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Conserved domains on  [gi|40548387|ref|NP_620154|]
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lysophospholipid acyltransferase 2 isoform 1 [Homo sapiens]

Protein Classification

membrane-bound O-acyltransferase family protein( domain architecture ID 326)

membrane-bound O-acyltransferase (MBOAT) family protein may be an integral transmembrane enzyme that modifies protective cell-surface polymers, catalyzing the transfer of an acetyl group from acetyl-CoA to its target substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MBOAT super family cl00738
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
13-450 4.25e-77

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


The actual alignment was detected with superfamily member PLN02332:

Pssm-ID: 445070  Cd Length: 465  Bit Score: 249.97  E-value: 4.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   13 QPLSNAVQLPIDQVNFVVCqLFA--LLAAIWfRTYlhsskTSSFIRHVVATLLGLYLALFCFGWYA-LHFLVQSGISYCI 89
Cdd:PLN02332   6 ESLASAIGVSVPVLRFLLC-FVAsiPLSALW-RFI-----PSGTLRHLYAALSGAFLSYLSFGFSSnLHFVVPMIAGYLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   90 MIIigvenMHNYC----FVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMfRKDEELTSSQRD 165
Cdd:PLN02332  79 MAL-----ARRRCgaitFLFAFAYLIYCHVFYMSGDAWKEGGIDFTGALMVLTLKVISCAMNYQDGL-LKEEGLREAQKK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  166 LAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRsyhitqsgenGKEETQYERTEPSPNTAVVQKLLVCGLSLL 245
Cdd:PLN02332 153 NRLIQLPSLIEYLGYCLCCGSHLAGPVFEFRDYLDWTEGK----------GLWDPNAKGKCPSPYGATLRALLQAAICMG 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  246 FHLTICTTLPVEYNIDEHFQATASWpTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENG--AARWDLISNL 323
Cdd:PLN02332 223 LYLYLTPQFPLSRFTEPDYQEWGFW-HRFGYQYMSGFTARWKYYFIWSISEAAIIISGLGFSGWDGEGkpKAKWDRAKNV 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  324 RIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERT-------SFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAM 396
Cdd:PLN02332 302 DILGVELAKSAVQIPLVWNIQVSTWLRHYVYERLvpkgkkpGFFQLLATQTVSAVWHGLYPGYILFFVQSALMIAGSRVI 381
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 40548387  397 RNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY 450
Cdd:PLN02332 382 YRWQQAIPPSMALARNLLVFINFLYTVLVLNYSCVGFMLLSLDETLAAYGSVYY 435
 
Name Accession Description Interval E-value
PLN02332 PLN02332
membrane bound O-acyl transferase (MBOAT) family protein
13-450 4.25e-77

membrane bound O-acyl transferase (MBOAT) family protein


Pssm-ID: 215190  Cd Length: 465  Bit Score: 249.97  E-value: 4.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   13 QPLSNAVQLPIDQVNFVVCqLFA--LLAAIWfRTYlhsskTSSFIRHVVATLLGLYLALFCFGWYA-LHFLVQSGISYCI 89
Cdd:PLN02332   6 ESLASAIGVSVPVLRFLLC-FVAsiPLSALW-RFI-----PSGTLRHLYAALSGAFLSYLSFGFSSnLHFVVPMIAGYLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   90 MIIigvenMHNYC----FVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMfRKDEELTSSQRD 165
Cdd:PLN02332  79 MAL-----ARRRCgaitFLFAFAYLIYCHVFYMSGDAWKEGGIDFTGALMVLTLKVISCAMNYQDGL-LKEEGLREAQKK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  166 LAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRsyhitqsgenGKEETQYERTEPSPNTAVVQKLLVCGLSLL 245
Cdd:PLN02332 153 NRLIQLPSLIEYLGYCLCCGSHLAGPVFEFRDYLDWTEGK----------GLWDPNAKGKCPSPYGATLRALLQAAICMG 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  246 FHLTICTTLPVEYNIDEHFQATASWpTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENG--AARWDLISNL 323
Cdd:PLN02332 223 LYLYLTPQFPLSRFTEPDYQEWGFW-HRFGYQYMSGFTARWKYYFIWSISEAAIIISGLGFSGWDGEGkpKAKWDRAKNV 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  324 RIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERT-------SFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAM 396
Cdd:PLN02332 302 DILGVELAKSAVQIPLVWNIQVSTWLRHYVYERLvpkgkkpGFFQLLATQTVSAVWHGLYPGYILFFVQSALMIAGSRVI 381
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 40548387  397 RNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY 450
Cdd:PLN02332 382 YRWQQAIPPSMALARNLLVFINFLYTVLVLNYSCVGFMLLSLDETLAAYGSVYY 435
COG5202 COG5202
Predicted membrane protein [Function unknown];
33-450 2.76e-60

