NCBI Conserved Domain Search

Conserved domains on [gi|268607658|ref|NP_666965|]

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olfactory receptor 556 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name

Accession

Description

Interval

E-value

7tm_GPCRs super family

cl28897

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

29-304

7.09e-150

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

The actual alignment was detected with superfamily member cd15950:

Pssm-ID: 475119 Cd Length: 275 Bit Score: 421.82 E-value: 7.09e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15950    1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15950  241 GQG-VPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

Name

Accession

Description

Interval

E-value

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-304

7.09e-150

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 421.82 E-value: 7.09e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15950    1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15950  241 GQG-VPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

35-312

1.03e-76

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 236.24 E-value: 1.03e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658   35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  115 ETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLGQdRVP 274
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH-NVP 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 268607658  275 LHTQVLLADLYLIIPPTLNPIIYGIRTRQIRERIWSLL 312
Cdd:pfam13853 240 PLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

29-163

1.68e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 39.76 E-value: 1.68e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMdSTLQEPMYFFLCVLAAVDIVMASsVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:PHA03087  41 TILIVVYSTIFFFGLVGNIIVIYVLTK-TKIKTPMDIYLLNLAVSDLLFVM-TLPFQIYYYILFQWSFGEFACKIVSGLY 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRIltRHVMLGI--SVTITVRAVIFMTPL 163
Cdd:PHA03087 119 YIGFYNSMNFITVMSVDRYIAIVHPVKSNKI--NTVKYGYivSLVIWIISIIETTPI 173

Name

Accession

Description

Interval

E-value

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-304

7.09e-150

Pssm-ID: 320616 Cd Length: 275 Bit Score: 421.82 E-value: 7.09e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15950    1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15950  241 GQG-VPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-304

1.76e-131

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 375.47 E-value: 1.76e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15917    1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15917   81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15917  161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15917  241 GHH-VPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-304

7.87e-113

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 328.10 E-value: 7.87e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15221    1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15221   81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15221  161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQdRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15221  241 GR-HIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-304

2.24e-108

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 316.90 E-value: 2.24e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15953    1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15953   81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15953  161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15953  241 GQG-IAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-304

2.93e-106

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 311.20 E-value: 2.93e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15951    1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15951   81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15951  161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15951  241 GHN-VPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

30-304

2.12e-102

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 301.34 E-value: 2.12e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVH 109
Cdd:cd15222    2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVA 189
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 190 KLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLG 269
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 270 QDRVPLhTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15222  242 KHASPL-VHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-304

1.71e-99

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 294.29 E-value: 1.71e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15952    1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15952   81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVgSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15952  161 AKLACASIRINIIYGLFAISVLV-LDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRF 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15952  240 GHN-IPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

30-308

1.88e-97

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 289.19 E-value: 1.88e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVH 109
Cdd:cd15223    2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVA 189
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 190 KLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLG 269
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607658 270 QDRVPlHTQVLLADLYLIIPPTLNPIIYGIRTRQIRERI 308
Cdd:cd15223  242 KTIPP-DVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

28-305

2.44e-88

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 266.00 E-value: 2.44e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  28 YLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYF 107
Cdd:cd15948    1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 108 VHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMA 187
Cdd:cd15948   81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 188 VAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAW 267
Cdd:cd15948  161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 268607658 268 LGQDRVPlHTQVLLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15948  241 FARHVAP-HVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

13-305

2.31e-87

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 263.95 E-value: 2.31e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  13 PGTFFLLGIPGFQSSYLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSG 92
Cdd:cd15949    1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  93 DSSISFNACFTQMYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPF 172
Cdd:cd15949   81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 173 CASNVVPHSYCEHMAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVM 252
Cdd:cd15949  161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 268607658 253 ALYYLPGMASIYVAWLGQDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15949  241 LAFYVPIAVSSLIHRFGQN-VPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

29-300

1.93e-80

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 245.47 E-value: 1.93e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYVAWL 268
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTII-FMYVRPS 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 269 GQDrvPLHTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd13954  240 SSY--SSDLDKVVSVFYTVVTPMLNPIIYSLR 269

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-304

2.92e-80

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 245.16 E-value: 2.92e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVH 109
Cdd:cd15956    2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVA 189
Cdd:cd15956   82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 190 KLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLG 269
Cdd:cd15956  162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 270 QDrVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15956  242 HS-VPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

30-304

1.87e-79

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 243.14 E-value: 1.87e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVH 109
Cdd:cd15955    2 WIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLS-HLPFCASNVVPHSYCEHMAV 188
Cdd:cd15955   82 TLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15955  162 VKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRF 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQdRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15955  242 GH-HVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

35-312

1.03e-76

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 236.24 E-value: 1.03e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658   35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  115 ETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLGQdRVP 274
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH-NVP 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 268607658  275 LHTQVLLADLYLIIPPTLNPIIYGIRTRQIRERIWSLL 312
Cdd:pfam13853 240 PLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-304

1.35e-75

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 233.18 E-value: 1.35e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15954    1 IWISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15954   81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWL 268
Cdd:cd15954  161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 269 GQDRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15954  241 GGHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

37-306

1.15e-67

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 213.09 E-value: 1.15e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15225    9 LIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHV---------MLGISVTITVRAVIFmtplswmlsHLPFCASNVVPHSYCEHMA 187
Cdd:cd15225   89 FLLAAMAYDRYVAICNPLRYTLIMNRRVclqlvagswLSGILVSLGQTTLIF---------SLPFCGSNEINHFFCDIPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 188 VAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpGMASI-YV- 265
Cdd:cd15225  160 VLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFY--GCASFtYLr 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 268607658 266 ----AWLGQDRvplhtqvLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15225  238 pkssYSPETDK-------LLSLFYTVVTPMLNPIIYSLRNKEVKG 275

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

31-300

2.03e-65

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 206.95 E-value: 2.03e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15912    3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15912   83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYVAWLGQ 270
Cdd:cd15912  163 LSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIF-MYVRPSQS 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 268607658 271 DRVPLHTQVLLadLYLIIPPTLNPIIYGIR 300
Cdd:cd15912  242 SSLDLNKVVAL--LNTVVTPLLNPFIYTLR 269

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

37-306

4.48e-65

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 206.30 E-value: 4.48e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15235   10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTitvravifmtplSWMLSH------------LPFCASNVVPHSYCE 184
Cdd:cd15235   90 FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAG------------SWLLSHlhsllhtllmsrLSFCGSNEIPHFFCD 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 185 HMAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMA--- 261
Cdd:cd15235  158 LQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGvyf 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 268607658 262 ---SIYVAwlGQDRVplhtqvlLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15235  238 qpsSSYSA--DKDRV-------ATVMYTVVTPMLNPFIYSLRNKDVKG 276

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

37-300

9.86e-64

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 202.84 E-value: 9.86e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15918    9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHV---MLGISVTITVRAVIFMTPLswmLSHLPFCASNVVPHSYCEHMAVAKLAC 193
Cdd:cd15918   89 FLLAVMAYDRYVAICHPLHYTTIMSPRLcilLVAASWVITNLHSLLHTLL---MARLSFCASNEIPHFFCDLNPLLKLSC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 194 ADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYvawlgqdrV 273
Cdd:cd15918  166 SDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYL--------S 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 274 PLHTQ-----VLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15918  238 PPSSHsaskdSVAAVMYTVVTPMLNPFIYSLR 269

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

37-304

8.78e-63

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 200.47 E-value: 8.78e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15421    9 LIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAEC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADp 196
Cdd:cd15421   89 LLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCAD- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 197 mpSSLYS---LIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYVAwLGQDRV 273
Cdd:cd15421  168 --TSAYEtvvYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAI-FTYMR-PGSYHS 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 274 PLHTQVLLAdLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15421  244 PEQDKVVSV-FYTILTPMLNPLIYSLRNKEV 273

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

38-300

1.00e-60

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 195.03 E-value: 1.00e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15230   10 IYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15230   90 LLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTH 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGM------ASIYVawLGQD 271
Cdd:cd15230  170 INELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIfmylrpSSSYS--LDQD 247

                        250       260
                 ....*....|....*....|....*....
gi 268607658 272 RVplhtqvlLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15230  248 KV-------VSVFYTVVIPMLNPLIYSLR 269

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

31-300

1.08e-59

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 192.49 E-value: 1.08e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15237    3 LFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHV---MLGISVTITVRAVIFMTPLSWmlsHLPFCASNVVPHSYCEHMA 187
Cdd:cd15237   83 LGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVcvrLAATSWASGFLNSLVLTSLTL---RLPFCGPNHINHFFCEAPA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 188 VAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYVaw 267
Cdd:cd15237  160 VLKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAI-FMYM-- 236

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 268607658 268 lgqdrVPLHTQV-----LLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15237  237 -----RPHSTHSpdqdkMISVFYTIVTPMLNPLIYSLR 269

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

36-306

1.80e-59

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 192.16 E-value: 1.80e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  36 STMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVE 115
Cdd:cd15420    8 SLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 116 TGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACAD 195
Cdd:cd15420   88 CVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACAD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 196 PMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpGMASIYVAWLGQDRVPL 275
Cdd:cd15420  168 TWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFY--GTAMFMYMVPGSSNSAE 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 276 HTQVLLAdLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15420  246 QEKILSL-FYSLFNPMLNPLIYSLRNKQVKG 275

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

38-300

8.75e-59

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 189.97 E-value: 8.75e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15227   10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRhvmlgisvtitvRAVIFMTPLSWMLS------------HLPFCASNVVPHSYCEH 185
Cdd:cd15227   90 LLTVMAYDRYVAICHPLHYEVIMNR------------GACVQMAAASWLSGllygalhtantfSLPFCGSNVIHQFFCDI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 186 MAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMasiyV 265
Cdd:cd15227  158 PQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGS----F 233

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 266 AWLG-QDRVPLHTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15227  234 AYLKpPSDSPSLLDLLLSVFYSVVPPTLNPIIYSLR 269

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

16-305

1.85e-57

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 187.14 E-value: 1.85e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  16 FFLLGIPGFQSSYLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSS 95
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  96 ISFNACFTQMYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCAS 175
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 176 NVVPHSYCEHMAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALY 255
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 256 YlPGMASIYVA-----WLGQDRVplhtqvlLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15408  241 Y-GSLAFMYLRpssrySLDLDKV-------ASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

39-300

1.14e-56

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 184.61 E-value: 1.14e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15911   11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15911   91 LAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYVawlgqdrVPLHTQ 278
Cdd:cd15911  171 VELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLII-VYV-------VPSTNT 242

                        250       260
                 ....*....|....*....|....*..
gi 268607658 279 V-----LLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15911  243 SrdlnkVFSLFYTVLTPLVNPLIYSLR 269

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

31-306

1.57e-56

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 184.39 E-value: 1.57e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGM------ASIY 264
Cdd:cd15231  163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIfnynrpSSGY 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 268607658 265 vawlgqdrvPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15231  243 ---------SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKG 275

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

29-300

6.93e-56

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 182.40 E-value: 6.93e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15226   81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNaQWKALSTCGSHVGVMALYYLPGMasIYVAWL 268
Cdd:cd15226  161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGG-SSKALSTCSAHITVVVLFFGPCI--FIYVWP 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 269 GQDrvpLHTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15226  238 FST---FPVDKFLAVFYTVITPLLNPIIYTLR 266

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

29-300

7.94e-56

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 182.46 E-value: 7.94e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLstmYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15232    4 FWLFLFL---YAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgMASIY---- 264
Cdd:cd15232  161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYY---STVIYtyir 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607658 265 ---VAWLGQDRVplhtqvlLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15232  238 pssSYSPEKDKV-------VAVLYSVVTPTLNPLIYSLR 269

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

35-300

2.66e-55

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 180.88 E-value: 2.66e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:cd15431    7 LLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGIT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAvIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:cd15431   87 ECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSA-FLLTVIPVLTMPLHFCGPNVINHFFCEVQALLKLACS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYVawLGQDRVP 274
Cdd:cd15431  166 DTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAI-FMYL--RPQSKSS 242

                        250       260
                 ....*....|....*....|....*.
gi 268607658 275 LHTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15431  243 SDQDKIISVFYGVVTPMLNPLIYSLR 268

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

31-300

2.82e-54

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 178.20 E-value: 2.82e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15947    3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15947   83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGmasIYVAWLGQ 270
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTA---IYMYLQPP 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 268607658 271 DRVPLHTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15947  240 SSYSQDQGKFISLFYTVVTPTLNPLIYTLR 269

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

39-306

3.72e-54

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 178.28 E-value: 3.72e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15411   11 YVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15411   91 LGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYV-----AWLGQDRV 273
Cdd:cd15411  171 NEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIF-TYLrpsssYSLGQDKV 249

                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607658 274 plhtqvlLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15411  250 -------ASVFYTVVIPMLNPLIYSLRNKEVKN 275

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

38-300

4.46e-54

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 177.79 E-value: 4.46e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15939   10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15939   90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRnAQWKALSTCGSHVGVMALYYLPGMAsIYVawlgQDRVPLHT 277
Cdd:cd15939  170 VIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSE-GRRKALSTCGSHITVVVLFFVPCIF-IYM----RPVTTFPI 243

                        250       260
                 ....*....|....*....|...
gi 268607658 278 QVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15939  244 DKVVAVFYTIITPMLNPLIYTLR 266

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

37-306

5.35e-54

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 177.77 E-value: 5.35e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15234    9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRH---VMLGISVTItvrAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLAC 193
Cdd:cd15234   89 FLLAVMAYDRYVAICHPLHYTVIMNPClcgLLVLLSLLI---SILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 194 ADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMAsiyvAWLGQDRV 273
Cdd:cd15234  166 SDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLG----VYISSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607658 274 PLHTQVLLADL-YLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15234  242 HSSRKTAVASVmYTVVTPMLNPFIYSLRNKDMKG 275

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

37-309

1.22e-53

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 177.21 E-value: 1.22e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15412    9 VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHVMlgISVTITVRAVIFMTPL--SWMLSHLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:cd15412   89 YMLAVMAYDRYMAICNPLLYSVKMSRRVC--ISLVTFPYIYGFLNGLiqTILTFRLSFCGSNVINHFYCADPPLIKLSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgmASIYVAWLgqdRVP 274
Cdd:cd15412  167 DTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFY----GTLFCMYL---RPP 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607658 275 LHTQV----LLADLYLIIPPTLNPIIYGIRTRQIRERIW 309
Cdd:cd15412  240 SEESVeqskIVAVFYTFVSPMLNPLIYSLRNKDVKQALK 278

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

16-312

1.74e-53

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 177.08 E-value: 1.74e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  16 FFLLGIPGFQSSYLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSS 95
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  96 ISFNACFTQMYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCAS 175
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 176 NVVPHSYCEHMAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMA-- 253
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITif 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 254 ------LYYLPgmASIYvawlgqdrvPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRERIWSLL 312
Cdd:cd15410  241 hgtilfMYCRP--SSSY---------SLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

37-306

2.37e-53

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 176.34 E-value: 2.37e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15419    9 VIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHV-MLGISVTITVRAVIFMTPLSWMLShLPFCASNVVPHSYCEHMAVAKLACAD 195
Cdd:cd15419   89 FLLAAMAYDRFIAICNPLLYPVIMSRRVcVQLVAGSYLCGCINSIIQTSFTFS-LSFCGSNEIDHFFCDVPPLLKLSCSD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 196 PMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpGMASIYVAWLGQDRVPL 275
Cdd:cd15419  168 TFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFY--GTVFFMYAQPGAVSSPE 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 276 HTQVlLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15419  246 QSKV-VSVFYTLVIPMLNPLIYSLRNKDVKE 275

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

39-308

3.68e-53

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 175.65 E-value: 3.68e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15434   11 YLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHV---MLGISVTITVRAVIFMTPLSWmlsHLPFCASNVVPHSYCEHMAVAKLACAD 195
Cdd:cd15434   91 LAVMAYDRYAAVCQPLHYTVVMHPRLcwkLVAMSWLIGFGNSLVLSPLTL---SLPRCGHHRVDHFFCEMPALIKLACVD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 196 PMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgMASIYVAWLGQDRVPL 275
Cdd:cd15434  168 TTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFY---GTIIYMYLQPKNSVSQ 244

                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607658 276 HTQVLLADLYLIIPPTLNPIIYGIRTRQIRERI 308
Cdd:cd15434  245 DQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

29-300

1.82e-52

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 173.71 E-value: 1.82e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgmASIYVAWL 268
Cdd:cd15914  161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFF----GSVSFMYL 236

                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607658 269 G-QDRVPLHTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15914  237 RlSKSYSLDYDRAIAVVYAVLTPFFNPIIYSLR 269

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

29-306

3.64e-52

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 172.97 E-value: 3.64e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15429    1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15429   81 LALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpGMASIYVAWL 268
Cdd:cd15429  161 VRLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCY--GTAIFTYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 268607658 269 GQDRVPLHTQvLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15429  239 RSGSSALQEK-MISLFYAVVTPMLNPLIYSLRNKEVKG 275

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

39-304

5.43e-52

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 172.61 E-value: 5.43e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15424   11 YLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15424   91 LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYVawLGQDRVPLHTQ 278
Cdd:cd15424  171 TEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVI-SMYM--RPRSGSTPDRD 247

                        250       260
                 ....*....|....*....|....*.
gi 268607658 279 VLLADLYLIIPPTLNPIIYGIRTRQI 304
Cdd:cd15424  248 KQIAVFYIVITPLLNPIIYTLRNKDV 273

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

39-306

8.33e-52

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 172.01 E-value: 8.33e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15229   11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHV---MLGISVTITVRAVIFMTPLswmLSHLPFCASNVVPHSYCEHMAVAKLACAD 195
Cdd:cd15229   91 LSAMAYDRYAAICHPLHYVQIMSKQVcvqLVGGAWALGFLYALINTLL---LLNLHFCGPNEINHFSCELPSLLPLSCSD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 196 PMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASiYVAWLGQDRVPL 275
Cdd:cd15229  168 TFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFR-YLRPNSASSSVL 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 276 htQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15229  247 --DRVFSIQYSILTPMLNPIIYSLKNKEVKA 275

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

31-309

2.02e-51

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 171.45 E-value: 2.02e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15407   83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGmasIYVAWLGQ 270
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTV---IFMYLQPS 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607658 271 DRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRERIW 309
Cdd:cd15407  240 SSHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFK 278

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

16-306

4.11e-51

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 171.08 E-value: 4.11e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  16 FFLLGIPGFQSSYLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSS 95
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  96 ISFNACFTQMYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCAS 175
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 176 NVVPHSYCEHMAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALY 255
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268607658 256 YlpgMASIYVAWLGQDRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15945  241 Y---GTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKE 288

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

35-306

9.23e-51

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 169.51 E-value: 9.23e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:cd15409    7 FLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILTRHV---MLGISVTITVRAVIFMTPLSWMLShlpFCASNVVPHSYCEHMAVAKL 191
Cdd:cd15409   87 ECFLLAAMAYDRYVAICNPLLYPVVMSNRLcvqLITASYIGGFLHSMIHVGLTFRLS---FCGSNEINHFFCDIPPLLKI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 192 ACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLGQD 271
Cdd:cd15409  164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 272 rvpLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15409  244 ---LDQDMMDSLFYTIVIPLLNPFIYSLRNKEVID 275

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

31-300

9.80e-51

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 169.03 E-value: 9.80e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15913    3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVI-FMTPLSwMLSHLPFCASNVVPHSYCEHMAVA 189
Cdd:cd15913   83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLwFLIPVV-LISQLPFCGPNIIDHFLCDPGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 190 KLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYVAWLG 269
Cdd:cd15913  162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMV-MYVSPGS 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 270 QDRVPLHTQVLLadLYLIIPPTLNPIIYGIR 300
Cdd:cd15913  241 GNSTGMQKIVTL--FYSVVTPLLNPLIYSLR 269

