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Conserved domains on  [gi|264681550|ref|NP_663489|]
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WD repeat-containing protein 26 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
327-621 1.14e-48

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 1.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 327 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 406
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 407 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 483
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 484 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 559
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 264681550 560 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 136-211 7.61e-06

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 43.71  E-value: 7.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681550   136 EHPSATKFRNHVMEGDWDKAENDLNELKPlvhsphaivvrgaleisqTLLGIIVRMKFLLLQQKYLEYLEDGKVLE 211
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKP------------------PLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 106-133 1.93e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 1.93e-05
                          10        20
                  ....*....|....*....|....*...
gi 264681550  106 DVIRLIGQHLNGLGLNQTVDLLMQESGC 133
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
327-621 1.14e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 1.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 327 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 406
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 407 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 483
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 484 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 559
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 264681550 560 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 329-621 1.45e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.88  E-value: 1.45e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 329 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDSYLVACGPDDCseLW 408
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 409 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 475
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 476 DGKTVLASDTHQRVRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 554
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681550 555 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 621
Cdd:cd00200  226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 585-621 4.57e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.57e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 264681550   585 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
585-621 3.01e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 264681550  585 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 557-621 6.57e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 6.57e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681550 557 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 621
Cdd:PTZ00420  85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 136-211 7.61e-06

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 43.71  E-value: 7.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681550   136 EHPSATKFRNHVMEGDWDKAENDLNELKPlvhsphaivvrgaleisqTLLGIIVRMKFLLLQQKYLEYLEDGKVLE 211
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKP------------------PLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 106-133 1.93e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 1.93e-05
                          10        20
                  ....*....|....*....|....*...
gi 264681550  106 DVIRLIGQHLNGLGLNQTVDLLMQESGC 133
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
327-621 1.14e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 1.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 327 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 406
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 407 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 483
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 484 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 559
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 264681550 560 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
328-621 6.68e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.78  E-value: 6.68e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 328 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPdthlLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsEL 407
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 408 WLWNVQTGELRTKMSqSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLASD 484
Cdd:COG2319  145 RLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGhtGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 485 THQRVRGYnfeDLTDRNIVQE----DHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFGG 560
Cdd:COG2319  224 ADGTVRLW---DLATGKLLRTltghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681550 561 hNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:COG2319  299 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 329-621 1.45e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.88  E-value: 1.45e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 329 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDSYLVACGPDDCseLW 408
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 409 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 475
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 476 DGKTVLASDTHQRVRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 554
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681550 555 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 621
Cdd:cd00200  226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
331-621 6.86e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 6.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 331 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDdcSELWLW 410
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLL----DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--GTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 411 NVQTGELRTKmSQSHEDSLTSVAWNPDGKRFVTGgqrgqfyqcdldgnlldswegvrvqclwclSDGKTVlasdthqrvr 490
Cdd:COG2319  106 DLATGLLLRT-LTGHTGAVRSVAFSPDGKTLASG------------------------------SADGTV---------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 491 gynfedltdrnivqedhpimsftiskngrlallnvatqgvHLWDLQDRVLVRKYQGVTQGFYTIhsCFGgHNEDFIASGS 570
Cdd:COG2319  145 ----------------------------------------RLWDLATGKLLRTLTGHSGAVTSV--AFS-PDGKLLASGS 181

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 264681550 571 EDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 325-446 4.11e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 4.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 325 CYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPdDSYLVACGPDDC 404
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW----DLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 264681550 405 SeLWLWNVQTGELrTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 446
Cdd:cd00200  242 T-IRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSA 281
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 331-458 6.33e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 55.45  E-value: 6.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 331 LTEHCNEVWFCKFSNDGTKLA-TGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSyiaWSPDDSYLV-ACGPDDCSELW 408
Cdd:COG0823   26 LTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPS---WSPDGKRLAfVSRSDGRFDIY 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 264681550 409 LWNVQTGELRTkmsqsHEDSLTSVAWNPDGKRFV---TGGQRGQFYQCDLDGN 458
Cdd:COG0823  103 VLDLDGGAPRR-----LTDGPGSPSWSPDGRRIVfssDRGGRPDLYVVDLDGR 150
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 585-621 4.57e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.57e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 264681550   585 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
585-621 3.01e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 264681550  585 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 557-621 6.57e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 6.57e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681550 557 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 621
Cdd:PTZ00420  85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 136-211 7.61e-06

