NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|238624156|ref|NP_663406|]
View 

notchless protein homolog 1 [Mus musculus]

Protein Classification

NLE and WD40 domain-containing protein( domain architecture ID 12087049)

NLE and WD40 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-484 3.11e-105

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 319.55  E-value: 3.11e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQV 180
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 181 LLWDPSTGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Cdd:COG2319  145 RLWDLATG-KLLRTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQ 339
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 340 gpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Cdd:COG2319  260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 238624156 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319  336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 5.43e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 69.47  E-value: 5.43e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624156   17 LLVQFQDEGGQL--LGSPFDVPVDITPDKLQLVCNALLAQEE---PLPLAFYVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-484 3.11e-105

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 319.55  E-value: 3.11e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQV 180
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 181 LLWDPSTGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Cdd:COG2319  145 RLWDLATG-KLLRTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQ 339
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 340 gpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Cdd:COG2319  260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 238624156 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319  336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-484 4.05e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.83  E-value: 4.05e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDP 185
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 186 STGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 264
Cdd:cd00200   81 ETG-ECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 265 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 344
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 345 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 424
Cdd:cd00200  185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 425 DSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 5.43e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 69.47  E-value: 5.43e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624156   17 LLVQFQDEGGQL--LGSPFDVPVDITPDKLQLVCNALLAQEE---PLPLAFYVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-142 1.23e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.23e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 238624156   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-443 2.08e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 159 VLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 231
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 232 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 305
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 306 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 378
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624156 379 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 443
Cdd:PLN00181 715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
105-142 2.65e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.65e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 238624156  105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 114-172 3.10e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 39.95  E-value: 3.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624156  114 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGKKLA 172
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLA 249
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-484 3.11e-105

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 319.55  E-value: 3.11e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQV 180
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 181 LLWDPSTGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Cdd:COG2319  145 RLWDLATG-KLLRTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQ 339
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 340 gpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Cdd:COG2319  260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 238624156 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319  336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
104-444 2.82e-93

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 288.73  E-value: 2.82e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 104 TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLW 183
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 184 DPSTGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYS 262
Cdd:COG2319  190 DLATG-KLLRTLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 263 ASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpe 342
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD---------------------------------------GK--- 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 343 RLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW 422
Cdd:COG2319  302 LLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                        330       340
                 ....*....|....*....|..
gi 238624156 423 SADSRLLVSGSSDSTLKVWDVK 444
Cdd:COG2319  381 SPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
96-485 4.03e-92

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 285.65  E-value: 4.03e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156  96 AVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGC 175
Cdd:COG2319   18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 176 KNGQVLLWDPSTGLQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWG 255
Cdd:COG2319   98 ADGTVRLWDLATGLLL-RTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 256 GDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassryn 334
Cdd:COG2319  172 PDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD------------------------------------ 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 335 lvrGQgpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHV 414
Cdd:COG2319  216 ---GK---LLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624156 415 AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Cdd:COG2319  289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-484 4.05e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.83  E-value: 4.05e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDP 185
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 186 STGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 264
Cdd:cd00200   81 ETG-ECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 265 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 344
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 345 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 424
Cdd:cd00200  185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 425 DSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
121-483 1.40e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 242.89  E-value: 1.40e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 121 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSK 200
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 201 WITGLSWEPLHmnpecRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVL 279
Cdd:COG2319   80 AVLSVAFSPDG-----RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 280 CRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpA 359
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-L 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 360 EDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 238624156 440 VWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Cdd:COG2319  272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-299 2.78e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.08  E-value: 2.78e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 184
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 185 PSTGlQVGRTLTGHSKWITGLSWEPlhmnPECRYVASSSkDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 263
Cdd:cd00200  164 LRTG-KCVATLTGHTGEVNSVAFSP----DGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASG 237

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 238624156 264 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-273 6.67e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.83  E-value: 6.67e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 184
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 185 PSTGLQVGrTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 263
Cdd:cd00200  206 LSTGKCLG-TLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279