Predicted membrane protein [Function unknown];


Pssm-ID: 227529  Cd Length: 512  Bit Score: 206.74  E-value: 2.76e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  33 LFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWY--ALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYL 110
Cdd:COG5202  26 LACLLLTLPFVSILKRNPTRIRTHNLFSISLILFYLFGVRHLVsgAYILASISLFTYLLRYFYRSAYMPTVLFIVILGHY 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 111 TVCQVTRvYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFrKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAG 190
Cdd:COG5202 106 KIFHAAQ-LFEERISTSFDITGSQMVLTMKLTSFAWSYYDGKE-YSSDLTEHQKSRARRGTPTVLDFLSYIFFIPGLLLG 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 191 PLCSYKDYITFIegrsyhiTQSGENGKEETQYERTEPSPNTAVVQKLLVCGLS-LLFHLTICTTLPVEYNIDEHFqATAS 269
Cdd:COG5202 184 PAFDYADFDSWL-------TCEMFRSLMENPYERPKRPPNGKLALATFLKGLGwLILFQVGRISIPRKHLLEEDF-PVRL 255
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 270 WPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWL 349
Cdd:COG5202 256 LPMRWAYLYLFTFGNRIKYYFAWHFSHGSCILFGLGYNGPDSTQKIRWDRVRNIDFMKVELATNVKDLLEAWNMNTNKWL 335
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 350 KRVCY-------ERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIE-----PSQLKLFYDVI 417
Cdd:COG5202 336 KNSVYlrvvkkgKKPGFWSTLGTFAISALWHGINPGYYLTFLSLAASQTIVKENRRLLRPFFLRedgvtPLPSKSLYDVL 415
                       410       420       430
                ....*....|....*....|....*....|...
gi 40548387 418 TWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY 450
Cdd:COG5202 416 GRIAMLLLTTYFSASFFLLSLKDSMYVWRSVYF 448
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
118-430 2.29e-17

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 83.26  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   118 VYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKdEELTSSQRDLAV----------------------RRMPSLL 175
Cdd:pfam03062   4 YSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKG-SELTWDQKELLKlllfsyrpvslsfrklasaaalSQDPSLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   176 EYLSYNCNFMGILAGPLCSYKDYITFIEGrsyhitqsgengkEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLP 255
Cdd:pfam03062  83 EYLGYVFFYPGLLVGPIFSYSDYMSFPRD-------------PLFRWLYYVKRNLAPALGALFLGLTYLILIQYLLSHLP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   256 VEYnIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAA-----GFGFRGYDenGAARWDLISnlriqQIEM 330
Cdd:pfam03062 150 DKD-FSKFKFLSYAFLLRFSVIMRILLGLLWLFLLIFDFLGWLFAEGedilfGLGFNGWD--RVAPENIYR-----CWEN 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   331 STSFKMFLDNWNIQTALWLKRVCYER--------TSFSpTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRH 402
Cdd:pfam03062 222 AVSFSEFWRAWNIPVHKWLKRYVYKPlgkkgklnKFLA-TLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRL 300
                         330       340
                  ....*....|....*....|....*....
gi 40548387   403 YFIEPSQLKLFY-DVITWIVTQVAISYTV 430
Cdd:pfam03062 301 SFLKTDRRRPNLsNVIFWLGAFLGPSLAL 329
 
Name Accession Description Interval E-value
PLN02332 PLN02332
membrane bound O-acyl transferase (MBOAT) family protein
13-450 4.25e-77