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 43.71  E-value: 7.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681550   136 EHPSATKFRNHVMEGDWDKAENDLNELKPlvhsphaivvrgaleisqTLLGIIVRMKFLLLQQKYLEYLEDGKVLE 211
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKP------------------PLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 329-362 1.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 264681550   329 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 362
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 106-133 1.93e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 1.93e-05
                          10        20
                  ....*....|....*....|....*...
gi 264681550  106 DVIRLIGQHLNGLGLNQTVDLLMQESGC 133
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
WD40 pfam00400
WD domain, G-beta repeat;
328-362 4.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 264681550  328 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 362
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
329-365 4.78e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 4.78e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 264681550 329 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVD 365
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 566-621 9.27e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 9.27e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 264681550 566 IASGSEDHKVYIWHKRS-ELPIAELTGHTRTVNCVSWNPQipSMMASASDDGTVRIW 621
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLW 687
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 585-621 9.95e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 9.95e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 264681550 585 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 621
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVW 36
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 557-621 2.80e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 2.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681550 557 CFGGHNEDFIASGSEDHKVYIWH-KRSELpIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 621
Cdd:PLN00181 539 CWNSYIKSQVASSNFEGVVQVWDvARSQL-VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 342-439 3.67e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550  342 KFSNDGTKLATGSKDTTviIW----------QVDPDthllkllktleGHAYGVSYIAWSPDDSYLV--ACGPDDCSELWL 409
Cdd:COG4946   395 VWSPDGKKIAFTDNRGR--LWvvdlasgkvrKVDTD-----------GYGDGISDLAWSPDSKWLAysKPGPNQLSQIFL 461

                          90       100       110
                  ....*....|....*....|....*....|
gi 264681550  410 WNVQTGELrTKMSQSHEDSlTSVAWNPDGK 439
Cdd:COG4946   462 YDVETGKT-VQLTDGRYDD-GSPAFSPDGK 489
PTZ00421 PTZ00421
coronin; Provisional
 346-473 6.02e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 6.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550 346 DGTKLATGSKDTTVIIWQVDPDTHLLKLLK---TLEGHAYGVSYIAWSPDDSYLVACGPDDcSELWLWNVQTGELRTKMS 422
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLTQNISDpivHLQGHTKKVGIVSFHPSAMNVLASAGAD-MVVNVWDVERGKAVEVIK 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 264681550 423 qSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCD-LDGNLLDSWE---GVRVQ-CLWC 473
Cdd:PTZ00421 166 -CHSDQITSLEWNLDGSLLCTTSKDKKLNIIDpRDGTIVSSVEahaSAKSQrCLWA 220
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 387-443 1.77e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 39.95  E-value: 1.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 264681550  387 IAWSPDDSYLVACGPDDCS-ELWLWNVQTgelRTKMSQSHEDSLTSVAWNPDGKRFVT 443
Cdd:pfam08662 106 IFWSPFGRLVLLAGFGNLAgDIEFWDVVN---KKKIATAEASNATLCEWSPDGRYFLT 160
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 343-439 2.77e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.79  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681550  343 FSNDGTKLA-----TGSKDttviIWQVDPDTHLLKLLKTLEGHAYgVSYIAWSPDDSYLVACgpDDCSELWLWNVQTGEL 417
Cdd:COG4946   350 WSPDGKSIAyfsdaSGEYE----LYIAPADGSGEPKQLTLGDLGR-VFNPVWSPDGKKIAFT--DNRGRLWVVDLASGKV 422

                          90       100
                  ....*....|....*....|..
gi 264681550  418 RTKMSQSHEDSLTSVAWNPDGK 439
Cdd:COG4946   423 RKVDTDGYGDGISDLAWSPDSK 444
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 329-363 3.12e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 3.12e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 264681550 329 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ 363
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 585-621 5.95e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 5.95e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 264681550 585 PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 621
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVW 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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