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Conserved domains on  [gi|22122329|ref|NP_666032|]
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limbin precursor [Mus musculus]

Protein Classification

kinesin family protein; PEPP family PH domain-containing protein( domain architecture ID 13780468)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has an ATPase-containing motor domain; similar to N-type kinesins that are (+) end-directed motors and have an N-terminal motor domain| PEPP (phosphoinositol 3-phosphate-binding protein) family PH (pleckstrin homology) domain-containing protein similar to PH domain region of vertebrate pleckstrin homology domain-containing family A member 4/5/6/7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
 147-570 0e+00

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


:

Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 612.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    147 GECYSVSYTASLDPTALGTGESLDLPARLIFQ-SPSQNRTQLK---APFTITVEEKIMVLPNHGLHAAGFIAAFLISLLL 222
Cdd:pfam12297    1 GEEYAVSYTAELDAKERGKGESLTLPAQLTFQnSSQNNRTQLGpltANLTLTVEEKTKVLPNHGLHAAGFFIGFLVSLVL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    223 TVAALFFLARGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQAD 302
Cdd:pfam12297   81 TLLAFFLLGRTRCLQGSLLSRNRRLSQESKLEYSQFTSAEGVKEDLAFEDQMIDILTFEDPGSMLQALENLEIATLLRAD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    303 ADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQR 382
Cdd:pfam12297  161 ADLEACRTQISKDIIAILLKNLRSSGHLSPQAEKRMSSVFNKQFLAMEGRLQEEYERKMAALAAECNLETREKMEAQHQR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    383 EMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKG 462
Cdd:pfam12297  241 EMAEKEEAEELLKHADEQEALECSSLLDKLHKLEQEHLQRSLLLRQEEDFAKAQRQLAVFQRVELHKIFFTQLKEATRKG 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    463 ELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGY 542
Cdd:pfam12297  321 ELKPEAAKRLLQDYSKIQEQIEELMDFFQANQRYHLSERFAQREYLVQSLQSLETRVSGLLNTAATQLTSLIQKMERAGY 400

                          410       420
                   ....*....|....*....|....*...
gi 22122329    543 LDEDQMETLLERAQTETFSIKQKLDNDL 570
Cdd:pfam12297  401 LDEEQMEMLLERAQKELLSVKQKLDNDL 428
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 505-987 1.70e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  505 REYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTEtfsikQKLDNDLKQEKKRlhQRLITR 584
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE-----EALLEAEAELAEA--EEELEE 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  585 RRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRL 664
Cdd:COG1196  384 LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  665 QSTAMTQELLKRSApwlFLQQILEEHSRESAARTTQLEAEERERGqeLVQGVRQRLQQDALEAYTEEQAELRHWEHLVFM 744
Cdd:COG1196  464 LLAELLEEAALLEA---ALAELLEELAEAAARLLLLLEAEADYEG--FLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEA 538

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  745 KLCCAAISLSEEDLLRVRQEAQGCFSQLdRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRG 824
Cdd:COG1196  539 ALEAALAAALQNIVVEDDEVAAAAIEYL-KAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYV 617

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  825 KAD-LLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLsvytallsiQDLL 903
Cdd:COG1196  618 LGDtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEEL---------AERL 688

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  904 LGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAI 983
Cdd:COG1196  689 AEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768


                 ....
gi 22122329  984 LRQA 987
Cdd:COG1196  769 LERL 772
 
Name Accession Description Interval E-value
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
 147-570 0e+00

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 612.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    147 GECYSVSYTASLDPTALGTGESLDLPARLIFQ-SPSQNRTQLK---APFTITVEEKIMVLPNHGLHAAGFIAAFLISLLL 222
Cdd:pfam12297    1 GEEYAVSYTAELDAKERGKGESLTLPAQLTFQnSSQNNRTQLGpltANLTLTVEEKTKVLPNHGLHAAGFFIGFLVSLVL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    223 TVAALFFLARGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQAD 302
Cdd:pfam12297   81 TLLAFFLLGRTRCLQGSLLSRNRRLSQESKLEYSQFTSAEGVKEDLAFEDQMIDILTFEDPGSMLQALENLEIATLLRAD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    303 ADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQR 382
Cdd:pfam12297  161 ADLEACRTQISKDIIAILLKNLRSSGHLSPQAEKRMSSVFNKQFLAMEGRLQEEYERKMAALAAECNLETREKMEAQHQR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    383 EMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKG 462
Cdd:pfam12297  241 EMAEKEEAEELLKHADEQEALECSSLLDKLHKLEQEHLQRSLLLRQEEDFAKAQRQLAVFQRVELHKIFFTQLKEATRKG 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    463 ELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGY 542
Cdd:pfam12297  321 ELKPEAAKRLLQDYSKIQEQIEELMDFFQANQRYHLSERFAQREYLVQSLQSLETRVSGLLNTAATQLTSLIQKMERAGY 400

