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Conserved domains on  [gi|22129563|ref|NP_666480|]
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olfactory receptor family 12 subfamily K member 8 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 24-300 2.80e-134

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15235:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 278  Bit Score: 382.34  E-value: 2.80e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  24 QPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFS 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 104 FMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITP 182
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGsNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 183 LLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPS 262
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 263 SSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
 
Name Accession Description Interval E-value
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 24-300 2.80e-134

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 382.34  E-value: 2.80e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  24 QPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFS 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 104 FMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITP 182
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGsNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 183 LLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPS 262
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 263 SSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 33-304 5.84e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 136.09  E-value: 5.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563    33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563   113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLKLSCTRP 191
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVlSHSYCLHMGLARLSCADI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563   192 VVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVM-----FLFGSLVHMYLKPSSSYn 266
Cdd:pfam13853 163 KVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLafytpMIGLSMVHRFGHNVPPL- 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 22129563   267 leQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRLF 304
Cdd:pfam13853 242 --LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 24-300 2.80e-134

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 382.34  E-value: 2.80e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  24 QPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFS 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 104 FMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITP 182
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGsNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 183 LLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPS 262
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 263 SSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 25-300 3.59e-116

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 336.35  E-value: 3.59e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15225   1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15225  81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGsNEINHFFCDIPPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15225 161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15225 241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 25-293 1.02e-114

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 332.53  E-value: 1.02e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGsNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd13954 241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 26-300 1.80e-107

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 314.49  E-value: 1.80e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGsREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 25-293 3.99e-107

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 313.29  E-value: 3.99e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGsNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15230 241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 11-304 1.37e-106

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 312.76  E-value: 1.37e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  11 EFVLLGLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNR 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  91 TISYNCCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 171 -NKVTHFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMF 249
Cdd:cd15943 161 sNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129563 250 LFGSLVHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRLF 304
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 25-293 3.47e-106

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 310.70  E-value: 3.47e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCAsNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 25-300 7.73e-106

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 310.35  E-value: 7.73e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15231   1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15231  81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGsNQISHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15231 161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15231 241 GYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 25-293 5.25e-105

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 308.05  E-value: 5.25e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGpNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15237 241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 12-297 2.66e-104

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 306.55  E-value: 2.66e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  12 FVLLGLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  92 ISYNCCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG- 170
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGs 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 171 NKVTHFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFL 250
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129563 251 FGSLVHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVK 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 12-304 4.46e-100

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 296.11  E-value: 4.46e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  12 FVLLGLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRT 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  92 ISYNCCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG- 170
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGs 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 171 NKVTHFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFL 250
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129563 251 FGSLVHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRLF 304
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 26-302 2.81e-96

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 286.13  E-value: 2.81e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGsNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 26-293 6.71e-96

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 284.76  E-value: 6.71e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGpNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 25-300 7.50e-96

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 284.87  E-value: 7.50e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15229   1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15229  81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGpNEINHFSCELPSL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15229 161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15229 241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 26-293 3.59e-95

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 282.96  E-value: 3.59e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLySVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGpNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 26-302 1.34e-94

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 281.90  E-value: 1.34e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15411   2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15411  82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGsNVINHFFCDTPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15411 162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15411 242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 27-300 5.91e-94

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 280.06  E-value: 5.91e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLK 185
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTiNHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129563 266 NLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 28-293 1.17e-93

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 278.95  E-value: 1.17e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  28 FGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTV 107
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 108 GSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLKL 186
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGsNVIHQFFCDIPQLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 187 SCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYN 266
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*..
gi 22129563 267 LEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 25-302 5.99e-93

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 277.75  E-value: 5.99e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGsNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15409 241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 26-293 3.05e-92

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 275.27  E-value: 3.05e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15947   2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15947  82 WLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGhHTLDHFFCEVPALI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15947 162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSS 241

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15947 242 YSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 26-302 3.67e-92

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 275.68  E-value: 3.67e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGpNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15417 242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 16-303 5.80e-92

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 275.40  E-value: 5.80e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  16 GLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYN 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  96 CCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVT 174
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGdNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 175 HFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSL 254
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129563 255 VHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRL 303
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 25-293 8.57e-92

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 274.36  E-value: 8.57e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15911   1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGpNEIDHFFCDFAPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15911 161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15911 241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 26-300 3.52e-91

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 273.05  E-value: 3.52e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGpNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 25-293 7.15e-91

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 271.87  E-value: 7.15e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15915   1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGpNKINHFFCDIKPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHM-HSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPS 262
Cdd:cd15915 161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129563 263 SSYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15915 241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 25-300 1.31e-90

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 271.56  E-value: 1.31e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGN-KVTHFFCDITPL 183
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHhRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 26-293 1.25e-89

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 268.74  E-value: 1.25e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGpNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15232 242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 12-302 1.09e-87

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 264.68  E-value: 1.09e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  12 FVLLGLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  92 ISYNCCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG- 170
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGs 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 171 NKVTHFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFL 250
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129563 251 FGSLVHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 25-300 1.78e-86

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 260.97  E-value: 1.78e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15234   1 PLLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGN-KVTHFFCDITPL 183
Cdd:cd15234  81 LLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDvEIPHFFCELAQV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15234 161 LKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAV 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15234 241 THSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 25-302 3.81e-85

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 257.71  E-value: 3.81e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGsNVINHFYCADPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 25-300 6.02e-85

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 256.97  E-value: 6.02e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15424   1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15424  81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGpNHINHFFCELPVV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15424 161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15424 241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 26-300 6.85e-85

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 257.02  E-value: 6.85e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15432   2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15432  82 GLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGrRRVDHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15432 162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15432 242 SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 12-304 7.02e-85

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 257.41  E-value: 7.02e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  12 FVLLGLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  92 ISYNCCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG- 170
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGs 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 171 NKVTHFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFL 250
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129563 251 FGSLVHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRLF 304
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 26-293 1.17e-84

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 256.14  E-value: 1.17e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15430   2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLL 184
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNViNHFTCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15430 242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 27-302 1.24e-84

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 256.48  E-value: 1.24e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLK 185
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGsNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15413 163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 266 NLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15413 243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 25-302 4.30e-84

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 255.03  E-value: 4.30e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15415   1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGpNVINHYFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15415 241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 26-302 1.62e-83

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 253.44  E-value: 1.62e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15416  82 TFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGpNEINHFFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15416 162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15416 242 YSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 26-293 2.98e-83

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 252.52  E-value: 2.98e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGpNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIgIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVI-LYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLeqDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15939 241 FPI--DKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 28-293 3.17e-83

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 252.59  E-value: 3.17e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  28 FGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTV 107
Cdd:cd15224   4 FLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 108 GSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLKL 186
Cdd:cd15224  84 ACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGpNVINHFFCDISPLLNL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 187 SCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYN 266
Cdd:cd15224 164 SCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISS 243

