NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|20270307|ref|NP_620125|]
View 

coiled-coil domain-containing protein 74A isoform 1 [Homo sapiens]

Protein Classification

CCDC92 and CCDC74_C domain-containing protein( domain architecture ID 10633023)

CCDC92 and CCDC74_C domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CCDC74_C super family cl20803
Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil ...
 262-375 7.12e-42

Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.


The actual alignment was detected with superfamily member pfam14917:

Pssm-ID: 464373  Cd Length: 123  Bit Score: 143.02  E-value: 7.12e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270307   262 LPLPLRKPTTLRQCEVLIRELWNTNLLQTQELRHLKSLLEGSQRPQAAPEEA-----SFPRDQEATHFPKVSTKSLSKKC 336
Cdd:pfam14917   2 LPPHAPRPPTLQECEVIIRQLWNANSLQAQELQHLKSDLRESQNSSKWTSDGyllgkSYPKDQDAIQLPKVPLKGQSVKC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 20270307   337 L---SPPVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHR 375
Cdd:pfam14917  82 LalsPAPVAERVILPALKQTLNNNFAERRKRQQAVQRRRLHR 123
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-100 2.22e-17

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


:

Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 75.40  E-value: 2.22e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 20270307    47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLHYKLIMNQTSQKKDG 100
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKDLTFKLVMSEGESSQQG 54
 
Name Accession Description Interval E-value
CCDC74_C pfam14917
Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil ...
 262-375 7.12e-42

Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.


Pssm-ID: 464373  Cd Length: 123  Bit Score: 143.02  E-value: 7.12e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270307   262 LPLPLRKPTTLRQCEVLIRELWNTNLLQTQELRHLKSLLEGSQRPQAAPEEA-----SFPRDQEATHFPKVSTKSLSKKC 336
Cdd:pfam14917   2 LPPHAPRPPTLQECEVIIRQLWNANSLQAQELQHLKSDLRESQNSSKWTSDGyllgkSYPKDQDAIQLPKVPLKGQSVKC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 20270307   337 L---SPPVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHR 375
Cdd:pfam14917  82 LalsPAPVAERVILPALKQTLNNNFAERRKRQQAVQRRRLHR 123
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-100 2.22e-17

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 75.40  E-value: 2.22e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 20270307    47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLHYKLIMNQTSQKKDG 100
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKDLTFKLVMSEGESSQQG 54
 
Name Accession Description Interval E-value
CCDC74_C pfam14917
Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil ...
 262-375 7.12e-42

Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.


Pssm-ID: 464373  Cd Length: 123  Bit Score: 143.02  E-value: 7.12e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270307   262 LPLPLRKPTTLRQCEVLIRELWNTNLLQTQELRHLKSLLEGSQRPQAAPEEA-----SFPRDQEATHFPKVSTKSLSKKC 336
Cdd:pfam14917   2 LPPHAPRPPTLQECEVIIRQLWNANSLQAQELQHLKSDLRESQNSSKWTSDGyllgkSYPKDQDAIQLPKVPLKGQSVKC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 20270307   337 L---SPPVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHR 375
Cdd:pfam14917  82 LalsPAPVAERVILPALKQTLNNNFAERRKRQQAVQRRRLHR 123
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-100 2.22e-17

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 75.40  E-value: 2.22e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 20270307    47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLHYKLIMNQTSQKKDG 100
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKDLTFKLVMSEGESSQQG 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH