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A-kinase anchoring protein 7 isoform beta [Homo sapiens]
AKAP7_RIRII_bdg domain-containing protein( domain architecture ID 10564600)
AKAP7_RIRII_bdg domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
46-101 | 2.17e-27 | ||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. : Pssm-ID: 463101 Cd Length: 56 Bit Score: 95.03 E-value: 2.17e-27
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Name | Accession | Description | Interval | E-value | ||
AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
46-101 | 2.17e-27 | ||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. Pssm-ID: 463101 Cd Length: 56 Bit Score: 95.03 E-value: 2.17e-27
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Name | Accession | Description | Interval | E-value | ||
AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
46-101 | 2.17e-27 | ||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. Pssm-ID: 463101 Cd Length: 56 Bit Score: 95.03 E-value: 2.17e-27
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