                        170
                 ....*....|
gi 238624156 264 SQDRTIKVWR 273
Cdd:cd00200  280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
105-276 3.04e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 3.04e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 184
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 185 PSTGlQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 263
Cdd:COG2319  317 LATG-KLLRTLTGHTGAVRSVAF-----SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASG 390

                        170
                 ....*....|...
gi 238624156 264 SQDRTIKVWRAHD 276
Cdd:COG2319  391 SADGTVRLWDLAT 403
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 5.43e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 69.47  E-value: 5.43e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624156   17 LLVQFQDEGGQL--LGSPFDVPVDITPDKLQLVCNALLAQEE---PLPLAFYVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 COG2319
WD40 repeat [General function prediction only];
379-484 3.12e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADE 458
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100
                 ....*....|....*....|....*.
gi 238624156 459 VYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWD 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-142 1.23e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.23e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 238624156   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 403-442 1.32e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.32e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238624156   403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-443 2.08e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 159 VLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 231
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 232 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 305
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 306 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 378
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624156 379 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 443
Cdd:PLN00181 715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
105-142 2.65e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.65e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 238624156  105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-184 3.83e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 3.83e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238624156   145 TETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 184
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 341-456 4.53e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 4.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 341 PERLVSGSDDFTLFLWS-PAEDKK-----PLARMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 413
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 238624156 414 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHA 456
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PTZ00421 PTZ00421
coronin; Provisional
 159-286 1.76e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 159 VLSISWSP-DGKKLASGCKNGQVLLWD-PSTGLQVGRT-----LTGHSKWITGLSWEPLHMNpecrYVASSSKDGSVRVW 231
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 238624156 232 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 286
Cdd:PTZ00421 154 DVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
404-442 2.13e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.13e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 238624156  404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 96-276 3.14e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.05  E-value: 3.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156  96 AVFRVRAVTRCTSS---LEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHFTCKGHRHWVLSISW 164
Cdd:PTZ00421  54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 165 SPDGKK-LASGCKNGQVLLWDPSTGLqVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILT 243
Cdd:PTZ00421 134 HPSAMNvLASAGADMVVNVWDVERGK-AVEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE 207

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 238624156 244 GH--TQSVTCLrWGGDGLL-----YSASQDRTIKVWRAHD 276
Cdd:PTZ00421 208 AHasAKSQRCL-WAKRKDLiitlgCSKSQQRQIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 361-400 4.47e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.47e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238624156   361 DKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 452-483 1.01e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.01e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 238624156   452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 370-482 1.37e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 370 GHQALINQVLFSP-DSRIVASASFDKSIKLWD-------GRTGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKV 440
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 238624156 441 WDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 482
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
362-400 1.62e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.62e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 238624156  362 KKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-272 2.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 238624156   236 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 272
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 129-272 3.39e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP-DGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSW 207
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624156 208 EplhmnpECRYVASSSKDGSVRVWDTTAGR---CERIltGHTQSVTCLRWGGDGLLYSASQDRTIKVW 272
Cdd:PLN00181 628 E------SGRSLAFGSADHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
447-483 3.62e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 3.62e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 238624156  447 KLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-232 4.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.74e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238624156   193 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 232
Cdd:smart00320   6 KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
147-184 6.21e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.21e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 238624156  147 TPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWD 184
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
236-272 7.40e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 7.40e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 238624156  236 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 272
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
193-232 1.16e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.16e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 238624156  193 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 232
Cdd:pfam00400   5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 159-207 3.94e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.96  E-value: 3.94e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 238624156  159 VLSISWSPDGKKLASGCKNGQVLLWDPSTGlQVGRTLTGHSKWITGLSW 207
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENG-KIVHHFSAGSDLITCLGW 88
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 374-483 4.09e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 4.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 374 LINQVLFSPDSRIVASASFDKSIKLW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWDVKA 445
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 238624156 446 QKLATDLPGHADEVYAVDW-SPDGQRVASGGKDKCLRIW 483
Cdd:PLN00181 565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 378-472 3.10e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.57  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156  378 VLFSPDSRIVASASfDKSiklwdGRTGKYLASLRGHVAA----------VYQIAWSADSRLLVSGSSDSTLKVWDV---K 444
Cdd:COG4946   348 PAWSPDGKSIAYFS-DAS-----GEYELYIAPADGSGEPkqltlgdlgrVFNPVWSPDGKKIAFTDNRGRLWVVDLasgK 421

