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Conserved domains on  [gi|110626040|ref|NP_660105|]
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cartilage acidic protein 1 isoform 1 precursor [Mus musculus]

Protein Classification

CRTAC homolog protein( domain architecture ID 10608433)

CRTAC homolog protein, similar to human cartilage acidic protein 1, which encodes a extracellular matrix protein of cartilage, is related to CRTAC1 and CRTAC2 genes throughout a wide taxomic spread

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 461-513 1.09e-13

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


:

Pssm-ID: 429555  Cd Length: 66  Bit Score: 66.07  E-value: 1.09e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 110626040  461 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGR-DEASSVEVTWPDGKM 513
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKV 53
EGF_CA pfam07645
Calcium-binding EGF domain;
560-596 2.58e-09

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 52.62  E-value: 2.58e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 110626040  560 DTNECIQFPFVCPRDkPVCVNTYGSYRCrtnkRCNRG 596
Cdd:pfam07645   1 DVDECATGTHNCPAN-TVCVNTIGSFEC----RCPDG 32
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 300-364 4.12e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.22  E-value: 4.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110626040  300 DFNRDGKVDIVYGNWNGPhRLYLQmsaHGKVRFRDIASPKFSTPSPVRTVIAADFDNDQELEVFF 364
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 256-310 8.22e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 43.75  E-value: 8.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 110626040  256 DIFCdNENGPNFLFHNQGNGTFVDTAASAGVDDPHqhGRGVALADFNRDGKVDIV 310
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 63-133 5.91e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.06  E-value: 5.91e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110626040   63 DVDHDGDFEIVVAGYTGPNLVLkyNRAQNRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 133
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYL--NNGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 461-513 1.09e-13

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


Pssm-ID: 429555  Cd Length: 66  Bit Score: 66.07  E-value: 1.09e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 110626040  461 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGR-DEASSVEVTWPDGKM 513
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKV 53
EGF_CA pfam07645
Calcium-binding EGF domain;
560-596 2.58e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 52.62  E-value: 2.58e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 110626040  560 DTNECIQFPFVCPRDkPVCVNTYGSYRCrtnkRCNRG 596
Cdd:pfam07645   1 DVDECATGTHNCPAN-TVCVNTIGSFEC----RCPDG 32
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 300-364 4.12e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.22  E-value: 4.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110626040  300 DFNRDGKVDIVYGNWNGPhRLYLQmsaHGKVRFRDIASPKFSTPSPVRTVIAADFDNDQELEVFF 364
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 256-310 8.22e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 43.75  E-value: 8.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 110626040  256 DIFCdNENGPNFLFHNQGNGTFVDTAASAGVDDPHqhGRGVALADFNRDGKVDIV 310
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 63-133 5.91e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.06  E-value: 5.91e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110626040   63 DVDHDGDFEIVVAGYTGPNLVLkyNRAQNRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 133
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYL--NNGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
EGF_CA smart00179
Calcium-binding EGF-like domain;
560-607 1.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 110626040   560 DTNECIQFPfVCPRDKpVCVNTYGSYRCrtnkRCNRGYepnEDGTACV 607
Cdd:smart00179   1 DIDECASGN-PCQNGG-TCVNTVGSYRC----ECPPGY---TDGRNCE 39
RGL11 cd10318
Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase ...
 45-157 3.09e-03

Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase of the polysaccharide lyase family 11 (RGL11) cleaves glycoside bonds in polygalacturonan as well as RG (rhamnogalacturonan) type-I through a beta-elimination reaction. Functionally characterized members of this family, YesW and YesX from Bacillus subtilis, cleave glycoside bonds between rhamnose and galacturonic acid residues in the RG-I region of plant cell wall pectin. YesW and YesX work synergistically, with YesW cleaving the glycoside bond of the RG chain endolytically, and YesX converting the resultant oligosaccharides through an exotype reaction. This domain is sometimes found in architectures with non-catalytic carbohydrate-binding modules (CBMs). There are two types of RG lyases, which both cleave the alpha-1,4 bonds of the RG-I main chain through a beta-elimination reaction, but belong to two structurally unrelated polysaccharide lyase (PL) families, 4 and 11.


