPTNPAVARTRgeplGIEVVEVPSDEGGTVD---LEA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  689 MVDQHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQvGICRPGDFGSDVSHLNLHKTF------- 761
Cdd:cd00613  152 LKEEVSEEVAALMVQYPNTLGVFEDLIKEIADIAHSAGALVYVDGDNLNLT-GLKPPGEYGADIVVGNLQKTGvphgggg 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  762 ------CiphggggpgmgpigVKKHLSPFLPSHPVISIKPTEGTwPVGTVSAA---------------PWGSSSILPISW 820
Cdd:cd00613  231 pgagffA--------------VKKELVRFLPGRLVGVTKDAEGN-RAFRLALQtreqhirrekatsniCTGQALLALMAA 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  821 AYIKMMGGKGLKEATEIAILNANYMAKRLEKHYRVLfrGARGYVAHEFILDTRPFkksANVEAVDVAKRLQDYGFHAPTM 900
Cdd:cd00613  296 MYIVYLGPEGLKEIAERAHLNANYLAKRLKEVGGVL--PFNGPFFHEFVLRLPPL---YGIRAEDLAKALIDGGFHAPTM 370

                        410       420
                 ....*....|....*....|....*...
gi 20070408  901 SWPVAGTLMIEPTESEDKAELDRFCDAM 928
Cdd:cd00613  371 YLPVDGTLMIEPTETETKEELDALLEAL 398
PRK04366 PRK04366
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
535-958 2.44e-143

aminomethyl-transferring glycine dehydrogenase subunit GcvPB;


Pssm-ID: 235292  Cd Length: 481  Bit Score: 437.24  E-value: 2.44e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   535 SETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNssselaP-ITWR-----EFANIHPFVPLDQAQGYQQLFQGLEKDLC 608
Cdd:PRK04366   50 SELEVVRHYTRLSQKNYGVDTGFYPLGSCTMKYN------PkINEKvarlpGFAELHPLQPEETVQGALELMYELQEWLK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   609 EITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKA 688
Cdd:PRK04366  124 EITGMDAVTLQPAAGAHGELTGLLMIRAYHEARGDTKRTEVIVPDSAHGTNPASAAMAGFKVVEIPSNEDGLVDLEALKA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   689 MVDqhkENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGG 768
Cdd:PRK04366  204 AVG---EDTAALMLTNPNTLGLFERNILEIAEIVHEAGGLLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFSTPHGGG 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   769 GPGMGPIGVKKHLSPFLPsHPVisIKPTEGTW--------PVGTVSAApWGSSSILPISWAYIKMMGGKGLKEATEIAIL 840
Cdd:PRK04366  281 GPGSGPVGVKEELAPFLP-VPV--VEKDGDRYrldydrpkSIGRVRAF-YGNFGVLVRAYAYIRSLGAEGLREVSEDAVL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   841 NANYMAKRLEKHYRVLFRGARgyvAHEFILDTRPFKKSaNVEAVDVAKRLQDYGFHAPTMSWP--VAGTLMIEPTESEDK 918
Cdd:PRK04366  357 NANYLKARLKDIYDLPYDRPC---MHEFVLSGKKLKET-GVRTLDIAKRLLDYGFHPPTIYFPliVPEALMIEPTETESK 432

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 20070408   919 AELDRFCDAMISIRqeiadiEEGRIDPRVnpLKMSPHSLT 958
Cdd:PRK04366  433 ETLDAFIAAMKQIA------EEAKENPEL--VKEAPHNTP 464
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
77-489 1.08e-124

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 387.19  E-value: 1.08e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    77 DKDRREMLQALGLASIDELIEKtVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWR---SYIGMGYYNCSVPqTIL 153
Cdd:PRK00451    9 EEDIREMLDAIGVKSIDELFAD-IPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEeypSFLGAGAYDHYIP-AVV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   154 RNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRKKFFVDPRCHPQ 233
Cdd:PRK00451   87 DHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVSGAVHPE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   234 TIAVVQTRAKYRGV-LVELKLPHEM-------DFSGKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALC 305
Cdd:PRK00451  167 YREVLKTYLKGQGIeVVEVPYEDGVtdlealeAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIVGVDPVSLG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   306 ILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSN 385
Cdd:PRK00451  247 LLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIRREKATSN 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   386 ICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDL-FFDTLKVQCGCSVKEVLGRAAQRQI- 463
Cdd:PRK00451  327 ICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIGGVELFDGpFFNEFVVRLPKPAEEVNEALLEKGIl 406

                         410       420       430
                  ....*....|....*....|....*....|...
gi 20070408   464 -------NFRLFDDGTLgISLDETVTEKDLDDL 489
Cdd:PRK00451  407 ggydlgrYYPELGNHLL-VCVTEKRTKEDIDAL 438
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 603-762 1.53e-10