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

38-300

1.39e-50

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 168.70 E-value: 1.39e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15430   10 MYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHV---MLGISVTITVRAVIFMTPLSWMlshLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:cd15430   90 LLAVMAYDRYVAICNPLRYPIIMNKRLcvqMAAGSWVTGFLNSLVETVLAMQ---LPFCGNNVINHFTCEILAVLKLACV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgmASIYVAWLGQDRVP 274
Cdd:cd15430  167 DISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFY----GTILFMYMKPKSKN 242

                        250       260
                 ....*....|....*....|....*..
gi 268607658 275 LH-TQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15430  243 AQiSDKLITLFYGVVTPMLNPIIYSLR 269

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

39-300

2.63e-50

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 168.25 E-value: 2.63e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15915   11 YLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAML 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADP-M 197
Cdd:cd15915   91 LAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTsL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSdVAFISASYSLILKAVFGLS-SRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLG----QDR 272
Cdd:cd15915  171 NLWLLNIVTGSIALGT-FILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGdsleQDR 249

                        250       260
                 ....*....|....*....|....*...
gi 268607658 273 VPlhtqvllADLYLIIPPTLNPIIYGIR 300
Cdd:cd15915  250 IV-------ALLYTVVTPVLNPLIYTLR 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

38-312

3.85e-50

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 168.31 E-value: 3.85e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15943   24 IYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15943  104 LLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTH 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGM------ASIYVawLGQD 271
Cdd:cd15943  184 VNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLfmylrpSSSYS--LDQD 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 268607658 272 RVplhtqvlLADLYLIIPPTLNPIIYGIRTRQIRERIWSLL 312
Cdd:cd15943  262 KV-------VSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

35-300

1.09e-49

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 166.36 E-value: 1.09e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:cd15936    7 FLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:cd15936   87 EVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILkAVFGLSSRNAQWKALSTCGSHVGVMALYYLPgmaSIYVAWLGQDRVP 274
Cdd:cd15936  167 DTFLLELLMVSNSGLVTLLIFFILLISYTVIL-VKIRTHVTEGKRKALSTCASQITVVTLIFVP---CIYIYARPFQTFP 242

                        250       260
                 ....*....|....*....|....*.
gi 268607658 275 LHTQVLLadLYLIIPPTLNPIIYGIR 300
Cdd:cd15936  243 MDKAVSV--LYTVITPMLNPMIYTLR 266

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

31-305

1.10e-48

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 164.14 E-value: 1.10e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPgMASIYVAWLGQ 270
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVP-LTFIYLRPGSQ 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 271 DrvPLHTQVllADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15942  242 D--PLDGVV--AVFYTTVTPLLNPVIYTLRNKEMK 272

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

38-306

4.30e-48

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 162.49 E-value: 4.30e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15413   10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTR---HVMLGISVTITVRAVIFMTPLSWMLShlpFCASNVVPHSYCEHMAVAKLACA 194
Cdd:cd15413   90 LLSAMAYDRYVAICNPLLYTVIMSQrvcIVLVAIPYLYSFFVALFHTIKTFRLS---FCGSNVINHFYCDDLPLLALSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlPGMASIYVAwlGQDRVP 274
Cdd:cd15413  167 DTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFY-GTLIFMYLQ--PKSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 275 LHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15413  244 LDTDKMASVFYTLVIPMLNPLIYSLRNKEVKD 275

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

39-308

1.13e-47

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 161.83 E-value: 1.13e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15414   11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15414   91 LASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPgMASIYV---AW--LGQDRV 273
Cdd:cd15414  171 NKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGT-LFFIYVrpsSSssLDLDKV 249

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 274 plhtqvlLADLYLIIPPTLNPIIYGIRTRQIRERI 308
Cdd:cd15414  250 -------VSVFYTAVIPMLNPLIYSLRNKEVKDAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

38-306

1.41e-47

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 161.38 E-value: 1.41e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15416   10 IYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHV-MLGISVTITVRAVIFMTPLSWMLShLPFCASNVVPHSYCEHMAVAKLACADP 196
Cdd:cd15416   90 LLAAMAYDRYVAICNPLLYSTIMSQKVcVLLVAASYLGGCLNALVFTTCVFS-LSFCGPNEINHFFCDFPPLLKLSCSDI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 197 MPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpGMAS-IYVawLGQDRVPL 275
Cdd:cd15416  169 RLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFY--GTITfIYV--MPNSSYSM 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 276 HTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15416  245 DQNKVVSVFYMVVIPMLNPLIYSLRNKEVKG 275

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

39-300

4.94e-47

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 159.76 E-value: 4.94e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15224   11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15224   91 LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgMASIYVAWLGQDRVPLHTQ 278
Cdd:cd15224  171 AELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFY---SATLFMYARPKAISSFDSN 247

                        250       260
                 ....*....|....*....|..
gi 268607658 279 VLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15224  248 KLVSVLYTVVTPLLNPIIYCLR 269

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

38-305

3.49e-46

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 157.62 E-value: 3.49e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15236   10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15236   90 LLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLGQDRVplhT 277
Cdd:cd15236  170 LNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSD---K 246

                        250       260
                 ....*....|....*....|....*...
gi 268607658 278 QVLLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15236  247 DIVASVMYTVVTPMLNPFIYSLRNRDIK 274

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

36-300

4.32e-46

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 157.22 E-value: 4.32e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  36 STMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVE 115
Cdd:cd15940    8 LVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 116 TGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACAD 195
Cdd:cd15940   88 IFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 196 PMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRnAQWKALSTCGSHVGVMALYYLPGMAsIYVawlgQDRVPL 275
Cdd:cd15940  168 TYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTE-GRRKALSTCASHLTVVTLFFGPCIF-IYT----RPSTSF 241

                        250       260
                 ....*....|....*....|....*
gi 268607658 276 HTQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15940  242 SEDKVVSVFYTVVTPLLNPIIYTLR 266

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

39-306

8.20e-46

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 156.65 E-value: 8.20e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15417   11 YLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRIltrhvmlgISVTITVRAVI------FMTPLSWMLS--HLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15417   91 LAAMAYDRYVAICNPLLYSVI--------MSPRLCVQLVAgaylggFLNSLIQTVSmfQLSFCGPNVIDHFFCDIPPLLS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYV----- 265
Cdd:cd15417  163 LSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGL-FVYLrpsss 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 268607658 266 AWLGQDRVplhtqvlLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15417  242 HSQDQDKV-------ASVFYTVVIPMLNPLIYSLRNKEIKD 275

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

31-305

1.25e-45

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 156.10 E-value: 1.25e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMaSIYVAwlGQ 270
Cdd:cd15428  163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVL-STYMR--PK 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 271 DRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15428  240 SSTSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVK 274

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

16-306

5.27e-44

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 152.63 E-value: 5.27e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  16 FFLLGIPGFQSSYLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSS 95
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  96 ISFNACFTQMYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHV----MLGISVTITVRAVIFmTPLSWMLShlp 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVclqlMAGSYLAGLVNLVIH-TTATFSLS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 172 FCASNVVPHSYCEHMAVAKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGV 251
Cdd:cd15944  157 FCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTG 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 252 MALYYlpgMASIYVAWLGQDRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15944  237 VTLFY---GTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKE 288

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

31-305

7.01e-44

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 151.43 E-value: 7.01e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15228    3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15228   83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADpmPSSLYSLIFSSIIVGSDVAF--ISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPgMASIYVAwl 268
Cdd:cd15228  163 LACAD--TSIAETVSFTNVGLVPLTCFllILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGP-CALIYTQ-- 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 268607658 269 gqdrvPLHTQVLLADLYL---IIPPTLNPIIYGIRTRQIR 305
Cdd:cd15228  238 -----PTPSPVLVTPVQIfnnVVTPMLNPLIYTLRNKEVK 272

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

38-305

2.31e-43

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 150.29 E-value: 2.31e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDS-SISFNACFTQMYFVHAATAVET 116
Cdd:cd15916   10 IYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGkVISFGGCVAQLYFFHFLGSTEC 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 117 GLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADP 196
Cdd:cd15916   90 FLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 197 MPSSLysLIFSSIIVGSDVAF--ISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYVAWLGQDrvP 274
Cdd:cd15916  170 TINEL--VIFASIGVVALGCFilILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVF-IYLRPGSKE--A 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 275 LHTQVllADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15916  245 LDGVI--AVFYTVVTPLLNPLIYTLRNKEVK 273

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

38-300

2.40e-43

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 149.94 E-value: 2.40e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15946   10 IYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15946   90 LFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMasiYVAWLGQDRVPLHT 277
Cdd:cd15946  170 LNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAM---FMYMRPGSNYSPER 246

                        250       260
                 ....*....|....*....|...
gi 268607658 278 QVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15946  247 DKKISLFYNVFTALLNPVIYSLR 269

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

31-306

3.13e-43

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 149.94 E-value: 3.13e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15432    3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAK 190
Cdd:cd15432   83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 LACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgMASIYVAWLGQ 270
Cdd:cd15432  163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFY---GTAISMYLQPP 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 271 DRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15432  240 SNSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKE 275

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

38-306

4.22e-43

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 149.49 E-value: 4.22e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15415   10 IYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15415   90 LLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTH 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASiYVA-----WLGQDR 272
Cdd:cd15415  170 INELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFS-YIQpssqySLEQEK 248

                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607658 273 VplhtqvlLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15415  249 V-------SAVFYTLVIPMLNPLIYSLRNKDVKD 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

39-300

6.72e-43

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 148.87 E-value: 6.72e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15938   11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15938   91 LTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVfglSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYVAWLGQDRVPLHTQ 278
Cdd:cd15938  171 TELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIF-IYARPFSTFPVDKHVS 246

                        250       260
                 ....*....|....*....|..
gi 268607658 279 VlladLYLIIPPTLNPIIYGIR 300
Cdd:cd15938  247 V----LYNVITPMLNPLIYTLR 264