                          410       420
                   ....*....|....*....|....*...
gi 22122329    543 LDEDQMETLLERAQTETFSIKQKLDNDL 570
Cdd:pfam12297  401 LDEEQMEMLLERAQKELLSVKQKLDNDL 428
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 505-987 1.70e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  505 REYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTEtfsikQKLDNDLKQEKKRlhQRLITR 584
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE-----EALLEAEAELAEA--EEELEE 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  585 RRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRL 664
Cdd:COG1196  384 LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  665 QSTAMTQELLKRSApwlFLQQILEEHSRESAARTTQLEAEERERGqeLVQGVRQRLQQDALEAYTEEQAELRHWEHLVFM 744
Cdd:COG1196  464 LLAELLEEAALLEA---ALAELLEELAEAAARLLLLLEAEADYEG--FLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEA 538

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  745 KLCCAAISLSEEDLLRVRQEAQGCFSQLdRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRG 824
Cdd:COG1196  539 ALEAALAAALQNIVVEDDEVAAAAIEYL-KAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYV 617

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  825 KAD-LLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLsvytallsiQDLL 903
Cdd:COG1196  618 LGDtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEEL---------AERL 688

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  904 LGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAI 983
Cdd:COG1196  689 AEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768


                 ....
gi 22122329  984 LRQA 987
Cdd:COG1196  769 LERL 772
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 508-1004 5.84e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.07  E-value: 5.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    508 LVQRLQAMETRVQGLLNTAATQLT-----SLIHKHERAgylDEDQMETLLERAQTETFSIKQKL---DNDLKQEKKRLHQ 579
Cdd:pfam12128  232 AIAGIMKIRPEFTKLQQEFNTLESaelrlSHLHFGYKS---DETLIASRQEERQETSAELNQLLrtlDDQWKEKRDELNG 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    580 RLITRRrrELLQKHKEQ------QKEQVSLGEASSTAEDAVQyLHQWRSvmaehtaALEELQERLDqAALDDLRvlTVSL 653
Cdd:pfam12128  309 ELSAAD--AAVAKDRSElealedQHGAFLDADIETAAADQEQ-LPSWQS-------ELENLEERLK-ALTGKHQ--DVTA 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    654 SEKATEELRRLQSTAMTQELLKRSAPwlflqqileehSRESAARttqLEAEERERGQELVQGVRQRLQQDALEAyteEQA 733
Cdd:pfam12128  376 KYNRRRSKIKEQNNRDIAGIKDKLAK-----------IREARDR---QLAVAEDDLQALESELREQLEAGKLEF---NEE 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    734 ELRHWEHLVFMKLCCAAISLSEEDLLRVR---------QEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQ 804
Cdd:pfam12128  439 EYRLKSRLGELKLRLNQATATPELLLQLEnfderieraREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEER 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    805 ALAAPELQ--------SKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGEL----LQERVQRLEAQEAHFA 872
Cdd:pfam12128  519 QSALDELElqlfpqagTLLHFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELnlygVKLDLKRIDVPEWAAS 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    873 ESLVALQFQKVARAAETLSVYTALLSIQDLL----LGELSESETLTKSAcvqiLESHRPELQELQELERKLEDQLVQQEE 948
Cdd:pfam12128  599 EEELRERLDKAEEALQSAREKQAAAEEQLVQangeLEKASREETFARTA----LKNARLDLRRLFDEKQSEKDKKNKALA 674

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 22122329    949 AEQQRVLESwqrwaadgpglsepeemdpERQVSAILRQALNKGQKLLEQHQQRVRE 1004
Cdd:pfam12128  675 ERKDSANER-------------------LNSLEAQLKQLDKKHQAWLEEQKEQKRE 711
PTZ00121 PTZ00121
MAEBL; Provisional
 537-1004 2.28e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   537 HERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQY 616
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKK 1330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   617 LHQWRSvMAEHTAALEELQERLDQAALDDLRV---------LTVSLSEKATEELRRLQSTAMTQELLKRSAPWlfLQQIL 687
Cdd:PTZ00121 1331 ADAAKK-KAEEAKKAAEAAKAEAEAAADEAEAaeekaeaaeKKKEEAKKKADAAKKKAEEKKKADEAKKKAEE--DKKKA 1407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   688 EEHSRESAARTTQLE----AEERERGQELVQGVRQRLQQDALEAYTEEQAElrhwehlvfmklccaaislsEEDLLRVRQ 763
Cdd:PTZ00121 1408 DELKKAAAAKKKADEakkkAEEKKKADEAKKKAEEAKKADEAKKKAEEAKK--------------------AEEAKKKAE 1467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   764 EAQGcfSQLDRSLALPRVRARVLQQQAQMAWREAefrklDQALAAPELQSKARKLR-SKGRGKADLLKKNLE----DKIR 838
Cdd:PTZ00121 1468 EAKK--ADEAKKKAEEAKKADEAKKKAEEAKKKA-----DEAKKAAEAKKKADEAKkAEEAKKADEAKKAEEakkaDEAK 1540

