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Conserved domains on  [gi|22209001|ref|NP_663748|]
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tigger transposable element-derived protein 1 [Homo sapiens]

Protein Classification

DNA-binding domain-containing protein( domain architecture ID 10514952)

DNA-binding domain-containing protein containing a Tc5 transposase-like DNA-binding domain; similar to Chaetomium globosum chaetoglobosin A biosynthesis cluster protein C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 216-403 1.43e-63

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


:

Pssm-ID: 367380  Cd Length: 177  Bit Score: 206.86  E-value: 1.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001   216 KDRLTLLLGANAAGDFKLKPMLIYHSENPRALKN-YTKSTLPVLYKWNSKARMTAHLFTAWFTEYFKPTVETycsekKIP 294
Cdd:pfam03184   1 KERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFKNeKTPKPLPVEYKSNGKAWMTTSIFEEWLQKWFDPRMRE-----SPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001   295 FKILLLIDNAPSHPrALMEIYE----EINVIFMPANTTSILQPMDQGVISTFKSYYLRNTFHKALAAMDSdvsdgsgqsk 370
Cdd:pfam03184  76 RKVLLLLDGSGSHP-TVELIRScglqNIFLVFLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNNL---------- 144

                         170       180       190
                  ....*....|....*....|....*....|...
gi 22209001   371 LKTFWKGFTILDAIKNIRDSWEEVKLSTLTGVW 403
Cdd:pfam03184 145 LSPPWKKLTLLDALKWIAKAWNAVSPSTITSGF 177
CENP-B_N super family cl47877
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 9-60 1.21e-16

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


The actual alignment was detected with superfamily member pfam04218:

Pssm-ID: 461229  Cd Length: 53  Bit Score: 73.99  E-value: 1.21e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22209001     9 RKSRTSLTLNQKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNAKEKFLKE 60
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGESKASLARRFGVPASTLRRILKNKKKLLQQ 52
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
76-149 2.65e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


:

Pssm-ID: 197828  Cd Length: 66  Bit Score: 67.70  E-value: 2.65e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22209001     76 NSLIADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLFNSMKaergveaaEEKFEASRGWFMRFKERSHFHNIK 149
Cdd:smart00674   1 RRLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLG--------LENFKASKGWLTRFKKRHNIVKTK 66
 
Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 216-403 1.43e-63

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 206.86  E-value: 1.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001   216 KDRLTLLLGANAAGDFKLKPMLIYHSENPRALKN-YTKSTLPVLYKWNSKARMTAHLFTAWFTEYFKPTVETycsekKIP 294
Cdd:pfam03184   1 KERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFKNeKTPKPLPVEYKSNGKAWMTTSIFEEWLQKWFDPRMRE-----SPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001   295 FKILLLIDNAPSHPrALMEIYE----EINVIFMPANTTSILQPMDQGVISTFKSYYLRNTFHKALAAMDSdvsdgsgqsk 370
Cdd:pfam03184  76 RKVLLLLDGSGSHP-TVELIRScglqNIFLVFLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNNL---------- 144

                         170       180       190
                  ....*....|....*....|....*....|...
gi 22209001   371 LKTFWKGFTILDAIKNIRDSWEEVKLSTLTGVW 403
Cdd:pfam03184 145 LSPPWKKLTLLDALKWIAKAWNAVSPSTITSGF 177
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 9-60 1.21e-16

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 73.99  E-value: 1.21e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22209001     9 RKSRTSLTLNQKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNAKEKFLKE 60
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGESKASLARRFGVPASTLRRILKNKKKLLQQ 52
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
76-149 2.65e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 67.70  E-value: 2.65e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22209001     76 NSLIADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLFNSMKaergveaaEEKFEASRGWFMRFKERSHFHNIK 149
Cdd:smart00674   1 RRLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLG--------LENFKASKGWLTRFKKRHNIVKTK 66
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
80-149 1.42e-13

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 65.73  E-value: 1.42e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001    80 ADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLfnsmkAERGVEAAEEKFEASRGWFMRFKERshfHNIK 149
Cdd:pfam03221   2 PDLEKALYEWILQLRARGIPITGPMIREKALEL-----AQLAADLGEPDFKASKGWLDRFKKR---HGIK 63
 
Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 216-403 1.43e-63

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 206.86  E-value: 1.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001   216 KDRLTLLLGANAAGDFKLKPMLIYHSENPRALKN-YTKSTLPVLYKWNSKARMTAHLFTAWFTEYFKPTVETycsekKIP 294
Cdd:pfam03184   1 KERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFKNeKTPKPLPVEYKSNGKAWMTTSIFEEWLQKWFDPRMRE-----SPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001   295 FKILLLIDNAPSHPrALMEIYE----EINVIFMPANTTSILQPMDQGVISTFKSYYLRNTFHKALAAMDSdvsdgsgqsk 370
Cdd:pfam03184  76 RKVLLLLDGSGSHP-TVELIRScglqNIFLVFLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNNL---------- 144

                         170       180       190
                  ....*....|....*....|....*....|...
gi 22209001   371 LKTFWKGFTILDAIKNIRDSWEEVKLSTLTGVW 403
Cdd:pfam03184 145 LSPPWKKLTLLDALKWIAKAWNAVSPSTITSGF 177
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 9-60 1.21e-16

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 73.99  E-value: 1.21e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22209001     9 RKSRTSLTLNQKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNAKEKFLKE 60
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGESKASLARRFGVPASTLRRILKNKKKLLQQ 52
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
76-149 2.65e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 67.70  E-value: 2.65e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22209001     76 NSLIADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLFNSMKaergveaaEEKFEASRGWFMRFKERSHFHNIK 149
Cdd:smart00674   1 RRLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLG--------LENFKASKGWLTRFKKRHNIVKTK 66
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
80-149 1.42e-13

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 65.73  E-value: 1.42e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22209001    80 ADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLfnsmkAERGVEAAEEKFEASRGWFMRFKERshfHNIK 149
Cdd:pfam03221   2 PDLEKALYEWILQLRARGIPITGPMIREKALEL-----AQLAADLGEPDFKASKGWLDRFKKR---HGIK 63
HTH_23 pfam13384
Homeodomain-like domain;
19-53 6.98e-04

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 37.63  E-value: 6.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 22209001    19 QKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNA 53
Cdd:pfam13384   6 RRARALLLLAEGLSVKEIAELLGVSRRTVYRWLKR 40
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
9-54 1.00e-03

Helix-turn-helix domain of resolvase;


Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 37.33  E-value: 1.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 22209001     9 RKSrtSLTLNQKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNAK 54
Cdd:pfam02796   2 RPP--KLNEEDINEVITLLEEGISIKQIAKIFGISRSTVYRYLAAS 45
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 19-52 4.79e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 35.26  E-value: 4.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 22209001    19 QKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVN 52
Cdd:pfam13518   1 ERLKIVLLALEGESIKEAARLFGISRSTVYRWIR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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