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Conserved domains on  [gi|289666762|ref|NP_690004|]
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zinc finger protein 555 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289666762    3 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-595 3.10e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 198 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 274
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 275 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 353
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 354 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 427
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 428 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 500
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 501 RHTAEKLYKCK--QCGKAFS-----WPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 569
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 289666762 570 GKAFNCSSSLRRHVRIHTTEKQYKCN 595
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289666762    3 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-48 4.44e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.44e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 289666762     4 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-42 2.12e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.12e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 289666762   6 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 42
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-595 3.10e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 198 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 274
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 275 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 353
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 354 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 427
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 428 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 500
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 501 RHTAEKLYKCK--QCGKAFS-----WPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 569
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 289666762 570 GKAFNCSSSLRRHVRIHTTEKQYKCN 595
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-462 1.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.40e-04
                          10        20
                  ....*....|....*....|....*
gi 289666762  438 SLRKHMRTHTREKPYECKQCGKAFS 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 199-247 8.25e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 8.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 289666762 199 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 247
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289666762    3 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-48 4.44e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.44e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 289666762     4 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-42 2.12e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.12e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 289666762   6 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 42
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-595 3.10e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 198 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 274
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 275 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 353
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 354 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 427
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 428 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 500
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 501 RHTAEKLYKCK--QCGKAFS-----WPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 569
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 289666762 570 GKAFNCSSSLRRHVRIHTTEKQYKCN 595
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-468 1.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 207 KTFPRTSSLNRHVRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTITHTGEKPYKC 286
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 287 KECAEAFSYSSTFRRHMISHTGE-------KPHKCKECGEAFSYSSAFRRHM--ITHTGE--KPYEC--KQCGKTFIYLQ 353
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 354 SFRRHERIHTGEKPYECK--QCGKTF-----IYPQSFRRHERTHGGEKPYEC--NQCGKAFSHPSSFRGHMRVHTGEKPY 424
Cdd:COG5048  338 ALKRHILLHTSISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 289666762 425 ECK--QCGKTFNWPISLRKHMRTHTREKPYECKQCGKAFSLSACFR 468
Cdd:COG5048  418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-387 1.11e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 121 GEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKSPITVHTGHK---PYQCQECGQAYSCRSHLRMHVRTHNGE 197
Cdd:COG5048  173 ANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 198 RPYVCKLCG------KTFPRTSSLNRHVRIHTAEKT-YECKQCGKAFIDFSSLTSHLRS--HTGE--KPYKCKE--CGKA 264
Cdd:COG5048  253 SSSSASESPrsslptASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 265 FSYSSTFRRHTITHTGEKPYKCKEC-----------AEAFSYSSTFRRHMISHTGEKPHKCKEcgEAFSYSSAFRRHMIT 333
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEKLLnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCI--RNFKRDSNLSLHIIT 410

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289666762 334 HTGEKPYECK--QCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHE 387
Cdd:COG5048  411 HLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-359 1.30e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762  87 IWDSLSIEDQTTNQGRNLSRNHGLERLCESNDQCGEALSQIPHLNLYKKIPPGVKQYEYNTYGKVF-----MHRRTSLKS 161
Cdd:COG5048  171 LPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSS 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 162 PITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGER-PYVCKLCGKTFPRTSSLNRHVR--IHTAE--KTYEC--KQCG 234
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCG 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 235 KAFIDFSSLTSHLRSHTGEKPYKCK--ECGKAFSYSSTFRRHTIT--HTGEKPYKCKECA-----EAFSYSSTFRRHMIS 305
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLsnsciRNFKRDSNLSLHIIT 410

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289666762 306 HTGEKPH--KCKECGEAFSYSSAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHE 359
Cdd:COG5048  411 HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-600 7.51e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 7.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 282 KPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYS--SAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHE 359
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 360 RIHTGE-KPYECKQCGKTFIYPQSFRRHERTH---GGEKPYECNQCGKAFSHPSSFRGHMRVHTgekpyeckQCGKTFNW 435
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPANS--------LSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 436 PISLRKHMRTHTREKPYECKQCGKAFSLSACFREHVRMHPEDkSYECKLCGKAfyCHISLQKHMRRHTAEKLYK--CKQC 513
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQL--SPKSLLSQSPSSLSSSDSSssASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 514 GKAFSWPELLQQ--HVRTHTVE-----KPYECKECGKVFKWPSSLPIHMR--LHTGE--KPYQCKH--CGKAFNCSSSLR 580
Cdd:COG5048  261 PRSSLPTASSQSssPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340
                 ....*....|....*....|
gi 289666762 581 RHVRIHTTEKQYKCNVGHPP 600
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSS 360
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-462 1.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.40e-04
                          10        20
                  ....*....|....*....|....*
gi 289666762  438 SLRKHMRTHTREKPYECKQCGKAFS 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
534-627 1.57e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666762 534 KPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKAFNCS--SSLRRHVRIHTTEKQYKCNVGHPPANEF--MCSAS 609
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSSLS 111

                         90
                 ....*....|....*...
gi 289666762 610 EKSHQERDLIKVVNMVLP 627
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP 129
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-351 1.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666762  326 AFRRHMITHTGEKPYECKQCGKTFIY 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666762  242 SLTSHLRSHTGEKPYKCKECGKAFSY 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-379 2.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666762  354 SFRRHERIHTGEKPYECKQCGKTFIY 379
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-546 3.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.25e-04
                          10        20
                  ....*....|....*....|....
gi 289666762  523 LQQHVRTHTVEKPYECKECGKVFK 546
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-323 3.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.69e-04
                          10        20
                  ....*....|....*....|....*
gi 289666762  299 FRRHMISHTGEKPHKCKECGEAFSY 323
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-407 6.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666762  382 SFRRHERTHGGEKPYECNQCGKAFSH 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
554-575 9.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.28e-04
                          10        20
                  ....*....|....*....|..
gi 289666762  554 HMRLHTGEKPYQCKHCGKAFNC 575
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-434 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|.
gi 289666762  414 HMRVHTGEKPYECKQCGKTFN 434
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-518 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*
gi 289666762  494 SLQKHMRRHTAEKLYKCKQCGKAFS 518
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-237 3.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....
gi 289666762  214 SLNRHVRIHTAEKTYECKQCGKAF 237
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-209 4.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.51e-03
                          10        20
                  ....*....|....*....|....
gi 289666762  186 HLRMHVRTHNGERPYVCKLCGKTF 209
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-295 6.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|....*
gi 289666762  271 FRRHTITHTGEKPYKCKECAEAFSY 295
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 199-247 8.25e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 8.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 289666762 199 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 247
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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