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Conserved domains on  [gi|22749079|ref|NP_689729|]
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COMM domain-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

COMM domain-containing protein 1( domain architecture ID 10140826)

COMM domain-containing protein 1 (COMMD1) may act as a scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins

Gene Ontology:  GO:0005507|GO:0070300|GO:0019871|GO:0042803|GO:1901981|GO:0015031
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 12-185 3.87e-108

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 306.75  E-value: 3.87e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  12 LSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQA 91
Cdd:cd04749   1 LSGLLNGIAQKEYYGNAEITEELLRSELYPEDPLEEFRALHNKMRGLLKSIASADMDINQLEAFLTAQTKKQGGITSLQA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  92 AVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQI 171
Cdd:cd04749  81 AVIAKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVELELGKTGQESEFVCLEFDEAKVNRV 160

                       170
                ....*....|....
gi 22749079 172 LKTLSEVEESISTL 185
Cdd:cd04749 161 LKQLAEIQESLDAL 174
 
Name Accession Description Interval E-value
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 12-185 3.87e-108

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 306.75  E-value: 3.87e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  12 LSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQA 91
Cdd:cd04749   1 LSGLLNGIAQKEYYGNAEITEELLRSELYPEDPLEEFRALHNKMRGLLKSIASADMDINQLEAFLTAQTKKQGGITSLQA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  92 AVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQI 171
Cdd:cd04749  81 AVIAKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVELELGKTGQESEFVCLEFDEAKVNRV 160

                       170
                ....*....|....
gi 22749079 172 LKTLSEVEESISTL 185
Cdd:cd04749 161 LKQLAEIQESLDAL 174
COMMD1_N pfam17221
COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.
 6-107 7.75e-63

COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.


Pssm-ID: 465387  Cd Length: 102  Bit Score: 189.50  E-value: 7.75e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079     6 LEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGG 85
Cdd:pfam17221   1 VEGAKPLSGLLNGVAQRTYYGNTEITEELLKEELYPDVSPDEFRALLDKMRGLLKSIASADMDLNQLEAFLTAQTKKQGG 80

                          90       100
                  ....*....|....*....|..
gi 22749079    86 ITSDQAAVISKFWKSHKTKIRE 107
Cdd:pfam17221  81 LSAEQAAAIAKFWKSHKTKIRE 102
 
Name Accession Description Interval E-value
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 12-185 3.87e-108

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 306.75  E-value: 3.87e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  12 LSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQA 91
Cdd:cd04749   1 LSGLLNGIAQKEYYGNAEITEELLRSELYPEDPLEEFRALHNKMRGLLKSIASADMDINQLEAFLTAQTKKQGGITSLQA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  92 AVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQI 171
Cdd:cd04749  81 AVIAKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVELELGKTGQESEFVCLEFDEAKVNRV 160

                       170
                ....*....|....
gi 22749079 172 LKTLSEVEESISTL 185
Cdd:cd04749 161 LKQLAEIQESLDAL 174
COMMD1_N pfam17221
COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.
 6-107 7.75e-63

COMMD1 N-terminal domain; This helical domain is found at the N-terminus of COMMD1.


Pssm-ID: 465387  Cd Length: 102  Bit Score: 189.50  E-value: 7.75e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079     6 LEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGG 85
Cdd:pfam17221   1 VEGAKPLSGLLNGVAQRTYYGNTEITEELLKEELYPDVSPDEFRALLDKMRGLLKSIASADMDLNQLEAFLTAQTKKQGG 80

                          90       100
                  ....*....|....*....|..
gi 22749079    86 ITSDQAAVISKFWKSHKTKIRE 107
Cdd:pfam17221  81 LSAEQAAAIAKFWKSHKTKIRE 102
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 97-182 2.40e-23

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 88.52  E-value: 2.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  97 FWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQ-ESEFLCLEFDEVKVNQILKTL 175
Cdd:cd04748   1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNnSSEKICFEMTKEELQNFLNKL 80


                ....*..
gi 22749079 176 SEVEESI 182
Cdd:cd04748  81 KKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 115-178 3.16e-10

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 53.71  E-value: 3.16e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22749079   115 WNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEV 178
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 58-149 1.05e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 38.18  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749079  58 ILKSIASADMDFNQLEAFLtaqtkKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQ 137
Cdd:cd04752  51 ILSSAAKYNVDGESLSSEL-----QQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQE 125

                        90
                ....*....|..
gi 22749079 138 IHTPVAIIELEL 149
Cdd:cd04752 126 VNEPLVQLRLKV 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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