                       250       260
                ....*....|....*....|....*..
gi 22129563 267 LEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15224 244 FDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 27-300 1.85e-81

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 248.16  E-value: 1.85e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLK 185
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGhNKINHFLCEMPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129563 266 NLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 26-300 3.22e-80

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 245.06  E-value: 3.22e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFC-GNKVTHFFCDITPLL 184
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCaDNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15236 242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 25-293 4.98e-79

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 241.61  E-value: 4.98e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15946   1 SILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15946  81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGpNEINHYFCEVPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15946 161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15946 241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 25-293 1.27e-78

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 240.74  E-value: 1.27e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15914  81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGpNQIQHIFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15914 241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 25-300 6.60e-78

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 239.31  E-value: 6.60e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15233   1 PVLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15233  81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGpNVINHFFCDLPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15233 161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15233 241 VYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 26-306 1.40e-77

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 238.48  E-value: 1.40e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGpNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRLFRK 306
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 26-302 1.55e-77

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 238.47  E-value: 1.55e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15407   2 PLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15407  82 VFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKsNVINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15407 162 ALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 265 YNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWR 302
Cdd:cd15407 242 HSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 24-303 3.72e-77

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 237.37  E-value: 3.72e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  24 QPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFS 103
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 104 FMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITP 182
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGdNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 183 LLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPS 262
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129563 263 SSYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRL 303
Cdd:cd15418 241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 27-300 4.57e-77

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 236.93  E-value: 4.57e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFC-GNKVTHFFCDITPLLK 185
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCdSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129563 266 NLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 27-300 3.12e-76

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 235.04  E-value: 3.12e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVN-RTISYNCCMTQLFSFM 105
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGpNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YNLeqDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15916 243 EAL--DGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 26-300 1.91e-75

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 232.71  E-value: 1.91e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15228   2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15228  82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGsNVVDYFFCDIFPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15228 162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YNLeqDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15228 242 PVL--VTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 26-293 3.49e-75

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 231.71  E-value: 3.49e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGpNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIgIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVI-LVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLeqDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15226 241 FPV--DKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 25-300 2.46e-74

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 230.06  E-value: 2.46e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNK-VTHFFCDITPL 183
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRlLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129563 264 SYNLEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15433 241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 25-293 1.92e-71

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 222.21  E-value: 1.92e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15936   1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPL 183
Cdd:cd15936  81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGpNVLDNFYCDVPQV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIgIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15936 161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVI-LVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQ 239

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 264 syNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15936 240 --TFPMDKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 27-293 8.53e-70

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 218.08  E-value: 8.53e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15940   3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLK 185
Cdd:cd15940  83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGpNEIDSFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIaHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSL-RKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                       250       260
                ....*....|....*....|....*...
gi 22129563 266 NLeqDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15940 242 SE--DKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 27-300 6.92e-68

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 213.45  E-value: 6.92e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFC-GNKVTHFFCDITPLLK 185
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGqKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129563 266 NLeqDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15942 243 PL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 28-293 1.50e-67

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 212.56  E-value: 1.50e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  28 FGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTV 107
Cdd:cd15913   4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 108 GSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLKL 186
Cdd:cd15913  84 GTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGpNIIDHFLCDPGPLLAL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 187 SCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYN 266
Cdd:cd15913 164 SCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNS 243

                       250       260
                ....*....|....*....|....*..
gi 22129563 267 LEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15913 244 TGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 27-293 2.71e-63

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 201.25  E-value: 2.71e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMT 106
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 107 VGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLK 185
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGpNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 LSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIahmHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSY 265
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                       250       260
                ....*....|....*....|....*...
gi 22129563 266 NLeqDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15938 240 PV--DKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 28-300 2.03e-61

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 196.99  E-value: 2.03e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  28 FGVVLIMYLMAVLGNTLLVLVACSDPKLHT-PMYFLLSQLSLIDISLTTIIVPQMLVHTLSVN-RTISYNCCMTQLFSFM 105
Cdd:cd15941   4 FLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFH 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15941  84 FLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGpCQIAYFFCDIPPVL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15941 164 KLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129563 265 YnlEQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15941 244 Q--AGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 26-293 2.29e-60

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 193.80  E-value: 2.29e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGpNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIgIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSS 264
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFL-LAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                       250       260
                ....*....|....*....|....*....
gi 22129563 265 YNLeqDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15937 241 FPM--DKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 27-293 1.86e-57

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 186.51  E-value: 1.86e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMAVLGNTLLVLVACSDPKL-HTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLL 184
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGpNELDNFYCDVPQVI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 KLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYvriGIVIAHMHSVAALQ--KALSTCSSHVLVVMFLFGSLVHMYLKPS 262
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSY---GIILTTLRGRFREGggKALSTCSSHLTVVSLIFVPCIFVYLRPF 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129563 263 SSYNLeqDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd15935 240 SSSSV--DKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 32-300 2.47e-56

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 184.03  E-value: 2.47e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSME 111
Cdd:cd15223   8 LLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAME 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 112 VHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLKLSCTR 190
Cdd:cd15223  88 SSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSsNVIEHCYCDHMALVSLACGD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 191 PVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYNLEQD 270
Cdd:cd15223 168 TTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPPD 247

                       250       260       270
                ....*....|....*....|....*....|..
gi 22129563 271 RQV--AIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15223 248 VHVllSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 34-296 7.65e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 179.79  E-value: 7.65e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  34 MYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEVH 113
Cdd:cd15917  10 MYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 114 LLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLKLSCTRPV 192
Cdd:cd15917  90 VLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNViSHSYCEHMAVVKLACGDTR 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 193 VNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYNLEQDRQ 272
Cdd:cd15917 170 VNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPPHVH 249

                       250       260
                ....*....|....*....|....*.
gi 22129563 273 V--AIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15917 250 IllANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 31-296 7.26e-51

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 169.75  E-value: 7.26e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  31 VLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSM 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 111 EVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKVT-HFFCDITPLLKLSCT 189
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIpHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 190 RPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMF-----LFGSLVHMYLK--PS 262
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMsytpaLFSFLTHRFGQgiAP 246

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129563 263 SSYNLeqdrqVAIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15953 247 HIHII-----LANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 33-296 9.61e-50

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 166.82  E-value: 9.61e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15950   9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLKLSCTRP 191
Cdd:cd15950  89 GVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGsRVVPHSYCEHMAVVKLACADP 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 192 VVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVV-MFLFGSLVHMYLKpSSSYNLEQD 270
Cdd:cd15950 169 RPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVIlLFYIPGLLSIYTQ-RFGQGVPPH 247

                       250       260
                ....*....|....*....|....*...
gi 22129563 271 RQV--AIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15950 248 TQVllADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 33-296 2.23e-48