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   839 LFEErapVELADQVR-GELLQERVQRLEAQEAHFAES--LVALQFQKVARAAETLSVYTALlsiqdlllgELSESETLTK 915
Cdd:PTZ00121 1541 KAEE---KKKADELKkAEELKKAEEKKKAEEAKKAEEdkNMALRKAEEAKKAEEARIEEVM---------KLYEEEKKMK 1608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   916 SACVQILESHRPELQELQ--ELERKLEDQLVQQEE-----AEQQRVLESWQRWAADgpglSEPEEMDPERQVSAILRQAL 988
Cdd:PTZ00121 1609 AEEAKKAEEAKIKAEELKkaEEEKKKVEQLKKKEAeekkkAEELKKAEEENKIKAA----EEAKKAEEDKKKAEEAKKAE 1684

                         490
                  ....*....|....*.
gi 22122329   989 NKGQKLLEQHQQRVRE 1004
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEE 1700
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 621-979 6.86e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 6.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    621 RSVMAEHTAALEELQERLDQAALDdlrvltVSLSEKATEELRRLQStAMTQELLKrsapwlfLQQILEEHSRESAARTTQ 700
Cdd:TIGR02168  669 NSSILERRREIEELEEKIEELEEK------IAELEKALAELRKELE-ELEEELEQ-------LRKELEELSRQISALRKD 734

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    701 LEAEERERGQELVQGVRQRLQQDALEAYTEEQAElrhwehlvfmklccaaiSLSEEDLLRVRQEAQgcfsqldrslaLPR 780
Cdd:TIGR02168  735 LARLEAEVEQLEERIAQLSKELTELEAEIEELEE-----------------RLEEAEEELAEAEAE-----------IEE 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    781 VRARVLQQQAQMAWREAEFRKLDQALAapELQSKARKLRSKgrgkadllKKNLEDKIRLFEERApVELADQVRGelLQER 860
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELT--LLNEEAANLRER--------LESLERRIAATERRL-EDLEEQIEE--LSED 853

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    861 VQRLEAQEAHFAESLVALQfqkvaraaETLSVYTALLSIQDLLLGELsESETLTKSACVQILESHRPEL-QELQELERKL 939
Cdd:TIGR02168  854 IESLAAEIEELEELIEELE--------SELEALLNERASLEEALALL-RSELEELSEELRELESKRSELrRELEELREKL 924

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 22122329    940 EDQLVQQEEAE------QQRVLESWQRWAADGPGLSEPEEMDPERQ 979
Cdd:TIGR02168  925 AQLELRLEGLEvridnlQERLSEEYSLTLEEAEALENKIEDDEEEA 970
 
Name Accession Description Interval E-value
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
 147-570 0e+00

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 612.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    147 GECYSVSYTASLDPTALGTGESLDLPARLIFQ-SPSQNRTQLK---APFTITVEEKIMVLPNHGLHAAGFIAAFLISLLL 222
Cdd:pfam12297    1 GEEYAVSYTAELDAKERGKGESLTLPAQLTFQnSSQNNRTQLGpltANLTLTVEEKTKVLPNHGLHAAGFFIGFLVSLVL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    223 TVAALFFLARGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQAD 302
Cdd:pfam12297   81 TLLAFFLLGRTRCLQGSLLSRNRRLSQESKLEYSQFTSAEGVKEDLAFEDQMIDILTFEDPGSMLQALENLEIATLLRAD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    303 ADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQR 382
Cdd:pfam12297  161 ADLEACRTQISKDIIAILLKNLRSSGHLSPQAEKRMSSVFNKQFLAMEGRLQEEYERKMAALAAECNLETREKMEAQHQR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    383 EMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKG 462
Cdd:pfam12297  241 EMAEKEEAEELLKHADEQEALECSSLLDKLHKLEQEHLQRSLLLRQEEDFAKAQRQLAVFQRVELHKIFFTQLKEATRKG 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    463 ELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGY 542
Cdd:pfam12297  321 ELKPEAAKRLLQDYSKIQEQIEELMDFFQANQRYHLSERFAQREYLVQSLQSLETRVSGLLNTAATQLTSLIQKMERAGY 400

                          410       420
                   ....*....|....*....|....*...
gi 22122329    543 LDEDQMETLLERAQTETFSIKQKLDNDL 570
Cdd:pfam12297  401 LDEEQMEMLLERAQKELLSVKQKLDNDL 428
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 505-987 1.70e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  505 REYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTEtfsikQKLDNDLKQEKKRlhQRLITR 584
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE-----EALLEAEAELAEA--EEELEE 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  585 RRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRL 664
Cdd:COG1196  384 LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  665 QSTAMTQELLKRSApwlFLQQILEEHSRESAARTTQLEAEERERGqeLVQGVRQRLQQDALEAYTEEQAELRHWEHLVFM 744
Cdd:COG1196  464 LLAELLEEAALLEA---ALAELLEELAEAAARLLLLLEAEADYEG--FLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEA 538

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  745 KLCCAAISLSEEDLLRVRQEAQGCFSQLdRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRG 824
Cdd:COG1196  539 ALEAALAAALQNIVVEDDEVAAAAIEYL-KAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYV 617

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  825 KAD-LLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLsvytallsiQDLL 903
Cdd:COG1196  618 LGDtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEEL---------AERL 688