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 60.86  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  603 LEKDLCEIT--GYDRVSFQPnSGAQGEYAGLATIRayldqkgERHRTVcLIPKSAHGTNPAS-AHMAGMKIQPVEVDRYG 679
Cdd:cd01494    5 LEEKLARLLqpGNDKAVFVP-SGTGANEAALLALL-------GPGDEV-IVDANGHGSRYWVaAELAGAKPVPVPVDDAG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  680 NiDVAHLKAMVD-QHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGI--CRPGDFGSDVSHLN 756
Cdd:cd01494   76 Y-GGLDVAILEElKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPApgVLIPEGGADVVTFS 154


                 ....*.
gi 20070408  757 LHKTFC 762
Cdd:cd01494  155 LHKNLG 160
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
591-734 2.67e-06

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 50.29  E-value: 2.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408    591 DQAQGYQQLFQGLEKDLCEITGYDRVSFQPnSGAQGEYAGLATirayLDQKGerHRTVCLIPksAHG---TNPASAHMAG 667
Cdd:pfam01212   25 DEVYGGDPTVNRLEDRVAELFGKEAALFVP-SGTAANQLALMA----HCQRG--DEVICGEP--AHIhfdETGGHAELGG 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20070408    668 MKIQPVEVDRYGNIDVAHLKAMVDQHK----ENLAAIMITypSTNG------VFEENIGDVCALIHQHGGQVYLDGA 734
Cdd:pfam01212   96 VQPRPLDGDEAGNMDLEDLEAAIREVGadifPPTGLISLE--NTHNsaggqvVSLENLREIAALAREHGIPVHLDGA 170
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
822-928 2.58e-05

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 47.83  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408   822 YIKMMGGKGLKEATEIAILNANYMAKRLEKH-YRVLFRGARGyvaHEFILDTrpfkksaNVEAVDVAKRLQDYGFHA--- 897
Cdd:PRK00451  341 YMSLLGPEGLRELAEQNHQKAHYLAERLAEIgGVELFDGPFF---NEFVVRL-------PKPAEEVNEALLEKGILGgyd 410

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 20070408   898 -----PTMswpvAGTLMIEPTESEDKAELDRFCDAM 928
Cdd:PRK00451  411 lgryyPEL----GNHLLVCVTEKRTKEDIDALVAAL 442
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 663-752 2.56e-04

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 44.64  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  663 AHMAGMKIqpVEVDRY-GNIDVAHLKAMVDqhkENLAAIMITYPSTNGVFEEnIGDVCALIHQHGGQVYLdGANMNAQVG 741
Cdd:COG0403  176 AEPLGIEV--VEVPDEdGVTDLEALKALLD---DDVAGVLVQYPNFFGVIED-LRAIAEAAHAAGALVIV-AADPLSLGL 248

                         90
                 ....*....|.
gi 20070408  742 ICRPGDFGSDV 752
Cdd:COG0403  249 LKPPGELGADI 259
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 826-928 3.37e-04

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 44.25  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  826 MGGKGLKEATEIAILNANYMAKRLEK-HYRVLFRGArgyVAHEFILDTrpfkksaNVEAVDVAKRLQDYGFHAPT-MSWP 903
Cdd:COG0403  346 HGPEGLKEIAERIHQKAHYLAERLAAlGVEVPFNGP---FFDEFVVRL-------PKPAAEINAALLEKGILGGLnLRRV 415

                         90       100
                 ....*....|....*....|....*
gi 20070408  904 VAGTLMIEPTESEDKAELDRFCDAM 928
Cdd:COG0403  416 DDDTLLVAVTETTTKEDIDALVEAL 440
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 628-734 7.65e-04

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 42.96  E-value: 7.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070408  628 YAGLAT---IRAYLDQKGER--HRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKAMVDQHK-ENLAAIM 701
Cdd:cd06450   72 LALLAArdrARKRLKAGGGRgiDKLVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAIDEDKaEGLNPIM 151

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 20070408  702 I--TYPSTN-GVFE--ENIGDVCaliHQHGGQVYLDGA 734
Cdd:cd06450  152 VvaTAGTTDtGAIDplEEIADLA---EKYDLWLHVDAA 186
tnaA PRK13238
tryptophanase;
679-734 4.31e-03

tryptophanase;


Pssm-ID: 237314  Cd Length: 460  Bit Score: 40.95  E-value: 4.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20070408   679 GNIDVAHLKAMVDQH-KENLAAIMITypSTNG------VFEENIGDVCALIHQHGGQVYLDGA 734
Cdd:PRK13238  159 GNFDLEKLEALIEEVgAENVPFIVMT--ITNNsaggqpVSMANLRAVYEIAKKYGIPVVIDAA 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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