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 163.23  E-value: 2.23e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15221   9 SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSwVVVSLNSLLYSV-LVTRLTFCG-NKVTHFFCDITPLLKLSCTR 190
Cdd:cd15221  89 AILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAA-VARSFCIVFPFVfLLKRLPYCGhNVIPHTYCEHMGIARLACAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 191 PVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVV-MF----LFGSLVHMYLK--PSS 263
Cdd:cd15221 168 ITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVIlMFytpaFFSFLTHRFGRhiPRH 247

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129563 264 SYNLeqdrqVAIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15221 248 VHIL-----LANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 33-296 3.64e-47

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 160.20  E-value: 3.64e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFC-GNKVTHFFCDITPLLKLSCTRP 191
Cdd:cd15951  89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCrTNIIPHTYCEHMAVVKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 192 VVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMF-----LFGSLVHMYLKpsssyn 266
Cdd:cd15951 169 RVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVfyipaLFSFLTHRFGH------ 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129563 267 lEQDRQVAIF----YTLISPMLNPLIYSLRNQEV 296
Cdd:cd15951 243 -NVPPHVHILianvYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 33-296 5.29e-47

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 159.59  E-value: 5.29e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15222   9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCG-NKVTHFFCDITPLLKLSCTRP 191
Cdd:cd15222  89 SVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHsNVLSHSYCLHQDVMKLACSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 192 VVNE-----MLIFTEGVAVVvspifFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFG-----SLVHMYLKP 261
Cdd:cd15222 169 RVNSiyglfVVLSTMGLDSL-----LILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiglSMVHRFGKH 243

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129563 262 SSSYnleqdrqVAIF----YTLISPMLNPLIYSLRNQEV 296
Cdd:cd15222 244 ASPL-------VHVLmanvYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 33-296 1.02e-46

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 158.70  E-value: 1.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15952   9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLKLSCTRP 191
Cdd:cd15952  89 AVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIiPHTYCEHMGIAKLACASI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 192 VVNemLIFTEGVA-VVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYNLEQD 270
Cdd:cd15952 169 RIN--IIYGLFAIsVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRY 246

                       250       260
                ....*....|....*....|....*...
gi 22129563 271 RQ--VAIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15952 247 IHilLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 34-297 2.41e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 142.35  E-value: 2.41e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  34 MYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEVH 113
Cdd:cd15948  11 AFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESA 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 114 LLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLKLSCTRPV 192
Cdd:cd15948  91 VLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHViAHCYCEHMAVVKLACGDTR 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 193 VNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLF-----GSLVHMYLKPSSSYnl 267
Cdd:cd15948 171 FNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYtpvvlSSTMHRFARHVAPH-- 248

                       250       260       270
                ....*....|....*....|....*....|
gi 22129563 268 eQDRQVAIFYTLISPMLNPLIYSLRNQEVK 297
Cdd:cd15948 249 -VHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 34-296 2.20e-39

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 140.00  E-value: 2.20e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  34 MYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEVH 113
Cdd:cd15956  10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 114 LLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLKLSCTRPV 192
Cdd:cd15956  90 VLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTiAHTYCEHMAVVKLACGATT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 193 VNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYNLEQDRQ 272
Cdd:cd15956 170 VDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVPSAAH 249

                       250       260
                ....*....|....*....|....*.
gi 22129563 273 VAI--FYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15956 250 VLLsnLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 10-297 3.18e-39

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 139.91  E-value: 3.18e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  10 TEFVLLGLSSQPEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVN 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  90 RTISYNCCMTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLT-F 168
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPwY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 169 CGNKVTHFFCDITPLLKLSCTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVM 248
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 249 FLF-----GSLVHMYLK--PSSSYNLeqdrqVAIFYTLISPMLNPLIYSLRNQEVK 297
Cdd:cd15949 242 AFYvpiavSSLIHRFGQnvPPPTHIL-----LANFYLLIPPMLNPIVYGVRTKQIQ 292
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 33-304 5.84e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 136.09  E-value: 5.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563    33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563   113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKV-THFFCDITPLLKLSCTRP 191
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVlSHSYCLHMGLARLSCADI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563   192 VVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVM-----FLFGSLVHMYLKPSSSYn 266
Cdd:pfam13853 163 KVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLafytpMIGLSMVHRFGHNVPPL- 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 22129563   267 leQDRQVAIFYTLISPMLNPLIYSLRNQEVKGALWRLF 304
Cdd:pfam13853 242 --LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 33-296 1.55e-35

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 129.89  E-value: 1.55e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15955   9 IMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRL--TFCGNKVTHFFCDITPLLKLSCTR 190
Cdd:cd15955  89 GILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKLRlhHFRSTVISHSYCEHMAVVKLAADD 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 191 PVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMF-----LFGSLVHMY---LKPS 262
Cdd:cd15955 169 VRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLfytlaFFSFFAHRFghhVAPY 248

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129563 263 SSYNLeqdrqvAIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15955 249 VHILL------SNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 34-296 3.95e-34

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 126.09  E-value: 3.95e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  34 MYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEVH 113
Cdd:cd15954  10 MYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 114 LLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFC-GNKVTHFFCDITPLLKLSCTRPV 192
Cdd:cd15954  90 VLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCrGNFIPHTYCDHMSVVKLACANIR 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 193 VNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSHVLVVMF-----LFGSLVHMYlkpsSSYNL 267
Cdd:cd15954 170 VDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVItytpaFFTFFAHRF----GGHHI 245

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129563 268 EQDRQ--VAIFYTLISPMLNPLIYSLRNQEV 296
Cdd:cd15954 246 TPHIHiiMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 41-289 1.07e-28

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 110.85  E-value: 1.07e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563    41 GNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNR-TISYNCCMTQLFSFMTVGSMEVHLLGAMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563   120 YDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKvtHFFCDITPLLKLSCTRPVVNEMLIF 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN--VTVCFIDFPEDLSKPVSYTLLISVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563   200 tegvaVVVSPIFFIFGSYVRIGIVIAHMHSVAA-------LQKALSTCSSHVLVVMFLFGSLVHMYLKPSSSYNLEQDR- 271
Cdd:pfam00001 159 -----GFLLPLLVILVCYTLIIRTLRKSASKQKssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRl 233

                         250       260
                  ....*....|....*....|...
gi 22129563   272 -----QVAIFYTLISPMLNPLIY 289
Cdd:pfam00001 234 ldkalSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 30-293 5.29e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 85.03  E-value: 5.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGS 109
Cdd:cd00637   4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 110 MEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKVTHFFCDITPLLKlsct 189
Cdd:cd00637  84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK---- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 190 rpvvneMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSH----------VLVVMFLFG------- 252
Cdd:cd00637 160 ------AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktLLIVVVVFLlcwlpyf 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22129563 253 -SLVHMYLKPSSSYNLEQDRQVAIFYTLISPMLNPLIYSLRN 293
Cdd:cd00637 234 iLLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 26-300 4.05e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 67.97  E-value: 4.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLysVLVTRLTFCGNKVTHFFCDitpllk 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP--PLVGWRDETQPSVVDCECE------ 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 186 lsctrPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIgIVIAHMHSVAAlqKALStcsshVLVVMFLFG-------SLVHMY 258
Cdd:cd14967 153 -----FTPNKIYVLVSSVISFFIPLLIMIVLYARI-FRVARRELKAA--KTLA-----IIVGAFLLCwlpffiiYLVSAF 219

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22129563 259 LKPSSsynleQDRQV-AIFYTL--ISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd14967 220 CPPDC-----VPPILyAVFFWLgyLNSALNPIIYALFNRDFRRAF 259
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 26-291 7.41e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 61.80  E-value: 7.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNtLLVLVACSDPK-LHTPMYFLLSQLSLIDISLTTIIVPqmlvhtLSVNRTIsYNC-------C 97
Cdd:cd15055   2 LLYIVLSSISLLTVLGN-LLVIISISHFKqLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSI-ETCwyfgdtfC 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  98 MTQLFSFMTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVvslnSLLYSVLvtrLTFCGNKVTHFF 177
Cdd:cd15055  74 KLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFV----SALYSSV---LLYDNLNQPGLI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 178 CDITPLlkLSCTRpVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIV-IAHMHSVAALQKALSTCSSH------------- 243
Cdd:cd15055 147 RYNSCY--GECVV-VVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVaRSQARAIRSHTAQVSLEGSSkkvskkserkaak 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22129563 244 ---VLVVMFLF-------GSLVHMYLKPSSSYnleqdRQVAIFYTLISPMLNPLIYSL 291
Cdd:cd15055 224 tlgIVVGVFLLcwlpyyiVSLVDPYISTPSSV-----FDVLIWLGYFNSCLNPLIYAL 276
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 32-300 8.65e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 58.81  E-value: 8.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTIsYNCCMTQLFSFMTVGSME 111
Cdd:cd14968   8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF-HGCLFMACLVLVLTQSSI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 112 VHLLgAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVvslnsllySVLVTRLTFCG--NKVTHFFCDITPLLKLSCT 189
Cdd:cd14968  87 FSLL-AIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVL--------SFLVGLTPMFGwnNGAPLESGCGEGGIQCLFE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 190 RPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVI-----------AHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMY 258
Cdd:cd14968 158 EVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIrkqlrqiesllRSRRSRSTLQKEVKAAKSLAIILFLFALCWLPLH 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129563 259 LKPSSSYNLEQDRQ------VAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd14968 238 IINCITLFCPECKVpkiltyIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 29-300 3.43e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 56.92  E-value: 3.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDIsLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVG 108
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADL-LAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 109 SMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVvslnSLLYSVLVTRLTFCGNKVTHFFCDITPLLKLSc 188
Cdd:cd14972  82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVW----SVLLALLPVLGWNCVLCDQESCSPLGPGLPKS- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 189 trpvvneMLIFTegVAVVVSPIFFIFGSYVRI-GIVIAHMHSVAALQKALSTCSSH----------VLVVMFLFG---SL 254
Cdd:cd14972 157 -------YLVLI--LVFFFIALVIIVFLYVRIfWCLWRHANAIAARQEAAVPAQPStsrklaktvvIVLGVFLVCwlpLL 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129563 255 VHMYLKPSSSYNLEQDRQVAIF--YTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd14972 228 ILLVLDVLCPSVCDIQAVFYYFlvLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 32-297 4.39e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 53.78  E-value: 4.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLvhTLSVNRTISYNCCMTQLFSFMTVGSME 111
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--TISLGFCTDFHSCLFLACFVLVLTQSS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 112 VHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV---VVSLNSLL-YSVLVTRLTFCGNKVTHFFCDITPLLKLS 187
Cdd:cd15069  86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVlafGIGLTPFLgWNKAMSATNNSTNPADHGTNHSCCLISCL 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 188 CTRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHM--------HSVAALQKALSTCSSHVLVV-MFLFGSLVHMY 258
Cdd:cd15069 166 FENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQlqrtelmdHSRTTLQREIHAAKSLAIIVgIFALCWLPVHI 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129563 259 LKPSSSYNLEQDR-------QVAIFYTLISPMLNPLIYSLRNQEVK 297
Cdd:cd15069 246 LNCITLFQPEFSKskpkwamNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 32-294 1.37e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 52.22  E-value: 1.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPM-YFLLSqLSLIDISLTTIIVPQMLVHtlSVNRTISYNCCMTQLFSFM--TVG 108
Cdd:cd14993   8 VVVFLLALVGNSLVIAVVLRNKHMRTVTnYFLVN-LAVADLLVSLFCMPLTLLE--NVYRPWVFGEVLCKAVPYLqgVSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 109 SMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV-VSLNSLL---YSVLVTRLTFCGNKVTHFFCDITPLl 184
Cdd:cd14993  85 SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIaIIIMLPLlvvYELEEIISSEPGTITIYICTEDWPS- 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 185 klsctrPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSH-------------VLVVMFLF 251
Cdd:cd14993 164 ------PELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmliVVVVLFAL 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129563 252 G----SLVHMYLKPSSSYNLEQDRQVAIFYTL------ISPMLNPLIYSLRNQ 294
Cdd:cd14993 238 SwlpyYVLSILLDFGPLSSEESDENFLLILPFaqllgySNSAINPIIYCFMSK 290
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
 32-224 2.02e-07

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 51.45  E-value: 2.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSvnRTISYNCCMTQLFSFMTVGSME 111
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLT--KNWPFGSILCKLVPSLQGVSIF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 112 VHL--LGAMAYDRYVAICDPLRysSIVSHSLCLRITLTSWVVVSLNSLLYSVLVtrltfcgnKVTHFFCDITPLLKLSCT 189
Cdd:cd15203  86 VSTltLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIFQ--------ELSDVPIEILPYCGYFCT 155

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 22129563 190 R--PVVNEMLIFTEGVAVV--VSPIFFIFGSYVRIGIVI 224
Cdd:cd15203 156 EswPSSSSRLIYTISVLVLqfVIPLLIISFCYFRISLKL 194
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 27-156 3.22e-07