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  904 LGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAI 983
Cdd:COG1196  689 AEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768


                 ....
gi 22122329  984 LRQA 987
Cdd:COG1196  769 LERL 772
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 508-1004 5.84e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.07  E-value: 5.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    508 LVQRLQAMETRVQGLLNTAATQLT-----SLIHKHERAgylDEDQMETLLERAQTETFSIKQKL---DNDLKQEKKRLHQ 579
Cdd:pfam12128  232 AIAGIMKIRPEFTKLQQEFNTLESaelrlSHLHFGYKS---DETLIASRQEERQETSAELNQLLrtlDDQWKEKRDELNG 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    580 RLITRRrrELLQKHKEQ------QKEQVSLGEASSTAEDAVQyLHQWRSvmaehtaALEELQERLDqAALDDLRvlTVSL 653
Cdd:pfam12128  309 ELSAAD--AAVAKDRSElealedQHGAFLDADIETAAADQEQ-LPSWQS-------ELENLEERLK-ALTGKHQ--DVTA 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    654 SEKATEELRRLQSTAMTQELLKRSAPwlflqqileehSRESAARttqLEAEERERGQELVQGVRQRLQQDALEAyteEQA 733
Cdd:pfam12128  376 KYNRRRSKIKEQNNRDIAGIKDKLAK-----------IREARDR---QLAVAEDDLQALESELREQLEAGKLEF---NEE 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    734 ELRHWEHLVFMKLCCAAISLSEEDLLRVR---------QEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQ 804
Cdd:pfam12128  439 EYRLKSRLGELKLRLNQATATPELLLQLEnfderieraREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEER 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    805 ALAAPELQ--------SKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGEL----LQERVQRLEAQEAHFA 872
Cdd:pfam12128  519 QSALDELElqlfpqagTLLHFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELnlygVKLDLKRIDVPEWAAS 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    873 ESLVALQFQKVARAAETLSVYTALLSIQDLL----LGELSESETLTKSAcvqiLESHRPELQELQELERKLEDQLVQQEE 948
Cdd:pfam12128  599 EEELRERLDKAEEALQSAREKQAAAEEQLVQangeLEKASREETFARTA----LKNARLDLRRLFDEKQSEKDKKNKALA 674

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 22122329    949 AEQQRVLESwqrwaadgpglsepeemdpERQVSAILRQALNKGQKLLEQHQQRVRE 1004
Cdd:pfam12128  675 ERKDSANER-------------------LNSLEAQLKQLDKKHQAWLEEQKEQKRE 711
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 510-940 1.93e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.25  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  510 QRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRREL 589
Cdd:COG1196  333 EELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEAL 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  590 LQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTvsLSEKATEELRRLQSTAM 669
Cdd:COG1196  413 LERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA--LLEAALAELLEELAEAA 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  670 TQELLKRSA---PWLFLQQILEEHSRESAARTTQLEAEERERGQELVQGVRQRLQQDALEAYTE-EQAELRHWEHLVFMK 745
Cdd:COG1196  491 ARLLLLLEAeadYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEdDEVAAAAIEYLKAAK 570

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  746 LCCAAI--------------------SLSEEDLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQA 805
Cdd:COG1196  571 AGRATFlpldkiraraalaaalargaIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVT 650

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  806 LAAPELQSKARKLRSKGRGKADLLKKNLEDKIRLFEERApvELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVAR 885
Cdd:COG1196  651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA--EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEE 728

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 22122329  886 AAETLSVYTALLSIQDLLLGELSESETLTKSACVQILEShrpElqeLQELERKLE 940
Cdd:COG1196  729 QLEAEREELLEELLEEEELLEEEALEELPEPPDLEELER---E---LERLEREIE 777
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 549-867 1.19e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.74  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    549 ETLLERAQTETFsikQKLDND-LKQEKKRLHQRLitRRRRELLQKHKEQQKEqvslgeassTAEDAVQYLHQWRSVMaEH 627
Cdd:pfam17380  282 KAVSERQQQEKF---EKMEQErLRQEKEEKAREV--ERRRKLEEAEKARQAE---------MDRQAAIYAEQERMAM-ER 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    628 TAALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQstamtqelLKRSAPWLFLQQILEehsresAARTTQLEAEERE 707
Cdd:pfam17380  347 ERELERIRQEERKRELERIRQEEIAMEISRMRELERLQ--------MERQQKNERVRQELE------AARKVKILEEERQ 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    708 RgqelvqgvRQRLQQDALEAYTEEQAELRHWEHLVfmklccaaisLSEE---DLLRVRQEAQGCFSQLDRSLALPRVRAR 784
Cdd:pfam17380  413 R--------KIQQQKVEMEQIRAEQEEARQREVRR----------LEEErarEMERVRLEEQERQQQVERLRQQEEERKR 474

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    785 VLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRgKADLLKKNLEDKIR-LFEERAPVELADQVRGELLQERVQR 863
Cdd:pfam17380  475 KKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEER-KRKLLEKEMEERQKaIYEEERRREAEEERRKQQEMEERRR 553