membrane bound O-acyl transferase (MBOAT) family protein


Pssm-ID: 215190  Cd Length: 465  Bit Score: 249.97  E-value: 4.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   13 QPLSNAVQLPIDQVNFVVCqLFA--LLAAIWfRTYlhsskTSSFIRHVVATLLGLYLALFCFGWYA-LHFLVQSGISYCI 89
Cdd:PLN02332   6 ESLASAIGVSVPVLRFLLC-FVAsiPLSALW-RFI-----PSGTLRHLYAALSGAFLSYLSFGFSSnLHFVVPMIAGYLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   90 MIIigvenMHNYC----FVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMfRKDEELTSSQRD 165
Cdd:PLN02332  79 MAL-----ARRRCgaitFLFAFAYLIYCHVFYMSGDAWKEGGIDFTGALMVLTLKVISCAMNYQDGL-LKEEGLREAQKK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  166 LAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRsyhitqsgenGKEETQYERTEPSPNTAVVQKLLVCGLSLL 245
Cdd:PLN02332 153 NRLIQLPSLIEYLGYCLCCGSHLAGPVFEFRDYLDWTEGK----------GLWDPNAKGKCPSPYGATLRALLQAAICMG 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  246 FHLTICTTLPVEYNIDEHFQATASWpTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENG--AARWDLISNL 323
Cdd:PLN02332 223 LYLYLTPQFPLSRFTEPDYQEWGFW-HRFGYQYMSGFTARWKYYFIWSISEAAIIISGLGFSGWDGEGkpKAKWDRAKNV 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  324 RIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERT-------SFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAM 396
Cdd:PLN02332 302 DILGVELAKSAVQIPLVWNIQVSTWLRHYVYERLvpkgkkpGFFQLLATQTVSAVWHGLYPGYILFFVQSALMIAGSRVI 381
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 40548387  397 RNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY 450
Cdd:PLN02332 382 YRWQQAIPPSMALARNLLVFINFLYTVLVLNYSCVGFMLLSLDETLAAYGSVYY 435
COG5202 COG5202
Predicted membrane protein [Function unknown];
33-450 2.76e-60

Predicted membrane protein [Function unknown];


Pssm-ID: 227529  Cd Length: 512  Bit Score: 206.74  E-value: 2.76e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387  33 LFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWY--ALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYL 110
Cdd:COG5202  26 LACLLLTLPFVSILKRNPTRIRTHNLFSISLILFYLFGVRHLVsgAYILASISLFTYLLRYFYRSAYMPTVLFIVILGHY 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 111 TVCQVTRvYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFrKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAG 190
Cdd:COG5202 106 KIFHAAQ-LFEERISTSFDITGSQMVLTMKLTSFAWSYYDGKE-YSSDLTEHQKSRARRGTPTVLDFLSYIFFIPGLLLG 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 191 PLCSYKDYITFIegrsyhiTQSGENGKEETQYERTEPSPNTAVVQKLLVCGLS-LLFHLTICTTLPVEYNIDEHFqATAS 269
Cdd:COG5202 184 PAFDYADFDSWL-------TCEMFRSLMENPYERPKRPPNGKLALATFLKGLGwLILFQVGRISIPRKHLLEEDF-PVRL 255
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 270 WPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWL 349
Cdd:COG5202 256 LPMRWAYLYLFTFGNRIKYYFAWHFSHGSCILFGLGYNGPDSTQKIRWDRVRNIDFMKVELATNVKDLLEAWNMNTNKWL 335
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387 350 KRVCY-------ERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIE-----PSQLKLFYDVI 417
Cdd:COG5202 336 KNSVYlrvvkkgKKPGFWSTLGTFAISALWHGINPGYYLTFLSLAASQTIVKENRRLLRPFFLRedgvtPLPSKSLYDVL 415
                       410       420       430
                ....*....|....*....|....*....|...
gi 40548387 418 TWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY 450
Cdd:COG5202 416 GRIAMLLLTTYFSASFFLLSLKDSMYVWRSVYF 448
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
118-430 2.29e-17

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 83.26  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   118 VYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKdEELTSSQRDLAV----------------------RRMPSLL 175
Cdd:pfam03062   4 YSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKG-SELTWDQKELLKlllfsyrpvslsfrklasaaalSQDPSLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   176 EYLSYNCNFMGILAGPLCSYKDYITFIEGrsyhitqsgengkEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLP 255
Cdd:pfam03062  83 EYLGYVFFYPGLLVGPIFSYSDYMSFPRD-------------PLFRWLYYVKRNLAPALGALFLGLTYLILIQYLLSHLP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   256 VEYnIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAA-----GFGFRGYDenGAARWDLISnlriqQIEM 330
Cdd:pfam03062 150 DKD-FSKFKFLSYAFLLRFSVIMRILLGLLWLFLLIFDFLGWLFAEGedilfGLGFNGWD--RVAPENIYR-----CWEN 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548387   331 STSFKMFLDNWNIQTALWLKRVCYER--------TSFSpTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRH 402
Cdd:pfam03062 222 AVSFSEFWRAWNIPVHKWLKRYVYKPlgkkgklnKFLA-TLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRL 300
                         330       340
                  ....*....|....*....|....*....
gi 40548387   403 YFIEPSQLKLFY-DVITWIVTQVAISYTV 430
Cdd:pfam03062 301 SFLKTDRRRPNLsNVIFWLGAFLGPSLAL 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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