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 50.82  E-value: 3.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMYLMA-VLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSvNRTISYNCCMTQLFSFM 105
Cdd:cd15067   1 LLGVVLSLFCLVtVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMT-GGYWLFGRDWCDVWHSF 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129563 106 TVGSMEVHLLG--AMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNS 156
Cdd:cd15067  80 DVLASTASILNlcVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS 132
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 26-300 4.57e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 50.28  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMY-LMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd14969   1 YVLAVYLSLIgVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIvSHSLCLRITLTSWvvvslnslLYSVLVTRLTFCG-NKVTHFfcditpL 183
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIW--------LYGLFWALPPLFGwSSYVPE------G 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 184 LKLSC-----TRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAHMHSVAALQKALSTCSSH------------VLV 246
Cdd:cd14969 146 GGTSCsvdwySKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakmvlVMI 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22129563 247 VMFLFG-------SLVHMYLKPSSSynleqdRQVAIFYTLI----SPMLNPLIYSLRNQEVKGAL 300
Cdd:cd14969 226 VAFLIAwtpyavvSLYVSFGGESTI------PPLLATIPALfaksSTIYNPIIYVFMNKQFRRAL 284
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 26-151 1.19e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 49.27  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNtLLVLVACSDPK-LHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLS-------VNRTISYNCC 97
Cdd:cd15312   2 AMYLFMAGAILLTVFGN-LMVIISISHFKqLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVEscwyfgdLFCKIHSSLD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129563  98 MTqlfsfMTVGSMeVHLlGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15312  81 MM-----LSTTSI-FHL-CFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSV 127
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 26-133 1.34e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 48.86  E-value: 1.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVL-IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15064   1 VLISVLLsLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80

                        90       100
                ....*....|....*....|....*....
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYS 133
Cdd:cd15064  81 VTCCTASILHLCVIALDRYWAITDAVEYA 109
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 32-297 2.17e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 48.39  E-value: 2.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTIsYNCCMTQLFSFMTVGSME 111
Cdd:cd15068   8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC-HGCLFIACFVLVLTQSSI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 112 VHLLgAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV---VVSLNSLLYSVLVTRLTfcGNKVTHFFCDiTPLLKLSC 188
Cdd:cd15068  87 FSLL-AIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVlsfAIGLTPMLGWNNCGQPK--EGKNHSQGCG-EGQVACLF 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 189 TRPVVNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVIAH------------MHSVAALQKALSTCSSHVLVV-MFLFGSLV 255
Cdd:cd15068 163 EDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRqlkqmesqplpgERARSTLQKEVHAAKSLAIIVgLFALCWLP 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129563 256 HMYLKPSSSYNLEQDRQ------VAIFYTLISPMLNPLIYSLRNQEVK 297
Cdd:cd15068 243 LHIINCFTFFCPDCSHAplwlmyLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 29-158 2.27e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.60  E-value: 2.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMA-VLGNTLLVLVACSDPKLHT-PMYFLLSqLSLIDISLTTIIVPQMLVHTLSVNRTISYNCC--MTQLFSF 104
Cdd:cd15058   4 LLLLALIILAiVVGNLLVIIAIARTSRLQTmTNIFITS-LACADLVMGLLVVPLGATIVVTGKWQLGNFWCelWTSVDVL 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129563 105 MTVGSMEVhlLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15058  83 CVTASIET--LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFV 134
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
 26-151 2.77e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 47.93  E-value: 2.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15318   2 VIYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDT 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15318  82 LFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLV 127
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 26-220 3.67e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 47.71  E-value: 3.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGV-VLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHtlSVNRTISYNCCMTQLFSF 104
Cdd:cd15083   1 YVLGIfILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVIS--SFSGRWIFGKTGCDMYGF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 M--TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWvvvsLNSLLYSVLV----TRLTFCGNKVThffC 178
Cdd:cd15083  79 SggLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVW----LYSLLWVLPPlfgwSRYVLEGLLTS---C 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129563 179 DITPLLKLSCTRPVVNEMLIFtegvaVVVSPIFFIFGSYVRI 220
Cdd:cd15083 152 SFDYLSRDDANRSYVICLLIF-----GFVLPLLIIIYCYSFI 188
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 36-297 4.53e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 47.47  E-value: 4.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  36 LMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVN---RTISYNCCMTQLFSFMTVGSmev 112
Cdd:cd15070  12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTihfYSCLFMSCLLVVFTHASIMS--- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 113 hlLGAMAYDRYVAICDPLRYSSIVSHSlclRItltsWVVVSLNSLLYSVLVTRLTFCGNKVTHFFCDITPLLKLSCTRPV 192
Cdd:cd15070  89 --LLAIAVDRYLRVKLTVRYRIVTTQR---RI----WLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVM 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 193 VNEMLIFTEGVAVVVSPIFFIFGSYVRIGIVI---------AHMHSVAALQKALSTCSSHVLVVMFLFGSLVHMYLKPSS 263
Cdd:cd15070 160 RMDYMVYFSFFTWILIPLVIMCALYVDIFYIIrnklsqnatGFRETGAFYGREFKTAKSLALVLFLFAVCWLPLSIINCV 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 264 SYNLEQDRQVA----IFYTLISPMLNPLIYSLRNQEVK 297
Cdd:cd15070 240 VYFNPKVPKIAlylgILLSHANSMMNPIVYACKIKKFK 277
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 29-158 6.28e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 47.21  E-value: 6.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACS-DPKLHTPMYFLLSQLSLIDISLTTIIVPQmlVHTLSVNRTISYNCCMTQLFSFMTV 107
Cdd:cd15959   4 GALLSLAILVIVGGNLLVIVAIAkTPRLQTMTNVFVTSLACADLVMGLLVVPP--GATILLTGHWPLGTTVCELWTSVDV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129563 108 --GSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15959  82 lcVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFL 134
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 30-214 6.56e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 46.86  E-value: 6.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSdPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVN-----RTISYNCCMTQLFSF 104
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYsssflSYFYAYFLPYIYPLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVT-RLTFCGNKVTHFFCDITPL 183
Cdd:cd14978  85 NTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEvVECENCNNNSYYYVIPTLL 164

                       170       180       190
                ....*....|....*....|....*....|.
gi 22129563 184 LKLSCTRPVVNemlIFTEGVAVVVSPIFFIF 214
Cdd:cd14978 165 RQNETYLLKYY---FWLYAIFVVLLPFILLL 192
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 26-151 1.17e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 46.29  E-value: 1.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNtLLVLVACSDPK-LHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15317   2 IIYIVLVLAMLITVSGN-LVVIISISHFKqLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15317  81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 25-157 1.70e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 45.54  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGvvlIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVP-QMLVHTLSVNRTISYNCCMTQLFS 103
Cdd:cd14971   4 PLFFA---LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPfTATIYPLPGWVFGDFMCKFVHYFQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129563 104 FMTVgSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSL 157
Cdd:cd14971  81 QVSM-HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 30-300 1.99e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 45.31  E-value: 1.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNR-TISYNCCMTQLFSFMTVG 108
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 109 SMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRltfcgnkvthffcditpllklsc 188
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQ----------------------- 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 189 trpvvNEMLIFTEGVAVVVSPIFFIFGSYVRIGI-----VIAHMHSVAALQKALST--CSSHVL-VVMFLF--------- 251
Cdd:cd15304 143 -----DDSKVFKEGSCLLADENFVLIGSFVAFFIpltimVITYFLTIKSLQQSISNeqKASKVLgIVFFLFvvmwcpffi 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129563 252 GSLVHMYLKPSSSYNLEQD-RQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15304 218 TNVMAVICKESCNEVVIGGlLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 33-177 2.54e-05