                   ....
gi 22122329    864 LEAQ 867
Cdd:pfam17380  554 IQEQ 557
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
564-1014 1.60e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.00  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  564 QKLDNDLKQEKKRLHQ-RLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSvMAEHTAALEELQERLDQ-- 640
Cdd:COG4717   74 KELEEELKEAEEKEEEyAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQE-LEALEAELAELPERLEEle 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  641 AALDDLRVLTVSLsEKATEELRRLQsTAMTQELLKRSAPWLFLQQILEEHSRESAARTTQLEaEERERGQELVQGVRQRL 720
Cdd:COG4717  153 ERLEELRELEEEL-EELEAELAELQ-EELEELLEQLSLATEEELQDLAEELEELQQRLAELE-EELEEAQEELEELEEEL 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  721 QQDALEAYTEEQAELRHWEHLVFMklccaAISLseedLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEfr 800
Cdd:COG4717  230 EQLENELEAAALEERLKEARLLLL-----IAAA----LLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKA-- 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  801 KLDQALAAPELQSKARKLRSKGRgKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVAL-- 878
Cdd:COG4717  299 SLGKEAEELQALPALEELEEEEL-EELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALla 377

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  879 --------QFQKVARAAETLSVYTALL-SIQDLLLGELSESETLTKSACVQILESHRPELQ-ELQELERKLEDQLVQQEE 948
Cdd:COG4717  378 eagvedeeELRAALEQAEEYQELKEELeELEEQLEELLGELEELLEALDEEELEEELEELEeELEELEEELEELREELAE 457

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22122329  949 AEQQ-RVLESWQRWAAdgpGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREEWQnGAVLED 1014
Cdd:COG4717  458 LEAElEQLEEDGELAE---LLQELEELKAELRELAEEWAALKLALELLEEAREEYREERL-PPVLER 520
PTZ00121 PTZ00121
MAEBL; Provisional
 537-1004 2.28e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   537 HERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQY 616
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKK 1330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   617 LHQWRSvMAEHTAALEELQERLDQAALDDLRV---------LTVSLSEKATEELRRLQSTAMTQELLKRSAPWlfLQQIL 687
Cdd:PTZ00121 1331 ADAAKK-KAEEAKKAAEAAKAEAEAAADEAEAaeekaeaaeKKKEEAKKKADAAKKKAEEKKKADEAKKKAEE--DKKKA 1407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   688 EEHSRESAARTTQLE----AEERERGQELVQGVRQRLQQDALEAYTEEQAElrhwehlvfmklccaaislsEEDLLRVRQ 763
Cdd:PTZ00121 1408 DELKKAAAAKKKADEakkkAEEKKKADEAKKKAEEAKKADEAKKKAEEAKK--------------------AEEAKKKAE 1467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   764 EAQGcfSQLDRSLALPRVRARVLQQQAQMAWREAefrklDQALAAPELQSKARKLR-SKGRGKADLLKKNLE----DKIR 838
Cdd:PTZ00121 1468 EAKK--ADEAKKKAEEAKKADEAKKKAEEAKKKA-----DEAKKAAEAKKKADEAKkAEEAKKADEAKKAEEakkaDEAK 1540

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   839 LFEErapVELADQVR-GELLQERVQRLEAQEAHFAES--LVALQFQKVARAAETLSVYTALlsiqdlllgELSESETLTK 915
Cdd:PTZ00121 1541 KAEE---KKKADELKkAEELKKAEEKKKAEEAKKAEEdkNMALRKAEEAKKAEEARIEEVM---------KLYEEEKKMK 1608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   916 SACVQILESHRPELQELQ--ELERKLEDQLVQQEE-----AEQQRVLESWQRWAADgpglSEPEEMDPERQVSAILRQAL 988
Cdd:PTZ00121 1609 AEEAKKAEEAKIKAEELKkaEEEKKKVEQLKKKEAeekkkAEELKKAEEENKIKAA----EEAKKAEEDKKKAEEAKKAE 1684

                         490
                  ....*....|....*.
gi 22122329   989 NKGQKLLEQHQQRVRE 1004
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEE 1700
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 352-867 2.55e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  352 EIQEEYERKMLALTAEcDLEMRKKTEnQYQREMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAED 431
Cdd:COG1196  264 ELEAELEELRLELEEL-ELELEEAQA-EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  432 FAQAHRQLAvfqrNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQESVEELMDffQATKRYHLSKRFGHREYLVQR 511
Cdd:COG1196  342 LEEELEEAE----EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA--AAELAAQLEELEEAEEALLER 415

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  512 LQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEK-KRLHQRLITRRRRELL 590
Cdd:COG1196  416 LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAlAELLEELAEAAARLLL 495

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  591 QKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQSTAMT 670
Cdd:COG1196  496 LLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRAT 575

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  671 QELLKRSAPWLFLQQILEEHSRESAARTTQLEAEERERGQELVQG--VRQRLQQDALEAYTEEQAELRHWEHLVFmklcc 748
Cdd:COG1196  576 FLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDtlLGRTLVAARLEAALRRAVTLAGRLREVT----- 650