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

39-305

3.70e-42

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 147.25 E-value: 3.70e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15233   11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15233   91 LTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVawLGQDRVPLHTQ 278
Cdd:cd15233  171 NELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMR--LGSVYSSDKDK 248

                        250       260
                 ....*....|....*....|....*..
gi 268607658 279 VlLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15233  249 V-IGILNTVLSPMLNPLIYSLRNKDVK 274

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

38-306

4.71e-42

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 147.13 E-value: 4.71e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15406   19 IYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECY 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15406   99 MLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTY 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIY----VAWLGQDRV 273
Cdd:cd15406  179 INELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLkpssSSSMTQEKV 258

                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607658 274 PlhtqvllADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15406  259 S-------SVFYTTVIPMLNPLIYSLRNKDVKN 284

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

29-300

7.64e-42

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 146.04 E-value: 7.64e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15937    1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAV 188
Cdd:cd15937   81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 189 AKLACADPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQwKALSTCGSHVGVMALYYLPgmaSIYVAWL 268
Cdd:cd15937  161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKS-KAASTCITHIIIVFVMFGP---AIYIYAR 236

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 269 GQDRVPLHTQVllADLYLIIPPTLNPIIYGIR 300
Cdd:cd15937  237 PFRSFPMDKVV--AVFHTVIFPLLNPMIYTLR 266

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

38-305

2.43e-41

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 144.87 E-value: 2.43e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15405   10 IYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 118 LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPM 197
Cdd:cd15405   90 VLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 198 PSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPG----MASIYVAWLGQDRV 273
Cdd:cd15405  170 VNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGafmyLKPSSVGSVNQGKV 249

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 274 plhtqvlLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15405  250 -------SSVFYTNVVPMLNPLIYSLRNKDVK 274

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

29-300

2.93e-41

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 144.52 E-value: 2.93e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTL-QEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYF 107
Cdd:cd15935    1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 108 VHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMA 187
Cdd:cd15935   81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 188 VAKLACADPMPSSLYSLIFSSIIvgSDVAFIS--ASYSLILKAVFGlSSRNAQWKALSTCGSHVGVMALYYLPGMAsIYV 265
Cdd:cd15935  161 VIKLACMDTYVVEVLMVANSGLL--SLVCFLVllVSYGIILTTLRG-RFREGGGKALSTCSSHLTVVSLIFVPCIF-VYL 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 266 AWLGQDRVplhtQVLLADLYLIIPPTLNPIIYGIR 300
Cdd:cd15935  237 RPFSSSSV----DKVASVFYTLITPALNPLIYTLR 267

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

39-306

2.80e-40

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 142.23 E-value: 2.80e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15418   12 YILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPmp 198
Cdd:cd15418   92 LAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDT-- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 sSLYSLIFSSII---VGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlPGMASIYVA-----WLGQ 270
Cdd:cd15418  170 -RVYELILYFILgfnVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYY-GSILFIYSRpssshTPDR 247

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607658 271 DRVplhtqvlLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd15418  248 DKV-------VALFYTVVNPLLNPLIYSLRNKDVKE 276

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

37-305

9.39e-39

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 138.44 E-value: 9.39e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQE-PMYFFLCVLAAVDIVMASSVVPK-MVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:cd15941    9 LIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKvLAGLLTLSGRTISFEGCVVQLYAFHFLAST 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACA 194
Cdd:cd15941   89 ECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 195 DPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYLPGmASIYVawlgQDRVP 274
Cdd:cd15941  169 DTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPS-VFIYL----QPSSS 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607658 275 LHTQVLLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15941  244 QAGAGAPAVFYTIVTPMLNPFIYTLRNKEVK 274

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

39-305

1.51e-38

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 137.62 E-value: 1.51e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  39 YSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGL 118
Cdd:cd15433   11 YLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACADPMP 198
Cdd:cd15433   91 LAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDET 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGSHVGVMALYYlpgmASIYVAWLGQDRVPLHTQ 278
Cdd:cd15433  171 TEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFY----GSAIYTYLQPIHRYSQAH 246

                        250       260
                 ....*....|....*....|....*...
gi 268607658 279 VLLADL-YLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15433  247 GKFVSLfYTVMTPALNPLIYTLRNKDVK 274

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

45-297

5.14e-23

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 95.83 E-value: 5.14e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658   45 GNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDS-SISFNACFTQMYFVHAATAVETGLLLAMA 123
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  124 FDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHlpfCASNVVPHSYCEHMAVAKLACadPMPSSLYS 203
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSK--PVSYTLLI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  204 LIFSSIIVgsdVAFISASYSLILKAVFGLSSRNAQW-------KALSTCGSHVGVMALYYLP---GMASIYVAWLGQDRV 273
Cdd:pfam00001 156 SVLGFLLP---LLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPyhiVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 268607658  274 PLHTQVLLADLYLIIPPTLNPIIY 297
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

31-300

4.74e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 88.11 E-value: 4.74e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCehmavak 190
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 191 lacaDPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVF--------------GLSSRNAQWKALSTCGSHVGVMALYY 256
Cdd:cd00637  154 ----DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLCW 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 268607658 257 LPGMASIYVAWLGQDRVPLHTQVLLADLYLI-IPPTLNPIIYGIR 300
Cdd:cd00637  230 LPYFILLLLDVFGPDPSPLPRILYFLALLLAyLNSAINPIIYAFF 274

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

42-163

1.66e-11

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 63.81 E-value: 1.66e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  42 AVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLLA 121
Cdd:cd14968   14 SVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLA 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 268607658 122 MAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd14968   92 IAIDRYLAIKIPLRYKSLVTgRRAWGAIAVCWVLSFLVGLTPM 134

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

41-171

7.69e-10

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 58.80 E-value: 7.69e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd15068   13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLL 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRHVMLG-ISVTITVRAVIFMTP-LSWMLSHLP 171
Cdd:cd15068   91 AIAIDRYIAIRIPLRYNGLVTGTRAKGiIAICWVLSFAIGLTPmLGWNNCGQP 143

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-306

9.60e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 58.34 E-value: 9.60e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACftqmyfvH 109
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLC-------R 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 110 AATAVETGL-------LLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPLSWMLSHLPFCasnvVPHS 181
Cdd:cd14967   74 FWIALDVLCctasilnLCAISLDRYLAITRPLRYRQLMTkKRALIMIAAVWVYSLLISLPPLVGWRDETQPS----VVDC 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 182 YCEhmavaklacadPMPSSLYSLIFSSIIVGSDVAFISASYSLILKAVfglsSRNAqwKALSTCGSHVGVMALYYLPGM- 260
Cdd:cd14967  150 ECE-----------FTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVA----RREL--KAAKTLAIIVGAFLLCWLPFFi 212

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 268607658 261 ASIYVAWLGQDRVPLHTQVLLADL-YliIPPTLNPIIYGIRTRQIRE 306
Cdd:cd14967  213 IYLVSAFCPPDCVPPILYAVFFWLgY--LNSALNPIIYALFNRDFRR 257

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

35-297

1.08e-09

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 58.38 E-value: 1.08e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNAC--FTQMYFVHAAT 112
Cdd:cd15959    7 LSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCelWTSVDVLCVTA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 113 AVETglLLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPLS---WMLSH---LPFCASNVVPHSYCEH 185
Cdd:cd15959   87 SIET--LCAIAVDRYLAITNPLRYEALVTkRRARTAVCLVWAISAAISFLPIMnqwWRDGAdeeAQRCYDNPRCCDFVTN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 186 MAVAKLACADPMPSSLYSLIFSSIIVgsdvaFISASYSLIL----------KAVFGLSSRNAQW------------KALS 243
Cdd:cd15959  165 MPYAIVSSTVSFYVPLLVMIFVYVRV-----FVVATRQVRLirkdkvrfppEESPPAESRPACGrrpsrllaikehKALK 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 244 TCGSHVGVMALYYLPGMASIYVAWLGQDRVPlhTQVLLADLYL-IIPPTLNPIIY 297
Cdd:cd15959  240 TLGIIMGTFTLCWLPFFVANIIKVFCRSLVP--DPAFLFLNWLgYANSAFNPIIY 292

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

40-163

1.38e-09

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 58.02 E-value: 1.38e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  40 SIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIfsSGDSSISFNACFTQMYFVHAATAVETGLL 119
Cdd:cd15069   12 ALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITI--SLGFCTDFHSCLFLACFVLVLTQSSIFSL 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 268607658 120 LAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRA-VIFMTPL 163
Cdd:cd15069   90 LAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAfGIGLTPF 134

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

30-162

2.92e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 57.22 E-value: 2.92e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACftQMY-FV 108
Cdd:cd14969    2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGC--VIYgFA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 109 HAATAVETGLLLA-MAFDRYVAICKPLHYMRILTRHVMLGISVtITVRAVIFMTP 162
Cdd:cd14969   80 VTFLGLVSISTLAaLAFERYLVIVRPLKAFRLSKRRALILIAF-IWLYGLFWALP 133

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

30-142

5.42e-09

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 56.31 E-value: 5.42e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNAC--FTQMYF 107
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelWTSVDV 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 268607658 108 VHAATAVETglLLAMAFDRYVAICKPLHYMRILTR 142
Cdd:cd15058   82 LCVTASIET--LCVIAVDRYIAITRPLRYQVLLTK 114

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

33-168

5.35e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 53.33 E-value: 5.35e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  33 ISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVD-----IVMASSVVPKMVSIFSSGDSsisfnACFTQMYF 107
Cdd:cd15055    5 IVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADflvglLVMPFSMIRSIETCWYFGDT-----FCKLHSSL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268607658 108 VHAATAVETGLLLAMAFDRYVAICKPLHYmriltrhvmlgiSVTITVRAVIFMTPLSWMLS 168
Cdd:cd15055   80 DYILTSASIFNLVLIAIDRYVAVCDPLLY------------PTKITIRRVKICICLCWFVS 128