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 45.07  E-value: 2.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15206   9 VIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVST 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNS---LLYSVLVTRLTFCGNKVTHFF 177
Cdd:cd15206  89 FTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMspiLVFSNLIPMSRPGGHKCREVW 156
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
 26-133 2.55e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 45.17  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVL-IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15333   5 ISLAVLLaLITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSD 84

                        90       100
                ....*....|....*....|....*....
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYS 133
Cdd:cd15333  85 ITCCTASILHLCVIALDRYWAITDAVEYS 113
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 29-132 3.08e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 44.53  E-value: 3.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTI-IVPQMLVhtlsvnrTISY----NCCMTQLFS 103
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIW-------DITYrfygGDLLCRLVK 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 22129563 104 FMTVGSM--EVHLLGAMAYDRYVAICDPLRY 132
Cdd:cd15196  78 YLQVVGMyaSSYVLVATAIDRYIAICHPLSS 108
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
 30-158 3.37e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 44.89  E-value: 3.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPqmLVHTLSVNRTISYNCCMTQLFSFMTV-- 107
Cdd:cd15958   6 LMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVP--FGATLVVRGRWLYGSFFCELWTSVDVlc 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129563 108 GSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15958  84 VTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFL 134
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
 25-157 4.91e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 44.35  E-value: 4.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVnRTISYNCCMTQLFSF 104
Cdd:cd15394   1 PLIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEP-RGWVFGRFMCYFVFL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129563 105 MTVGSMEVHL--LGAMAYDRYVAICDPLRYSsiVSHSLCLRITLTSWVVVSLNSL 157
Cdd:cd15394  80 MQPVTVYVSVftLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLAL 132
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
 42-300 5.74e-05

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 43.77  E-value: 5.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  42 NTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFmtvgSMEVHLLGAMAYD 121
Cdd:cd15962  18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISLITVGFLVASF----TASVSSLLAITVD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 122 RYVAICDPLRYSSIVShSLCLRITLTSWVVVSLNSLLYSVLvtrltfcgnkvtHFFCdITPLLKLSCTRPVVNEmlifte 201
Cdd:cd15962  94 RYLSLYNALTYYSEKT-VLGVHLMLAATWGVSLCLGLLPVL------------GWNC-LEERASCSIVRPLTKS------ 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 202 GVAVVVSPIFFIFGS----YVRI-GIVIAHMHSVAALQKALSTcsSH-------VLVVMFLFGSLVHMYLkPSSSYNLEQ 269
Cdd:cd15962 154 NVTLLSASFFFIFILmlhlYIKIcKIVCRHAHQIALQQHFLTA--SHyvatkkgVSTLAIILGTFGASWL-PFAIYCVVG 230

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129563 270 DRQVAIFYTLIS-------PMLNPLIYSLRNQEVKGAL 300
Cdd:cd15962 231 DHEYPAVYTYATllpatynSMINPIIYAYRNQEIQRSM 268
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 32-239 5.74e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 44.27  E-value: 5.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNR--TISYNCCMTQLFSFMTVGS 109
Cdd:cd14979   8 VAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwaFGDGGCKLYYFLFEACTYA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 110 MEVHLLgAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFcgnkvtHFFCDITPLLKLSCT 189
Cdd:cd14979  88 TVLTIV-ALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYL------NGPLPGPVPDSAVCT 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129563 190 RPVVNEMLIFTEGVAVVVS---PIFFIFGSYVRIGIVIAHMHSVAALQKALST 239
Cdd:cd14979 161 LVVDRSTFKYVFQVSTFIFfvlPMFVISILYFRIGVKLRSMRNIKKGTRAQGT 213
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 29-159 5.75e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 44.02  E-value: 5.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTI----SYNCCMTQLFSF 104
Cdd:cd15103   5 EVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLvprdSFEQHIDNVIDS 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129563 105 MTVGSMEVHL--LGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLY 159
Cdd:cd15103  85 MICSSLLASIcsLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILF 141
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
 26-160 6.14e-05

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 43.83  E-value: 6.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVL-IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15048   1 IVLAVLIsVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 105 MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVvvsLNSLLYS 160
Cdd:cd15048  81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWI---LAFLLYG 133
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
 26-151 7.23e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 43.76  E-value: 7.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLgNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15335   3 IVLTLALITILTTVL-NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTI 127
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 29-161 1.02e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 43.24  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQ----LFSF 104
Cdd:cd15351   5 GLFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQhmdnVIDT 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22129563 105 MTVGSMEVHL--LGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSV 161
Cdd:cd15351  85 MICSSVVSSLsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIV 143
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 26-151 1.23e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 42.96  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVL-IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTL-----------SVNRTIS 93
Cdd:cd15325   1 IVLGVILgGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEIlgywafgrvfcNIWAAVD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22129563  94 YNCCMTQLFSfmtvgsmevhlLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15325  81 VLCCTASIMS-----------LCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVL 127
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 33-168 1.57e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 42.49  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVST 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTF 168
Cdd:cd15979  89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPV 144
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 27-129 1.66e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 42.42  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLIMY-LMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15073   2 IVAAYLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81

                        90       100
                ....*....|....*....|....
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDP 129
Cdd:cd15073  82 FFGMASIGLLTVVAVDRYLTICRP 105
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
 26-158 2.23e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 42.16  E-value: 2.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMA-VLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCC--MTQLF 102
Cdd:cd15957   1 VGMGIVMSLIVLAiVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCefWTSID 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 103 SFMTVGSMEVhlLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15957  81 VLCVTASIET--LCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFL 134
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 30-300 3.60e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 41.43  E-value: 3.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTL-SVNRTISYNCCMTQLFSFMTVG 108
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILyDYAWPLPRYLCPIWISLDVLFS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 109 SMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVvslnSLLYSVLVtrltfcgnkvthffcditPLLKLSc 188
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTI----SIGISMPI------------------PVIGLQ- 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 189 trpvvNEMLIFTEGVAVVVSPIFFIFGSYVRIGI-----VIAHMHSVAALQKALSTC----SSHVL-VVMFLF------- 251
Cdd:cd15305 143 -----DDEKVFVNGTCVLNDENFVLIGSFVAFFIpliimVITYCLTIQVLQRQQAINnerrASKVLgIVFFLFlimwcpf 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129563 252 --GSLVHMYLKPSSSYNL-EQDRQVAIFYTLISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15305 218 fiTNILSVLCKEACDQKLmEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 21-159 3.80e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 41.45  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  21 PEMQPVIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQ 100
Cdd:cd15321   3 VQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIY 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22129563 101 L-FSFMTVGSMEVHLLgAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV---VVSLNSLLY 159
Cdd:cd15321  83 LaLDVLFCTSSIVHLC-AISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLiaaVISLPPLIY 144
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
 33-131 4.20e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 41.19  E-value: 4.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTiSYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15392   9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYW-PFGEFMCPVVNYLQAVSVFV 87

