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Conserved domains on  [gi|169234964|ref|NP_689528|]
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NXPE family member 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neurexophilin super family cl05683
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
 3-123 1.01e-13

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


The actual alignment was detected with superfamily member pfam06312:

Pssm-ID: 428882  Cd Length: 209  Bit Score: 69.51  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234964    3 SPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARN--QGYDKIIFKGKFVNGTSHVFTECGL 80
Cdd:pfam06312  68 TVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFDLEQQYviEAKDSKIFNCRVESEKVDRTTKTNL 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 169234964   81 TLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREV 123
Cdd:pfam06312 148 CNYDPSKTCNQEHTQSHVSWFCSKPFKVICIYISFYSTDYRLV 190
 
Name Accession Description Interval E-value
Neurexophilin pfam06312
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
 3-123 1.01e-13

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


Pssm-ID: 428882  Cd Length: 209  Bit Score: 69.51  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234964    3 SPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARN--QGYDKIIFKGKFVNGTSHVFTECGL 80
Cdd:pfam06312  68 TVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFDLEQQYviEAKDSKIFNCRVESEKVDRTTKTNL 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 169234964   81 TLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREV 123
Cdd:pfam06312 148 CNYDPSKTCNQEHTQSHVSWFCSKPFKVICIYISFYSTDYRLV 190
 
Name Accession Description Interval E-value
Neurexophilin pfam06312
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
 3-123 1.01e-13

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


Pssm-ID: 428882  Cd Length: 209  Bit Score: 69.51  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234964    3 SPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARN--QGYDKIIFKGKFVNGTSHVFTECGL 80
Cdd:pfam06312  68 TVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFDLEQQYviEAKDSKIFNCRVESEKVDRTTKTNL 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 169234964   81 TLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREV 123
Cdd:pfam06312 148 CNYDPSKTCNQEHTQSHVSWFCSKPFKVICIYISFYSTDYRLV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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