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

31-165

7.66e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 52.72 E-value: 7.66e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15064    3 ISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP--LSAVYELTGRWILGQVLCDIWISLD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 268607658 111 ATAVETGL--LLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPLSW 165
Cdd:cd15064   81 VTCCTASIlhLCVIALDRYWAITDAVEYAHKRTpKRAAVMIALVWTLSICISLPPLFG 138

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

41-168

1.22e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 52.36 E-value: 1.22e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVD-----IVMASSVVPKMVSIFSSGDSSISFNACFTQMYfvhaaTAVE 115
Cdd:cd15312   13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDfllgfLVMPYSMVRSVESCWYFGDLFCKIHSSLDMML-----STTS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 268607658 116 TGLLLAMAFDRYVAICKPLHYmriltrhvmlgiSVTITVRAVIFMTPLSWMLS 168
Cdd:cd15312   88 IFHLCFIAVDRYYAVCDPLHY------------RTKITTPVIKVFLVISWSVP 128

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

31-209

1.45e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 51.97 E-value: 1.45e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15065    2 IGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVravifmtpLSWMLSHLPF---CASNVVPHSYC-EHM 186
Cdd:cd15065   82 CSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWI--------LSALISFLPIhlgWHRLSQDEIKGlNHA 153

                        170       180
                 ....*....|....*....|...
gi 268607658 187 AVAKLACADPMPsSLYSLIFSSI 209
Cdd:cd15065  154 SNPKPSCALDLN-PTYAVVSSLI 175

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

31-306

1.84e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 51.52 E-value: 1.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTmysIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVS--IFSSGDSSISFNACFTQMYFV 108
Cdd:cd14972    4 VAIVLGV---FIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSvlLVSLTPSPATWLLRKGSLVLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 109 HAATAVEtglLLAMAFDRYVAICKPLHYMRILTR-HVMLGISVTITVRAVIFMTPLswMLSHLPFCasnvvPHSYCehma 187
Cdd:cd14972   81 LLASAYS---LLAIAVDRYISIVHGLTYVNNVTNkRVKVLIALVWVWSVLLALLPV--LGWNCVLC-----DQESC---- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 188 vakLACADPMPSSLysLIFSSIIVGSDVAFISASYSLILkavFGLSSRNAQWKALSTCGSHV----------------GV 251
Cdd:cd14972  147 ---SPLGPGLPKSY--LVLILVFFFIALVIIVFLYVRIF---WCLWRHANAIAARQEAAVPAqpstsrklaktvvivlGV 218

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 252 MALYYLPGMASIYVAWLGQDRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIRE 306
Cdd:cd14972  219 FLVCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRR 273

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

35-162

1.97e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 51.47 E-value: 1.97e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMA-SSVVPKMVS----IFSSGDSsisfnAC----FTQM 105
Cdd:cd15196    7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWdityRFYGGDL-----LCrlvkYLQV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 268607658 106 YFVHAATAVetglLLAMAFDRYVAICKPLHYMRILTR--HVMLGISVTItvrAVIFMTP 162
Cdd:cd15196   82 VGMYASSYV----LVATAIDRYIAICHPLSSHRWTSRrvHLMVAIAWVL---SLLLSIP 133

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

42-163

3.60e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 50.55 E-value: 3.60e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  42 AVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIfsSGDSSISFNACFTQMYFVHAATAVETGLLLA 121
Cdd:cd15070   14 AVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVV--SLGVTIHFYSCLFMSCLLVVFTHASIMSLLA 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 268607658 122 MAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15070   92 IAVDRYLRVKLTVRYRIVTTqRRIWLALGLCWLVSFLVGLTPM 134

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

30-185

4.30e-07

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 50.58 E-value: 4.30e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISL-STMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15979    1 TVRILLySVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLM 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEH 185
Cdd:cd15979   81 GVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRH 157

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

32-158

6.46e-07

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 49.65 E-value: 6.46e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  32 AISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMV-SIFSSGDSSISFNAC-FTQMYFVH 109
Cdd:cd15053    4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVyVEVNGGKWYLGPILCdIYIAMDVM 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 268607658 110 AATAvETGLLLAMAFDRYVAICKPLHYMRIL-TRHVMLGISVTITVRAVI 158
Cdd:cd15053   84 CSTA-SIFNLCAISIDRYIAVTQPIKYARQKnSKRVLLTIAIVWVVSAAI 132

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

30-142

1.23e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 49.16 E-value: 1.23e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-KMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15304    2 WPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLD 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTR 142
Cdd:cd15304   82 VLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSR 115

7tmA_CB1

cd15340

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-180

1.36e-06

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320462 [Multi-domain] Cd Length: 292 Bit Score: 49.14 E-value: 1.36e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQ-EPMYFFLCVLAAVDIVMASSVVPKMVS--IFSSGDSSisfNACFTQM 105
Cdd:cd15340    1 LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRcRPSYHFIGSLAVADLLGSVIFVYSFLDfhVFHRKDSP---NVFLFKL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 106 YFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTR-HVMLGISVTITVRAVIFMTPL-SWMLSHLPFCASNVVPH 180
Cdd:cd15340   78 GGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRtKAVIAFCVMWTIAIVIAVLPLlGWNCKKLNSVCSDIFPL 154

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

41-159

1.38e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 49.17 E-value: 1.38e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDStLQEPMYFFLCVLAAVDIV-----MASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVE 115
Cdd:cd14978   13 FGIIGNILNLVVLTRKS-MRSSTNVYLAALAVSDILvllsaLPLFLLPYIADYSSSFLSYFYAYFLPYIYPLANTFQTAS 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 268607658 116 TGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIF 159
Cdd:cd14978   92 VWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLL 135

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

35-297

6.56e-06

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 46.65 E-value: 6.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:cd14964    5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLP-FCASNVVPHSYCEHMAVAKLAC 193
Cdd:cd14964   85 SIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPrYNTLTGSCYLICTTIYLTWGFL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 194 ADPMPSSLYSLIFSSIIVgsdVAFISASYSLILKAVFGLSSRNAqwKALSTCGSHVGVMALYYLPGMASIYVAWLGQDRV 273
Cdd:cd14964  165 LVSFLLPLVAFLVIFSRI---VLRLRRRVRAIRSAASLNTDKNL--KATKSLLILVITFLLCWLPFSIVFILHALVAAGQ 239

                        250       260
                 ....*....|....*....|....
gi 268607658 274 PLHTQVLLADLYLIIPPTLNPIIY 297
Cdd:cd14964  240 GLNLLSILANLLAVLASTLNPFIY 263

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

35-173

6.65e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 46.98 E-value: 6.65e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQE-PMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATA 113
Cdd:cd15104    6 LAVLSPLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCA 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 114 VETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVI-----FMTPLSWMLSHLPFC 173
Cdd:cd15104   86 ASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLigflpLISPQFQQTSYKGKC 150

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

30-172

8.16e-06

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 46.61 E-value: 8.16e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIV-----MASSVVPKMVSIFSSGDSsisfnACFTQ 104
Cdd:cd15206    2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLlavfcMPFTLVGQLLRNFIFGEV-----MCKLI 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268607658 105 MYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPF 172
Cdd:cd15206   77 PYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPM 144

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

36-176

9.75e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 46.40 E-value: 9.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  36 STMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIV-----MASSVVPKMVSIFSSGDSsisfnACFTQMYFVHA 110
Cdd:cd15978    8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMlclfcMPFTLIPNLLKDFIFGSA-----VCKTATYFMGI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASN 176
Cdd:cd15978   83 SVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRIN 148

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

25-171

1.17e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 46.39 E-value: 1.17e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  25 QSSYLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMAS-----SVVPKMVSIFSSGDSsisfn 99
Cdd:cd15084    7 RSTYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLfgssvSFSNNIVGFFVFGKT----- 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268607658 100 ACFTQMYFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLP 171
Cdd:cd15084   82 MCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVP 153

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

37-141

1.44e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 45.70 E-value: 1.44e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMY------FVHA 110
Cdd:cd15354    9 TLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsLICI 88

                         90       100       110
                 ....*....|....*....|....*....|.
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILT 141
Cdd:cd15354   89 SVVASMCSLLAIAVDRYVTIFYALRYHNIMT 119

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

31-166

1.59e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 45.68 E-value: 1.59e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmvsiFSSGDSSIS---FNACFTQMYF 107
Cdd:cd15321    9 IAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIP-----FSLANELMGywyFRKTWCEIYL 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268607658 108 VHAATAVETGL--LLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPLSWM 166
Cdd:cd15321   84 ALDVLFCTSSIvhLCAISLDRYWSVSRAIEYNSKRTpRRIKCIILIVWLIAAVISLPPLIYK 145

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

33-308

1.82e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 45.67 E-value: 1.82e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  33 ISLSTMYSI----AVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-KMVSIFSSGDSsisFNA--CFTQM 105
Cdd:cd14993    1 IVLIVLYVVvfllALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPWV---FGEvlCKAVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 106 YFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPhsyceh 185
Cdd:cd14993   78 YLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGT------ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 186 maVAKLACADPMPSSLYSLIFSSIIVGS----DVAFISASYSLIlkaVFGLSSRNAQWKALSTCGSH------------- 248
Cdd:cd14993  152 --ITIYICTEDWPSPELRKAYNVALFVVlyvlPLLIISVAYSLI---GRRLWRRKPPGDRGSANSTSsrrilrskkkvar 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268607658 249 -----VGVMALYYLPgmasIYVAWLGQDRVPLHTQVLLADLYLIIPPTL---------NPIIYGIRTRQIRERI 308
Cdd:cd14993  227 mlivvVVLFALSWLP----YYVLSILLDFGPLSSEESDENFLLILPFAQllgysnsaiNPIIYCFMSKKFRRGF 296

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

41-308

2.21e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 45.33 E-value: 2.21e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd14982   13 LGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGSILFLT 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLswMLSHLPFCASNVVPHSYCEHMavaklacadPMPSS 200
Cdd:cd14982   93 CISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPL--LLLRSTIAKENNSTTCFEFLS---------EWLAS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 201 LYSLIFSSIIVGSDVAF--ISASYSLILKAVFGLSSRNAQW----KALSTCGSHVGVMALYYLP--GMASIYVAWLGQDR 272
Cdd:cd14982  162 AAPIVLIALVVGFLIPLliILVCYSLIIRALRRRSKQSQKSvrkrKALRMILIVLAVFLVCFLPyhVTRILYLLVRLSFI 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 268607658 273 VPLHTQVLLADLYLI------IPPTLNPIIYGIRTRQIRERI 308
Cdd:cd14982  242 ADCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKTFRKRL 283

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

41-160

2.91e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 44.79 E-value: 2.91e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMY------FVHAATAV 114
Cdd:cd15103   13 VSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsMICSSLLA 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILT----RHVMLGISVTITVRAVIFM 160
Cdd:cd15103   93 SICSLLAIAVDRYITIFYALRYHSIMTvrraGVIITAIWVFCTVCGILFI 142

7TM_GPCR_Srsx

pfam10320

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...

41-142

3.64e-05

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.

Pssm-ID: 255903 [Multi-domain] Cd Length: 257 Bit Score: 44.51 E-value: 3.64e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658   41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFssGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:pfam10320   3 IGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLF--TGTQLTRNECFWMISFYIFGQTAQGPLML 80

                          90       100
                  ....*....|....*....|..
gi 268607658  121 AMAFDRYVAICKPLHYMRILTR 142
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSS 102

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

43-152

3.93e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 44.51 E-value: 3.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  43 VLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNAC--FTQMYFVHAATAVETglLL 120
Cdd:cd15958   15 VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCelWTSVDVLCVTASIET--LC 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRHVMLGISVTI 152
Cdd:cd15958   93 VIAIDRYLAITSPFRYQSLLTRARAKGIVCTV 124

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

37-305

3.97e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 44.44 E-value: 3.97e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQ-EPMYFFLCVLAAVDIvMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVE 115
Cdd:cd15099    9 LAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADM-LASVIFTISFLDFHVFHQRDSRNLFLFKLGGVTMAFTAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 116 TGLLLAMAFDRYVAICKPLHYMRILTR-HVMLGISVTITVRAVIFMTPL-SWMLSHLPFCASNVVPHSYCEHMAVAKLac 193
Cdd:cd15099   88 VGSLLLTALDRYLCIYQPSNYKLLVTRtRAKVAILLMWCVTIIISFLPLmGWRCKTWDSPCSRLFPYIDRHYLASWTG-- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 194 adpmpssLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKA--------LSTCGSHVGVMALYYLPGMASIYV 265
Cdd:cd15099  166 -------LQLVLLFLIIYAYPYILWKAHRHEANMGGPKLGRQQVKGQArmrmdirlAKTLSLILLVLAICWLPVLAFMLV 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 268607658 266 AWLGQDRVPLHTQVLLADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd15099  239 DVRVTLTNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELR 278

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

41-163

4.51e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 44.45 E-value: 4.51e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd15071   13 VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILALL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 268607658 121 AMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15071   91 AIAVDRYLRVKIPTRYKSVVTpRRAAVAIAGCWILSFLVGLTPM 134

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

31-163

4.60e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 44.34 E-value: 4.60e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGdsSISFNACFTQMYF--- 107
Cdd:cd15060    3 TTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLG--KWLFGIHLCQMWLtcd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 108 VHAATAVETGlLLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15060   81 ILCCTASILN-LCAIALDRYWAIHDPINYAQKRTlKRVLLMIVVVWALSALISVPPL 136

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

41-158

4.89e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 44.11 E-value: 4.89e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASS--VVPKMVSIFSSGDSSISFNAC------FTQMYFVHAAT 112
Cdd:cd15352   13 VSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnsLETIMIAVLNSGYLVISDQFIqhmdnvFDSMICISLVA 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 268607658 113 AVETglLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVI 158
Cdd:cd15352   93 SICN--LLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIV 136

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

36-172

5.33e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 43.96 E-value: 5.33e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  36 STMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVS-IFSSGDSSISFNACFTQMYFVHAATAV 114
Cdd:cd15394    8 SLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAyAFEPRGWVFGRFMCYFVFLMQPVTVYV 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHymRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPF 172
Cdd:cd15394   88 SVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEF 143

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

41-166

5.58e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 44.20 E-value: 5.58e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIV-----MASSVVP---KMVSIFSSgdssisfNACFTQMYFVHAAT 112
Cdd:cd14997   13 VGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLvllvcMPVALVEtwaREPWLLGE-------FMCKLVPFVELTVA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 268607658 113 AVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWM 166
Cdd:cd14997   86 HASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFI 139

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

37-141

5.92e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 43.74 E-value: 5.92e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVET 116
Cdd:cd15353    9 TLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVNIDNVIDSVICSS 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 268607658 117 GL-----LLAMAFDRYVAICKPLHYMRILT 141
Cdd:cd15353   89 LLasicsLLSIAVDRYFTIFYALQYHNIMT 118

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

43-207

7.12e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 43.80 E-value: 7.12e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  43 VLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNAC--FTQMYFVHAATAVETglLL 120
Cdd:cd15001   14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkaVAYLQLLSFICSVLT--LT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMavaklacadpMPSS 200
Cdd:cd15001   92 AISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKA----------WPST 161


                 ....*..
gi 268607658 201 LYSLIFS 207
Cdd:cd15001  162 LYSRLYV 168

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

42-163

7.78e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 43.52 E-value: 7.78e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  42 AVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSG---------DSSISFNACFTQMYFVHaat 112
Cdd:cd15066   13 AIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGrwmfgyfmcDVWNSLDVYFSTASILH--- 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 268607658 113 avetglLLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15066   90 ------LCCISVDRYYAIVQPLEYPSKMTkRRVAIMLANVWISPALISFLPI 135

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

30-160

1.06e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 43.36 E-value: 1.06e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-KMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15305    2 WPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLD 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTR-HVMLGISVTITVRAVIFM 160
Cdd:cd15305   82 VLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRtKAMMKIAAVWTISIGISM 134

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

41-136

1.15e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 42.89 E-value: 1.15e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd15301   13 VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLL 92

                         90
                 ....*....|....*.
gi 268607658 121 AMAFDRYVAICKPLHY 136
Cdd:cd15301   93 IISFDRYFSVTRPLTY 108

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

41-171

1.20e-04

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 42.90 E-value: 1.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMV-SIFSSGDSSISFNACFTQMYFVHAATAVETGLL 119
Cdd:cd15308   13 AIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVySEFQGGVWTLSPVLCDALMTMDVMLCTASIFNL 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 268607658 120 LAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLP 171
Cdd:cd15308   93 CAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVP 144

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

41-305

1.23e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 42.84 E-value: 1.23e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd14971   13 LGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAVAKLACAdpmpss 200
Cdd:cd14971   93 AMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRAHRRAFA------ 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 201 LYSLIFSSIIvgsDVAFISASYSLILK--------AVFGLSSRNAQWKALSTCGSHVGVMALYYLPGMASIYVAWLGQDR 272
Cdd:cd14971  167 LCTFLFGYLL---PLLLICVCYAAMLRhlwrvavrPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFP 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607658 273 VPLHTQVL--LADLYLIIPPTLNPIIYGIRTRQIR 305
Cdd:cd14971  244 LTYATYALriWAHCLAYSNSAVNPVLYAFLSEHFR 278

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

40-179

1.29e-04

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 43.17 E-value: 1.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  40 SIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHAA----TAVE 115
Cdd:cd15336   12 ITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSP--IFFVNSLHKRWIFGEKGCELYAFCGAlfgiTSMI 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 116 TglLLAMAFDRYVAICKPLHYMRILT-RHVMLGIsvtitvrAVIFMTPLSWMLSHLpFCASNVVP 179
Cdd:cd15336   90 T--LLAISLDRYLVITKPLASIRWVSkKRAMIII-------LLVWLYSLAWSLPPL-FGWSAYVP 144

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

29-169

1.37e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 42.60 E-value: 1.37e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15335    1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPLSWMLSH 169
Cdd:cd15335   81 MTCCTCSILHLCVIALDRYWAITDAIEYARKRTaKRAGLMILTVWTISIFISIPPLFWRNHH 142

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

35-158

1.64e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 42.86 E-value: 1.64e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  35 LSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMAS-SVVPKMVsifssGDSSISFNA----CFTQMYFVH 109
Cdd:cd15386    7 LAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLI-----WEITYRFQGpdllCRAVKYLQV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVI 158
Cdd:cd15386   82 LSMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCIL 130

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

31-162

1.98e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 42.43 E-value: 1.98e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15012    2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTP 162
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTP 133

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

30-146

2.43e-04

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 41.92 E-value: 2.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-KMVSIFSSGDSSISFNACFTQMY-- 106
Cdd:cd15052    2 WAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTld 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 268607658 107 -FVHAATAVEtglLLAMAFDRYVAICKPLHYMRILTRHVML 146
Cdd:cd15052   82 vLFCTASIMH---LCTISLDRYMAIRYPLRTRRNKSRTTVF 119

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

31-142

2.80e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 42.16 E-value: 2.80e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-----KMVSIFSSGDSSISFnacFTQM 105
Cdd:cd15957    3 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPfgaahILLKTWTFGNFWCEF---WTSI 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 268607658 106 YFVHAATAVETglLLAMAFDRYVAICKPLHYMRILTR 142
Cdd:cd15957   80 DVLCVTASIET--LCVIAVDRYFAITSPFKYQSLLTK 114

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

34-141

3.39e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 41.67 E-value: 3.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  34 SLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSI-SFNAC----FTQMYFV 108
Cdd:cd15005    6 TLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCkviaFLAVLFC 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 268607658 109 -HAATavetgLLLAMAFDRYVAICKPLHYMRILT 141
Cdd:cd15005   86 fHSAF-----TLFCIAVTRYMAIAHHRFYAKRMT 114

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

28-165

3.72e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 41.71 E-value: 3.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  28 YLWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMasSVVPKMVSIFSS--GDSSISFNACFTQM 105
Cdd:cd15082   13 FTVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLV--SLTGGTISFLTNarGYFFLGVWACVLEG 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268607658 106 YFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTP-LSW 165
Cdd:cd15082   91 FAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPvLGW 151

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

31-149

3.76e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 41.69 E-value: 3.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMAS-----SVVPKMVSIFSSGDSsisfnACFTQM 105
Cdd:cd15075    3 LSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVfggllSVVTNAVGYFNLGRV-----GCVLEG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 268607658 106 YFVHAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGIS 149
Cdd:cd15075   78 FAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIA 121

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

30-171

4.21e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 41.48 E-value: 4.21e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVH 109
Cdd:cd15307    2 YWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDV 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLP 171
Cdd:cd15307   82 LFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH 143

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

31-162

4.30e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 41.55 E-value: 4.30e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACftQMY--FV 108
Cdd:cd15083    3 LGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYgfSG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTP 162
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP 134

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

29-161

4.83e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 41.38 E-value: 4.83e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMysIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYfv 108
Cdd:cd15318    3 IYLACAIGML--IIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP--FSTIRSVESCWYFGDSFCRLH-- 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 109 haaTAVETGLLLAMAF-------DRYVAICKPLHY-----MRILTRHVMLGISVTITVRAVIFMT 161
Cdd:cd15318   77 ---TCLDTLFCLTSIFhlcfisiDRHCAICDPLLYpskftIRVACIFIAAGWLVPTVYTSVFLYT 138

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

33-184

5.70e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 41.05 E-value: 5.70e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  33 ISLSTMYSI----AVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-KMVSIFSsgdSSISFNACFTQMYF 107
Cdd:cd15203    1 IILILLYGLiivlGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTLT---KNWPFGSILCKLVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 108 VHAATA--VETGLLLAMAFDRYVAICKPLHYmRILTRHVMLGISVTITVrAVIFMTPLSWM--LSHLPFCASNvVPHSYC 183
Cdd:cd15203   78 SLQGVSifVSTLTLTAIAIDRYQLIVYPTRP-RMSKRHALLIIALIWIL-SLLLSLPLAIFqeLSDVPIEILP-YCGYFC 154


                 .
gi 268607658 184 E 184
Cdd:cd15203  155 T 155

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

31-136

5.81e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 40.72 E-value: 5.81e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd17790    3 IVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82

                         90       100
                 ....*....|....*....|....*.
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHY 136
Cdd:cd17790   83 ASNASVMNLLIISFDRYFSITRPLTY 108

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

41-161

6.79e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 40.55 E-value: 6.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMY------FVHAATAV 114
Cdd:cd15351   13 VSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidtMICSSVVS 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268607658 115 ETGLLLAMAFDRYVAICKPLHYMRILT----RHVMLGISVTITVRAVIFMT 161
Cdd:cd15351   93 SLSFLGAIAVDRYITIFYALRYHSIMTlqraVNAIAGIWLASTVSSTLFIV 143

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

31-136

6.88e-04

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 40.59 E-value: 6.88e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15008    2 ASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYL 81

                         90       100
                 ....*....|....*....|....*.
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHY 136
Cdd:cd15008   82 TPGVQIYVLLSICVDRFYTIVYPLSF 107

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

31-142

7.50e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 40.49 E-value: 7.50e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15050    3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYV 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTR 142
Cdd:cd15050   83 ASTASIFSLFILCIDRYRSVQQPLKYLKYRTK 114

7tmA_NPFFR

cd15207

neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...

119-306

7.67e-04

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.

Pssm-ID: 320335 [Multi-domain] Cd Length: 291 Bit Score: 40.68 E-value: 7.67e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 119 LLAMAFDRYVAICKPLHymRILTRHVMLGISVTITVRAVIFMTPLSWMLSHLPFCASNVVPHSYCEHMAvaklacadpmP 198
Cdd:cd15207   91 LVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFW----------P 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 SSLYSLIFS------------SIIVgsdVAFISASYSLILKAV-FGLSSRNAQWKALSTCGSHVGVM--------ALYYL 257
Cdd:cd15207  159 SDEYRKAYTtslfvlcyvaplLIIA---VLYVRIGYRLWFKPVpGGGSASREAQAAVSKKKVRVIKMlivvvvlfALSWL 235

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 268607658 258 PgmasIYVAWLGQDRVPL---HTQVLLADLYLI------IPPTLNPIIYGIRTRQIRE 306
Cdd:cd15207  236 P----LHTVTMLDDFGNLspnQREVLYVYIYPIahwlayFNSCVNPIVYGYFNRNFRK 289

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

41-237

7.77e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 40.73 E-value: 7.77e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSS-----GDSSISFNACFTQmyfvhaATAVE 115
Cdd:cd15095   13 VGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATpswvfGDFMCKFVNYMMQ------VTVQA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 116 TGL-LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTPLSwmLSHLPFCASNVVPHSYCEHMAVAKLAca 194
Cdd:cd15095   87 TCLtLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVA--IYYRLEEGYWYGPQTYCREVWPSKAF-- 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 268607658 195 dPMPSSLYSLIFSSIIvgsDVAFISASYSLILKAVFGLSSRNA 237
Cdd:cd15095  163 -QKAYMIYTVLLTYVI---PLAIIAVCYGLILRRLWRRSVDGN 201

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

33-138

7.98e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 40.49 E-value: 7.98e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  33 ISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMA-SSVVPKMVSIFSSGDSSISFnACFTQMYFVHAA 111
Cdd:cd15197    5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWRITVEWRAGDF-ACKVIRYLQVVV 83

                         90       100
                 ....*....|....*....|....*..
gi 268607658 112 TAVETGLLLAMAFDRYVAICKPLHYMR 138
Cdd:cd15197   84 TYASTYVLVALSIDRYDAICHPMNFSQ 110

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

30-154

9.34e-04

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 40.34 E-value: 9.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  30 WLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGD----SSISFNACFTQM 105
Cdd:cd15310    2 YYALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGvwnfSRICCDVFVTLD 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 268607658 106 YFVHAATAVEtglLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITV 154
Cdd:cd15310   82 VMMCTASILN---LCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLMITA 127

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

31-170

1.07e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 39.98 E-value: 1.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15048    3 LAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYT 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTrhvmlgisvtiTVRAVIFMTpLSWMLSHL 170
Cdd:cd15048   83 LCTASALTIVLISLDRYLSVTKAVKYRAKQT-----------KRRTVLLMA-LVWILAFL 130

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

31-163

1.15e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 39.85 E-value: 1.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmvsiFSSGDSSIS---FNACFTQMYF 107
Cdd:cd15324    3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIP-----FSLANEVMGywyFGSTWCAFYL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 268607658 108 VHAATAVETGL--LLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15324   78 ALDVLFCTSSIvhLCAISLDRYWSVTKAVSYNLKRTpKRIKRMIAVVWVISAVISFPPL 136

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

38-163

1.22e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 40.15 E-value: 1.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  38 MYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHAATAVETG 117
Cdd:cd15205   10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIP--FTLLQNISSNWLGGAFMCKMVPFVQSTAVVTS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268607658 118 LLLAM--AFDRYVAICKPLHYMRILTR---HVMLGIsvtITVRAVIFMTPL 163
Cdd:cd15205   88 ILTMTciAVERHQGIVHPLKMKWQYTNrraFTMLGL---VWIVSVIVGSPM 135

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

31-166

1.25e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 39.92 E-value: 1.25e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmvsiFSSGDSSIS---FNACFTQMYF 107
Cdd:cd15323    3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMP-----FSLANELMGywyFGQVWCNIYL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268607658 108 VHAATAVETGL--LLAMAFDRYVAICKPLHYMRILTRHVMLGISVTI-TVRAVIFMTPLSWM 166
Cdd:cd15323   78 ALDVLFCTSSIvhLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVwLISAVISFPPLISM 139

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

31-163

1.26e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 39.82 E-value: 1.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTL-QEPMYFFLCVLAAVDiVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVH 109
Cdd:cd15341    3 IAVLCTLCGLLCILENVAVLYLILSSPKLrRKPSYLFIGSLALAD-FLASVVFACSFVDFHVFHGVDSSAIFLLKLGGVT 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 110 AATAVETGLLLAMAFDRYVAICKPLHYMRILTR-HVMLGISVTITVRAVIFMTPL 163
Cdd:cd15341   82 MSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRkRALVALAVMWVLTALIAYLPL 136

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

31-163

1.29e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 39.88 E-value: 1.29e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkMVSIFSSGDSSIsFNACFTQMYF--- 107
Cdd:cd15325    3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP-FSAIFEILGYWA-FGRVFCNIWAavd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 108 VHAATAVETGlLLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15325   81 VLCCTASIMS-LCIISIDRYIGVSYPLRYPSIMTeRRGLLALLCVWVLSLVISIGPL 136

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

29-163

1.49e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 39.54 E-value: 1.49e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIP--FSLANEVMGYWYFGKVWCEIYLA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 268607658 109 HAATAVETGL--LLAMAFDRYVAICKPLHY-MRILTRHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15322   79 LDVLFCTSSIvhLCAISLDRYWSITQAIEYnLKRTPRRIKCIIFIVWVISAVISFPPL 136

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

31-163

1.54e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 39.63 E-value: 1.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYF--- 107
Cdd:cd15059    3 ISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMP--FSLVNELMGYWYFGSVWCEIWLald 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 108 VHAATAVETGlLLAMAFDRYVAICKPLHYMRILTRHVMLG-ISVTITVRAVIFMTPL 163
Cdd:cd15059   81 VLFCTASIVN-LCAISLDRYWSVTQAVEYNLKRTPRRAKAmIAAVWIISAVISLPPL 136

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

31-168

1.57e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 39.53 E-value: 1.57e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQmyfVHA 110
Cdd:cd15314    3 LYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMP--PSMVRSVETCWYFGDLFCK---IHS 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 268607658 111 ATAV--ETGLLLAMAF---DRYVAICKPLHYMRiltrhvmlgisvTITVRAVIFMTPLSWMLS 168
Cdd:cd15314   78 SFDItlCTASILNLCFisiDRYYAVCQPLLYRS------------KITVRVVLVMILISWSVS 128

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

31-154

1.62e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 39.49 E-value: 1.62e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmvsiFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15326    3 LGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP-----FSATLEILGYWVFGRIFCDIWA 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 268607658 111 ATAV-----ETGLLLAMAFDRYVAICKPLHYMRILTRH----VMLGISVTITV 154
Cdd:cd15326   78 AVDVlcctaSILSLCAISIDRYIGVRHSLQYPTIVTRKrailALLGVWVLSTV 130

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

29-163

1.68e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 39.76 E-value: 1.68e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMdSTLQEPMYFFLCVLAAVDIVMASsVVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:PHA03087  41 TILIVVYSTIFFFGLVGNIIVIYVLTK-TKIKTPMDIYLLNLAVSDLLFVM-TLPFQIYYYILFQWSFGEFACKIVSGLY 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607658 109 HAATAVETGLLLAMAFDRYVAICKPLHYMRIltRHVMLGI--SVTITVRAVIFMTPL 163
Cdd:PHA03087 119 YIGFYNSMNFITVMSVDRYIAIVHPVKSNKI--NTVKYGYivSLVIWIISIIETTPI 173

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

36-163

2.12e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 39.15 E-value: 2.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  36 STMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCV--LAAVD---IVMASSVVpkmVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd14981    8 ALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLVagLAITDllgILLTSPVV---LAVYASNFEWDGGQPLCDYFGFMMS 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607658 111 ATAVETGLLL-AMAFDRYVAICKP-LHYMRILTRHVMLGISVTITVRAVIFMTPL 163
Cdd:cd14981   85 FFGLSSLLIVcAMAVERFLAITHPfFYNSHVKKRRARLMLGAVWAFALLIASLPL 139

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

31-165

2.26e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 38.88 E-value: 2.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkMVSIFSSGDSSISFNACFTQMYF--- 107
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP-FSILHEMTGGYWLFGRDWCDVWHsfd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 268607658 108 VHAATAVETGlLLAMAFDRYVAICKPLHY-MRILTRHVMLGISVTITVRAVIFMTPLSW 165
Cdd:cd15067   81 VLASTASILN-LCVISLDRYWAITDPISYpSRMTKRRALIMIALVWICSALISFPAIAW 138

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

37-152

2.28e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 38.99 E-value: 2.28e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASS--------VVPKMVSIFSSGDSSISFNACFTQMYFV 108
Cdd:cd15350    9 TIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktleniliILADMGYLNRRGPFETKLDDIMDSLFCL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 268607658 109 HAATAVETglLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTI 152
Cdd:cd15350   89 SLLGSIFS--ILAIAADRYITIFHALRYHNIMTMRRTLVILAII 130

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

31-165

2.43e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 38.78 E-value: 2.43e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15334    3 ISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMP--FSIMYIVKETWIMGQVVCDIWLSVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 268607658 111 ATAVETGL--LLAMAFDRYVAICKPLHYMRILT-RHVMLGISVTITVRAVIFMTPLSW 165
Cdd:cd15334   81 ITCCTCSIlhLSAIALDRYRAITDAVEYARKRTpKHAGIMIAVVWIISIFISMPPLFW 138

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

37-151

2.53e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 38.88 E-value: 2.53e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  37 TMYSI----AVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmvsiFSSGDSSIS----FNA--CFTQMY 106
Cdd:cd15392    5 LMYSTifvlAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVP-----FSFIALLILqywpFGEfmCPVVNY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 268607658 107 FVHAATAVETGLLLAMAFDRYVAICKPLHyMRILTRHVMLGISVT 151
Cdd:cd15392   80 LQAVSVFVSAFTLVAISIDRYVAIMWPLR-PRMTKRQALLLIAVI 123

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

29-136

2.88e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 38.97 E-value: 2.88e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMysIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVP-KMVSIFSS----GDSSISFNACft 103
Cdd:cd15317    3 IYIVLVLAML--ITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfSMIRTVETcwyfGDLFCKFHTG-- 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 268607658 104 qMYFVHAATAVetGLLLAMAFDRYVAICKPLHY 136
Cdd:cd15317   79 -LDLLLCTTSI--FHLCFIAIDRYYAVCDPLRY 108

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

34-162

4.14e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 38.47 E-value: 4.14e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  34 SLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATA 113
Cdd:cd15218    6 SLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSC 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 268607658 114 VETG-LLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTP 162
Cdd:cd15218   86 FHTAfMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFP 135

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

41-163

4.64e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 38.07 E-value: 4.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd15049   13 VTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLL 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 268607658 121 AMAFDRYVAICKPLHY-MRILTRHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15049   93 LISFDRYFSVTRPLTYrAKRTPKRAILMIALAWVISFVLWAPAI 136

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

41-136

4.65e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 38.08 E-value: 4.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd15300   13 ITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLL 92

                         90
                 ....*....|....*.
gi 268607658 121 AMAFDRYVAICKPLHY 136
Cdd:cd15300   93 VISFDRYFSITRPLTY 108

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

31-142

5.15e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 37.85 E-value: 5.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPkmvsiFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd15062    3 VGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP-----FSATLEVLGYWAFGRIFCDVWA 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 268607658 111 ATAV-----ETGLLLAMAFDRYVAICKPLHYMRILTR 142
Cdd:cd15062   78 AVDVlcctaSIMSLCVISVDRYIGVRYPLNYPTIVTA 114

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

31-162

5.56e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 37.80 E-value: 5.56e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHA 110
Cdd:cd14992    3 LGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 268607658 111 ATAVETGLLLAMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTP 162
Cdd:cd14992   83 SVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIP 134

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

31-163

5.95e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 37.70 E-value: 5.95e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  31 LAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSS---------ISFNAC 101
Cdd:cd15051    3 LGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPlgpvfcniyISLDVM 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 268607658 102 FTQMYFVHaatavetglLLAMAFDRYVAICKPLHY-MRILTRHVMLGISVTITVRAVIFMTPL 163
Cdd:cd15051   83 LCTASILN---------LFAISLDRYLAITAPLRYpSRVTPRRVAIALAAIWVVSLAVSFLPI 136

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

29-148

6.14e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 37.64 E-value: 6.14e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  29 LWLAISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMasSVVPKMVSIFSSGDSSISFNACFTQMY-- 106
Cdd:cd15074    1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGI--SVFGYPLAIISAFAHRWLFGDIGCVFYgf 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 268607658 107 --FVHAATAVETglLLAMAFDRYVAICKPLHYMRILTRHVMLGI 148
Cdd:cd15074   79 cgFLFGCCSINT--LTAISIYRYLKICHPPYGPKLSRRHVCIVI 120

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

43-158

7.17e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 37.45 E-value: 7.17e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  43 VLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLLAM 122
Cdd:cd15209   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAI 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 268607658 123 AFDRYVAICKPLHYMRILTRH---VMLGISVTITVRAVI 158
Cdd:cd15209   95 AINRYCYICHSLQYDRLYSLRntcCYLCLTWLLTVLAVL 133

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

32-162

7.21e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 37.66 E-value: 7.21e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  32 AISLSTMYSIAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAA 111
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268607658 112 TAVETGLLLAMAFDRYVAICKPLHymRILTRHVMLGISVTITVRAVIFMTP 162
Cdd:cd15390   84 VAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALP 132

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

43-305

7.24e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 37.45 E-value: 7.24e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  43 VLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVpkmVSIFSSGDSSISFNAC--FTQMYFVHAATAVETGLLL 120
Cdd:cd15102   15 VLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYL---ANILLSGARTLRLSPAqwFLREGSMFVALSASVFSLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRHVMLGISVTITVRAVIFMTP-LSW-MLSHLPFCaSNVVPhSYCEHMAvaklacadpmp 198
Cdd:cd15102   92 AIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPiLGWnCLGALDAC-STVLP-LYSKHYV----------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658 199 ssLYSLIFSSIIVGSDVAFISASYSLILKAVFGLSSRNAQWKALSTCGShVGVMALYYLPGMASIYVAWLGQDRVPLHTQ 278
Cdd:cd15102  159 --LFCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRSLALLKT-VLIVLLVFIACWGPLFILLLLDVACPVKTC 235

                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607658 279 VLL--ADLYL---IIPPTLNPIIYGIRTRQIR 305
Cdd:cd15102  236 PILykADWFLalaVLNSALNPIIYTLRSRELR 267

DUF4827

pfam16109

Domain of unknown function (DUF4827); This family consists of uncharacterized proteins around ...

77-129

8.38e-03

Domain of unknown function (DUF4827); This family consists of uncharacterized proteins around 200 residues in length and is mainly found in various Bacteroides species. Distant homology prediction algorithms consistently suggest a homology between this family and FKBP-type peptidyl-prolyl cis-trans isomerases (PF00254), but this relation is as yet not confirmed. The function of this family is unknown.

Pssm-ID: 435142 Cd Length: 177 Bit Score: 36.49 E-value: 8.38e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 268607658   77 MASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLLAMAFDRYVA 129
Cdd:pfam16109  98 NNSSYPDKFRYTNSSGTFTGSFTDGSGLMYSYYGSTSVPSGWLVPLTYVGNIA 150

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

41-153

9.07e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 37.23 E-value: 9.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607658  41 IAVLGNMLIIIVICMDSTLQEPMYFFLCVLAAVDIVMASSVVPKMVSIFSSGDSSISFNACFTQMYFVHAATAVETGLLL 120
Cdd:cd15299   16 VTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLL 95

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 268607658 121 AMAFDRYVAICKPLHYMRILTRH---VMLGISVTIT 153
Cdd:cd15299   96 VISFDRYFSITRPLTYRAKRTTKragVMIGLAWVIS 131

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01