Pssm-ID: 199906 [Multi-domain]  Cd Length: 564  Bit Score: 40.71  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626040  45 PPDYDSNPTQLNYG-----VAVTDVDHDGDFEIVV------------AGYTGPNLVLKYNRAQNRL--VNIAVDERSSPY 105
Cdd:cd10318   95 KPAGGTTPDGETYTytandASVGDLDGDGEYEIVLkwdpsnskdnsqSGYTGNVYLDAYKLDGTRLwrIDLGKNIRAGAH 174

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110626040 106 YAlrdrqgnaiGVTACDIDGDGREEIYFLNTNNAFSGVAT-YTDKLFKFRNNR 157
Cdd:cd10318  175 YT---------QFMVYDLDGDGKAEVAVKTADGTKDGTGNvIGDASADYRNSS 218
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 560-607 7.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 7.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 110626040 560 DTNECiQFPFVCPRDKpVCVNTYGSYRCrtnkRCNRGYEpnedGTACV 607
Cdd:cd00054    1 DIDEC-ASGNPCQNGG-TCVNTVGSYRC----SCPPGYT----GRNCE 38
 
Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 461-513 1.09e-13

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


Pssm-ID: 429555  Cd Length: 66  Bit Score: 66.07  E-value: 1.09e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 110626040  461 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGR-DEASSVEVTWPDGKM 513
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKV 53
EGF_CA pfam07645
Calcium-binding EGF domain;
560-596 2.58e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 52.62  E-value: 2.58e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 110626040  560 DTNECIQFPFVCPRDkPVCVNTYGSYRCrtnkRCNRG 596
Cdd:pfam07645   1 DVDECATGTHNCPAN-TVCVNTIGSFEC----RCPDG 32
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 300-364 4.12e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.22  E-value: 4.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110626040  300 DFNRDGKVDIVYGNWNGPhRLYLQmsaHGKVRFRDIASPKFSTPSPVRTVIAADFDNDQELEVFF 364
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 256-310 8.22e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 43.75  E-value: 8.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 110626040  256 DIFCdNENGPNFLFHNQGNGTFVDTAASAGVDDPHqhGRGVALADFNRDGKVDIV 310
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 63-133 5.91e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.06  E-value: 5.91e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110626040   63 DVDHDGDFEIVVAGYTGPNLVLkyNRAQNRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 133
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYL--NNGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
EGF_CA smart00179
Calcium-binding EGF-like domain;
560-607 1.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 110626040   560 DTNECIQFPfVCPRDKpVCVNTYGSYRCrtnkRCNRGYepnEDGTACV 607
Cdd:smart00179   1 DIDECASGN-PCQNGG-TCVNTVGSYRC----ECPPGY---TDGRNCE 39
RGL11 cd10318
Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase ...
 45-157 3.09e-03

Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase of the polysaccharide lyase family 11 (RGL11) cleaves glycoside bonds in polygalacturonan as well as RG (rhamnogalacturonan) type-I through a beta-elimination reaction. Functionally characterized members of this family, YesW and YesX from Bacillus subtilis, cleave glycoside bonds between rhamnose and galacturonic acid residues in the RG-I region of plant cell wall pectin. YesW and YesX work synergistically, with YesW cleaving the glycoside bond of the RG chain endolytically, and YesX converting the resultant oligosaccharides through an exotype reaction. This domain is sometimes found in architectures with non-catalytic carbohydrate-binding modules (CBMs). There are two types of RG lyases, which both cleave the alpha-1,4 bonds of the RG-I main chain through a beta-elimination reaction, but belong to two structurally unrelated polysaccharide lyase (PL) families, 4 and 11.


Pssm-ID: 199906 [Multi-domain]  Cd Length: 564  Bit Score: 40.71  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626040  45 PPDYDSNPTQLNYG-----VAVTDVDHDGDFEIVV------------AGYTGPNLVLKYNRAQNRL--VNIAVDERSSPY 105
Cdd:cd10318   95 KPAGGTTPDGETYTytandASVGDLDGDGEYEIVLkwdpsnskdnsqSGYTGNVYLDAYKLDGTRLwrIDLGKNIRAGAH 174

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110626040 106 YAlrdrqgnaiGVTACDIDGDGREEIYFLNTNNAFSGVAT-YTDKLFKFRNNR 157
Cdd:cd10318  175 YT---------QFMVYDLDGDGKAEVAVKTADGTKDGTGNvIGDASADYRNSS 218
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 560-607 7.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 7.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 110626040 560 DTNECiQFPFVCPRDKpVCVNTYGSYRCrtnkRCNRGYEpnedGTACV 607
Cdd:cd00054    1 DIDEC-ASGNPCQNGG-TCVNTVGSYRC----SCPPGYT----GRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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