NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148664205|ref|NP_620411|]
View 

endothelial cell-selective adhesion molecule precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 11669303)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, which is often involved in functions such as cell adhesion, immune recognition, and protein-protein interactions; similar to Homo sapiens V-set and immunoglobulin domain containing 8 (VSIG8) endothelial cell-selective adhesion molecule (ESAM), and Embigin/basigin subgroup, all of which are members of the immunoglobulin superfamily (IgSF)

CATH:  2.60.40.10
PubMed:  9417933|7932691
SCOP:  3000071

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-150 3.18e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.30  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205   40 LQAVEGGEVVLPAWYtlhgevSSSQPWEVPFVMWFFKQKEKEDQVL----SYINGVTTSKPGVSLVYSMPSRNLSLRLEG 115
Cdd:pfam07686   6 VTVALGGSVTLPCTY------SSSMSEASTSVYWYRQPPGKGPTFLiayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 148664205  116 LQEKDSGPYSCSVNVQDKQGKSRGHsiktlELNVL 150
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKGT-----RLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 166-241 3.51e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205   166 VGANVTLSCQSPrSKPAVQYQWDRQLPSFQTFFapalDVIRGSLSLTNLS-------SSMAGVYVCKAHNEVGTAQCNVT 238
Cdd:smart00410   8 EGESVTLSCEAS-GSPPPEVTWYKQGGKLLAES----GRFSVSRSGSTSTltisnvtPEDSGTYTCAATNSSGSASSGTT 82


                   ...
gi 148664205   239 LEV 241
Cdd:smart00410  83 LTV 85
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-150 3.18e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.30  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205   40 LQAVEGGEVVLPAWYtlhgevSSSQPWEVPFVMWFFKQKEKEDQVL----SYINGVTTSKPGVSLVYSMPSRNLSLRLEG 115
Cdd:pfam07686   6 VTVALGGSVTLPCTY------SSSMSEASTSVYWYRQPPGKGPTFLiayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 148664205  116 LQEKDSGPYSCSVNVQDKQGKSRGHsiktlELNVL 150
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKGT-----RLTVL 109
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 42-128 3.13e-05

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 42.82  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205  42 AVEGGEVVLPAWYTLHGEVSSSQpwevpfVMWFFKQKEKEDQVLSY--INGVTTSKPGVS----LVYSMPSRNLSLRLEG 115
Cdd:cd05718   11 GFLGGSVTLPCSLTSPGTTKITQ------VTWMKIGAGSSQNVAVFhpQYGPSVPNPYAErvefLAARLGLRNATLRIRN 84

                         90
                 ....*....|...
gi 148664205 116 LQEKDSGPYSCSV 128
Cdd:cd05718   85 LRVEDEGNYICEF 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 166-241 3.51e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205   166 VGANVTLSCQSPrSKPAVQYQWDRQLPSFQTFFapalDVIRGSLSLTNLS-------SSMAGVYVCKAHNEVGTAQCNVT 238
Cdd:smart00410   8 EGESVTLSCEAS-GSPPPEVTWYKQGGKLLAES----GRFSVSRSGSTSTltisnvtPEDSGTYTCAATNSSGSASSGTT 82


                   ...
gi 148664205   239 LEV 241
Cdd:smart00410  83 LTV 85
I-set pfam07679
Immunoglobulin I-set domain;
219-241 7.67e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 7.67e-04
                          10        20
                  ....*....|....*....|...
gi 148664205  219 AGVYVCKAHNEVGTAQCNVTLEV 241
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 153-242 1.10e-03

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 37.92  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205 153 PAPPSCRLQGVPHV-------GANVTLSCQSPRSKPAVqyqwdrqLPSFQTFFapaLDVIRGSLSLTNlsssmAGVYVCK 225
Cdd:cd07693   17 PATLNCKAEGRPTPtiqwlknGQPLETDKDDPRSHRIV-------LPSGSLFF---LRVVHGRKGRSD-----EGVYVCV 81

                         90
                 ....*....|....*...
gi 148664205 226 AHNEVGTAQC-NVTLEVS 242
Cdd:cd07693   82 AHNSLGEAVSrNASLEVA 99
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-150 3.18e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.30  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205   40 LQAVEGGEVVLPAWYtlhgevSSSQPWEVPFVMWFFKQKEKEDQVL----SYINGVTTSKPGVSLVYSMPSRNLSLRLEG 115
Cdd:pfam07686   6 VTVALGGSVTLPCTY------SSSMSEASTSVYWYRQPPGKGPTFLiayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 148664205  116 LQEKDSGPYSCSVNVQDKQGKSRGHsiktlELNVL 150
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKGT-----RLTVL 109
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 42-128 3.13e-05

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 42.82  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205  42 AVEGGEVVLPAWYTLHGEVSSSQpwevpfVMWFFKQKEKEDQVLSY--INGVTTSKPGVS----LVYSMPSRNLSLRLEG 115
Cdd:cd05718   11 GFLGGSVTLPCSLTSPGTTKITQ------VTWMKIGAGSSQNVAVFhpQYGPSVPNPYAErvefLAARLGLRNATLRIRN 84

                         90
                 ....*....|...
gi 148664205 116 LQEKDSGPYSCSV 128
Cdd:cd05718   85 LRVEDEGNYICEF 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 166-241 3.51e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205   166 VGANVTLSCQSPrSKPAVQYQWDRQLPSFQTFFapalDVIRGSLSLTNLS-------SSMAGVYVCKAHNEVGTAQCNVT 238
Cdd:smart00410   8 EGESVTLSCEAS-GSPPPEVTWYKQGGKLLAES----GRFSVSRSGSTSTltisnvtPEDSGTYTCAATNSSGSASSGTT 82


                   ...
gi 148664205   239 LEV 241
Cdd:smart00410  83 LTV 85
I-set pfam07679
Immunoglobulin I-set domain;
219-241 7.67e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 7.67e-04
                          10        20
                  ....*....|....*....|...
gi 148664205  219 AGVYVCKAHNEVGTAQCNVTLEV 241
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 153-242 1.10e-03

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 37.92  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664205 153 PAPPSCRLQGVPHV-------GANVTLSCQSPRSKPAVqyqwdrqLPSFQTFFapaLDVIRGSLSLTNlsssmAGVYVCK 225
Cdd:cd07693   17 PATLNCKAEGRPTPtiqwlknGQPLETDKDDPRSHRIV-------LPSGSLFF---LRVVHGRKGRSD-----EGVYVCV 81

                         90
                 ....*....|....*...
gi 148664205 226 AHNEVGTAQC-NVTLEVS 242
Cdd:cd07693   82 AHNSLGEAVSrNASLEVA 99
IgI_2_Necl-4 cd05885
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...
 150-189 1.61e-03

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409468  Cd Length: 100  Bit Score: 37.63  E-value: 1.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 148664205 150 LVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDR 189
Cdd:cd05885    1 LVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH