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Conserved domains on  [gi|27262645|ref|NP_663760|]
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ataxin-2-like protein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 123-196 1.62e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.62e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645    123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 264-326 1.54e-17

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.54e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645    264 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 326
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 398-942 2.48e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   398 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNR--PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTS 474
Cdd:PHA03247 2456 ARTILGAPFSLSLLLGELFPGAPVYRRPAEArfPFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRM 2533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   475 SASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFK 553
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGP 2611

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   554 LQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS------------------DKEDKPPLAPS 615
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPT 2691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   616 GGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHST 692
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAP 2771

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   693 PSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaa 772
Cdd:PHA03247 2772 PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------ 2844

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   773 aagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2845 ----------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQP 2911

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   851 QALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PG 929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPA 2983

                         570
                  ....*....|...
gi 27262645   930 PSAQSPQSSFPQP 942
Cdd:PHA03247 2984 PSREAPASSTPPL 2996
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 870-1054 2.55e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   870 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQN--LYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYA 947
Cdd:PRK07764  594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPaeASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKA 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   948 IHHQQlphgfTNMAHVTQAHVQTGITAAPPPHPGAPhppqvmllHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHP 1027
Cdd:PRK07764  674 GGAAP-----AAPPPAPAPAAPAAPAGAAPAQPAPA--------PAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                         170       180
                  ....*....|....*....|....*..
gi 27262645  1028 QGEQPGQAPGFPGGADDRIPPLPPPGE 1054
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPA 767
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 123-196 1.62e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.62e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645    123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 264-326 1.54e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.54e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645    264 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 326
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 398-942 2.48e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   398 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNR--PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTS 474
Cdd:PHA03247 2456 ARTILGAPFSLSLLLGELFPGAPVYRRPAEArfPFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRM 2533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   475 SASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFK 553
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGP 2611

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   554 LQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS------------------DKEDKPPLAPS 615
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPT 2691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   616 GGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHST 692
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAP 2771

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   693 PSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaa 772
Cdd:PHA03247 2772 PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------ 2844

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   773 aagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2845 ----------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQP 2911

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   851 QALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PG 929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPA 2983

                         570
                  ....*....|...
gi 27262645   930 PSAQSPQSSFPQP 942
Cdd:PHA03247 2984 PSREAPASSTPPL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 829-991 5.79e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 5.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    829 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 906
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    907 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 986
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350


                   ....*
gi 27262645    987 QVMLL 991
Cdd:pfam09770  351 QLAQL 355
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 870-1054 2.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   870 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQN--LYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYA 947
Cdd:PRK07764  594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPaeASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKA 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   948 IHHQQlphgfTNMAHVTQAHVQTGITAAPPPHPGAPhppqvmllHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHP 1027
Cdd:PRK07764  674 GGAAP-----AAPPPAPAPAAPAAPAGAAPAQPAPA--------PAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                         170       180
                  ....*....|....*....|....*..
gi 27262645  1028 QGEQPGQAPGFPGGADDRIPPLPPPGE 1054
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPA 767
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 867-1053 5.06e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 5.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    867 QLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHlgSGQP--------QQNLYHP-----GALTGTPPSLPPGPSAQ 933
Cdd:pfam09770   99 QVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQ--PSKPvrtgyekyKEPEPIPdlqvdASLWGVAPKKAAAPAPA 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    934 SPQSSFP-------------------------QPAAVYAIHHQQLPHGftnmahvtQAHVQTGITAAPPPHPGAPHPPQV 988
Cdd:pfam09770  177 PQPAAQPaslpapsrkmmsleeveaamraqakKPAQQPAPAPAQPPAA--------PPAQQAQQQQQFPPQIQQQQQPQQ 248

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27262645    989 MLLHPPQSHGGPPQGAV---PQSGVPALSASTPSPYPYIGH----PQGEQPGQA---PGFPGGADDRIPPLPPPG 1053
Cdd:pfam09770  249 QPQQPQQHPGQGHPVTIlqrPQSPQPDPAQPSIQPQAQQFHqqppPVPVQPTQIlqnPNRLSAARVGYPQNPQPG 323
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 123-196 1.62e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.62e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645    123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 264-326 1.54e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.54e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645    264 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 326
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 398-942 2.48e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   398 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNR--PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTS 474
Cdd:PHA03247 2456 ARTILGAPFSLSLLLGELFPGAPVYRRPAEArfPFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRM 2533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   475 SASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFK 553
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGP 2611

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   554 LQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS------------------DKEDKPPLAPS 615
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPT 2691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   616 GGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHST 692
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAP 2771

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   693 PSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaa 772
Cdd:PHA03247 2772 PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------ 2844

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   773 aagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2845 ----------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQP 2911

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   851 QALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PG 929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPA 2983

                         570
                  ....*....|...
gi 27262645   930 PSAQSPQSSFPQP 942
Cdd:PHA03247 2984 PSREAPASSTPPL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 829-991 5.79e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 5.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    829 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 906
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    907 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 986
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350


                   ....*
gi 27262645    987 QVMLL 991
Cdd:pfam09770  351 QLAQL 355
PHA03247 PHA03247
large tegument protein UL36; Provisional
 336-850 1.80e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   336 GRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGP-----------GSEARGINGG 404
Cdd:PHA03247 2513 SRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrpaprpsepavTSRARRPDAP 2592

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   405 PSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSV 484
Cdd:PHA03247 2593 PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL 2670

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   485 SDPGVGSISPASPKISLAPTDVKELST----KEPGRTLEPQELARIAGKVPGLQNEQKRfqleelrkfgaqfklqpSSSP 560
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSladpPPPPPTPEPAPHALVSATPLPPGPAAAR-----------------QASP 2733

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   561 ENSLDPFPPrilkeePKGKEKEVDGllTSEPMGSPVSSKTESVSdkedKPPLAPSGGTEGPEQPPPPCPSQTGSPpvGLI 640
Cdd:PHA03247 2734 ALPAAPAPP------AVPAGPATPG--GPARPARPPTTAGPPAP----APPAAPAAGPPRRLTRPAVASLSESRE--SLP 2799

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   641 KGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPllsvnKSTSTPTSPGPRthSTPSIPVLTAGqsGLYSPQyisyipqihmG 720
Cdd:PHA03247 2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPP-----PTSAQPTAPPPP--PGPPPPSLPLG--GSVAPG----------G 2860

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   721 PAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQP- 799
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPq 2940

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 27262645   800 AMMQPMAHYPSQPV---FAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2941 PPLAPTTDPAGAGEpsgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTP 2994
PHA03247 PHA03247
large tegument protein UL36; Provisional
 668-1054 3.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   668 PTKPLLSVNKSTSTPTSPGPrTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQ-QGKYRG 746
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRaRRLGRA 2673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   747 AKGSLPPQRSdqHQPASAPPMMQAAAAAGPPLVAATPYssyiPYNPQQFPGQPAMMQPMAHYPSQPVfAPMLQSNPRMLT 826
Cdd:PHA03247 2674 AQASSPPQRP--RRRAARPTVGSLTSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPA-LPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   827 SGSHPQAIVSSSTPQYPSA-EQPTPQALYATVhqsyPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPhlG 905
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGpPAPAPPAAPAAG----PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP--P 2820

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   906 SGQPQQNLYHPGALTGTPPSLPPGPSAQS------------------PQSSFPQPAAVYAIHHQQLPHGFTNMAHVTQAH 967
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   968 VQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQPGQAPGFPGGADDRIP 1047
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP 2980


                  ....*..
gi 27262645  1048 PLPPPGE 1054
Cdd:PHA03247 2981 QPAPSRE 2987
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 652-916 1.71e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 48.88  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    652 EQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPrthSTPSIPVLTagqsGLYSPQYISYIPQIH-------MGPAVQ 724
Cdd:pfam09770   98 EQVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQS---QQPSKPVRT----GYEKYKEPEPIPDLQvdaslwgVAPKKA 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    725 APQMYPYPVSNSVPGQQGKYRG--------AKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFP 796
Cdd:pfam09770  171 AAPAPAPQPAAQPASLPAPSRKmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQP 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    797 GQPAMMQPMAHYPSQpvfapmLQsnpRMlTSGSHPQAIVSSSTPQYPSAEQPTPQalyatvhqsyPHHATQLHAHQPQPA 876
Cdd:pfam09770  251 QQPQQHPGQGHPVTI------LQ---RP-QSPQPDPAQPSIQPQAQQFHQQPPPV----------PVQPTQILQNPNRLS 310

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 27262645    877 TTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQnLYHP 916
Cdd:pfam09770  311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITHP 349
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 791-1008 6.01e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    791 NPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSG----SHPQAI----VSSS------TPQYPSAEQPTPQALYAT 856
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEPIpdlqVDASlwgvapKKAAAPAPAPQPAAQPAS 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    857 VHQSYPHHAT------QLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPP-- 928
Cdd:pfam09770  186 LPAPSRKMMSleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVti 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    929 --GPSAQSPQSSFPQPAAVYAIHHQQLPhgfTNMAHVTQA-------HVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGG 999
Cdd:pfam09770  266 lqRPQSPQPDPAQPSIQPQAQQFHQQPP---PVPVQPTQIlqnpnrlSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQ 342


                   ....*....
gi 27262645   1000 PPQGAVPQS 1008
Cdd:pfam09770  343 APIITHPQQ 351
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 661-941 7.95e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 7.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   661 PNAKEFNP-------TKPLLSVNKSTS-TPTSPGPRTHSTPSIPVLTAgQSGLYSPQY-ISYIPQIHMGPAVQAPQMYPY 731
Cdd:PRK10263  302 PEYDEYDPllngapiTEPVAVAAAATTaTQSWAAPVEPVTQTPPVASV-DVPPAQPTVaWQPVPGPQTGEPVIAPAPEGY 380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   732 PvsnsvPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQqfPGQPAMMQPMAHYPSQ 811
Cdd:PRK10263  381 P-----QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA--PEQPVAGNAWQAEEQQ 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   812 PVFAPmlqsNPRMLTSGSHPQAIVSSSTPQYPSAEQPT-----------------PQALYATVHQSYPHHATQLHA-HQ- 872
Cdd:PRK10263  454 STFAP----QSTYQTEQTYQQPAAQEPLYQQPQPVEQQpvvepepvveetkparpPLYYFEEVEEKRAREREQLAAwYQp 529

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27262645   873 -PQPATTP---TGSQPQSQHAAPSPVQHQAGQAPhLGSGQPQQNLYHPGALTGTPPSLPP----GPSAQSPQSSFPQ 941
Cdd:PRK10263  530 iPEPVKEPepiKSSLKAPSVAAVPPVEAAAAVSP-LASGVKKATLATGAAATVAAPVFSLansgGPRPQVKEGIGPQ 605
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
870-945 1.51e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.51e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27262645   870 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 945
Cdd:PRK14971  389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 374-696 2.90e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.07  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   374 PGLSSLPPRGPHHLDNSS----PGPGSEARGINGGPSRMSP----KAQRPLRGAKTLSSP--SNRPSGETSVPPPPavgR 443
Cdd:PTZ00449  514 PEASGLPPKAPGDKEGEEgeheDSKESDEPKEGGKPGETKEgevgKKPGPAKEHKPSKIPtlSKKPEFPKDPKHPK---D 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   444 MYPPRSPKS--AAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPgVGSISPASPKISLAPTDVKE-LSTKEPGRTLEP 520
Cdd:PTZ00449  591 PEEPKKPKRprSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRP-PPPQRPSSPERPEGPKIIKSpKPPKSPKPPFDP 669

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   521 ---QELARIAGKVPGLQNEQKRFQL--EELRKFGAQFKLQPSSSPENSLDPFPPRIlkeepkgkekEVDGLLTSEPMGSP 595
Cdd:PTZ00449  670 kfkEKFYDDYLDAAAKSKETKTTVVldESFESILKETLPETPGTPFTTPRPLPPKL----------PRDEEFPFEPIGDP 739

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   596 VSsktESVSDKE-DKPPLAPSggtegpeqpPPPCPSQTGSPPVGLIKGEDKDEGPVAEqvkksTLNPNAKEFNPTKPlls 674
Cdd:PTZ00449  740 DA---EQPDDIEfFTPPEEER---------TFFHETPADTPLPDILAEEFKEEDIHAE-----TGEPDEAMKRPDSP--- 799

                         330       340
                  ....*....|....*....|..
gi 27262645   675 vnkSTSTPTSPGprTHstPSIP 696
Cdd:PTZ00449  800 ---SEHEDKPPG--DH--PSLP 814
PRK10927 PRK10927
cell division protein FtsN;
841-944 5.79e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 43.13  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   841 QYPSAEQpTPQALYATVH-QSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGAL 919
Cdd:PRK10927  138 EVPWNEQ-TPEQRQQTLQrQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAH 216

                          90       100
                  ....*....|....*....|....*.
gi 27262645   920 TGTPPSLP-PGPSAQSPQSsfPQPAA 944
Cdd:PRK10927  217 TTAQSKPQqAAPVTRAADA--PKPTA 240
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 793-942 8.85e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 8.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   793 QQFPG-QPAMMQPMAHypSQPVFAPMlqsnPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAH 871
Cdd:PRK10263  709 QRYSGeQPAGANPFSL--DDFEFSPM----KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ 782

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27262645   872 QPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPgaltgTPPSLPPGPSAQSPQSSFPQP 942
Cdd:PRK10263  783 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ-----PQYQQPQQPVAPQPQDTLLHP 848
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 734-1052 1.68e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    734 SNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPV 813
Cdd:pfam03154  145 SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQST 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    814 FAPM------LQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAHQPQP------ATTPTG 881
Cdd:pfam03154  225 AAPHtliqqtPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPvppqpfPLTPQS 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    882 SQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSS----FPQPAAVYAIHHQQLPHGF 957
Cdd:pfam03154  305 SQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTpipqLPNPQSHKHPPHLSGPSPF 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    958 TNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLhpPQSHGGPPQGAVP-----QSGVPALSASTPSPYPYIGHPQGEQP 1032
Cdd:pfam03154  385 QMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLM--PQSQQLPPPPAQPpvltqSQSLPPPAASHPPTSGLHQVPSQSPF 462

                          330       340
                   ....*....|....*....|
gi 27262645   1033 GQAPGFPGGADDRIPPLPPP 1052
Cdd:pfam03154  463 PQHPFVPGGPPPITPPSGPP 482
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
 658-916 1.76e-03

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 42.38  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    658 TLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsv 737
Cdd:pfam03326  310 TLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADHQTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV----- 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    738 pgqqGKYRGAKGsLPPQRSDQHQPAsappmmQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapm 817
Cdd:pfam03326  383 ----GGKQFFQG-LRDSRSTSFLTA------PEATSAISDVFQGTEVCQPKRIRALHPPGSP------------------ 433

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    818 lqSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYAT--VHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQ 895
Cdd:pfam03326  434 --SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDAApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRG 511

                          250       260
                   ....*....|....*....|.
gi 27262645    896 HQAGQAPHLGSGQPQQNLYHP 916
Cdd:pfam03326  512 QLDELTTTLESMTEDLNLDSP 532
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 870-1054 2.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   870 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQN--LYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYA 947
Cdd:PRK07764  594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPaeASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKA 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   948 IHHQQlphgfTNMAHVTQAHVQTGITAAPPPHPGAPhppqvmllHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHP 1027
Cdd:PRK07764  674 GGAAP-----AAPPPAPAPAAPAAPAGAAPAQPAPA--------PAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                         170       180
                  ....*....|....*....|....*..
gi 27262645  1028 QGEQPGQAPGFPGGADDRIPPLPPPGE 1054
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPA 767
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
409-552 3.13e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   409 SPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRMYPPrsPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPG 488
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAA--AQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAV 447

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27262645   489 VGSISPASPKISLAPTDVKELSTKEPGRtlEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQF 552
Cdd:PRK14971  448 RPAQFKEEKKIPVSKVSSLGPSTLRPIQ--EKAEQATGNIKEAPTGTQKEIFTEEDLQYYWQEF 509
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
359-528 4.14e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   359 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPS-NRPSGETSVPP 437
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPaTADRGDDAADG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   438 PPAVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRT 517
Cdd:PRK07003  446 DAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAA 525

                         170
                  ....*....|.
gi 27262645   518 LEPQELARIAG 528
Cdd:PRK07003  526 APPAPEARPPT 536
PHA03247 PHA03247
large tegument protein UL36; Provisional
 332-532 4.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   332 RQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHH-------------LDNSSPGPGSEA 398
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRraarptvgsltslADPPPPPPTPEP 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   399 RGINGGPSRMSPKAQRPLRGAK--TLSSPSNRPSGETSVPP-----------PPAVGRMYPPRSPKSAAP--APISASCP 463
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASpaLPAAPAPPAVPAGPATPggparparpptTAGPPAPAPPAAPAAGPPrrLTRPAVAS 2790

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27262645   464 EPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPG 532
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG 2859
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 867-1053 5.06e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 5.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    867 QLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHlgSGQP--------QQNLYHP-----GALTGTPPSLPPGPSAQ 933
Cdd:pfam09770   99 QVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQ--PSKPvrtgyekyKEPEPIPdlqvdASLWGVAPKKAAAPAPA 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645    934 SPQSSFP-------------------------QPAAVYAIHHQQLPHGftnmahvtQAHVQTGITAAPPPHPGAPHPPQV 988
Cdd:pfam09770  177 PQPAAQPaslpapsrkmmsleeveaamraqakKPAQQPAPAPAQPPAA--------PPAQQAQQQQQFPPQIQQQQQPQQ 248

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27262645    989 MLLHPPQSHGGPPQGAV---PQSGVPALSASTPSPYPYIGH----PQGEQPGQA---PGFPGGADDRIPPLPPPG 1053
Cdd:pfam09770  249 QPQQPQQHPGQGHPVTIlqrPQSPQPDPAQPSIQPQAQQFHqqppPVPVQPTQIlqnPNRLSAARVGYPQNPQPG 323
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 394-555 6.88e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   394 PGSEARGINGGPSRMSPKAQRPLRGAKTLSSPsnRPSGETSVPPPPAVGRMYPPRSP-----KSAAPAPISASCPEPPIG 468
Cdd:PRK14951  374 APAEKKTPARPEAAAPAAAPVAQAAAAPAPAA--APAAAASAPAAPPAAAPPAPVAApaaaaPAAAPAAAPAAVALAPAP 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   469 SAVPTSSASIPVTSSVSDPGVGS----ISPASPKISLAPTD--------VKELSTKEPGRTLePQELAriagkvpgLQNE 536
Cdd:PRK14951  452 PAQAAPETVAIPVRVAPEPAVASaapaPAAAPAAARLTPTEegdvwhatVQQLAAAEAITAL-ARELA--------LQSE 522

                         170       180
                  ....*....|....*....|....*...
gi 27262645   537 ---------QKRFQLEELRKFGAQFKLQ 555
Cdd:PRK14951  523 lvardgdqwLLRVERESLNQPGARERLR 550
PHA03369 PHA03369
capsid maturational protease; Provisional
 396-709 9.30e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 39.98  E-value: 9.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   396 SEARGINGGPSRMSPKAQRPLRGAKTLSSPSnRPSGETSVPPPPAVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTss 475
Cdd:PHA03369  355 APSRVLAAAAKVAVIAAPQTHTGPADRQRPQ-RPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPE-- 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   476 asiPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEP--QELARIAGKVPGL--QNEQKRFQLEELRKFGAQ 551
Cdd:PHA03369  432 ---PVGPVPPQPTNPYVMPISMANMVYPGHPQEHGHERKRKRGGElkEELIETLKLVKKLkeEQESLAKELEATAHKSEI 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262645   552 fklqpSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQ 631
Cdd:PHA03369  509 -----KKIAESEFKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTSTTLAAAA 583

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262645   632 TGSPpvgliKGEDKDEGPVAEQVKKSTLNPnaKEFNPTKPLLSVNKSTSTPTSPgPRTHSTPSIPVLTAGQSGLYSPQ 709
Cdd:PHA03369  584 GQGS-----DTAEALAGAIETLLTQASAQP--AGLSLPAPAVPVNASTPASTPP-PLAPQEPPQPGTSAPSLETSLPQ 653
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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