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  749 AAISLSEEDLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRGKADL 828
Cdd:COG1196  651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 22122329  829 LKKNLEDKIRLFEERAPVELADQVRGEL------LQERVQRLEAQ 867
Cdd:COG1196  731 EAEREELLEELLEEEELLEEEALEELPEppdleeLERELERLERE 775
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 621-979 6.86e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 6.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    621 RSVMAEHTAALEELQERLDQAALDdlrvltVSLSEKATEELRRLQStAMTQELLKrsapwlfLQQILEEHSRESAARTTQ 700
Cdd:TIGR02168  669 NSSILERRREIEELEEKIEELEEK------IAELEKALAELRKELE-ELEEELEQ-------LRKELEELSRQISALRKD 734

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    701 LEAEERERGQELVQGVRQRLQQDALEAYTEEQAElrhwehlvfmklccaaiSLSEEDLLRVRQEAQgcfsqldrslaLPR 780
Cdd:TIGR02168  735 LARLEAEVEQLEERIAQLSKELTELEAEIEELEE-----------------RLEEAEEELAEAEAE-----------IEE 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    781 VRARVLQQQAQMAWREAEFRKLDQALAapELQSKARKLRSKgrgkadllKKNLEDKIRLFEERApVELADQVRGelLQER 860
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELT--LLNEEAANLRER--------LESLERRIAATERRL-EDLEEQIEE--LSED 853

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    861 VQRLEAQEAHFAESLVALQfqkvaraaETLSVYTALLSIQDLLLGELsESETLTKSACVQILESHRPEL-QELQELERKL 939
Cdd:TIGR02168  854 IESLAAEIEELEELIEELE--------SELEALLNERASLEEALALL-RSELEELSEELRELESKRSELrRELEELREKL 924

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 22122329    940 EDQLVQQEEAE------QQRVLESWQRWAADGPGLSEPEEMDPERQ 979
Cdd:TIGR02168  925 AQLELRLEGLEvridnlQERLSEEYSLTLEEAEALENKIEDDEEEA 970
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 491-956 8.11e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.27  E-value: 8.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    491 QATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLihkheragyLDEDQMETLLERAQTETfsikqkldnDL 570
Cdd:TIGR00618  374 QHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRT---------SAFRDLQGQLAHAKKQQ---------EL 435

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    571 KQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQErldqaaldDLRVLT 650
Cdd:TIGR00618  436 QQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQE--------EPCPLC 507

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    651 VSLSEKATEELRRLQSTAMTQELLKRSAPWLFLQQILE----------------EHSRESAARTTQLEAEERERGQELVQ 714
Cdd:TIGR00618  508 GSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEdvyhqltserkqraslKEQMQEIQQSFSILTQCDNRSKEDIP 587

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    715 GVRQRLQQdaLEAYTEEQAELRHwehlvfMKLCCAAISL----SEEDLLRVRQEAQGCFSQLDRSL-ALPRVRARVLQQQ 789
Cdd:TIGR00618  588 NLQNITVR--LQDLTEKLSEAED------MLACEQHALLrklqPEQDLQDVRLHLQQCSQELALKLtALHALQLTLTQER 659

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    790 AQMAW---REAEFRKLDQALAAP-ELQSKARKLRS--KGRGKADLLKKNLEDKI----RLFEERAPVELAD----QVRGE 855
Cdd:TIGR00618  660 VREHAlsiRVLPKELLASRQLALqKMQSEKEQLTYwkEMLAQCQTLLRELETHIeeydREFNEIENASSSLgsdlAARED 739

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    856 LLQERVQRLEAQEAHFAESLVALQFQKVARAA---ETLSVYTALLSIQDLLLGELSESETLTKSACVQIlESHRPElqel 932
Cdd:TIGR00618  740 ALNQSLKELMHQARTVLKARTEAHFNNNEEVTaalQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEI-GQEIPS---- 814

                          490       500
                   ....*....|....*....|....
gi 22122329    933 QELERKLEDQLVQQEEAEQQRVLE 956
Cdd:TIGR00618  815 DEDILNLQCETLVQEEEQFLSRLE 838
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 692-1025 9.03e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 9.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  692 RESAARTTQLEAEERERgqelvqgvRQRLQQDALEAYTEEQAELRhwehlvfmklccAAISLSEEDLLRVRQEAQgcfsQ 771
Cdd:COG1196  209 AEKAERYRELKEELKEL--------EAELLLLKLRELEAELEELE------------AELEELEAELEELEAELA----E 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  772 LDRSLAlpRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRskgrgkadllKKNLEDKIrlfEERAPVELADQ 851
Cdd:COG1196  265 LEAELE--ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER----------RRELEERL---EELEEELAELE 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  852 VRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLSVYTALLSIQDLLLGELSESETLTKSACVQILESHRPELQE 931
Cdd:COG1196  330 EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE 409

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  932 LQELERKL----EDQLVQQEEAEQQRVLESWQRWAADgpGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREEWQ 1007
Cdd:COG1196  410 EALLERLErleeELEELEEALAELEEEEEEEEEALEE--AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA 487