                        90       100
                ....*....|....*....|.
gi 22129563 113 --HLLGAMAYDRYVAICDPLR 131
Cdd:cd15392  88 saFTLVAISIDRYVAIMWPLR 108
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
 33-168 4.20e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 41.39  E-value: 4.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15978   9 LIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVST 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 113 HLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTF 168
Cdd:cd15978  89 FNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 25-150 5.12e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 41.11  E-value: 5.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLIMyLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVP-QMLVHTLSVNRTISYNCCMTQLFS 103
Cdd:cd15001   1 PVIIVYVITF-VLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPlKTAEYFSPTWSLGAFLCKAVAYLQ 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129563 104 FMTVGSmEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV 150
Cdd:cd15001  80 LLSFIC-SVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWI 125
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 26-158 6.31e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 40.65  E-value: 6.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMY-LMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTL-----------SVNRTIS 93
Cdd:cd15326   1 ILLGLVLGAFiLFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEIlgywvfgrifcDIWAAVD 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22129563  94 YNCCMTQLFSfmtvgsmevhlLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV---VVSLNSLL 158
Cdd:cd15326  81 VLCCTASILS-----------LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVlstVISIGPLL 137
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 26-158 6.81e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 40.55  E-value: 6.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVL-IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPqmLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15062   1 IVVGVALgAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP--FSATLEVLGYWAFGRIFCDVWAA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22129563 105 MTVGSMEVHLLG--AMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV---VVSLNSLL 158
Cdd:cd15062  79 VDVLCCTASIMSlcVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVlslVISIGPLL 137
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 32-151 7.44e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 40.41  E-value: 7.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPqMLVHTLSVNRTISYNCCMTQLFSFMTV--GS 109
Cdd:cd15053   8 LLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMP-FAVYVEVNGGKWYLGPILCDIYIAMDVmcST 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129563 110 MEVHLLGAMAYDRYVAICDPLRYS-SIVSHSLCLRITLTsWVV 151
Cdd:cd15053  87 ASIFNLCAISIDRYIAVTQPIKYArQKNSKRVLLTIAIV-WVV 128
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 33-157 7.72e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 40.74  E-value: 7.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTI--SYNCCMTQLFSFmTVGSM 110
Cdd:cd14997   9 VIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLlgEFMCKLVPFVEL-TVAHA 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129563 111 EVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSL 157
Cdd:cd14997  88 SVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSS 134
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 29-157 8.83e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 40.55  E-value: 8.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTI-IVPQMLVHtlsvnrtISYNCCMTQLF----S 103
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFqVLPQLIWE-------ITYRFQGPDLLcravK 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 104 FMTVGSM--EVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTsWVVVSLNSL 157
Cdd:cd15386  78 YLQVLSMfaSTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGAT-WLLSCILSL 132
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 33-158 9.79e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 40.31  E-value: 9.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLH--TPMYFLLSQLSLIDISLTTIIVPQMLVHTLSvNRTISYNCCMTQLFSFMTV--G 108
Cdd:cd14981   9 LMFVFGVLGNLLALIVLARSSKSHkwSVFYRLVAGLAITDLLGILLTSPVVLAVYAS-NFEWDGGQPLCDYFGFMMSffG 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129563 109 SMEVHLLGAMAYDRYVAICDPLRYSSIVSHSlCLRITLTS-WVVVSLNSLL 158
Cdd:cd14981  88 LSSLLIVCAMAVERFLAITHPFFYNSHVKKR-RARLMLGAvWAFALLIASL 137
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
 26-151 1.34e-03

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 39.91  E-value: 1.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVV-LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLV-HTLSVNRTISYNCCMTQLFS 103
Cdd:cd15207   1 VLFIVSySLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVdNILTGWPFGDVMCKLSPLVQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129563 104 FMTVGSmEVHLLGAMAYDRYVAICDPLRYSSIVSHSLClrITLTSWVV 151
Cdd:cd15207  81 GVSVAA-SVFTLVAIAVDRYRAVVHPTEPKLTNRQAFV--IIVAIWVL 125
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 30-177 1.55e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 39.49  E-value: 1.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDI------SLTTIIVPQMLVHTLSVNRTISYNccMTQLFS 103
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMlvsvsnSLETIMIAVLNSGYLVISDQFIQH--MDNVFD 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 104 FMTVGSMEVHL--LGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSVLVTRLTFCGNKVTHFF 177
Cdd:cd15352  84 SMICISLVASIcnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESKTVIVCLITMFF 159
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 23-169 1.95e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 39.32  E-value: 1.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  23 MQPVIFGVVlimYLMAVLGNTLLVLV-ACSDP--KLHTPMYFLLSqLSLIDISLTTIIVP-QMLVHTLS-------VNRT 91
Cdd:cd15098   2 IVPVVFGLI---FCLGVLGNSLVITVlARVKPgkRRSTTNVFILN-LSIADLFFLLFCVPfQATIYSLPewvfgafMCKF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  92 ISYNCCMTQLFSFMTvgsmevhlLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWV---VVSLNSLLYSVLVTR--- 165
Cdd:cd15098  78 VHYFFTVSMLVSIFT--------LVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVlslAMASPVAVHQDLVHHwta 149


