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Conserved domains on  [gi|20162570|ref|NP_619648|]
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melanoma-associated antigen E2 [Homo sapiens]

Protein Classification

MAGE domain-containing protein( domain architecture ID 2091)

MAGE (Melanoma-associated antigen) domain-containing protein similar to Homo sapiens melanoma-associated antigens that may play important physiological and pathological roles during embryogenesis, germ cell genesis, apoptosis, etc

CATH:  1.10.10.1210|1.10.10.1200
Gene Ontology:  GO:0000122
PubMed:  15222021|21093980
SCOP:  4006335

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGE super family cl03220
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 124-264 7.07e-07

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


The actual alignment was detected with superfamily member pfam01454:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 49.96  E-value: 7.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   124 QFPEILRRASAHLDQVFGLNLRVIDP--------------------QADTYNLVS------KRGFQITDRIAESLDMPKA 177
Cdd:pfam01454  32 LFKKVFEEAQKILRDVFGMELVELPAkeekkttvtsqqrraaakssRSKSYILVStlppeyRVPAIIWPSKAPSFVLDQD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   178 S-----LLALVLGHILLNGNRAREASIWDLLLKVDM-WDKPQRINNLFGNTRNLLTTdFVCMRFLEYWPVYGTNPLE--F 249
Cdd:pfam01454 112 EatytgILTVILSLILLSGGSISEQELLRYLRRLGIdTDGTKEIPPLNGNTDDLLKR-LVKQGYLVRTKEGASDDGEeiI 190

                         170
                  ....*....|....*
gi 20162570   250 EFLWGSRAHREITKM 264
Cdd:pfam01454 191 EYRVGPRAKVEFGPE 205
MAGE super family cl03220
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 407-478 4.70e-04

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


The actual alignment was detected with superfamily member pfam01454:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 41.49  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   407 ILGLIFLMGNRVKEANVWNLLRRFSVDVG--RKHSITR--------KLMRQRYLECRPLSYSNPVE--YELLWGPRAHHE 474
Cdd:pfam01454 122 ILSLILLSGGSISEQELLRYLRRLGIDTDgtKEIPPLNgntddllkRLVKQGYLVRTKEGASDDGEeiIEYRVGPRAKVE 201


                  ....
gi 20162570   475 TIKM 478
Cdd:pfam01454 202 FGPE 205
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 124-264 7.07e-07

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 49.96  E-value: 7.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   124 QFPEILRRASAHLDQVFGLNLRVIDP--------------------QADTYNLVS------KRGFQITDRIAESLDMPKA 177
Cdd:pfam01454  32 LFKKVFEEAQKILRDVFGMELVELPAkeekkttvtsqqrraaakssRSKSYILVStlppeyRVPAIIWPSKAPSFVLDQD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   178 S-----LLALVLGHILLNGNRAREASIWDLLLKVDM-WDKPQRINNLFGNTRNLLTTdFVCMRFLEYWPVYGTNPLE--F 249
Cdd:pfam01454 112 EatytgILTVILSLILLSGGSISEQELLRYLRRLGIdTDGTKEIPPLNGNTDDLLKR-LVKQGYLVRTKEGASDDGEeiI 190

                         170
                  ....*....|....*
gi 20162570   250 EFLWGSRAHREITKM 264
Cdd:pfam01454 191 EYRVGPRAKVEFGPE 205
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 407-478 4.70e-04

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 41.49  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   407 ILGLIFLMGNRVKEANVWNLLRRFSVDVG--RKHSITR--------KLMRQRYLECRPLSYSNPVE--YELLWGPRAHHE 474
Cdd:pfam01454 122 ILSLILLSGGSISEQELLRYLRRLGIDTDgtKEIPPLNgntddllkRLVKQGYLVRTKEGASDDGEeiIEYRVGPRAKVE 201


                  ....
gi 20162570   475 TIKM 478
Cdd:pfam01454 202 FGPE 205
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 124-264 7.07e-07

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 49.96  E-value: 7.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   124 QFPEILRRASAHLDQVFGLNLRVIDP--------------------QADTYNLVS------KRGFQITDRIAESLDMPKA 177
Cdd:pfam01454  32 LFKKVFEEAQKILRDVFGMELVELPAkeekkttvtsqqrraaakssRSKSYILVStlppeyRVPAIIWPSKAPSFVLDQD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   178 S-----LLALVLGHILLNGNRAREASIWDLLLKVDM-WDKPQRINNLFGNTRNLLTTdFVCMRFLEYWPVYGTNPLE--F 249
Cdd:pfam01454 112 EatytgILTVILSLILLSGGSISEQELLRYLRRLGIdTDGTKEIPPLNGNTDDLLKR-LVKQGYLVRTKEGASDDGEeiI 190

                         170
                  ....*....|....*
gi 20162570   250 EFLWGSRAHREITKM 264
Cdd:pfam01454 191 EYRVGPRAKVEFGPE 205
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 407-478 4.70e-04

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 41.49  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20162570   407 ILGLIFLMGNRVKEANVWNLLRRFSVDVG--RKHSITR--------KLMRQRYLECRPLSYSNPVE--YELLWGPRAHHE 474
Cdd:pfam01454 122 ILSLILLSGGSISEQELLRYLRRLGIDTDgtKEIPPLNgntddllkRLVKQGYLVRTKEGASDDGEeiIEYRVGPRAKVE 201


                  ....
gi 20162570   475 TIKM 478
Cdd:pfam01454 202 FGPE 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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