                        330
                 ....*....|....*...
gi 22122329 1008 NGAVLEDSLESIEADTMA 1025
Cdd:COG1196  488 EAAARLLLLLEAEADYEG 505
PTZ00121 PTZ00121
MAEBL; Provisional
 563-1022 2.87e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   563 KQKLDNDLKQEKKR----LHQRLITRRRRELLQKHKEQQKEQVS----LGEASSTAEDAVQylhqwrsvMAEHTAALEEL 634
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKkadaAKKKAEEKKKADEAKKKAEEDKKKADelkkAAAAKKKADEAKK--------KAEEKKKADEA 1436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   635 QERLDQAALDDLRVLTVSLSEKAtEELRRLQSTAMTQELLKRSAPWLFLQQILEEHSRESAARTTQLE--AEERERGQEL 712
Cdd:PTZ00121 1437 KKKAEEAKKADEAKKKAEEAKKA-EEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKkaAEAKKKADEA 1515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   713 VQGVRQRLQQDALEAYTEEQA-ELRHWEHLVfmklccAAISLSEEDLLRVRQEAQGCfsqldrslalprVRARVLQQQAQ 791
Cdd:PTZ00121 1516 KKAEEAKKADEAKKAEEAKKAdEAKKAEEKK------KADELKKAEELKKAEEKKKA------------EEAKKAEEDKN 1577

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   792 MAWREAE-FRKLDQAlaapELQSKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAH 870
Cdd:PTZ00121 1578 MALRKAEeAKKAEEA----RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELK 1653

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   871 FAESLVALQFQKVARAAEtlsvytallsiQDLLLGELSESETLTKSACVQILESHRPELQELQELERKLEDQL-----VQ 945
Cdd:PTZ00121 1654 KAEEENKIKAAEEAKKAE-----------EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeeLK 1722

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122329   946 QEEAEQQRVLESWQRWAADGPGLSEPEEMDPE--RQVSAILRQALNKGQKLLEQHQQRVREEWQNgavlEDSLESIEAD 1022
Cdd:PTZ00121 1723 KAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEekKKIAHLKKEEEKKAEEIRKEKEAVIEEELDE----EDEKRRMEVD 1797
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 625-984 3.54e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 3.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    625 AEHTAALEELQERLDQAaldDLRVLTVSLSEKAtEELRRLQSTamtqelLKRsapwlfLQQILEEHSRESAARTTQLEAE 704
Cdd:TIGR02168  209 AEKAERYKELKAELREL---ELALLVLRLEELR-EELEELQEE------LKE------AEEELEELTAELQELEEKLEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    705 ERERgQELVQgvRQRLQQDALEAYTEEQAEL-RHWEHLVFmklccaAISLSEEDLLRVRQEAQGCFSQLDRSLA-LPRVR 782
Cdd:TIGR02168  273 RLEV-SELEE--EIEELQKELYALANEISRLeQQKQILRE------RLANLERQLEELEAQLEELESKLDELAEeLAELE 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    783 ARVLQQQAQMAWREAEFRKLDQALAAPELQSKA-RKLRSKGRGKADLLKKNLEDkirlfeERAPVELADQvRGELLQERV 861
Cdd:TIGR02168  344 EKLEELKEELESLEAELEELEAELEELESRLEElEEQLETLRSKVAQLELQIAS------LNNEIERLEA-RLERLEDRR 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329    862 QRLEAQEAHFAESLVALQFQKVARAAETlsvytallsiqdllLGELSESETLTKSACVQILESHRPELQELQELERKLED 941
Cdd:TIGR02168  417 ERLQQEIEELLKKLEEAELKELQAELEE--------------LEEELEELQEELERLEEALEELREELEEAEQALDAAER 482

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 22122329    942 QLvqQEEAEQQRVLESWQRwAADGPGLSEPEEMDPERQVSAIL 984
Cdd:TIGR02168  483 EL--AQLQARLDSLERLQE-NLEGFSEGVKALLKNQSGLSGIL 522
PRK12704 PRK12704
phosphodiesterase; Provisional
 545-710 5.62e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.00  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   545 EDQMETLLERAQTETFSIKQKLDNDLKQE---KKRLHQRLITRRRRELLQKHKE-QQKEQvSLGEASSTAEDAVQYLHQW 620
Cdd:PRK12704   37 EEEAKRILEEAKKEAEAIKKEALLEAKEEihkLRNEFEKELRERRNELQKLEKRlLQKEE-NLDRKLELLEKREEELEKK 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   621 RSVMAEHTAALEELQERLDqaalddlrvltvslsEKATEELRRLQSTA-MTQELLKRsapwLFLQQILEEHSRESAARTT 699
Cdd:PRK12704  116 EKELEQKQQELEKKEEELE---------------ELIEEQLQELERISgLTAEEAKE----ILLEKVEEEARHEAAVLIK 176

                         170
                  ....*....|.
gi 22122329   700 QLEAEERERGQ 710
Cdd:PRK12704  177 EIEEEAKEEAD 187
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
575-1020 7.77e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  575 KRLHQRLIT-RRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSV--MAEHTAALEELQERLD--QAALDDLRvl 649
Cdd:COG4913  238 ERAHEALEDaREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQrrLELLEAELEELRAELArlEAELERLE-- 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  650 tvSLSEKATEELRRL-----------------QSTAMTQELLKRSAPWLFLQQ--------------ILEEHSRESAART 698
Cdd:COG4913  316 --ARLDALREELDELeaqirgnggdrleqlerEIERLERELEERERRRARLEAllaalglplpasaeEFAALRAEAAALL 393

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  699 TQLEAEERERGQELVQGVRQRlqQDALEAYTEEQAELRHWEH---------LVFMKLCCAAISLSEED------LLRVRQ 763
Cdd:COG4913  394 EALEEELEALEEALAEAEAAL--RDLRRELRELEAEIASLERrksniparlLALRDALAEALGLDEAElpfvgeLIEVRP 471

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  764 EA---QGCFSQLDRSLAL-----PRVRARVL------QQQAQMAWREAEFRKLDQALAAPELQSKARKLRSK-------- 821
Cdd:COG4913  472 EEerwRGAIERVLGGFALtllvpPEHYAAALrwvnrlHLRGRLVYERVRTGLPDPERPRLDPDSLAGKLDFKphpfrawl 551

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  822 -------------------------------GRGKADLLKKNLEDKIRL-----FEERAPVELADQVRGEL------LQE 859
Cdd:COG4913  552 eaelgrrfdyvcvdspeelrrhpraitragqVKGNGTRHEKDDRRRIRSryvlgFDNRAKLAALEAELAELeeelaeAEE 631

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  860 RVQRLEAQEAHFAESLVALQFQKVARAAE--TLSVYTALLSIQDLLLGELSESETLTK-----SACVQILESHRPELQEL 932
Cdd:COG4913  632 RLEALEAELDALQERREALQRLAEYSWDEidVASAEREIAELEAELERLDASSDDLAAleeqlEELEAELEELEEELDEL 711

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  933 QELERKLEDQL--VQQEEAEQQRVLES-------WQRWAADgPGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVR 1003
Cdd:COG4913  712 KGEIGRLEKELeqAEEELDELQDRLEAaedlarlELRALLE-ERFAAALGDAVERELRENLEERIDALRARLNRAEEELE 790

                        570       580
                 ....*....|....*....|....*
gi 22122329 1004 -------EEWQNGAV-LEDSLESIE 1020
Cdd:COG4913  791 ramrafnREWPAETAdLDADLESLP 815
PTZ00121 PTZ00121
MAEBL; Provisional
 582-869 1.12e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   582 ITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRsvmAEHTAALEELQERLDQAALDDLRvlTVSLSEKATEEL 661
Cdd:PTZ00121 1168 EARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARK---AEEERKAEEARKAEDAKKAEAVK--KAEEAKKDAEEA 1242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   662 RRLQSTAMTQELLKRSapwlflqqilEEHSRESAARTTQLEAEERERGQELVQGVRQRLQQDALEAYTEEQAElrhwehl 741
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFE----------EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKAD------- 1305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329   742 vfmklccAAISLSEEDllRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEfRKLDQALAAPELQSKARKLRSK 821
Cdd:PTZ00121 1306 -------EAKKKAEEA--KKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAE-AAADEAEAAEEKAEAAEKKKEE 1375

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 22122329   822 GRGKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEA 869
Cdd:PTZ00121 1376 AKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEA 1423
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
682-1021 3.08e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  682 FLQQILEEHSRESAA-------RTTQLEAEERERGQELVQGVRQRLQQ-----DALEAYTEEQAELRhwehlvfmklccA 749
Cdd:COG4717   42 FIRAMLLERLEKEADelfkpqgRKPELNLKELKELEEELKEAEEKEEEyaelqEELEELEEELEELE------------A 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  750 AISLSEEDLLRVRQEAQ-----GCFSQLDRSLALPRVRARVLQQQAQmAWREAEfRKLDQALAapELQSKARKLRSKGRG 824
Cdd:COG4717  110 ELEELREELEKLEKLLQllplyQELEALEAELAELPERLEELEERLE-ELRELE-EELEELEA--ELAELQEELEELLEQ 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  825 KADLLKKNLEDKIRLFEE-RAPVELADQVRgELLQERVQRLEAQEAHFAESLVALQ-FQKVARAAETLSVYTALLSIQDL 902
Cdd:COG4717  186 LSLATEEELQDLAEELEElQQRLAELEEEL-EEAQEELEELEEELEQLENELEAAAlEERLKEARLLLLIAAALLALLGL 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122329  903 LLGELSESETLTKSACVQI-LESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAAD--GPGLSEPEEMDPERQ 979
Cdd:COG4717  265 GGSLLSLILTIAGVLFLVLgLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAAlgLPPDLSPEELLELLD 344

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 22122329  980 VSAILRQALNKGQKLLEQHQQRVREEWQNGAVLEDSLESIEA 1021
Cdd:COG4717  345 RIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEE 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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