                ....*.
gi 22129563 166 --LTFC 169
Cdd:cd15098 150 snQTFC 155
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 27-158 2.73e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.87  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLImyLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTtiivpqMLVHTLSV-NRTISYN------CCMT 99
Cdd:cd15065   4 IFLSLII--VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVA------LLVMTFAVvNDLLGYWlfgetfCNIW 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22129563 100 QLFSFMTVGSMEVHLLgAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15065  76 ISFDVMCSTASILNLC-AISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFL 133
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 32-161 2.75e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 38.96  E-value: 2.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  32 LIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSME 111
Cdd:cd15012   7 TLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTAS 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129563 112 VHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSV 161
Cdd:cd15012  87 IGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFV 136
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
 33-151 2.99e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 38.80  E-value: 2.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQML-VHTLSVNRTISYNCCMTQLFSFMTVGSME 111
Cdd:cd15310   9 ALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMMCTAS 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129563 112 VHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITL---TSWVV 151
Cdd:cd15310  89 ILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLmitAVWVL 131
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
 29-300 3.40e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 38.61  E-value: 3.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  29 GVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLvhtLSVNRTISynccMTQLFSFMTVG 108
Cdd:cd15102   5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANIL---LSGARTLR----LSPAQWFLREG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 109 SMEVHL------LGAMAYDRYVAICDPLRYSSIVSHSLCLRITlTSWVVvslnsllySVLVTRLTFCGNKVTHFFCDITP 182
Cdd:cd15102  78 SMFVALsasvfsLLAIAIERHLTMAKMKPYGASKTSRVLLLIG-ACWLI--------SLLLGGLPILGWNCLGALDACST 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563 183 LLKLSCTRPVVNEMLIFTEGVAVVVspiffifGSYVRIGIVIAHMHSVAALQKA-------LSTCSSHVLVVMFLFGSLV 255
Cdd:cd15102 149 VLPLYSKHYVLFCVTIFAGILAAIV-------ALYARIYCLVRASGRKATRASAsprslalLKTVLIVLLVFIACWGPLF 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129563 256 HMYLKPSSSYNLEQD--RQVAIFYTL--ISPMLNPLIYSLRNQEVKGAL 300
Cdd:cd15102 222 ILLLLDVACPVKTCPilYKADWFLALavLNSALNPIIYTLRSRELRRAV 270
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 27-151 3.81e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 38.38  E-value: 3.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  27 IFGVVLImyLMAVLGNtLLVLVACSDPK-LHTPMYFLLSQLSLIDISLTTIIVPqmlvhtLSVNRTISYNCCMTQLF--- 102
Cdd:cd15314   5 IFLGLIS--LVTVCGN-LLVIISIAHFKqLHTPTNYLILSLAVADLLVGGLVMP------PSMVRSVETCWYFGDLFcki 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129563 103 --SF-MTVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15314  76 hsSFdITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSV 127
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 30-161 3.94e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 38.35  E-value: 3.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTI---SYNCCMTQLFSFMT 106
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTdaqSFTVNIDNVIDSVI 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129563 107 VGSMEVHL--LGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLLYSV 161
Cdd:cd15353  86 CSSLLASIcsLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFII 142
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 26-161 3.97e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 38.55  E-value: 3.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15336   2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGA 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWvvvsLNSLLYSV 161
Cdd:cd15336  82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVW----LYSLAWSL 133
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 30-131 4.04e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 38.26  E-value: 4.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTI-IVPQMLVHTLSVNRTISYNCcmtQLFSFMTVG 108
Cdd:cd15385   6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFqVLPQLCWDITYRFYGPDFLC---RIVKHLQVL 82

                        90       100
                ....*....|....*....|....*
gi 22129563 109 SM--EVHLLGAMAYDRYVAICDPLR 131
Cdd:cd15385  83 GMfaSTYMLVMMTADRYIAICHPLK 107
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
 33-133 4.09e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 38.39  E-value: 4.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15334   9 ILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSI 88

                        90       100
                ....*....|....*....|.
gi 22129563 113 HLLGAMAYDRYVAICDPLRYS 133
Cdd:cd15334  89 LHLSAIALDRYRAITDAVEYA 109
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 26-134 4.19e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 38.52  E-value: 4.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHtlSVNRTISYNCCMTQLFSFM 105
Cdd:cd15208   2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLV--DVTETWFFGQVLCKIIPYL 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 22129563 106 TVGSMEVHL--LGAMAYDRYVAICDPLRYSS 134
Cdd:cd15208  80 QTVSVSVSVltLSCIALDRWYAICHPLMFKS 110
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 28-151 4.44e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 38.12  E-value: 4.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  28 FGVVLIMYLMAVLGNTLLVLVACSDPKL--HTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15104   2 AGVILAVLSPLIITGNLLVIVALLKLIRkkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV 151
Cdd:cd15104  82 TSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLY 127
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
 33-161 4.50e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 38.09  E-value: 4.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15389   9 IIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVST 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129563 113 HLLGAMAYDRYVAICDPLRysSIVSHSLCLRITLTSWVVVSLNSLLYSV 161
Cdd:cd15389  89 LTLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPHAI 135
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
 26-157 4.98e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 38.02  E-value: 4.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  26 VIFGVVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFM 105
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129563 106 TVGSMEVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSL 157
Cdd:cd15329  82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI 133
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 30-137 5.12e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.99  E-value: 5.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  30 VVLIMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTI--------SYNCCMTQL 101
Cdd:cd15354   6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLviedafvrHIDNVFDSL 85

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 22129563 102 FSFMTVGSMEVHLlgAMAYDRYVAICDPLRYSSIVS 137
Cdd:cd15354  86 ICISVVASMCSLL--AIAVDRYVTIFYALRYHNIMT 119
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
 33-158 7.65e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 37.51  E-value: 7.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLH-TPMYFLLSQLSLIDIsLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSFMTVGSME 111
Cdd:cd15341   9 LCGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADF-LASVVFACSFVDFHVFHGVDSSAIFLLKLGGVTMSFTAS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129563 112 VHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15341  88 LGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYL 134
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 33-131 7.76e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 37.49  E-value: 7.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHtlSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd15202   9 FIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVR--AVNNTWIFGLFMCHFSNFAQYCSVHV 86

                        90       100
                ....*....|....*....|.
gi 22129563 113 HL--LGAMAYDRYVAICDPLR 131
Cdd:cd15202  87 SAytLTAIAVDRYQAIMHPLK 107
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 36-158 9.04e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 37.09  E-value: 9.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  36 LMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLVHTLSVNRTISYN-CCMTQLFSFMTVgSMEVHL 114
Cdd:cd15054  12 LLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDfCPIWYAFDVMCC-SASILN 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129563 115 LGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSLL 158
Cdd:cd15054  91 LCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFL 134
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
 25-164 9.30e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 37.05  E-value: 9.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  25 PVIFGVVLimyLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDisLTTIIVPQMLVHTLSVNRTISYNCCMTQLFSF 104
Cdd:cd15088   4 PSVFGCIC---VVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVAD--LLFMLGMPFLIHQFAIDGQWYFGEVMCKIITA 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22129563 105 MTVGSM--EVHLLGAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVVVSLNSL---LYSVLVT 164
Cdd:cd15088  79 LDANNQftSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILpvwVYSSLIY 143
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
 33-182 9.58e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 37.03  E-value: 9.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129563  33 IMYLMAVLGNTLLVLVACSDPKLHTPMYFLLSQLSLIDISLTTIIVPQMLvhTLSVNRTISYNCCMTQLFSFMTVGSMEV 112
Cdd:cd14992   9 VIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNF--TYVVSLSWEYGHFLCKIVNYLRTVSVYA 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22129563 113 HLL--GAMAYDRYVAICDPLRYSSIVSHSLCLRITLTSWVV---VSLNSLLYSVLVTRLTFCgNKVTHFFCDITP 182
Cdd:cd14992  87 SSLtlTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVsllLAIPQLYYATTEVLFSVK-NQEKIFCCQIPP 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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