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Conserved domains on  [gi|40255073|ref|NP_653318|]
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interleukin-20 receptor subunit beta precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 15-124 4.08e-32

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 115.17  E-value: 4.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073    15 LFMWFFYALIPCL-LTDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQgeyesLYTSHIWIPSSWCSLTE 93
Cdd:pfam01108   1 LLTLLLGLLLLALaSAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNIT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 40255073    94 GPECDVTDDIT-ATVPYNLRVRATLGSQTSAW 124
Cdd:pfam01108  76 RTECDLTDETSdLTETYYARVRAVSGGGTSSW 107
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 136-225 8.38e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 38.09  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073   136 TILTRPGMEITKDGFHLVI-------------ELEDLGPQFEFLVAYWR-REPGAEEHVKMVRSGgipVHLETMEPGAAY 201
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVtvkdpetregknlSLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSF---VVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 40255073   202 CVKAQTFVKAIGRYSAFSQTECVE 225
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 15-124 4.08e-32

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 115.17  E-value: 4.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073    15 LFMWFFYALIPCL-LTDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQgeyesLYTSHIWIPSSWCSLTE 93
Cdd:pfam01108   1 LLTLLLGLLLLALaSAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNIT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 40255073    94 GPECDVTDDIT-ATVPYNLRVRATLGSQTSAW 124
Cdd:pfam01108  76 RTECDLTDETSdLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 136-225 8.38e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 38.09  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073   136 TILTRPGMEITKDGFHLVI-------------ELEDLGPQFEFLVAYWR-REPGAEEHVKMVRSGgipVHLETMEPGAAY 201
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVtvkdpetregknlSLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSF---VVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 40255073   202 CVKAQTFVKAIGRYSAFSQTECVE 225
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 15-124 4.08e-32

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 115.17  E-value: 4.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073    15 LFMWFFYALIPCL-LTDEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQgeyesLYTSHIWIPSSWCSLTE 93
Cdd:pfam01108   1 LLTLLLGLLLLALaSAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNIT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 40255073    94 GPECDVTDDIT-ATVPYNLRVRATLGSQTSAW 124
Cdd:pfam01108  76 RTECDLTDETSdLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 136-225 8.38e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 38.09  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073   136 TILTRPGMEITKDGFHLVI-------------ELEDLGPQFEFLVAYWR-REPGAEEHVKMVRSGgipVHLETMEPGAAY 201
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVtvkdpetregknlSLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSF---VVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 40255073   202 CVKAQTFVKAIGRYSAFSQTECVE 225
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
fn3 pfam00041
Fibronectin type III domain;
36-125 3.46e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 35.85  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255073    36 PAPQNLSVLSTNMKHL-LMWSPVIAPGETV-YYSVEYQGEYESLYTSHIWIPSSWCSLTegpecdVTdDITATVPYNLRV 113
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLtVSWTPPPDGNGPItGYEVEYRPKNSGEPWNEITVPGTTTSVT------LT-GLKPGTEYEVRV 73

                          90
                  ....*....|..
gi 40255073   114 RATLGSQTSAWS 125
Cdd:pfam00041  74 QAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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