                          90       100
                  ....*....|....*....|....*...
gi 238624156  445 AQKLATDlpGHADEVYAVDWSPDGQRVA 472
Cdd:COG4946   422 VRKVDTD--GYGDGISDLAWSPDSKWLA 447
PTZ00420 PTZ00420
coronin; Provisional
 362-449 4.91e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 362 KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKY--------LASLRGHVAAVYQIAWSADSRLLVSG 432
Cdd:PTZ00420  64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCS 143

                         90
                 ....*....|....*...
gi 238624156 433 SS-DSTLKVWDVKAQKLA 449
Cdd:PTZ00420 144 SGfDSFVNIWDIENEKRA 161
PTZ00420 PTZ00420
coronin; Provisional
 110-304 6.42e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 6.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 110 LEGHSEAVISVAFSPT-GKYLASGSGDTTVRFWdlstETPHftckgHRHWVLSISwspdgkklasgckngqvllwDPSTg 188
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW----EIPH-----NDESVKEIK--------------------DPQC- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 189 lqvgrTLTGHSKWITGLSWEPLHMNPECryvaSSSKDGSVRVWDT-TAGRCERILTghTQSVTCLRWGGDGLLYSAS-QD 266
Cdd:PTZ00420 120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWDIeNEKRAFQINM--PKKLSSLKWNIKGNLLSGTcVG 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 238624156 267 RTIKVWRAHDGVLCRTLQGHGH-------WVNTMALSTDYALRTG 304
Cdd:PTZ00420 189 KHMHIIDPRKQEIASSFHIHDGgkntkniWIDGLGGDDNYILSTG 233
PTZ00420 PTZ00420
coronin; Provisional
 342-400 1.27e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238624156 342 ERLVSGSDDFTLFLWS-PAED------KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 400
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 128-274 3.14e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.20  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156 128 YLASGSGDTTVRFWDLSTETPH-FTckGHRHWVLSISWSPDGKKLA---SGCKNGQVLLWDPSTGLQvgRTLTGHSKWIT 203
Cdd:COG0823    3 FTLSRDGNSDIYVVDLDGGEPRrLT--NSPGIDTSPAWSPDGRRIAftsDRGGGPQIYVVDADGGEP--RRLTFGGGYNA 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624156 204 GLSWeplhmNPECRYVA-SSSKDGSVRVW--DTTAGRcERILTGHTQSVTclrWGGDG--LLYSASQDRTIKVWRA 274
Cdd:COG0823   79 SPSW-----SPDGKRLAfVSRSDGRFDIYvlDLDGGA-PRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYVV 145
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-165 6.91e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 6.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 238624156  107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 114-172 3.10e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 39.95  E-value: 3.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624156  114 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGKKLA 172
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLA 249
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 391-477 5.81e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156  391 SFdKSIKLWDGRTgkyLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV--------KAQKLATDLP--------- 453
Cdd:pfam20426 105 SF-QVISLNDGRM---VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEFPrkdhviaet 180

                          90       100       110
                  ....*....|....*....|....*....|
gi 238624156  454 ------GHADEVYAVDWSPDGQRVASGGKD 477
Cdd:pfam20426 181 pfhilcGHDDIITCLYVSVELDIVISGSKD 210
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 162-255 6.86e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624156  162 ISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERI 241
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAW-----RPDGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|....
gi 238624156  242 LTGHTQSVTCLRWG 255
Cdd:pfam12894  76 FSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH