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Conserved domains on  [gi|22749459|ref|NP_689955|]
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glypican-2 precursor [Homo sapiens]

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
29-512 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 691.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459    29 TRSCAETRQVLGARGYSLNLIPPALISGEHLRVCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFD 108
Cdd:pfam01153  18 ARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTNHRKFD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   109 EFFLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHPQYSFPPDY 188
Cdd:pfam01153  98 EFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYHFSDDY 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   189 LLCLSRLASstdgSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSEALKVPVSEGCSQALMRLIGCPLCRGVPS 268
Cdd:pfam01153 178 LECLSKQTE----QLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLPS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   269 LMPCQGFCLNVVRGCLSSRG-LEPDWGNYLDGLLILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECG 347
Cdd:pfam01153 254 VKPCYNYCLNVMRGCLANQAdLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCG 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   348 PPDPVPARNRRAPPPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAADASLEAA 427
Cdd:pfam01153 334 TPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNEDK 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   428 pCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAATARMKTAALGHDLDGQDADEDASGSGGGQQ 507
Cdd:pfam01153 414 -CWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDG 492


                  ....*
gi 22749459   508 YADDW 512
Cdd:pfam01153 493 CPSDL 497
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
29-512 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 691.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459    29 TRSCAETRQVLGARGYSLNLIPPALISGEHLRVCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFD 108
Cdd:pfam01153  18 ARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTNHRKFD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   109 EFFLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHPQYSFPPDY 188
Cdd:pfam01153  98 EFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYHFSDDY 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   189 LLCLSRLASstdgSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSEALKVPVSEGCSQALMRLIGCPLCRGVPS 268
Cdd:pfam01153 178 LECLSKQTE----QLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLPS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   269 LMPCQGFCLNVVRGCLSSRG-LEPDWGNYLDGLLILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECG 347
Cdd:pfam01153 254 VKPCYNYCLNVMRGCLANQAdLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCG 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   348 PPDPVPARNRRAPPPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAADASLEAA 427
Cdd:pfam01153 334 TPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNEDK 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   428 pCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAATARMKTAALGHDLDGQDADEDASGSGGGQQ 507
Cdd:pfam01153 414 -CWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDG 492


                  ....*
gi 22749459   508 YADDW 512
Cdd:pfam01153 493 CPSDL 497
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
29-512 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 691.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459    29 TRSCAETRQVLGARGYSLNLIPPALISGEHLRVCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFD 108
Cdd:pfam01153  18 ARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTNHRKFD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   109 EFFLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHPQYSFPPDY 188
Cdd:pfam01153  98 EFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYHFSDDY 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   189 LLCLSRLASstdgSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSEALKVPVSEGCSQALMRLIGCPLCRGVPS 268
Cdd:pfam01153 178 LECLSKQTE----QLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLPS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   269 LMPCQGFCLNVVRGCLSSRG-LEPDWGNYLDGLLILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECG 347
Cdd:pfam01153 254 VKPCYNYCLNVMRGCLANQAdLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCG 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   348 PPDPVPARNRRAPPPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAADASLEAA 427
Cdd:pfam01153 334 TPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNEDK 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749459   428 pCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAATARMKTAALGHDLDGQDADEDASGSGGGQQ 507
Cdd:pfam01153 414 -CWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDG 492


                  ....*
gi 22749459   508 YADDW 512
Cdd:pfam01153 493 CPSDL 497
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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